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Yıl 2025, Cilt: 29 Sayı: 3, 937 - 946, 04.06.2025

Muhammad Ilyas Apriyanto Apriyanto Adriatman Rasak Asriullah Jabbar Nasrudin Nasrudin Sri Susanty I Ketut Sudiana Jusak Nugraha Zulkifli Halid

https://doi.org/10.12991/jrespharm.1693768

Öz

Kaynakça

  • 1] The Global Cancer Observatory. Cancer incident in Indonesia. International Agency for Research on Cancer. 2022; 858: 1–2. https://gco.iarc.fr/today/data/factsheets/populations/360-indonesia-fact-sheets.pdf
  • [2] Wahyuni W, Diantini A, Ghozali M, Subarnas A, Julaeha E, Amalia R, Sahidin I. Cytotoxic and antimigration activity of Etlingera alba (A.D.) Poulsen Rhizome. Adv Pharmacol Pharm Sci. 2021; 2021: 6597402. https://doi.org/10.1155/2021/6597402
  • [3] Cejalvo JM, Pascual T, Fernández-Martínez A, Braso-Maristany F, Gomis RR, Perou CM, Muñoz M, Prat A. Clinical implications of the non-luminal intrinsic subtypes in hormone receptor-positive breast cancer. Cancer Treat Rev. 2018; 67(3): 63–70. https://doi.org/10.1016/j.ctrv.2018.04.015
  • [4] American Cancer Society. Facts & Figures 2022. American Cancer Society. 2022: 1–76.
  • [5] Ilyas MY, Diantini A, Ghozali M, Sahidin I, Fristiohady A. Immunomodulatory potency Etlingera rubroloba A.D. poulsen fruit ethanol extract against macrophage phagocytic activity and CD4 levels in wistar male rats. Res J Pharm Technol. 2022; 15(9): 4067–4072. https://doi.org/10.52711/0974-360X.2022.00682
  • [6] Ilyas MY, Sahidin I, Jabbar A, Yodha AWM, Diantini A, Pradipta IS, Amalia R, Febrianti RM, Hadisaputri YE, Ghozali M, Julaeha E. Effect of immunomodulating extract and some isolates from Etlingera rubroloba A.D. Poulsen fruits on diabetic patients with tuberculosis. Molecules. 2023; 28: 2401. https://doi.org/10.3390/molecules28052401
  • [7] Ilyas MY, Diantini A, Halimah E, Amalia R, Ghozali M, Julaeha E. Phytochemical analysis and immunomodulatory potential on diabetic-infected tuberculosis by fruit Etlingera rubroloba A.D. Poulsen. Pakistan J Biol Sci. 2022; 25(7): 669–675. https://doi.org/10.3923/pjbs.2022.669.675
  • [8] Hong J, Fristiohady A, Nguyen CH, Milovanovic D, Huttary N, Krieger S, Hong J, Geleff S, Birner P, Jager W, Ozmen A, Krenn L, Krupitza G. Apigenin and luteolin attenuate the breaching of MDA-MB231 breast cancer spheroids through the lymph endothelial barrier in vitro. Front Pharmacol. 2018; 14(9): 220. https://doi.org/10.3389/fphar.2018.00220
  • [9] Yusuf MI, Wahyuni, Susanty S, Ruslan, Fawwaz M. Antioxidant and antidiabetic potential of galing stem extract (Cayratia trifolia Domin). Pharmacogn J. 2018; 10(4): 686-689. https://doi.org/10.5530/pj.2018.4.113
  • [10] Holzner S, Brenner S, Georgiev A, Senfter D, Stadler S, Huu C, Fristiohady A, Milovanovic D, Huttary N, Sigurd Krieger S, Bago-Horvath Z, Wever O, Tentes I, Ozmen A, Jager W, Dolznig H, Dirsch VM, Mader RM, Krenn L, Krupitza G. Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro. Food Chem Toxicol. 2018; 111(11): 114–124. https://doi.org/10.1016/j.fct.2017.11.015
  • [11] Ilyas MY, Diantini A, Halimah E, Amalia RM, Ghozali M, Julaeha E, Sahidin I. Potential immunomodulator fraction fruit of Etlingera rubroloba A.D Poulsen against macrophage phagocytosis and interleukin-12 levels in BCG-stimulated Balb/C mice. Int J Pharm Res. 2021; 13(1): 3262–3269. https://doi.org/10.31838/ijpr/2021.13.01.478
  • [12] Decendit A, Mamani-Matsuda MV, Amount P, Waffo-Tugeo D, Moynet K, Boniface E, Richard S, Krisa J, Rambert JM, Merillon MD, Mosallayi. Malvidin-3-O-β glucoside, major grape anthocyanin, inhibits human macrhophage-derived inflamatory mediators and decreases clinical scores in arthritic rats. J Biochem Pharmacol. 2013; 86(10): 1461–1467. https://doi.org/10.1016/j.bcp.2013.06.010
  • [13] Jang JY. Mechanism of resveratrol-induced programmed cell death and new drug discovery against cancer : A Review. Int J Mol Sci. 2022; 23(22): 13689. https://doi.org/10.3390/ijms232213689
  • [14] Brockmueller A, Sameri S, Liskova A, Zhai K, Varghese E, Samuel SM., Büsselberg D, Kubatka P, Shakibaei M. Resveratrols anti-cancer effects through the modulation of tumor glucose metabolism. Cancers (Basel). 2021; 13(2): 188. https://doi.org/10.3390/cancers13020188
  • [15] Rojas-Armas JP, Arroyo-Acevedo JL, Palomino-Pacheco M, Herrera-Calderón O, Ortiz-Sánchez JM, Rojas-Armas A, Calva J, Castro-Luna A, Hilario-Vargas J. The essential oil of Cymbopogon citratus Stapt and carvacrol: An approach of the antitumor effect on 7,12-Dimethylbenz-[α]-anthracene (DMBA)-induced breast cancer in female rats. Molecules. 2020;25(14):3284. https://doi.org/10.3390/molecules25143284
  • [16] Kumar D, Kumar S, Gupta J, Arya R, Gupta A. A review on chemical and biological properties of Cayratia trifolia Linn. (Vitaceae). Pharmacogn Rev. 2011; 5(10): 184–188. https://doi.org/10.4103/0973-7847.91117
  • [17] Amini P, Moazamiyanfar R, Dakkali MS, Khani A, Jafarzadeh E, Mouludi K, Khodamoradi E, Johari R, Taeb S, Najafi M. Resveratrol in cancer therapy: From stimulation of genomic stability to adjuvant cancer therapy: A comprehensive review. Curr Top Med Chem. 2023;23(8):629-648. https://dx.doi.org/10.2174/1568026623666221014152759
  • [18] Lalani AR, Fakhari F, Radgoudarzi S, Rastegar-Pouyani N, Moloudi K, Khodamoradi E, Taeb S, Najafi M. Immunoregulation by resveratrol; implications for normal tissue protection and tumour suppression. Clin Exp Pharmacol Physiol. 2023; 50(5): 353-368. https://doi.org/10.1111/1440-1681.13760
  • [19] Jang JY, Im E, Kim ND. Mechanism of resveratrol-induced programmed cell death and new drug discovery against cancer : A Review. Int J Mol Sci. 2022; 23(22): 13689. https://doi.org/10.3390/ijms232213689
  • [20] Hassan M, Watari H, AbuAlmaaty A, Ohba Y, Sakuragi N. Apoptosis and molecular targeting therapy in cancer. Biomed Res Int. 2014; 2014: 150845. https://doi.org/10.1155/2014/150845
  • [21] Wadsworth TL, Koop DR. Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages. Biochem Pharmacol. 1999; 57(8): 941-949. https://doi.org/10.1016/s0006-2952(99)00002-7
  • [22] Kumar D, Arya V, Kaur R, Bhat ZA, Gupta VK, Kumar V. A review of immunomodulators in the Indian traditional health care system. J Microbiol Immunol Infect. 2012; 45(3): 165–184. http://dx.doi.org/10.1016/j.jmii.2011.09.030
  • [23] Jabbar A, Sahidin I, Malik F, Ilyas MY, Rusli N, Apriyanto, Reymon, Qadar J. Evaluation of xanthine oxidase inhibitory activity of sinapyl alcohol diacetate and stigmasterol compounds and phytochemical screening stem of Etlingera. Food Res. 2023; 7(4): 101–105. https://doi.org/10.26656/fr.2017.7(4).009
  • [24] Imran, Wahyuni, Fristiohady A, Leorita M, Malaka MH, Ilyas MY, Musadar, Rahmatika NS, Darmawan A, Fajriah S, Yodha AWM, Sahidin I. Radical scavenger and anti-diabetic potencies of Etlingera elatior fruits growing in south east Sulawesi-Indonesia. Res J Pharm Technol. 2022; 15(5): 2141-2146. https://doi.org/10.52711/0974-360X.2022.00355
  • [25] Yahfoufi N, Alsadi N, Jambi M, Matar C. The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients. 2018; 10(11): 1618. https://doi.org/10.3390/nu10111618
  • [26] Jabbar A, Sahidin I, Monstavevi SA, Malaka MH, Malik F, Ilyas MY. Antioxidant and anti-inflammatory activity of ethanol extract stem of Etlingera rubroloba A.D. Poulsen. Pakistan J Biol Sci. 2022; 25(10): 885–891. https://doi.org/10.31838/ecb/2022.11.05.009
  • [27] Fristiohady A, Leorita M, Malik F, Thamrin ASW, Ilyas MY, Wahyuni, Purnama LOMJ, Sahidin I. Pancreatic histological profile on the efficacy of extract of Etlingera calophrys (K.Schum) A.D. Poulsen stem against streptozotocin-induced diabetes in diabetic model rats. Biointerface Res Appl Chem. 2021; 11(2): 9209–9217. https://doi.org/10.33263/BRIAC112.92099217
  • [28] Irma, Tee SA, Fithria, Ilyas MY. The antibacterial inhibition test of gonad sea urchin (Diadema setosum) against the growth of Staphylococcus aureus. J Phys Conf Ser. 2021; 1899(1). https://doi.org/10.1088/1742-6596/1899/1/012053
  • [29] Barros ACSD, Muranaka ENK, Mori LJ, Pelizon CHT, Iriya K, Giocondo G, Pinotti JA. induction of experimental mammary carcinogenesis in rats with 7,12-dimethyl-benz(a)antrhacene. Rev Hosp Clin Fac Med S Paulo. 2004; 59(5): 257-261. https://doi.org/10.1590/s0041-87812004000500006
  • [30] Koivunen ME, Krogsrud RL. Principles of immunochemical techniques used in clinical laboratories. Lab Med. 2006; 37(8): 490–497. https://doi.org/10.1309/MV9RM1FDLWAUWQ3F
  • [31] Miller JL, Bartlett AP, Harman RM, Majhi PD, Jerry DJ, Van de Walle GR. Induced mammary cancer in rat models: Pathogenesis, genetics, and relevance to female breast cancer. J Mammary Gland Biol Neoplasia. 2022; 27(2): 185-210. https://doi.org/10.1007/s10911-022-09522-w
  • [32] Duderstadt EL, McQuaide SA, Sanders MA, Samuelson DJ. Chemical carcinogen-induced rat mammary carcinogenesis is a potential model of p21-activated kinase positive female breast cancer. Physiol Genomics. 2021; 53(2): 61-68. https://doi.org/10.1152/physiolgenomics.00112.2020

Immunostimulatory effects of ethyl acetate extract of galing plants on breast cancer model mouse: Analysis of Interferon Gamma and CD14 expression

Yıl 2025, Cilt: 29 Sayı: 3, 937 - 946, 04.06.2025

Muhammad Ilyas Apriyanto Apriyanto Adriatman Rasak Asriullah Jabbar Nasrudin Nasrudin Sri Susanty I Ketut Sudiana Jusak Nugraha Zulkifli Halid

https://doi.org/10.12991/jrespharm.1693768

Öz

Breast cancer continues to be a significant global health concern, resulting in considerable morbidity and mortality. This is primarily due to the fact that patients frequently encounter compromised cellular immune function, which is the primary means by which cancer cells are eliminated; therefore, effective treatment strategies that increase the patient's immune system's workload are required. For enhancing immune system functionality in cancer, the galing plant (Cayratia trifolia L. Domin) may present a viable alternative due to the presence of active compounds such as delphinidin, malvidin, resveratrol, and quercetin. These compounds have been empirically validated for their ability to regulate both non-specific and specific cellular immune responses. The objective of this research endeavor is to investigate the potential of galing ethyl acetate extract to modulate the cellular immune system in white mouse models of breast cancer by upregulating the expression of IFN-γ and CD14. Inducing the carcinogen DMBA transformed a cohort of 22 female white mouse into a model of breast cancer. These mice were subsequently divided into three groups: normal mouse (K0), cancer model mouse (K1), and those that received a 300 mg/kgBW galing ethyl acetate extract. after administering for a duration of 28 days. Following this, a monoclonal antibody immunohistochemical examination was conducted using anti-rat CD14 and anti-rat IFN-γ. The findings of the study demonstrated that the administration of galing ethyl acetate extract significantly increased the levels of IFN-γ and CD14 expression in comparison to the negative and normal control groups (p<0.05). Furthermore, a robust correlation was observed between the increase in IFN-γ expression and CD14 expression (p<0.01). Consequently, this research sheds light on the potential therapeutic applications of galing plants as immunostimulatory agents.

Anahtar Kelimeler

Cayratia trifolia L (Domin) breast cancer IFN-γ CD14 immunostimulatory

Kaynakça

  • 1] The Global Cancer Observatory. Cancer incident in Indonesia. International Agency for Research on Cancer. 2022; 858: 1–2. https://gco.iarc.fr/today/data/factsheets/populations/360-indonesia-fact-sheets.pdf
  • [2] Wahyuni W, Diantini A, Ghozali M, Subarnas A, Julaeha E, Amalia R, Sahidin I. Cytotoxic and antimigration activity of Etlingera alba (A.D.) Poulsen Rhizome. Adv Pharmacol Pharm Sci. 2021; 2021: 6597402. https://doi.org/10.1155/2021/6597402
  • [3] Cejalvo JM, Pascual T, Fernández-Martínez A, Braso-Maristany F, Gomis RR, Perou CM, Muñoz M, Prat A. Clinical implications of the non-luminal intrinsic subtypes in hormone receptor-positive breast cancer. Cancer Treat Rev. 2018; 67(3): 63–70. https://doi.org/10.1016/j.ctrv.2018.04.015
  • [4] American Cancer Society. Facts & Figures 2022. American Cancer Society. 2022: 1–76.
  • [5] Ilyas MY, Diantini A, Ghozali M, Sahidin I, Fristiohady A. Immunomodulatory potency Etlingera rubroloba A.D. poulsen fruit ethanol extract against macrophage phagocytic activity and CD4 levels in wistar male rats. Res J Pharm Technol. 2022; 15(9): 4067–4072. https://doi.org/10.52711/0974-360X.2022.00682
  • [6] Ilyas MY, Sahidin I, Jabbar A, Yodha AWM, Diantini A, Pradipta IS, Amalia R, Febrianti RM, Hadisaputri YE, Ghozali M, Julaeha E. Effect of immunomodulating extract and some isolates from Etlingera rubroloba A.D. Poulsen fruits on diabetic patients with tuberculosis. Molecules. 2023; 28: 2401. https://doi.org/10.3390/molecules28052401
  • [7] Ilyas MY, Diantini A, Halimah E, Amalia R, Ghozali M, Julaeha E. Phytochemical analysis and immunomodulatory potential on diabetic-infected tuberculosis by fruit Etlingera rubroloba A.D. Poulsen. Pakistan J Biol Sci. 2022; 25(7): 669–675. https://doi.org/10.3923/pjbs.2022.669.675
  • [8] Hong J, Fristiohady A, Nguyen CH, Milovanovic D, Huttary N, Krieger S, Hong J, Geleff S, Birner P, Jager W, Ozmen A, Krenn L, Krupitza G. Apigenin and luteolin attenuate the breaching of MDA-MB231 breast cancer spheroids through the lymph endothelial barrier in vitro. Front Pharmacol. 2018; 14(9): 220. https://doi.org/10.3389/fphar.2018.00220
  • [9] Yusuf MI, Wahyuni, Susanty S, Ruslan, Fawwaz M. Antioxidant and antidiabetic potential of galing stem extract (Cayratia trifolia Domin). Pharmacogn J. 2018; 10(4): 686-689. https://doi.org/10.5530/pj.2018.4.113
  • [10] Holzner S, Brenner S, Georgiev A, Senfter D, Stadler S, Huu C, Fristiohady A, Milovanovic D, Huttary N, Sigurd Krieger S, Bago-Horvath Z, Wever O, Tentes I, Ozmen A, Jager W, Dolznig H, Dirsch VM, Mader RM, Krenn L, Krupitza G. Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro. Food Chem Toxicol. 2018; 111(11): 114–124. https://doi.org/10.1016/j.fct.2017.11.015
  • [11] Ilyas MY, Diantini A, Halimah E, Amalia RM, Ghozali M, Julaeha E, Sahidin I. Potential immunomodulator fraction fruit of Etlingera rubroloba A.D Poulsen against macrophage phagocytosis and interleukin-12 levels in BCG-stimulated Balb/C mice. Int J Pharm Res. 2021; 13(1): 3262–3269. https://doi.org/10.31838/ijpr/2021.13.01.478
  • [12] Decendit A, Mamani-Matsuda MV, Amount P, Waffo-Tugeo D, Moynet K, Boniface E, Richard S, Krisa J, Rambert JM, Merillon MD, Mosallayi. Malvidin-3-O-β glucoside, major grape anthocyanin, inhibits human macrhophage-derived inflamatory mediators and decreases clinical scores in arthritic rats. J Biochem Pharmacol. 2013; 86(10): 1461–1467. https://doi.org/10.1016/j.bcp.2013.06.010
  • [13] Jang JY. Mechanism of resveratrol-induced programmed cell death and new drug discovery against cancer : A Review. Int J Mol Sci. 2022; 23(22): 13689. https://doi.org/10.3390/ijms232213689
  • [14] Brockmueller A, Sameri S, Liskova A, Zhai K, Varghese E, Samuel SM., Büsselberg D, Kubatka P, Shakibaei M. Resveratrols anti-cancer effects through the modulation of tumor glucose metabolism. Cancers (Basel). 2021; 13(2): 188. https://doi.org/10.3390/cancers13020188
  • [15] Rojas-Armas JP, Arroyo-Acevedo JL, Palomino-Pacheco M, Herrera-Calderón O, Ortiz-Sánchez JM, Rojas-Armas A, Calva J, Castro-Luna A, Hilario-Vargas J. The essential oil of Cymbopogon citratus Stapt and carvacrol: An approach of the antitumor effect on 7,12-Dimethylbenz-[α]-anthracene (DMBA)-induced breast cancer in female rats. Molecules. 2020;25(14):3284. https://doi.org/10.3390/molecules25143284
  • [16] Kumar D, Kumar S, Gupta J, Arya R, Gupta A. A review on chemical and biological properties of Cayratia trifolia Linn. (Vitaceae). Pharmacogn Rev. 2011; 5(10): 184–188. https://doi.org/10.4103/0973-7847.91117
  • [17] Amini P, Moazamiyanfar R, Dakkali MS, Khani A, Jafarzadeh E, Mouludi K, Khodamoradi E, Johari R, Taeb S, Najafi M. Resveratrol in cancer therapy: From stimulation of genomic stability to adjuvant cancer therapy: A comprehensive review. Curr Top Med Chem. 2023;23(8):629-648. https://dx.doi.org/10.2174/1568026623666221014152759
  • [18] Lalani AR, Fakhari F, Radgoudarzi S, Rastegar-Pouyani N, Moloudi K, Khodamoradi E, Taeb S, Najafi M. Immunoregulation by resveratrol; implications for normal tissue protection and tumour suppression. Clin Exp Pharmacol Physiol. 2023; 50(5): 353-368. https://doi.org/10.1111/1440-1681.13760
  • [19] Jang JY, Im E, Kim ND. Mechanism of resveratrol-induced programmed cell death and new drug discovery against cancer : A Review. Int J Mol Sci. 2022; 23(22): 13689. https://doi.org/10.3390/ijms232213689
  • [20] Hassan M, Watari H, AbuAlmaaty A, Ohba Y, Sakuragi N. Apoptosis and molecular targeting therapy in cancer. Biomed Res Int. 2014; 2014: 150845. https://doi.org/10.1155/2014/150845
  • [21] Wadsworth TL, Koop DR. Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages. Biochem Pharmacol. 1999; 57(8): 941-949. https://doi.org/10.1016/s0006-2952(99)00002-7
  • [22] Kumar D, Arya V, Kaur R, Bhat ZA, Gupta VK, Kumar V. A review of immunomodulators in the Indian traditional health care system. J Microbiol Immunol Infect. 2012; 45(3): 165–184. http://dx.doi.org/10.1016/j.jmii.2011.09.030
  • [23] Jabbar A, Sahidin I, Malik F, Ilyas MY, Rusli N, Apriyanto, Reymon, Qadar J. Evaluation of xanthine oxidase inhibitory activity of sinapyl alcohol diacetate and stigmasterol compounds and phytochemical screening stem of Etlingera. Food Res. 2023; 7(4): 101–105. https://doi.org/10.26656/fr.2017.7(4).009
  • [24] Imran, Wahyuni, Fristiohady A, Leorita M, Malaka MH, Ilyas MY, Musadar, Rahmatika NS, Darmawan A, Fajriah S, Yodha AWM, Sahidin I. Radical scavenger and anti-diabetic potencies of Etlingera elatior fruits growing in south east Sulawesi-Indonesia. Res J Pharm Technol. 2022; 15(5): 2141-2146. https://doi.org/10.52711/0974-360X.2022.00355
  • [25] Yahfoufi N, Alsadi N, Jambi M, Matar C. The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients. 2018; 10(11): 1618. https://doi.org/10.3390/nu10111618
  • [26] Jabbar A, Sahidin I, Monstavevi SA, Malaka MH, Malik F, Ilyas MY. Antioxidant and anti-inflammatory activity of ethanol extract stem of Etlingera rubroloba A.D. Poulsen. Pakistan J Biol Sci. 2022; 25(10): 885–891. https://doi.org/10.31838/ecb/2022.11.05.009
  • [27] Fristiohady A, Leorita M, Malik F, Thamrin ASW, Ilyas MY, Wahyuni, Purnama LOMJ, Sahidin I. Pancreatic histological profile on the efficacy of extract of Etlingera calophrys (K.Schum) A.D. Poulsen stem against streptozotocin-induced diabetes in diabetic model rats. Biointerface Res Appl Chem. 2021; 11(2): 9209–9217. https://doi.org/10.33263/BRIAC112.92099217
  • [28] Irma, Tee SA, Fithria, Ilyas MY. The antibacterial inhibition test of gonad sea urchin (Diadema setosum) against the growth of Staphylococcus aureus. J Phys Conf Ser. 2021; 1899(1). https://doi.org/10.1088/1742-6596/1899/1/012053
  • [29] Barros ACSD, Muranaka ENK, Mori LJ, Pelizon CHT, Iriya K, Giocondo G, Pinotti JA. induction of experimental mammary carcinogenesis in rats with 7,12-dimethyl-benz(a)antrhacene. Rev Hosp Clin Fac Med S Paulo. 2004; 59(5): 257-261. https://doi.org/10.1590/s0041-87812004000500006
  • [30] Koivunen ME, Krogsrud RL. Principles of immunochemical techniques used in clinical laboratories. Lab Med. 2006; 37(8): 490–497. https://doi.org/10.1309/MV9RM1FDLWAUWQ3F
  • [31] Miller JL, Bartlett AP, Harman RM, Majhi PD, Jerry DJ, Van de Walle GR. Induced mammary cancer in rat models: Pathogenesis, genetics, and relevance to female breast cancer. J Mammary Gland Biol Neoplasia. 2022; 27(2): 185-210. https://doi.org/10.1007/s10911-022-09522-w
  • [32] Duderstadt EL, McQuaide SA, Sanders MA, Samuelson DJ. Chemical carcinogen-induced rat mammary carcinogenesis is a potential model of p21-activated kinase positive female breast cancer. Physiol Genomics. 2021; 53(2): 61-68. https://doi.org/10.1152/physiolgenomics.00112.2020
Toplam 32 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri (Diğer)
Bölüm Articles
Yazarlar

Muhammad Ilyas

Apriyanto Apriyanto

Adriatman Rasak

Asriullah Jabbar

Nasrudin Nasrudin

Sri Susanty

I Ketut Sudiana

Jusak Nugraha

Zulkifli Halid

Yayımlanma Tarihi 4 Haziran 2025
Gönderilme Tarihi 17 Nisan 2024
Kabul Tarihi 27 Haziran 2024
Yayımlandığı Sayı Yıl 2025 Cilt: 29 Sayı: 3

Kaynak Göster

APA Ilyas, M., Apriyanto, A., Rasak, A., Jabbar, A., vd. (2025). Immunostimulatory effects of ethyl acetate extract of galing plants on breast cancer model mouse: Analysis of Interferon Gamma and CD14 expression. Journal of Research in Pharmacy, 29(3), 937-946. https://doi.org/10.12991/jrespharm.1693768
AMA Ilyas M, Apriyanto A, Rasak A, Jabbar A, Nasrudin N, Susanty S, Sudiana IK, Nugraha J, Halid Z. Immunostimulatory effects of ethyl acetate extract of galing plants on breast cancer model mouse: Analysis of Interferon Gamma and CD14 expression. J. Res. Pharm. Haziran 2025;29(3):937-946. doi:10.12991/jrespharm.1693768
Chicago Ilyas, Muhammad, Apriyanto Apriyanto, Adriatman Rasak, Asriullah Jabbar, Nasrudin Nasrudin, Sri Susanty, I Ketut Sudiana, Jusak Nugraha, ve Zulkifli Halid. “Immunostimulatory Effects of Ethyl Acetate Extract of Galing Plants on Breast Cancer Model Mouse: Analysis of Interferon Gamma and CD14 Expression”. Journal of Research in Pharmacy 29, sy. 3 (Haziran 2025): 937-46. https://doi.org/10.12991/jrespharm.1693768.
EndNote Ilyas M, Apriyanto A, Rasak A, Jabbar A, Nasrudin N, Susanty S, Sudiana IK, Nugraha J, Halid Z (01 Haziran 2025) Immunostimulatory effects of ethyl acetate extract of galing plants on breast cancer model mouse: Analysis of Interferon Gamma and CD14 expression. Journal of Research in Pharmacy 29 3 937–946.
IEEE M. Ilyas, A. Apriyanto, A. Rasak, A. Jabbar, N. Nasrudin, S. Susanty, I. K. Sudiana, J. Nugraha, ve Z. Halid, “Immunostimulatory effects of ethyl acetate extract of galing plants on breast cancer model mouse: Analysis of Interferon Gamma and CD14 expression”, J. Res. Pharm., c. 29, sy. 3, ss. 937–946, 2025, doi: 10.12991/jrespharm.1693768.
ISNAD Ilyas, Muhammad vd. “Immunostimulatory Effects of Ethyl Acetate Extract of Galing Plants on Breast Cancer Model Mouse: Analysis of Interferon Gamma and CD14 Expression”. Journal of Research in Pharmacy 29/3 (Haziran 2025), 937-946. https://doi.org/10.12991/jrespharm.1693768.
JAMA Ilyas M, Apriyanto A, Rasak A, Jabbar A, Nasrudin N, Susanty S, Sudiana IK, Nugraha J, Halid Z. Immunostimulatory effects of ethyl acetate extract of galing plants on breast cancer model mouse: Analysis of Interferon Gamma and CD14 expression. J. Res. Pharm. 2025;29:937–946.
MLA Ilyas, Muhammad vd. “Immunostimulatory Effects of Ethyl Acetate Extract of Galing Plants on Breast Cancer Model Mouse: Analysis of Interferon Gamma and CD14 Expression”. Journal of Research in Pharmacy, c. 29, sy. 3, 2025, ss. 937-46, doi:10.12991/jrespharm.1693768.
Vancouver Ilyas M, Apriyanto A, Rasak A, Jabbar A, Nasrudin N, Susanty S, Sudiana IK, Nugraha J, Halid Z. Immunostimulatory effects of ethyl acetate extract of galing plants on breast cancer model mouse: Analysis of Interferon Gamma and CD14 expression. J. Res. Pharm. 2025;29(3):937-46.