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YARA ÖRTÜLERİNDE GÜNCEL TEKNOLOJİLER VE FARMASÖTİK KARAKTERİZASYON YÖNTEMLERİ

Yıl 2025, Cilt: 49 Sayı: 2, 25 - 25

Ayşe Nur Büke , Müge Kılıçarslan

https://doi.org/10.33483/jfpau.1625859

Öz

Amaç: Bu derlemede yara örtüsü üzerine yapılan çalışmalar incelenerek yara bakım prensipleri, ideal yara örtüsü özellikleri, yara örtülerinin sınıflandırmaları, hazırlanma yöntemleri ve yara örtülerinde yapılan karakterizasyon çalışmaları karşılaştırmalı olarak değerlendirerek en güncel yara örtüsü üretim teknolojilerinin araştırılması amaçlanmıştır.
Sonuç ve Tartışma: İdeal bir yara örtüsü temel yara bakım prensiplerini karşılamalıdır. Yara iyileşme sürecini kolaylaştırmak ve hızlandırmak için geçmişten günümüze dek pek çok çalışma yapılmıştır. Günümüzde modern teknolojilerin gelişmesiyle birlikte, gazlı bezler gibi geleneksel örtüler yerine doğal ve sentetik polimerler ve bunların kombinasyonlarından oluşan modern yara örtüleri kullanılmaya başlamıştır. Temeli polimerlere dayanan modern yara örtüleri sayesinde, bünyesinde yara iyileşmesini kolaylaştıran ve hızlandıran etkin maddeleri taşıyabilen ve farklı fiziksel formlarda uyarlanabilen yara örtüleri geliştirilmiştir. Bu derlemede modern yara örtüleri filmler ve hidrojeller, nanolifler, köpükler ve süngerler, kompozitler ve iskeleler, biyoaktif yara örtüleri ve biyolojik yara örtüleri olarak sınıflandırılmıştır. Hazırlama yöntemleri, çeşitli avantajları ve dezavantajları, onaylı piyasa preparatlarından örnekler verilerek açıklanmıştır. Hem stabilite hem etkinlik açısından yara örtülerinden beklenen özelliklerin karakterizasyon çalışmaları değerlendirilmiştir. Konuyla ilgili incelemelerimiz sonucunda, farklı yara türlerine uygun ideal tek bir yara örtüsünden bahsedilemese de özellikle hastaya özgü kronik yaraların boyutuna uygun yara örtülerinin hazırlanabildiği 3B baskı, nanolif teknolojileri gibi deriyi neredeyse birebir taklit edebilen teknolojilerin veya püskürtülebilir-partiküler yara örtüsü sistemlerinin kullanımı sayesinde kitlesel olarak üretilen terapötik sistemlerin kişiye özel hale getirilebileceği tespit edilmiştir.

Anahtar Kelimeler

Biyomateryal polimerik ilaç taşıyıcı sistemler yara iyileşmesi yara örtüsü yara yönetimi in vitro karakterizasyon

Etik Beyan

-

Destekleyen Kurum

TÜBİTAK

Proje Numarası

121R076 TÜBİTAK 1001

Teşekkür

Bu çalışma, 121R076 nolu TÜBİTAK-1001 projesi ile desteklenen birinci yazarın ikinci yazar danışmanlığında hazırladığı doktora tezi çalışmasından üretilmiştir.

Kaynakça

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CURRENT TECHNOLOGIES IN WOUND DRESSINGS AND PHARMACEUTICAL CHARACTERIZATION METHODS

Yıl 2025, Cilt: 49 Sayı: 2, 25 - 25

Ayşe Nur Büke , Müge Kılıçarslan

https://doi.org/10.33483/jfpau.1625859

Öz

Objective: This review aims to evaluate studies on wound dressings by comparatively analyzing wound care principles, ideal wound dressing properties, classifications of wound dressings, preparation methods, and characterization studies of wound dressings. Additionally, it seeks to investigate the latest technologies in wound dressing production.
Result and Discussion: An ideal wound dressing must meet the fundamental principles of wound care. Numerous studies have been performed from past to present to facilitate and accelerate the wound healing process. With the advancement of modern technologies, traditional wound dressings such as gauze have been replaced by modern wound dressings made from natural and synthetic polymers or their combinations. Modern polymer-based wound dressings enable the development of products that can carry drugs facilitating and accelerating wound healing and can be adapted into various physical forms. In this review, modern wound dressings are classified into films and hydrogels, nanofibers, foams and sponges, composites and scaffolds, bioactive wound dressings, and biological wound dressings. Preparation methods, advantages, disadvantages, and examples of approved market preparations are discussed. The characterization studies of wound dressings regarding their stability and efficacy are also evaluated. As a result of our studies on the subject, although a single ideal wound dressing suitable for different wound types cannot be identified, it has been determined that mass-produced therapeutic systems can be customized where wound dressings can be prepared according to the size of patient-specific chronic wounds thanks to the use of technologies that can almost exactly mimic the skin such as 3D printing, nanofiber technologies, or use of sprayable-particulate wound dressing systems.

Anahtar Kelimeler

Biomaterial polymeric drug delivery systems wound healing wound dressing wound management in vitro characterization

Proje Numarası

121R076 TÜBİTAK 1001

Kaynakça

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  • 67. Choi, J.S., Kim, D.W., Kim, D.S., Kim, J.O., Yong, C.S., Cho, K.H., Youn, Y.S., Jin, S.G., Choi, H.G. (2016). Novel neomycin sulfate-loaded hydrogel dressing with enhanced physical dressing properties and wound-curing effect. Drug Delivery, 23(8), 2806-2812. [CrossRef]
  • 68. Kim, J.O., Park, J.K., Kim, J.H., Jin, S.G., Yong, C.S., Li, D.X., Choi, J.Y., Woo, J.S., Yoo, B.K., Lyoo, W.S., Kim, J.A., Choi, H.G. (2008). Development of polyvinyl alcohol-sodium alginate gel-matrix-based wound dressing system containing nitrofurazone. International Journal of Pharmaceutics, 359(1-2), 79-86. [CrossRef]
  • 69. Jin, S.G., Kim, K.S., Kim, D.W., Kim, D.S., Seo, Y.G., Go, T.G., Youn, Y.S., Kim, J.O., Yong, C.S., Choi, H.G. (2016). Development of a novel sodium fusidate-loaded triple polymer hydrogel wound dressing: Mechanical properties and effects on wound repair. International Journal of Pharmaceutics, 497(1-2), 114-122. [CrossRef]
  • 70. Singh, B., Pal, L. (2012). Sterculia crosslinked pva and pva-poly(aam) hydrogel wound dressings for slow drug delivery: Mechanical, mucoadhesive, biocompatible and permeability properties. Journal of the Mechanical Behavior of Biomedical Materials, 9, 9-21. [CrossRef]
  • 71. Ahmady, A.R., Razmjooee, K., Saber-Samandari, S., Toghraie, D. (2022). Fabrication of chitosan-gelatin films incorporated with thymol-loaded alginate microparticles for controlled drug delivery, antibacterial activity and wound healing: In-vitro and in-vivo studies. International Journal of Biological Macromolecules, 223(Part A), 567-582. [CrossRef]
  • 72. Nunes, P.S., Albuquerque, R.L., Jr., Cavalcante, D.R., Dantas, M.D., Cardoso, J.C., Bezerra, M.S., Souza, J.C., Serafini, M.R., Quitans, L.J., Jr., Bonjardim, L.R., Araujo, A.A. (2011). Collagen-based films containing liposome-loaded usnic acid as dressing for dermal burn healing. Journal of Biomedicine and Biotechnology, 2011(1), 761593. [CrossRef]
  • 73. Nunes, P.S., Rabelo, A.S., Souza, J.C., Santana, B.V., da Silva, T.M., Serafini, M.R., Dos Passos Menezes, P., Dos Santos Lima, B., Cardoso, J.C., Alves, J.C., Frank, L.A., Guterres, S.S., Pohlmann, A.R., Pinheiro, M.S., de Albuquerque, R.L.J., Araujo, A.A. (2016). Gelatin-based membrane containing usnic acid-loaded liposome improves dermal burn healing in a porcine model. International Journal of Pharmaceutics, 513(1-2), 473-482. [CrossRef]
  • 74. Pagano, C., Ceccarini, M.R., Calarco, P., Scuota, S., Conte, C., Primavilla, S., Ricci, M., Perioli, L. (2019). Bioadhesive polymeric films based on usnic acid for burn wound treatment: Antibacterial and cytotoxicity studies. Colloids and Surfaces B: Biointerfaces, 178, 488-499. [CrossRef]
  • 75. Monteiro, N., Martins, M., Martins, A., Fonseca, N.A., Moreira, J.N., Reis, R.L., Neves, N.M. (2015). Antibacterial activity of chitosan nanofiber meshes with liposomes immobilized releasing gentamicin. Acta Biomaterialia, 18, 196-205. [CrossRef]
  • 76. Almukainzi, M., El-Masry, T.A., Negm, W.A., Elekhnawy, E., Saleh, A., Sayed, A.E., Ahmed, H.M., Abdelkader, D.H. (2022). Co-delivery of gentiopicroside and thymoquinone using electrospun m-peg/pvp nanofibers: In-vitro and in vivo studies for antibacterial wound dressing in diabetic rats. International Journal of Pharmaceutics, 625, 122106. [CrossRef]
  • 77. Daristotle, J.L., Lau, L.W., Erdi, M., Hunter, J., Djoum, A., Jr., Srinivasan, P., Wu, X., Basu, M., Ayyub, O.B., Sandler, A.D., Kofinas, P. (2020). Sprayable and biodegradable, intrinsically adhesive wound dressing with antimicrobial properties. Bioengineering & Translational Medicine, 5(1), e10149. [CrossRef]
  • 78. Ahtzaz, S., Sher Waris, T., Shahzadi, L., Anwar Chaudhry, A., Ur Rehman, I., Yar, M. (2019). Boron for tissue regeneration-it’s loading into chitosan/collagen hydrogels and testing on chorioallantoic membrane to study the effect on angiogenesis. International Journal of Polymeric Materials and Polymeric Biomaterials, 69(8), 525-534. [CrossRef]
  • 79. Ali, M., Motaal, A.A., Ahmed, M.A., Alsayari, A., El-Gazayerly, O.N. (2018). An in vivo study of Hypericum perforatum in a niosomal topical drug delivery system. Drug Delivery, 25(1), 417-425. [CrossRef]
  • 80. Yadollah-Damavandi, S., Chavoshi-Nejad, M., Jangholi, E., Nekouyian, N., Hosseini, S., Seifaee, A., Rafiee, S., Karimi, H., Ashkani-Esfahani, S., Parsa, Y., Mohsenikia, M. (2015). Topical Hypericum perforatum improves tissue regeneration in full-thickness excisional wounds in diabetic rat model. Evidence-Based Complementary and Alternative Medicine, 2015(1), 245328. [CrossRef]
  • 81. Kıyan, S., Uyanıkgil, Y., Altuncı, Y.A., Cavusoglu, T., Cetin Uyanikgil, E.O., Karabey, F. (2015). Investigation of acute effects of Hypericum perforatum (st. John's wort-kantaron) treatment in experimental thermal burns and comparison with silver sulfadiazine treatment. Ulusal Travma ve Acil Cerrahi Dergisi, 21(5), 323-336.
  • 82. Hurler, J., Skalko-Basnet, N. (2012). Potentials of chitosan-based delivery systems in wound therapy: Bioadhesion study. Journal of Functional Biomaterials, 3(1), 37-48. [CrossRef]
  • 83. Gong, C., Wu, Q., Wang, Y., Zhang, D., Luo, F., Zhao, X., Wei, Y., Qian, Z. (2013). A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing. Biomaterials, 34(27), 6377-6387. [CrossRef]
  • 84. Hurler, J., Zakelj, S., Mravljak, J., Pajk, S., Kristl, A., Schubert, R., Skalko-Basnet, N. (2013). The effect of lipid composition and liposome size on the release properties of liposomes-in-hydrogel. International Journal of Pharmaceutics, 456(1), 49-57. [CrossRef]
  • 85. Tran, N.Q., Joung, Y.K., Lih, E., Park, K.D. (2011). In situ forming and rutin-releasing chitosan hydrogels as injectable dressings for dermal wound healing. Biomacromolecules, 12(8), 2872-2880. [CrossRef]
  • 86. Dogan, A., Demirci, S., Caglayan, A.B., Kilic, E., Gunal, M.Y., Uslu, U., Cumbul, A., Sahin, F. (2014). Sodium pentaborate pentahydrate and pluronic containing hydrogel increases cutaneous wound healing in vitro and in vivo. Biological Trace Element Research, 162, 72-79. [CrossRef]
  • 87. Demirci, S., Dogan, A., Aydin, S., Dulger, E.C., Sahin, F. (2016). Boron promotes streptozotocin-induced diabetic wound healing: Roles in cell proliferation and migration, growth factor expression, and inflammation. Molecular and Cellular Biochemistry, 417, 119-133. [CrossRef]
  • 88. Demirci, S., Dogan, A., Karakus, E., Halici, Z., Topcu, A., Demirci, E., Sahin, F. (2015). Boron and poloxamer (f68 and f127) containing hydrogel formulation for burn wound healing. Biological Trace Element Research, 168, 169-180. [CrossRef]
  • 89. Dharashivkar, S.S., Sahasrabuddhe, S.H., Saoji, A.N. (2015). Niosomally encapsulated silver sulfadiazine gel for burn treatment. Journal of Microencapsulation, 32(2), 137-142. [CrossRef]
  • 90. Xu, W., Gao, X., Tan, H., Li, S., Zhou, T., Li, J., Chen, Y. (2022). Covalent and biodegradable chitosan-cellulose hydrogel dressing containing microspheres for drug delivery and wound healing. Materials Today Communications, 33, 104163. [CrossRef]
  • 91. Li, W., Wang, B., Zhang, M., Wu, Z., Wei, J., Jiang, Y., Sheng, N., Liang, Q., Zhang, D., Chen, S. (2020). All-natural injectable hydrogel with self-healing and antibacterial properties for wound dressing. Cellulose, 27, 2637-2650. [CrossRef]
  • 92. Elsner, J.J., Egozi, D., Ullmann, Y., Berdicevsky, I., Shefy-Peleg, A., Zilberman, M. (2011). Novel biodegradable composite wound dressings with controlled release of antibiotics: Results in a guinea pig burn model. Burns, 37(5), 896-904. [CrossRef]
  • 93. Hong, H.J., Jin, S.E., Park, J.S., Ahn, W.S., Kim, C.K. (2008). Accelerated wound healing by smad3 antisense oligonucleotides-impregnated chitosan/alginate polyelectrolyte complex. Biomaterials, 29(36), 4831-4837. [CrossRef]
  • 94. Coyne, J., Zhao, N., Olubode, A., Menon, M., Wang, Y. (2020). Development of hydrogel-like biomaterials via nanoparticle assembly and solid-hydrogel transformation. Journal of Controlled Release, 318, 185-196. [CrossRef]
  • 95. Romic, M.D., Klaric, M.S., Lovric, J., Pepic, I., Cetina-Cizmek, B., Filipovic-Grcic, J., Hafner, A. (2016). Melatonin-loaded chitosan/pluronic(r) f127 microspheres as in situ forming hydrogel: An innovative antimicrobial wound dressing. European Journal of Pharmaceutics and Biopharmaceutics 107, 67-79. [CrossRef]
  • 96. De Cicco, F., Porta, A., Sansone, F., Aquino, R.P., Del Gaudio, P. (2014). Nanospray technology for an in situ gelling nanoparticulate powder as a wound dressing. International Journal of Pharmaceutics, 473(1-2), 30-37. [CrossRef]
  • 97. Basha, M., AbouSamra, M.M., Awad, G.A., Mansy, S.S. (2018). A potential antibacterial wound dressing of cefadroxil chitosan nanoparticles in situ gel, Fabrication, in vitro optimization and in vivo evaluation. International Journal of Pharmaceutics, 544(1), 129-140. [CrossRef]
  • 98. Devi, N., Dutta, J. (2017). Preparation and characterization of chitosan-bentonite nanocomposite films for wound healing application. International Journal of Biological Macromolecules, 104(Part B), 1897-1904. [CrossRef]
  • 99. Kilicarslan, M., Ilhan, M., Orhan, K. (2020). Micro-computed tomography (Micro-CT) analysis as a new approach for characterization of drug delivery systems. In: K. Orhan (Ed.), Micro-Computed Tomography (Micro-Ct) in Medicine and Engineering, (pp. 213-223). Switzerland: Springer Nature.
  • 100. Parvez, S., Rahman, M.M., Khan, M.A., Khan, M.A.H., Islam, J.M.M., Ahmed, M., Rahman, M.F., Ahmed, B. (2012). Preparation and characterization of artificial skin using chitosan and gelatin composites for potential biomedical application. Polymer Bulletin, 69, 715-731. [CrossRef]
Toplam 100 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular İlaç Dağıtım Teknolojileri
Bölüm Derleme
Yazarlar

Ayşe Nur Büke 0000-0002-6517-4170

Müge Kılıçarslan 0000-0003-3710-7445

Proje Numarası 121R076 TÜBİTAK 1001
Erken Görünüm Tarihi 4 Mayıs 2025
Yayımlanma Tarihi
Gönderilme Tarihi 23 Ocak 2025
Kabul Tarihi 24 Şubat 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 49 Sayı: 2

Kaynak Göster

APA Büke, A. N., & Kılıçarslan, M. (2025). YARA ÖRTÜLERİNDE GÜNCEL TEKNOLOJİLER VE FARMASÖTİK KARAKTERİZASYON YÖNTEMLERİ. Journal of Faculty of Pharmacy of Ankara University, 49(2), 25-25. https://doi.org/10.33483/jfpau.1625859
AMA Büke AN, Kılıçarslan M. YARA ÖRTÜLERİNDE GÜNCEL TEKNOLOJİLER VE FARMASÖTİK KARAKTERİZASYON YÖNTEMLERİ. Ankara Ecz. Fak. Derg. Mayıs 2025;49(2):25-25. doi:10.33483/jfpau.1625859
Chicago Büke, Ayşe Nur, ve Müge Kılıçarslan. “YARA ÖRTÜLERİNDE GÜNCEL TEKNOLOJİLER VE FARMASÖTİK KARAKTERİZASYON YÖNTEMLERİ”. Journal of Faculty of Pharmacy of Ankara University 49, sy. 2 (Mayıs 2025): 25-25. https://doi.org/10.33483/jfpau.1625859.
EndNote Büke AN, Kılıçarslan M (01 Mayıs 2025) YARA ÖRTÜLERİNDE GÜNCEL TEKNOLOJİLER VE FARMASÖTİK KARAKTERİZASYON YÖNTEMLERİ. Journal of Faculty of Pharmacy of Ankara University 49 2 25–25.
IEEE A. N. Büke ve M. Kılıçarslan, “YARA ÖRTÜLERİNDE GÜNCEL TEKNOLOJİLER VE FARMASÖTİK KARAKTERİZASYON YÖNTEMLERİ”, Ankara Ecz. Fak. Derg., c. 49, sy. 2, ss. 25–25, 2025, doi: 10.33483/jfpau.1625859.
ISNAD Büke, Ayşe Nur - Kılıçarslan, Müge. “YARA ÖRTÜLERİNDE GÜNCEL TEKNOLOJİLER VE FARMASÖTİK KARAKTERİZASYON YÖNTEMLERİ”. Journal of Faculty of Pharmacy of Ankara University 49/2 (Mayıs 2025), 25-25. https://doi.org/10.33483/jfpau.1625859.
JAMA Büke AN, Kılıçarslan M. YARA ÖRTÜLERİNDE GÜNCEL TEKNOLOJİLER VE FARMASÖTİK KARAKTERİZASYON YÖNTEMLERİ. Ankara Ecz. Fak. Derg. 2025;49:25–25.
MLA Büke, Ayşe Nur ve Müge Kılıçarslan. “YARA ÖRTÜLERİNDE GÜNCEL TEKNOLOJİLER VE FARMASÖTİK KARAKTERİZASYON YÖNTEMLERİ”. Journal of Faculty of Pharmacy of Ankara University, c. 49, sy. 2, 2025, ss. 25-25, doi:10.33483/jfpau.1625859.
Vancouver Büke AN, Kılıçarslan M. YARA ÖRTÜLERİNDE GÜNCEL TEKNOLOJİLER VE FARMASÖTİK KARAKTERİZASYON YÖNTEMLERİ. Ankara Ecz. Fak. Derg. 2025;49(2):25-.
 Kapak Resmi İndir

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.