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Impact of Hemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score on Mortality in Above-Ankle Amputation of Diabetic Foot Infection

Yıl 2025, Cilt: 9 Sayı: 2, 258 - 266, 31.05.2025

Hilal Yağar , Abdussamed Vural , Turgut Dolanbay

https://doi.org/10.30621/jbachs.1451540

Öz

Background and Purpose: :Diabetic foot ulcers are one of the important reasons for amputations The hemoglobin–albumin–lymphocyte–platelet (HALP) score is a marker of the inflammatory and nutritional status of the individual. Aim of this study is to investigate the relationship between the HALP score and mortality in patients undergoing above-ankle amputation due to diabetic foot infection.
Methods: The demographic data (age, sex), deaths during hospitalization, laboratory values and mortality through 3-6-9-12 months were recorded. Chi square and t test were used for categorical comparation and logistic regression tests were used for mortality risk estimation.
Results:. The mortality rates in hospital and in the 3rd, 6th, 9th, and 12th months were 13.1%, 37.7%, 48.5%, 53.8%, and 56.2%. HALP score below 21.55 had a 1-year mortality risk that was 2.975 times than that of score above 21.55 (odds ratio=2.975, 95% CI [1.252-7.069]; p=0.014). Female gender and a HALP score of less than 21.55 and older age than 65 estimates a 20.2% overall 1-year mortality risk (Nagelkerke R square: 0.202).
Conclusion: The HALP score is an essential predictor of prognosis in patients undergoing amputation for diabetic foot ulcers. Also; older age and female gender are independent risk factors for 1-year mortality.

Anahtar Kelimeler

diabetic foot infection HALP score prognosis amputation mortality

Etik Beyan

The study protocol was approved by the Non-Invasive Clinical Research Ethics Committee of Niğde Ömer Halisdemir University (Date: 29.08.2023, Decision No: 401670, Protocol No: 2023/51). The study was conducted following the criteria of the Declaration of Helsinki.

Kaynakça

  • Graz H, D'Souza VK, Alderson DEC, Graz M. Diabetes-related amputations create considerable public health burden in the UK. Diabetes Res Clin Pract 2018;135:158-165.
  • Holman N, Young RJ, Jeffcoate WJ. Variation in the recorded incidence of amputation of the lower limb in England. Diabetologia 2012;55(7):1919-25.
  • Slovenkai MP. Foot problems in diabetes. Med Clin North Am 1998;82(4):949-71.
  • Moulik PK, Mtonga R, Gill GV. Amputation and mortality in new-onset diabetic foot ulcers stratified by etiology. Diabetes Care 2003;26(2):491-4.
  • Rush DS, Huston CC, Bivins BA, Hyde GL. Operative and late mortality rates of above-knee and below-knee amputations. Am Surg 1981;47(1):36-9.
  • Bondor CI, Veresiu IA, Florea B, Vinik EJ, Vinik AI, Gavan NA. Epidemiology of Diabetic Foot Ulcers and Amputations in Romania: Results of a Cross-Sectional Quality of Life Questionnaire Based Survey. J Diabetes Res 2016;2016:5439521.
  • Larsson J, Apelqvist J. Towards less amputations in diabetic patients. Incidence, causes, cost, treatment, and prevention--a review. Acta Orthop Scand 1995;66(2):181-92.
  • Boulton AJ, Vileikyte L, Ragnarson-Tennvall G, Apelqvist J. The global burden of diabetic foot disease. Lancet 2005;366(9498):1719-24.
  • Oyibo SO, Jude EB, Tarawneh I, Nguyen HC, Harkless LB, Boulton AJ. A comparison of two diabetic foot ulcer classification systems: the Wagner and the University of Texas wound classification systems. Diabetes Care 2001;24(1):84-8.
  • Reiber GE, Vileikyte L, Boyko EJ, del Aguila M, Smith DG, Lavery LA, Boulton AJ. Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings. Diabetes Care 1999;22(1):157-62.
  • Wagner FW. A classification and treatment program for diabetic, neuropathic, and dysvascular foot problems. Instr Course Lect 1979;28(1):143-65.
  • Mehraj M, Shah I. A review of Wagner classification and current concepts in management of diabetic foot. Int J Orthop Sci 2018;4(1):933-5.
  • Setacci C, Sirignano P, Mazzitelli G, Setacci F, Messina G, Galzerano G, de Donato G. Diabetic foot: surgical approach in emergency. Int J Vasc Med 2013;2013:296169.
  • Xu SS, Li S, Xu HX, Li H, Wu CT, Wang WQ, Gao HL, Jiang W, Zhang WH, Li TJ, Ni QX, Liu L, Yu XJ. Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer. World J Gastroenterol 2020;26(8):828-838.
  • Tian M, Li Y, Wang X, Tian X, Pei LL, Wang X, Zhang L, Sun W, Wu J, Sun S, Ning M, Buonanno F, Xu Y, Song B. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score Is Associated With Poor Outcome of Acute Ischemic Stroke. Front Neurol 2021;11:610318.
  • Zhai B, Chen J, Wu J, Yang L, Guo X, Shao J, Xu H, Shen A. Predictive value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and lymphocyte-to-monocyte ratio (LMR) in patients with non-small cell lung cancer after radical lung cancer surgery. Ann Transl Med 2021;9(12):976.
  • Sen P, Demirdal T. Evaluation of mortality risk factors in diabetic foot infections. Int Wound J 2020;17(4):880-889.
  • Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y. Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis. Ann Med 2017;49(2):106-116.
  • Nather A, Bee CS, Huak CY, Chew JL, Lin CB, Neo S, Sim EY. Epidemiology of diabetic foot problems and predictive factors for limb loss. J Diabetes Complications 2008;22(2):77-82.
  • Hicks CW, Selvarajah S, Mathioudakis N, Perler BA, Freischlag JA, Black JH 3rd, Abularrage CJ. Trends and determinants of costs associated with the inpatient care of diabetic foot ulcers. J Vasc Surg 2014;60(5):1247-1254.e2.
  • Lynar SA, Robinson CH, Boutlis CS, Commons RJ. Risk factors for mortality in patients with diabetic foot infections: a prospective cohort study. Intern Med J 2019;49(7):867-873.
  • Chen L, Sun S, Gao Y, Ran X. Global mortality of diabetic foot ulcer: A systematic review and meta-analysis of observational studies. Diabetes Obes Metab 2023;25(1):36-45.
  • Seghieri G, Policardo L, Gualdani E, Anichini R, Francesconi P. Gender difference in the risk for cardiovascular events or mortality of patients with diabetic foot syndrome. Acta Diabetol 2019;56(5):561-567.
  • Lavery LA, van Houtum WH, Armstrong DG, Harkless LB, Ashry HR, Walker SC. Mortality following lower extremity amputation in minorities with diabetes mellitus. Diabetes Res Clin Pract 1997;37(1):41-7.
  • Adeleye OO, Ugwu ET, Gezawa ID, Okpe I, Ezeani I, Enamino M. Predictors of intra-hospital mortality in patients with diabetic foot ulcers in Nigeria: data from the MEDFUN study. BMC Endocr Disord 2020;20(1):134.
  • Nirantharakumar K, Saeed M, Wilson I, Marshall T, Coleman JJ. In-hospital mortality and length of stay in patients with diabetes having foot disease. J Diabetes Complications 2013;27(5):454-8.
  • Malyar NM, Freisinger E, Meyborg M, Lüders F, Gebauer K, Reinecke H, Lawall H. Amputations and mortality in in-hospital treated patients with peripheral artery disease and diabetic foot syndrome. J Diabetes Complications 2016;30(6):1117-22.
  • Costa RHR, Cardoso NA, Procópio RJ, Navarro TP, Dardik A, de Loiola Cisneros L. Diabetic foot ulcer carries high amputation and mortality rates, particularly in the presence of advanced age, peripheral artery disease and anemia. Diabetes Metab Syndr 2017;11 Suppl 2:S583-S587.
  • Vuorlaakso M, Kiiski J, Salonen T, Karppelin M, Helminen M, Kaartinen I. Major Amputation Profoundly Increases Mortality in Patients With Diabetic Foot Infection. Front Surg 2021;8:655902.
  • Armstrong DG, Wrobel J, Robbins JM. Guest Editorial: are diabetes-related wounds and amputations worse than cancer? Int Wound J 2007;4(4):286-7.
  • Martins-Mendes D, Monteiro-Soares M, Boyko EJ, Ribeiro M, Barata P, Lima J, Soares R. The independent contribution of diabetic foot ulcer on lower extremity amputation and mortality risk. J Diabetes Complications 2014;28(5):632-8.
  • Kahraman C, Yümün G, Kahraman NK, Namdar ND, Cosgun S. Neutrophil-to-lymphocyte ratio in diabetes mellitus patients with and without diabetic foot ulcer. Eur J Med Sci. 2014;1(1):8-13.
  • Chen W, Chen K, Xu Z, Hu Y, Liu Y, Liu W, Hu X, Ye T, Hong J, Zhu H, Shen F. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Predict Mortality in Patients with Diabetic Foot Ulcers Undergoing Amputations. Diabetes Metab Syndr Obes 2021;14:821-829.
  • Demirdal T, Sen P. The significance of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and lymphocyte-monocyte ratio in predicting peripheral arterial disease, peripheral neuropathy, osteomyelitis and amputation in diabetic foot infection. Diabetes Res Clin Pract 2018;144:118-125.
  • Muller M, Trocme C, Lardy B, Morel F, Halimi S, Benhamou PY. Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing. Diabet Med 2008;25(4):419-26.
  • Zhang SS, Tang ZY, Fang P, Qian HJ, Xu L, Ning G. Nutritional status deteriorates as the severity of diabetic foot ulcers increases and independently associates with prognosis. Exp Ther Med 2013;5(1):215-222.
  • Gau BR, Chen HY, Hung SY, Yang HM, Yeh JT, Huang CH, Sun JH, Huang YY. The impact of nutritional status on treatment outcomes of patients with limb-threatening diabetic foot ulcers. J Diabetes Complications 2016;30(1):138-42.
  • Lauwers P, Dirinck E, Van Bouwel S, Verrijken A, Van Dessel K, Van Gils C, Sels M, Peiffer F, Van Schil P, De Block C, Hendriks J. Malnutrition and its relation with diabetic foot ulcer severity and outcome: a review. Acta Clin Belg 2022;77(1):79-85.
  • Xu M, Chen L, Hu Y, Wu J, Wu Z, Yang S, Kang W, He J, Ren W. The HALP (hemoglobin, albumin, lymphocyte, and platelet) score is associated with early-onset post-stroke cognitive impairment. Neurological Sciences. 2023;44(1):237-45.
  • Liu Y, Wang Y, Meng Y, Wang Q, Guo Y. Correlation between the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score and Left Ventricular Hypertrophy in Older Patients with Hypertension. Cardiovascular Innovations and Applications. 2023;8(1):20230068.
  • Eskin F, Tutan D. A novel prognostic tool for predicting mortality in palliative care patients: HALP score: HALP score and prediction of mortality. The Injector 2023;2(1):43-51.
  • Fuadhi SA, Handaya AY, Setyawan N, Barmawi A, Sofii I. The comparison of GNRI versus HALP score as an outcome predictor in geriatric rectal cancer patients. Bali Medical Journal 2023;12(2):2312-9.
  • Forster S, Gariballa S. Age as a determinant of nutritional status: a cross sectional study. Nutr J 2005;4:28.
  • Agarwalla R, Saikia AM, Baruah R. Assessment of the nutritional status of the elderly and its correlates. J Family Community Med 2015;22(1):39-43.
  • Yu JM, Yang M, Xu HX, Li W, Fu ZM, Lin Y, Shi YY, Song CH, Shi HP, Guo ZQ; Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group. Association Between Serum C-Reactive Protein Concentration and Nutritional Status of Malignant Tumor Patients. Nutr Cancer 2019;71(2):240-245.
  • Tan CS, Read JA, Phan VH, Beale PJ, Peat JK, Clarke SJ. The relationship between nutritional status, inflammatory markers and survival in patients with advanced cancer: a prospective cohort study. Support Care Cancer 2015;23(2):385-91.

Impact of Hemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score on Mortality in Above-Ankle Amputation of Diabetic Foot Infection

Yıl 2025, Cilt: 9 Sayı: 2, 258 - 266, 31.05.2025

Hilal Yağar , Abdussamed Vural , Turgut Dolanbay

https://doi.org/10.30621/jbachs.1451540

Öz

Kaynakça

  • Graz H, D'Souza VK, Alderson DEC, Graz M. Diabetes-related amputations create considerable public health burden in the UK. Diabetes Res Clin Pract 2018;135:158-165.
  • Holman N, Young RJ, Jeffcoate WJ. Variation in the recorded incidence of amputation of the lower limb in England. Diabetologia 2012;55(7):1919-25.
  • Slovenkai MP. Foot problems in diabetes. Med Clin North Am 1998;82(4):949-71.
  • Moulik PK, Mtonga R, Gill GV. Amputation and mortality in new-onset diabetic foot ulcers stratified by etiology. Diabetes Care 2003;26(2):491-4.
  • Rush DS, Huston CC, Bivins BA, Hyde GL. Operative and late mortality rates of above-knee and below-knee amputations. Am Surg 1981;47(1):36-9.
  • Bondor CI, Veresiu IA, Florea B, Vinik EJ, Vinik AI, Gavan NA. Epidemiology of Diabetic Foot Ulcers and Amputations in Romania: Results of a Cross-Sectional Quality of Life Questionnaire Based Survey. J Diabetes Res 2016;2016:5439521.
  • Larsson J, Apelqvist J. Towards less amputations in diabetic patients. Incidence, causes, cost, treatment, and prevention--a review. Acta Orthop Scand 1995;66(2):181-92.
  • Boulton AJ, Vileikyte L, Ragnarson-Tennvall G, Apelqvist J. The global burden of diabetic foot disease. Lancet 2005;366(9498):1719-24.
  • Oyibo SO, Jude EB, Tarawneh I, Nguyen HC, Harkless LB, Boulton AJ. A comparison of two diabetic foot ulcer classification systems: the Wagner and the University of Texas wound classification systems. Diabetes Care 2001;24(1):84-8.
  • Reiber GE, Vileikyte L, Boyko EJ, del Aguila M, Smith DG, Lavery LA, Boulton AJ. Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings. Diabetes Care 1999;22(1):157-62.
  • Wagner FW. A classification and treatment program for diabetic, neuropathic, and dysvascular foot problems. Instr Course Lect 1979;28(1):143-65.
  • Mehraj M, Shah I. A review of Wagner classification and current concepts in management of diabetic foot. Int J Orthop Sci 2018;4(1):933-5.
  • Setacci C, Sirignano P, Mazzitelli G, Setacci F, Messina G, Galzerano G, de Donato G. Diabetic foot: surgical approach in emergency. Int J Vasc Med 2013;2013:296169.
  • Xu SS, Li S, Xu HX, Li H, Wu CT, Wang WQ, Gao HL, Jiang W, Zhang WH, Li TJ, Ni QX, Liu L, Yu XJ. Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer. World J Gastroenterol 2020;26(8):828-838.
  • Tian M, Li Y, Wang X, Tian X, Pei LL, Wang X, Zhang L, Sun W, Wu J, Sun S, Ning M, Buonanno F, Xu Y, Song B. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score Is Associated With Poor Outcome of Acute Ischemic Stroke. Front Neurol 2021;11:610318.
  • Zhai B, Chen J, Wu J, Yang L, Guo X, Shao J, Xu H, Shen A. Predictive value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and lymphocyte-to-monocyte ratio (LMR) in patients with non-small cell lung cancer after radical lung cancer surgery. Ann Transl Med 2021;9(12):976.
  • Sen P, Demirdal T. Evaluation of mortality risk factors in diabetic foot infections. Int Wound J 2020;17(4):880-889.
  • Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y. Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis. Ann Med 2017;49(2):106-116.
  • Nather A, Bee CS, Huak CY, Chew JL, Lin CB, Neo S, Sim EY. Epidemiology of diabetic foot problems and predictive factors for limb loss. J Diabetes Complications 2008;22(2):77-82.
  • Hicks CW, Selvarajah S, Mathioudakis N, Perler BA, Freischlag JA, Black JH 3rd, Abularrage CJ. Trends and determinants of costs associated with the inpatient care of diabetic foot ulcers. J Vasc Surg 2014;60(5):1247-1254.e2.
  • Lynar SA, Robinson CH, Boutlis CS, Commons RJ. Risk factors for mortality in patients with diabetic foot infections: a prospective cohort study. Intern Med J 2019;49(7):867-873.
  • Chen L, Sun S, Gao Y, Ran X. Global mortality of diabetic foot ulcer: A systematic review and meta-analysis of observational studies. Diabetes Obes Metab 2023;25(1):36-45.
  • Seghieri G, Policardo L, Gualdani E, Anichini R, Francesconi P. Gender difference in the risk for cardiovascular events or mortality of patients with diabetic foot syndrome. Acta Diabetol 2019;56(5):561-567.
  • Lavery LA, van Houtum WH, Armstrong DG, Harkless LB, Ashry HR, Walker SC. Mortality following lower extremity amputation in minorities with diabetes mellitus. Diabetes Res Clin Pract 1997;37(1):41-7.
  • Adeleye OO, Ugwu ET, Gezawa ID, Okpe I, Ezeani I, Enamino M. Predictors of intra-hospital mortality in patients with diabetic foot ulcers in Nigeria: data from the MEDFUN study. BMC Endocr Disord 2020;20(1):134.
  • Nirantharakumar K, Saeed M, Wilson I, Marshall T, Coleman JJ. In-hospital mortality and length of stay in patients with diabetes having foot disease. J Diabetes Complications 2013;27(5):454-8.
  • Malyar NM, Freisinger E, Meyborg M, Lüders F, Gebauer K, Reinecke H, Lawall H. Amputations and mortality in in-hospital treated patients with peripheral artery disease and diabetic foot syndrome. J Diabetes Complications 2016;30(6):1117-22.
  • Costa RHR, Cardoso NA, Procópio RJ, Navarro TP, Dardik A, de Loiola Cisneros L. Diabetic foot ulcer carries high amputation and mortality rates, particularly in the presence of advanced age, peripheral artery disease and anemia. Diabetes Metab Syndr 2017;11 Suppl 2:S583-S587.
  • Vuorlaakso M, Kiiski J, Salonen T, Karppelin M, Helminen M, Kaartinen I. Major Amputation Profoundly Increases Mortality in Patients With Diabetic Foot Infection. Front Surg 2021;8:655902.
  • Armstrong DG, Wrobel J, Robbins JM. Guest Editorial: are diabetes-related wounds and amputations worse than cancer? Int Wound J 2007;4(4):286-7.
  • Martins-Mendes D, Monteiro-Soares M, Boyko EJ, Ribeiro M, Barata P, Lima J, Soares R. The independent contribution of diabetic foot ulcer on lower extremity amputation and mortality risk. J Diabetes Complications 2014;28(5):632-8.
  • Kahraman C, Yümün G, Kahraman NK, Namdar ND, Cosgun S. Neutrophil-to-lymphocyte ratio in diabetes mellitus patients with and without diabetic foot ulcer. Eur J Med Sci. 2014;1(1):8-13.
  • Chen W, Chen K, Xu Z, Hu Y, Liu Y, Liu W, Hu X, Ye T, Hong J, Zhu H, Shen F. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Predict Mortality in Patients with Diabetic Foot Ulcers Undergoing Amputations. Diabetes Metab Syndr Obes 2021;14:821-829.
  • Demirdal T, Sen P. The significance of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and lymphocyte-monocyte ratio in predicting peripheral arterial disease, peripheral neuropathy, osteomyelitis and amputation in diabetic foot infection. Diabetes Res Clin Pract 2018;144:118-125.
  • Muller M, Trocme C, Lardy B, Morel F, Halimi S, Benhamou PY. Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing. Diabet Med 2008;25(4):419-26.
  • Zhang SS, Tang ZY, Fang P, Qian HJ, Xu L, Ning G. Nutritional status deteriorates as the severity of diabetic foot ulcers increases and independently associates with prognosis. Exp Ther Med 2013;5(1):215-222.
  • Gau BR, Chen HY, Hung SY, Yang HM, Yeh JT, Huang CH, Sun JH, Huang YY. The impact of nutritional status on treatment outcomes of patients with limb-threatening diabetic foot ulcers. J Diabetes Complications 2016;30(1):138-42.
  • Lauwers P, Dirinck E, Van Bouwel S, Verrijken A, Van Dessel K, Van Gils C, Sels M, Peiffer F, Van Schil P, De Block C, Hendriks J. Malnutrition and its relation with diabetic foot ulcer severity and outcome: a review. Acta Clin Belg 2022;77(1):79-85.
  • Xu M, Chen L, Hu Y, Wu J, Wu Z, Yang S, Kang W, He J, Ren W. The HALP (hemoglobin, albumin, lymphocyte, and platelet) score is associated with early-onset post-stroke cognitive impairment. Neurological Sciences. 2023;44(1):237-45.
  • Liu Y, Wang Y, Meng Y, Wang Q, Guo Y. Correlation between the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score and Left Ventricular Hypertrophy in Older Patients with Hypertension. Cardiovascular Innovations and Applications. 2023;8(1):20230068.
  • Eskin F, Tutan D. A novel prognostic tool for predicting mortality in palliative care patients: HALP score: HALP score and prediction of mortality. The Injector 2023;2(1):43-51.
  • Fuadhi SA, Handaya AY, Setyawan N, Barmawi A, Sofii I. The comparison of GNRI versus HALP score as an outcome predictor in geriatric rectal cancer patients. Bali Medical Journal 2023;12(2):2312-9.
  • Forster S, Gariballa S. Age as a determinant of nutritional status: a cross sectional study. Nutr J 2005;4:28.
  • Agarwalla R, Saikia AM, Baruah R. Assessment of the nutritional status of the elderly and its correlates. J Family Community Med 2015;22(1):39-43.
  • Yu JM, Yang M, Xu HX, Li W, Fu ZM, Lin Y, Shi YY, Song CH, Shi HP, Guo ZQ; Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group. Association Between Serum C-Reactive Protein Concentration and Nutritional Status of Malignant Tumor Patients. Nutr Cancer 2019;71(2):240-245.
  • Tan CS, Read JA, Phan VH, Beale PJ, Peat JK, Clarke SJ. The relationship between nutritional status, inflammatory markers and survival in patients with advanced cancer: a prospective cohort study. Support Care Cancer 2015;23(2):385-91.
Toplam 46 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Acil Tıp, Ortopedi
Bölüm Research Article
Yazarlar

Hilal Yağar 0000-0001-5544-0458

Abdussamed Vural 0000-0003-4506-916X

Turgut Dolanbay 0000-0002-4092-1192

Yayımlanma Tarihi 31 Mayıs 2025
Gönderilme Tarihi 12 Mart 2024
Kabul Tarihi 5 Mart 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 9 Sayı: 2

Kaynak Göster

APA Yağar, H., Vural, A., & Dolanbay, T. (2025). Impact of Hemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score on Mortality in Above-Ankle Amputation of Diabetic Foot Infection. Journal of Basic and Clinical Health Sciences, 9(2), 258-266. https://doi.org/10.30621/jbachs.1451540
AMA Yağar H, Vural A, Dolanbay T. Impact of Hemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score on Mortality in Above-Ankle Amputation of Diabetic Foot Infection. JBACHS. Mayıs 2025;9(2):258-266. doi:10.30621/jbachs.1451540
Chicago Yağar, Hilal, Abdussamed Vural, ve Turgut Dolanbay. “Impact of Hemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score on Mortality in Above-Ankle Amputation of Diabetic Foot Infection”. Journal of Basic and Clinical Health Sciences 9, sy. 2 (Mayıs 2025): 258-66. https://doi.org/10.30621/jbachs.1451540.
EndNote Yağar H, Vural A, Dolanbay T (01 Mayıs 2025) Impact of Hemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score on Mortality in Above-Ankle Amputation of Diabetic Foot Infection. Journal of Basic and Clinical Health Sciences 9 2 258–266.
IEEE H. Yağar, A. Vural, ve T. Dolanbay, “Impact of Hemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score on Mortality in Above-Ankle Amputation of Diabetic Foot Infection”, JBACHS, c. 9, sy. 2, ss. 258–266, 2025, doi: 10.30621/jbachs.1451540.
ISNAD Yağar, Hilal vd. “Impact of Hemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score on Mortality in Above-Ankle Amputation of Diabetic Foot Infection”. Journal of Basic and Clinical Health Sciences 9/2 (Mayıs 2025), 258-266. https://doi.org/10.30621/jbachs.1451540.
JAMA Yağar H, Vural A, Dolanbay T. Impact of Hemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score on Mortality in Above-Ankle Amputation of Diabetic Foot Infection. JBACHS. 2025;9:258–266.
MLA Yağar, Hilal vd. “Impact of Hemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score on Mortality in Above-Ankle Amputation of Diabetic Foot Infection”. Journal of Basic and Clinical Health Sciences, c. 9, sy. 2, 2025, ss. 258-66, doi:10.30621/jbachs.1451540.
Vancouver Yağar H, Vural A, Dolanbay T. Impact of Hemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score on Mortality in Above-Ankle Amputation of Diabetic Foot Infection. JBACHS. 2025;9(2):258-66.
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