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Yıl 2024, Cilt: 28 Sayı: 6, 1911 - 1920, 28.06.2025

Sevda Türk , Didem Akkaya , Burak Kırılmaz Ezgi Merve Önal Burak Barut

https://doi.org/10.29228/jrp.864

Öz

Kaynakça

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Synthesis, characterization and biological activity potential of some novel thiourea derivatives

Yıl 2024, Cilt: 28 Sayı: 6, 1911 - 1920, 28.06.2025

Sevda Türk , Didem Akkaya , Burak Kırılmaz Ezgi Merve Önal Burak Barut

https://doi.org/10.29228/jrp.864

Öz

Within the scope of this study, a new series of thiourea derivatives were synthesized by refluxing different anthranilic acid derivatives with various isothiocyanates in dry acetone medium. The synthesized compounds were purified by crystallization and their purity was determined by TLC method. The structures of the obtained compounds were elucidated by using different spectroscopic methods such as IR, 1H-NMR, 13C-NMR, besides elemental analysis. The inhibitory effects of the compounds against DPPH radical scavenging, α-glucosidase and acetylcholinesterase were investigated by using spectrophotometric method. The results showed that the compounds had moderate radical scavenging activity according to gallic acid (92.25 ± 0.14% at 100 µM) which was used as a reference compound. Compound 5 in the presence of trifluoromethyl group demonstrated the highest α-glucosidase inhibitory effect with 52.26 ± 2.35% at 100 µM. On the other hand, the compounds demonstrated low AChE inhibitory effects compared to galantamine (80.33 ± 0.77% at 100 µM) which was used as a reference compound.

Anahtar Kelimeler

Thiourea anthranilic acid DPPH radical scavenging α-glucosidase acetylcholinesterase

Kaynakça

  • [1] Schroeder, DC. Thioureas. Chem Rev. 1955; 55 (1): 181-228. https://doi.org/10.1021/cr50001a005
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  • [3] Ngaini Z, Abd Halim, AN, Rasin F, Wan Zullkiplee, WSH. Synthesis and structure–activity relationship studies of mono-and bis-thiourea derivatives featuring halogenated azo dyes with antimicrobial properties. Phosphorus Sulfur Silicon Relat. Elem. 2022; 197(9): 909-917. https://doi.org/10.1080/10426507.2022.2046577
  • [4] Lafifi I, Khatmi D. Theorical Investigation of the Intramolecular H-Bonding on Tautomerism. Adv Quantum Chem. 2014; 68: 257-268. https://doi.org/10.1016/B978-0-12-800536-1.00013-7
  • [5] Başaran MM, Bacanlı M. Drug induced taste and smell disorders. TJFMPC. 2020; 14(1): 153-162. https://doi.org/10.21763/tjfmpc.616997
  • [6] Ghorab MM, El-Gaby M, Soliman A, Alsaid M, Abdel-Aziz, M, Elaasser M. Synthesis, docking study and biological evaluation of some new thiourea derivates bearing benzenesulfonamide moiety. Chem Cent J. 2017; 11: 42. https://doi.org/10.1186%2Fs13065-017-0271-7
  • [7] McCarthy A, Pirrie L, Hollick J, Ronseaux S, Campbell J, Higgins M, Staples O, Tran F, Slawin A, Lain S, Westwood N. Synthesis and biological characterisation of sirtuin inhibitors based on tenovins. Bioorg Med Chem. 2012; 20: 1779-1793. https://doi.org/10.1016/j.bmc.2012.01.001
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Toplam 51 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmasotik Kimya
Bölüm Articles
Yazarlar

Sevda Türk 0000-0002-4567-6739

Didem Akkaya 0000-0002-0711-951X

Burak Kırılmaz 0009-0003-3585-4997

Ezgi Merve Önal 0009-0004-6814-9845

Burak Barut 0000-0002-7441-8771

Yayımlanma Tarihi 28 Haziran 2025
Gönderilme Tarihi 2 Ağustos 2024
Kabul Tarihi 6 Eylül 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 28 Sayı: 6

Kaynak Göster

APA Türk, S., Akkaya, D., Kırılmaz, B., Önal, E. M., vd. (2025). Synthesis, characterization and biological activity potential of some novel thiourea derivatives. Journal of Research in Pharmacy, 28(6), 1911-1920. https://doi.org/10.29228/jrp.864
AMA Türk S, Akkaya D, Kırılmaz B, Önal EM, Barut B. Synthesis, characterization and biological activity potential of some novel thiourea derivatives. J. Res. Pharm. Temmuz 2025;28(6):1911-1920. doi:10.29228/jrp.864
Chicago Türk, Sevda, Didem Akkaya, Burak Kırılmaz, Ezgi Merve Önal, ve Burak Barut. “Synthesis, Characterization and Biological Activity Potential of Some Novel Thiourea Derivatives”. Journal of Research in Pharmacy 28, sy. 6 (Temmuz 2025): 1911-20. https://doi.org/10.29228/jrp.864.
EndNote Türk S, Akkaya D, Kırılmaz B, Önal EM, Barut B (01 Temmuz 2025) Synthesis, characterization and biological activity potential of some novel thiourea derivatives. Journal of Research in Pharmacy 28 6 1911–1920.
IEEE S. Türk, D. Akkaya, B. Kırılmaz, E. M. Önal, ve B. Barut, “Synthesis, characterization and biological activity potential of some novel thiourea derivatives”, J. Res. Pharm., c. 28, sy. 6, ss. 1911–1920, 2025, doi: 10.29228/jrp.864.
ISNAD Türk, Sevda vd. “Synthesis, Characterization and Biological Activity Potential of Some Novel Thiourea Derivatives”. Journal of Research in Pharmacy 28/6 (Temmuz 2025), 1911-1920. https://doi.org/10.29228/jrp.864.
JAMA Türk S, Akkaya D, Kırılmaz B, Önal EM, Barut B. Synthesis, characterization and biological activity potential of some novel thiourea derivatives. J. Res. Pharm. 2025;28:1911–1920.
MLA Türk, Sevda vd. “Synthesis, Characterization and Biological Activity Potential of Some Novel Thiourea Derivatives”. Journal of Research in Pharmacy, c. 28, sy. 6, 2025, ss. 1911-20, doi:10.29228/jrp.864.
Vancouver Türk S, Akkaya D, Kırılmaz B, Önal EM, Barut B. Synthesis, characterization and biological activity potential of some novel thiourea derivatives. J. Res. Pharm. 2025;28(6):1911-20.