Araştırma Makalesi
BibTex RIS Kaynak Göster

Yıl 2024, Cilt: 28 Sayı: 6, 2008 - 2016, 28.06.2025

Emrah Özdemir , Hakkı Çoknaz , Sıla Özlem Sener , Ufuk Özgen , Ali Gök

https://doi.org/10.29228/jrp.875

Öz

Kaynakça

  • [1] Akgün N. Egzersiz Fizyolojisi. Third ed., Gökçe Ofset Matbaacılık, Ankara, 1989.
  • [2] Leaf DA, Kleinman MT, Hamilton M, Barstow TJ. The effect of exercise intensity on lipid peroxidation. Med Sci Sports Exerc. 1997; 29(8): 1036-1039. https://doi.org/10.1097/00005768-199708000-00008
  • [3] Potteiger JA, Schroeder JM, Goff KL. Influence of music on ratings of perceived exertion during 20 minutes of moderate exercise. Percept https://doi.org/10.2466/pms.2000.91.3.848 Mot Skills. 2000; 91(3 Pt 1): 848-854.
  • [4] Urso ML, Clarkson PM. Oxidative stress, exercise and antioxidant supplementation. Toxicology. 2003; 189(1-2): 41 54. https://doi.org/10.1016/s0300-483x(03)00151-3
  • [5] Çelik A, Varol R, Onat T, Dağdelen Y, Tugay F. Akut egzersizin futbolcularda antioksidan sistem parametrelerine etkisi. Beden Eğitimi ve Spor Bilimleri Dergisi. 2007; 4: 167-172.
  • [6] Önal S. Oksidatif stres ve egzersiz. In: Karaduman A, Ülger Ö, Vardar Yağlı N, Kılınç M, Serel Arslan S. (Eds). Fizyoterapistler ve Öğrenciler İçin e-kitap. Hipokrat Kitabevi, Ankara, 2016; pp. 57-65.
  • [7] Karabulut H, Gülay MŞ. Antioksidanlar. https://doi.org/10.24880/maeuvfd.260790 MAE Vet Fak Derg. 2016; 1(1): 65-76.
  • [8] Poljsak B, Šuput D, Milisav I. Achieving the balance between ROS and antioxidants: When to use the synthetic antioxidants. Oxid Med Cell Longev. 2013; 2013: 956792. https://doi.org/10.1155/2013/956792
  • [9] Gallo MB, Sarachine MJ. Biological activities of lupeol. Int J Biomed Pharm Sci. 2009; 3(1): 46-66.
  • [10] Saleem M. Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene. Cancer Lett. 2009; 285(2): 109 115. https://doi.org/10.1016/j.canlet.2009.04.033
  • [11] Sener SÖ, Özgen U, Kanbolat S, Korkmaz N, Badem M, Hanci H, Dirmenci T, Arabaci T, Aliyazıcıoğlu R, Iscan GS. Investigation of therapeutic potential of three endemic Cirsium species for global health problem obesity. S Afr J Bot. 2021; 141: 243-254. https://doi.org/10.1016/j.sajb.2021.05.004
  • [12] Majumder S, Ghosh A, Bhattacharya M. Natural anti-inflammatory terpenoids in Camellia japonica leaf and probable biosynthesis pathways of the metabolome. Bull Natl Res Cent. 2020; 44(1): 141. https://doi.org/10.1186/s42269 020-00397-7
  • [13] Ji LL, Dillon D, Wu E. Alteration of antioxidant enzymes with aging in rat skeletal muscle and liver. Am J Physiol. 1990; 258: 918-923. https://doi.org/10.1152/ajpregu.1990.258.4.R918
  • [14] Bejma J, Ramires P, Ji LL. Free radical generation and oxidative stress with ageing and exercise: Differential effects in the myocardium and liver. Acta Phpsiol Scond. 2000; 169: 343-351. https://doi.org/10.1046/j.1365 201x.2000.00745.x
  • [15] Park JS, Rehman IU, Choe K, Ahmad R, Lee HJ, Kim MO. A triterpenoid lupeol as an antioxidant and anti neuroinflammatory agent: Impacts on oxidative stress in alzheimer's disease. Nutrients. 2023; 15(13): 3059. https://doi.org/10.3390/nu15133059
  • [16] Wenzel DG, Emick GH. An investigation of triterpenes as steroid hormones. J Am Pharm Assoc. 1956; 45(5): 284 287. https://doi.org/10.1002/jps.3030450504
  • [17] Zergeroğlu AM, Ersöz G, Yavuzer S. Dayanıklılık antrenmanlarında antioksidan savunma. Hacettepe J Sport Sci. 1997; 8(4): 25-31.
  • [18] Burneiko RC, Diniz YS, Galhardi CM, Rodrigues HG, Ebaid GM, Faine LA, Padovani CR, Cicogna AC, Novelli EL. Interaction of hypercaloric diet and physical exercise on lipid profile, oxidative stress and antioxidant defenses. Food Chem Toxicol. 2006 Jul;44(7):1167-1172. https://doi.org/10.1016/j.fct.2006.01.004
  • [19] Ji LL. Antioxidant enzyme response to exercise and aging. Med Sci Sports Exerc. 1993; 25(2): 225-231. [20] Elosua R, Molina L, Fito M, Arquer A, Sanchez-Quesada JL, Covas MI, Ordoñez-Llanos J, Marrugat J. Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women. Atherosclerosis. 2003; 167(2): 327-334. https://doi.org/10.1016/s0021 9150(03)00018-2
  • [21] Clarkson PM. Antioxidants and physical performance. Crit Rev Food Sci Nutr. 1995; 35: 131-141. https://doi.org/10.1080/10408399509527692
  • [22] Leeuwenburgh C, Hollander J, Leichtweis S, Griffiths M, Gore M, Ji LL. Adaptations of glutathione antioxidant system to endurance training are tissue and muscle fiber specific. Am J Physiol. 1997; 272(1 Pt 2): 363-369. https://doi.org/10.1152/ajpregu.1997.272.1.R363
  • [23] Kostaropoulos IA, Nikolaidis MG, Jamurtas AZ, Ikonomou GV, Makrygiannis V, Papadopoulos G, Kouretas D. Comparison of the blood redox status between long-distance and short-distance runners. Physiol Res. 2006; 55(6): 611-616. https://doi.org/10.33549/physiolres.930898
  • [24] Radák Z, Asano K, Inoue M, Kizaki T, Oh-Ishi S, Suzuki K, Taniguchi N, Ohno H. Superoxide dismutase derivative reduces oxidative damage in skeletal muscle of rats during exhaustive exercise. J Appl Physiol (1985). 1995; 79(1): 129-135. https://doi.org/10.1152/jappl.1995.79.1.129
  • [25] Sahlin K, Ekberg K, Cizinsky S. Changes in plasma hypoxanthine and free radical markers during exercise in man. Acta Physiol Scand. 1991; 142(2): 275-281. https://doi.org/10.1111/j.1748-1716.1991.tb09157.x
  • [26] Vina J, Mina JB, Gomez-Cabrera MC, Lloret A, Marquez R, Pallard FV, Sastre J. Free radicals in exhaustive physical exercise. IUBMB Life. 2000; 50(4-5): 271- 277.
  • [27] Ohishi S, Kizaki T, Ookawara T, Toshinai K, Haga S, Karasawa F, Satoh T, Nagata N, Ji LL, Ohno H. The effect of exhaustive exercise on the antioxidant enzyme system in skeletal muscle from calcium-deficient rats. Pflugers Arch. 1998;435(6):767-774. https://doi.org/10.1007/s004240050582
  • [28] Koz M, Erbaş D, Bilgihan A, Aricioğlu A. Effects of acute swimming exercise on muscle and erythrocyte malondialdehyde, serum myoglobin, and plasma ascorbic acid concentrations. Can J Physiol Pharmacol. 1992; 70(10): 1392-1395. https://doi.org/10.1139/y92-195
  • [29] Gül M, Öztaşan N, Taysi S, Gümüştekin K, Akar S, Bakan N, Dane Ş. Sıçanda oksidatif stres modeli olarak kısa süreli yüzme egzersizi. Hacettepe J Sport Sci. 2001; 12: 26-32.
  • [30] Ercan P, El SN. Koenzim Q10’un beslenme ve sağlık açısından önemi ve biyoyararlılığı. TUBAV Bilim Dergisi. 2010; 3(2): 192-200.
  • [31] Kwong LK, Kamzalov S, Rebrin I, Bayne AC, Jana CK, Morris P, Forster MJ, Sohal RS. Effects of coenzyme Q(10) administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radic Biol Med. 2002;33(5):627-638. https://doi.org/10.1016/s0891-5849(02)00916-4
  • [32] Eriksson JG, Forsén TJ, Mortensen SA, Rohde M. The effect of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus. Biofactors. 1999; 9(2-4): 315-318. https://doi.org/10.1002/biof.5520090229
  • [33] Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr. 2001;20(6):591-598. https://doi.org/10.1080/07315724.2001.10719063
  • [34] Braun B, Clarkson PM, Freedson PS, Kohl RL. Effects of coenzyme Q10 supplementation on exercise performance, VO2max, and lipid peroxidation in trained cyclists. Int J Sport Nutr. 1991; 1(4): 353-365. https://doi.org/10.1123/ijsn.1.4.353
  • [35] Marzatico F, Pansarasa O, Bertorelli L, Somenzini L, Della Valle G. Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidemic performances in highly trained aerobic and sprint athletes. J Sports Med Phys Fitness. 1997; 37(4): 235-239.
  • [36] Powers SK, Criswell D, Lawler J, Ji LL, Martin D, Herb R, Dudley G. Influences of exercise insity and fiber type on antioxidant enzyme actvitiy in rat skeletal muscle. Am J Physiol. 1994; 266: 375-380. https://doi.org/10.1152/ajpregu.1994.266.2.R375
  • [37] Turgut G, Demir S, Genç O, Karabulut I, Akalin N. The effect of swimming exercise on lipid peroxidation in the rat brain, liver and heart. Acta Physiol Pharmacol Bulg. 2003; 27(2-3): 43-45.
  • [38] Ji LL, Fu R. Responses of glutathione system and antioxidant enzymes to exhaustive exercise and hydroperoxide. J Appl Physiol (1985). 1992; 72(2): 549-554. https://doi.org/10.1152/jappl.1992.72.2.549
  • [39] Ji LL, Mitchell EW. Effects of Adriamycin on heart mitochondrial function in rested and exercised rats. Biochem Pharmacol. 1994; 47(5): 877-885. https://doi.org/10.1016/0006-2952(94)90488-x
  • [40] Tauler P, Aguiló A, Gimeno I, Guix P, Tur JA, Pons A. Different effects of exercise tests on the antioxidant enzyme activities in lymphocytes and neutrophils. J Nutr Biochem. 2004; 15(8): 479-484. https://doi.org/10.1016/j.jnutbio.2004.03.002
  • [41] Knez WL, Jenkins DG, Coombes JS. Oxidative stress in half and full Ironman triathletes. Med Sci Sports Exerc. 2007; 39(2): 283-288. https://doi.org/10.1249/01.mss.0000246999.09718.0c
  • [42] Manna I, Jana K, Samanta PK. Intensive swimming exercise-induced oxidative stress and reproductive dysfunction in male wistar rats: protective role of alpha-tocopherol succinate. Can J Appl Physiol. 2004; 29(2): 172-185. https://doi.org/10.1139/h04-013

Protective effects of lupeol on acute exercise-related oxidative stress in male rats

Yıl 2024, Cilt: 28 Sayı: 6, 2008 - 2016, 28.06.2025

Emrah Özdemir , Hakkı Çoknaz , Sıla Özlem Sener , Ufuk Özgen , Ali Gök

https://doi.org/10.29228/jrp.875

Öz

The aim of this study is to determine the protective effects of lupeol on acute exhaustive exercise-induced oxidative stress in male rats. Rats were randomly selected and divided into four groups (n=6/group): Control, exercise, lupeol and exercise+lupeol groups. At the end of the exercise protocol, the rats were sacrificed by cervical dislocation, blood samples were taken. The levels of superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), glutathione (GSH), coenzyme Q10 (CoQ10) and α-lipoic acid (ALA) and oxidative stress levels in serum samples were measured. As a result, it has been determined that lupeol, a natural triterpenoid compound, contributes positively to the level of antioxidants produced by the body and helps suppress oxidants. It has been observed that free radicals caused by oxidative stress that occur as a result of high-intensity exercise are reduced by lupeol. Accordingly, it has been determined that the use of lupeol during exercise in experimental animals exposed to oxidative stress inhibits free radicals formed by stress. In the light of these results, it is thought that lupeol may be included in the composition of pharmaceutical products against exercise-induced oxidative damage.

Anahtar Kelimeler

Antioxidant exercise free radical lupeol oxidative stress

Kaynakça

  • [1] Akgün N. Egzersiz Fizyolojisi. Third ed., Gökçe Ofset Matbaacılık, Ankara, 1989.
  • [2] Leaf DA, Kleinman MT, Hamilton M, Barstow TJ. The effect of exercise intensity on lipid peroxidation. Med Sci Sports Exerc. 1997; 29(8): 1036-1039. https://doi.org/10.1097/00005768-199708000-00008
  • [3] Potteiger JA, Schroeder JM, Goff KL. Influence of music on ratings of perceived exertion during 20 minutes of moderate exercise. Percept https://doi.org/10.2466/pms.2000.91.3.848 Mot Skills. 2000; 91(3 Pt 1): 848-854.
  • [4] Urso ML, Clarkson PM. Oxidative stress, exercise and antioxidant supplementation. Toxicology. 2003; 189(1-2): 41 54. https://doi.org/10.1016/s0300-483x(03)00151-3
  • [5] Çelik A, Varol R, Onat T, Dağdelen Y, Tugay F. Akut egzersizin futbolcularda antioksidan sistem parametrelerine etkisi. Beden Eğitimi ve Spor Bilimleri Dergisi. 2007; 4: 167-172.
  • [6] Önal S. Oksidatif stres ve egzersiz. In: Karaduman A, Ülger Ö, Vardar Yağlı N, Kılınç M, Serel Arslan S. (Eds). Fizyoterapistler ve Öğrenciler İçin e-kitap. Hipokrat Kitabevi, Ankara, 2016; pp. 57-65.
  • [7] Karabulut H, Gülay MŞ. Antioksidanlar. https://doi.org/10.24880/maeuvfd.260790 MAE Vet Fak Derg. 2016; 1(1): 65-76.
  • [8] Poljsak B, Šuput D, Milisav I. Achieving the balance between ROS and antioxidants: When to use the synthetic antioxidants. Oxid Med Cell Longev. 2013; 2013: 956792. https://doi.org/10.1155/2013/956792
  • [9] Gallo MB, Sarachine MJ. Biological activities of lupeol. Int J Biomed Pharm Sci. 2009; 3(1): 46-66.
  • [10] Saleem M. Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene. Cancer Lett. 2009; 285(2): 109 115. https://doi.org/10.1016/j.canlet.2009.04.033
  • [11] Sener SÖ, Özgen U, Kanbolat S, Korkmaz N, Badem M, Hanci H, Dirmenci T, Arabaci T, Aliyazıcıoğlu R, Iscan GS. Investigation of therapeutic potential of three endemic Cirsium species for global health problem obesity. S Afr J Bot. 2021; 141: 243-254. https://doi.org/10.1016/j.sajb.2021.05.004
  • [12] Majumder S, Ghosh A, Bhattacharya M. Natural anti-inflammatory terpenoids in Camellia japonica leaf and probable biosynthesis pathways of the metabolome. Bull Natl Res Cent. 2020; 44(1): 141. https://doi.org/10.1186/s42269 020-00397-7
  • [13] Ji LL, Dillon D, Wu E. Alteration of antioxidant enzymes with aging in rat skeletal muscle and liver. Am J Physiol. 1990; 258: 918-923. https://doi.org/10.1152/ajpregu.1990.258.4.R918
  • [14] Bejma J, Ramires P, Ji LL. Free radical generation and oxidative stress with ageing and exercise: Differential effects in the myocardium and liver. Acta Phpsiol Scond. 2000; 169: 343-351. https://doi.org/10.1046/j.1365 201x.2000.00745.x
  • [15] Park JS, Rehman IU, Choe K, Ahmad R, Lee HJ, Kim MO. A triterpenoid lupeol as an antioxidant and anti neuroinflammatory agent: Impacts on oxidative stress in alzheimer's disease. Nutrients. 2023; 15(13): 3059. https://doi.org/10.3390/nu15133059
  • [16] Wenzel DG, Emick GH. An investigation of triterpenes as steroid hormones. J Am Pharm Assoc. 1956; 45(5): 284 287. https://doi.org/10.1002/jps.3030450504
  • [17] Zergeroğlu AM, Ersöz G, Yavuzer S. Dayanıklılık antrenmanlarında antioksidan savunma. Hacettepe J Sport Sci. 1997; 8(4): 25-31.
  • [18] Burneiko RC, Diniz YS, Galhardi CM, Rodrigues HG, Ebaid GM, Faine LA, Padovani CR, Cicogna AC, Novelli EL. Interaction of hypercaloric diet and physical exercise on lipid profile, oxidative stress and antioxidant defenses. Food Chem Toxicol. 2006 Jul;44(7):1167-1172. https://doi.org/10.1016/j.fct.2006.01.004
  • [19] Ji LL. Antioxidant enzyme response to exercise and aging. Med Sci Sports Exerc. 1993; 25(2): 225-231. [20] Elosua R, Molina L, Fito M, Arquer A, Sanchez-Quesada JL, Covas MI, Ordoñez-Llanos J, Marrugat J. Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women. Atherosclerosis. 2003; 167(2): 327-334. https://doi.org/10.1016/s0021 9150(03)00018-2
  • [21] Clarkson PM. Antioxidants and physical performance. Crit Rev Food Sci Nutr. 1995; 35: 131-141. https://doi.org/10.1080/10408399509527692
  • [22] Leeuwenburgh C, Hollander J, Leichtweis S, Griffiths M, Gore M, Ji LL. Adaptations of glutathione antioxidant system to endurance training are tissue and muscle fiber specific. Am J Physiol. 1997; 272(1 Pt 2): 363-369. https://doi.org/10.1152/ajpregu.1997.272.1.R363
  • [23] Kostaropoulos IA, Nikolaidis MG, Jamurtas AZ, Ikonomou GV, Makrygiannis V, Papadopoulos G, Kouretas D. Comparison of the blood redox status between long-distance and short-distance runners. Physiol Res. 2006; 55(6): 611-616. https://doi.org/10.33549/physiolres.930898
  • [24] Radák Z, Asano K, Inoue M, Kizaki T, Oh-Ishi S, Suzuki K, Taniguchi N, Ohno H. Superoxide dismutase derivative reduces oxidative damage in skeletal muscle of rats during exhaustive exercise. J Appl Physiol (1985). 1995; 79(1): 129-135. https://doi.org/10.1152/jappl.1995.79.1.129
  • [25] Sahlin K, Ekberg K, Cizinsky S. Changes in plasma hypoxanthine and free radical markers during exercise in man. Acta Physiol Scand. 1991; 142(2): 275-281. https://doi.org/10.1111/j.1748-1716.1991.tb09157.x
  • [26] Vina J, Mina JB, Gomez-Cabrera MC, Lloret A, Marquez R, Pallard FV, Sastre J. Free radicals in exhaustive physical exercise. IUBMB Life. 2000; 50(4-5): 271- 277.
  • [27] Ohishi S, Kizaki T, Ookawara T, Toshinai K, Haga S, Karasawa F, Satoh T, Nagata N, Ji LL, Ohno H. The effect of exhaustive exercise on the antioxidant enzyme system in skeletal muscle from calcium-deficient rats. Pflugers Arch. 1998;435(6):767-774. https://doi.org/10.1007/s004240050582
  • [28] Koz M, Erbaş D, Bilgihan A, Aricioğlu A. Effects of acute swimming exercise on muscle and erythrocyte malondialdehyde, serum myoglobin, and plasma ascorbic acid concentrations. Can J Physiol Pharmacol. 1992; 70(10): 1392-1395. https://doi.org/10.1139/y92-195
  • [29] Gül M, Öztaşan N, Taysi S, Gümüştekin K, Akar S, Bakan N, Dane Ş. Sıçanda oksidatif stres modeli olarak kısa süreli yüzme egzersizi. Hacettepe J Sport Sci. 2001; 12: 26-32.
  • [30] Ercan P, El SN. Koenzim Q10’un beslenme ve sağlık açısından önemi ve biyoyararlılığı. TUBAV Bilim Dergisi. 2010; 3(2): 192-200.
  • [31] Kwong LK, Kamzalov S, Rebrin I, Bayne AC, Jana CK, Morris P, Forster MJ, Sohal RS. Effects of coenzyme Q(10) administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radic Biol Med. 2002;33(5):627-638. https://doi.org/10.1016/s0891-5849(02)00916-4
  • [32] Eriksson JG, Forsén TJ, Mortensen SA, Rohde M. The effect of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus. Biofactors. 1999; 9(2-4): 315-318. https://doi.org/10.1002/biof.5520090229
  • [33] Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr. 2001;20(6):591-598. https://doi.org/10.1080/07315724.2001.10719063
  • [34] Braun B, Clarkson PM, Freedson PS, Kohl RL. Effects of coenzyme Q10 supplementation on exercise performance, VO2max, and lipid peroxidation in trained cyclists. Int J Sport Nutr. 1991; 1(4): 353-365. https://doi.org/10.1123/ijsn.1.4.353
  • [35] Marzatico F, Pansarasa O, Bertorelli L, Somenzini L, Della Valle G. Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidemic performances in highly trained aerobic and sprint athletes. J Sports Med Phys Fitness. 1997; 37(4): 235-239.
  • [36] Powers SK, Criswell D, Lawler J, Ji LL, Martin D, Herb R, Dudley G. Influences of exercise insity and fiber type on antioxidant enzyme actvitiy in rat skeletal muscle. Am J Physiol. 1994; 266: 375-380. https://doi.org/10.1152/ajpregu.1994.266.2.R375
  • [37] Turgut G, Demir S, Genç O, Karabulut I, Akalin N. The effect of swimming exercise on lipid peroxidation in the rat brain, liver and heart. Acta Physiol Pharmacol Bulg. 2003; 27(2-3): 43-45.
  • [38] Ji LL, Fu R. Responses of glutathione system and antioxidant enzymes to exhaustive exercise and hydroperoxide. J Appl Physiol (1985). 1992; 72(2): 549-554. https://doi.org/10.1152/jappl.1992.72.2.549
  • [39] Ji LL, Mitchell EW. Effects of Adriamycin on heart mitochondrial function in rested and exercised rats. Biochem Pharmacol. 1994; 47(5): 877-885. https://doi.org/10.1016/0006-2952(94)90488-x
  • [40] Tauler P, Aguiló A, Gimeno I, Guix P, Tur JA, Pons A. Different effects of exercise tests on the antioxidant enzyme activities in lymphocytes and neutrophils. J Nutr Biochem. 2004; 15(8): 479-484. https://doi.org/10.1016/j.jnutbio.2004.03.002
  • [41] Knez WL, Jenkins DG, Coombes JS. Oxidative stress in half and full Ironman triathletes. Med Sci Sports Exerc. 2007; 39(2): 283-288. https://doi.org/10.1249/01.mss.0000246999.09718.0c
  • [42] Manna I, Jana K, Samanta PK. Intensive swimming exercise-induced oxidative stress and reproductive dysfunction in male wistar rats: protective role of alpha-tocopherol succinate. Can J Appl Physiol. 2004; 29(2): 172-185. https://doi.org/10.1139/h04-013
Toplam 41 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık Bilimleri
Bölüm Articles
Yazarlar

Emrah Özdemir 0000-0001-7928-9342

Hakkı Çoknaz 0000-0001-9495-8946

Sıla Özlem Sener 0000-0001-7679-7165

Ufuk Özgen 0000-0001-9839-6717

Ali Gök 0000-0003-4103-9537

Yayımlanma Tarihi 28 Haziran 2025
Gönderilme Tarihi 13 Ocak 2024
Kabul Tarihi 8 Mart 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 28 Sayı: 6

Kaynak Göster

APA Özdemir, E., Çoknaz, H., Sener, S. Ö., Özgen, U., vd. (2025). Protective effects of lupeol on acute exercise-related oxidative stress in male rats. Journal of Research in Pharmacy, 28(6), 2008-2016. https://doi.org/10.29228/jrp.875
AMA Özdemir E, Çoknaz H, Sener SÖ, Özgen U, Gök A. Protective effects of lupeol on acute exercise-related oxidative stress in male rats. J. Res. Pharm. Temmuz 2025;28(6):2008-2016. doi:10.29228/jrp.875
Chicago Özdemir, Emrah, Hakkı Çoknaz, Sıla Özlem Sener, Ufuk Özgen, ve Ali Gök. “Protective Effects of Lupeol on Acute Exercise-Related Oxidative Stress in Male Rats”. Journal of Research in Pharmacy 28, sy. 6 (Temmuz 2025): 2008-16. https://doi.org/10.29228/jrp.875.
EndNote Özdemir E, Çoknaz H, Sener SÖ, Özgen U, Gök A (01 Temmuz 2025) Protective effects of lupeol on acute exercise-related oxidative stress in male rats. Journal of Research in Pharmacy 28 6 2008–2016.
IEEE E. Özdemir, H. Çoknaz, S. Ö. Sener, U. Özgen, ve A. Gök, “Protective effects of lupeol on acute exercise-related oxidative stress in male rats”, J. Res. Pharm., c. 28, sy. 6, ss. 2008–2016, 2025, doi: 10.29228/jrp.875.
ISNAD Özdemir, Emrah vd. “Protective Effects of Lupeol on Acute Exercise-Related Oxidative Stress in Male Rats”. Journal of Research in Pharmacy 28/6 (Temmuz 2025), 2008-2016. https://doi.org/10.29228/jrp.875.
JAMA Özdemir E, Çoknaz H, Sener SÖ, Özgen U, Gök A. Protective effects of lupeol on acute exercise-related oxidative stress in male rats. J. Res. Pharm. 2025;28:2008–2016.
MLA Özdemir, Emrah vd. “Protective Effects of Lupeol on Acute Exercise-Related Oxidative Stress in Male Rats”. Journal of Research in Pharmacy, c. 28, sy. 6, 2025, ss. 2008-16, doi:10.29228/jrp.875.
Vancouver Özdemir E, Çoknaz H, Sener SÖ, Özgen U, Gök A. Protective effects of lupeol on acute exercise-related oxidative stress in male rats. J. Res. Pharm. 2025;28(6):2008-16.