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Phytochemical composition, ethnomedicinal uses, and pharmacological properties of Achillea ligustica All.: A review

Yıl 2024, Cilt: 28 Sayı: 1, 313 - 325, 28.06.2025

Azza Bouteche Ahmed Touil , Segueni Narimane

Öz

Achillea ligustica All., (Ligurian yarrow) is an aromatic herbaceous plant belonging to the Asteraceae family. This plant is widely distributed in the Mediterranean region and has been used in traditional medicine of some countries; it is used especially as a remedy to treat hemorrhage, stomach disorders, and skin diseases. Many chemical constituents were identified from different parts of the species; the most important are lactone sesquiterpenes, flavonoids, and essential oils (EOs). This chemical diversity is the main cause of its large spectrum of pharmacological properties. A. ligustica was reported to possess antioxidant, antimicrobial, anti-diabetic, and anti-psoriasis properties. Several studies have focused on the chemical composition and pharmacological properties of its EO suggesting using the EO in oral hygiene products. The present literature review draws up the importance of this medicinal plant by reviewing its recent ethnomedicinal uses, chemical constituents, and pharmacological activities.

Anahtar Kelimeler

Achillea ligustica phytoconstituents essential oil pharmacological properties antibacterial activity

Kaynakça

  • [1] Ghasemi A. Medicinal and fragrant plants, identification and evalaution of their effects, Islamic Azad University, Shahrekord Press, Shahrekord, Iran.
  • [2] Appelquist WL, Moerman DE. Yarrow (Achillea millefolium L.): A neglected panacea? A review of ethnobotany, bioactivity, and biomedical research. Econ Bot. 2011; 65(2): 209-225. https://doi.org/10.1007/s12231-011-9154-3.
  • [3] World Health Organization. Avialable online: www.who.int (accessed on 1 July 2023).
  • [4] European Medicines Agency. Avialable online: www.ema.europa.eu (accessed on 1 July 2023).
  • [5] Quezel P, Santa S. Nouvelle Flore de l’Algérie et des régions désertiques et méridionales, CNRS, Paris, France 1962.
  • [6] Bader A, Martini F, Schinella GR, Rios JL, Prieto JM. Modulation of Cox-1, 5-,12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases. Phytother Res. 2015; 29(1): 108- 113. https://doi.org/10.1002/ptr.5234.
  • [7] Filippi JJ, Lanfranchi DA, Prado S, Baldovini N, Meierhenrich UJ. Composition, enantiomeric distribution and antibacterial activity of the essential oil of Achillea ligustica All. from Corsica. J Agric Food Chem. 2006; 54(17): 6308-6313. https://doi.org/10.1021/jf060752y.
  • [8] Muselli A, Pau M, Desjobert JM, Foddai M, Usai M, Costa J. Volatile constituents of Achillea ligustica All. by HS-SPME/GC/GC-MS comparison with essential oils obtained by hydrodistillation from Corsica and Sardinia. Chromatographia. 2009 ; 69: 575-585. https://doi.org/10.1365/s10337-008-0939-1.
  • [9] Ben Jemia M, Rouis Z, Maggio A, Venditti A, Bruno M, Senatore F. Chemical composition and free radical scavenging activity of the essential oil of Achillea ligustica growing wild in Lipari (Aeolian Islands, Sicily). Nat Prod Commun. 2013; 8(11): 1629-1632. https://doi.org/10.1177/1934578X1300801132.
  • [10] Conforti F, Loizzo MR, Statti GA, Menichini F. Comparative radical scavenging and antidiabetic activities of methanolic extract and fractions from Achillea ligustica All. Biol Pharm Bull. 2005; 28(9): 1791-1794. https://doi.org/10.1248/bpb.28.1791.
  • [11] Maggi F, Bramucci M, Cecchini C, Coman MM, Cresci A, Cristalli G, Lupidi G, Papa F, Quassinti L, Sagratini G, Vittori S. Composition and biological activity of essential oil of Achillea ligustica All. (Asteraceae) naturalized in central Italy: Ideal candidate for anti-cariogenic formulations. Fitoterapia. 2009; 80(6): 313-319. https://doi.org/10.1016/j.fitote.2009.04.004.
  • [12] Tuberoso CIG, Montoro P, Piacente S, Corona G, Deiana M, Dessì MA, Pizza C, Cabras P. Flavonoid characterization and antioxidant activity of hydroalcoholic extracts from Achillea ligustica All. J Pharm Biomed Anal. 2009; 50(3): 440-448. https://doi.org/10.1016/j.jpba.2009.05.032.
  • [13] Barda C, Grafakou ME,Tomou EM, Skaltsa H. Phytochemistry and evidence-based traditional uses of the genus Achillea L.: An update (2011-2021). Sci Pharm. 2021; 89(4): 1-36. https://doi.org/10.3390/scipharm89040050.
  • [14] Mahammadhosseini M, Sarker DS, Akbarzadeh A. Chemical composition of the essential oils and extracts of Achillea species and their biological activities: A review. J Ethnopharmacol. 2017; 199: 257–315. https://doi.org/10.1016/j.jep.2017.02.010.
  • [15] Radulovic N, Zlatkovic B, Palic R, Gordana Stojanovic G. Chemotaxonomic significance of the Balkan Achillea volatiles. Nat Prod Commun. 2007; 2(4): 453-474. https://doi.org/10.1177/1934578X0700200417.
  • [16] Saeidnia S, Gohari AR, Mokhber-Dezfuli N, Kiuchi F. A review on phytochemistry and medicinal properties of the genus Achillea. Daru. 2011; 19(3): 173-186.
  • [17] Salehi B, Selamoglu Z, Sevindik M, Fahmy NM, Al-sayed E, El-Shazly M, Csupor-Loffler B, Csupor D, Yazdi SE, Shrifi-Rad J, Arserim-Uçar DK, Arserim EH, Karazhan N, Jahani A, Dey A, Azadi H, Vakili SA, Sharopov F, Martins N, Busselberg D. Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications. Cell Mol Biol. 2020; 66(4): 78-103. https://doi.org/10.14715/cmb/2020.66.4.13.
  • [18] Si XT, Zhang ML, Shi QW, Kiyota H. Chemical constituents of the plants in the genus Achillea. Chem Biodivers. 2006; 3(11): 1163-1180. https://doi.org/10.1002/cbdv.200690119.
  • [19] Figueiredo AC, Pais MSS, Scheffer JJC. Achillea millefolium L. ssp. Millefolium (Yarrow): in vitro culture and production of essential oils. Biotechnology in agriculture and forestry. In Medicinal and Aromatic Plants VIII. Bajaj YDS. (Ed.) Berlin: Springer-Verlag, 1995; pp. 1–20.
  • [20] Venditti A, Guarcini L, Bianco A, Rosselli S, Bruno M, Senatore F. Phytochemical analysis of Achillea ligustica All. from Lipari Island (Aeolian Islands). Nat Prod Res. 2016; 30(8): 912-919. https://doi.org/10.1080/14786419.2015.1079188.
  • [21] Bader A, Panizzi L, Cioni PL, Flamini G. Achillea ligustica: Composition and antimicrobial activity of essential oils from the leaves, flowers, and some pure constituents. Open Life Sci. 2007; 2(2): 206-212. https://doi.org/10.2478/s11535-007-0020-3.
  • [22] Bruni A, Ballero M, Poli F. Quantitative ethnopharmacological study of the Campidano Valley and Urzulei district, Sardinia, Italy. J Ethnopharmacol. 1997 ; 57(2): 97-124. https://doi.org/10.1016/s0378-8741(97)00055-X.
  • [23] Viegi L, Pieroni A, Guarrera PM, Vangelisti R. A review of plants used in folk veterinary medicine in Italy as basis for a databank. J Ethnopharmacol. 2003; 89(2-3): 221–244. https://doi.org/10.1016/j.jep.2003.08.003.
  • [24] Cornara L, La Rocca A, Terrizzano L, Dente F, Mariotti MG. Ethnobotanical and phytomedical knowledge in the North-Western Ligurian Alps. J Ethnopharmacol. 2014 ; 155(1): 463-484. https://doi.org/10.1016/j.jep.2014.05.046.
  • [25] Boudjerda A, Zaiter H, Benayache S, Chalchat JC, Gonzàlez Platas J, Leon F, Brouard I, Bermejo J, Benayache F. A new guaianolide and other constituents from Achillea ligustica. Biochem Syst Ecol. 2008; 36(5-6): 461-466. https://doi.org/10.1016/j.bse.2007.11.006.
  • [26] Bruno M, Herz W. Guaianolides and other constituents of Achillea ligustica. Phytochemistry. 1988; 27(6): 1871-1872. https://doi.org/10.1016/0031-9422(88)80466-7.
  • [27] Tzakou O, Couladis M, Evmorfia V, Loukis A. Leaf flavonoids of Achillea ligustica and Achillea holosericea. Biochem Syst Ecol. 1995; 23(5): 569-570. https://doi.org/10.1016/0305-1978(95)00044-U.
  • [28] Valant-Vetschera KM. Flavonoid glycoside accumulation trends of Achillea nobilis L. and related species. Biochem Syst Ecol. 1987; 15: 45-52. https://doi.org/10.1016/0305-1978(87)90078-0.
  • [29] Ahmed AA, Gàti T, Hussein TA, Ali AT, Tzakou O, Couladis MA, Mabry TJ. Ligustolide A and B two novel sesquiterpenes with rare skeletons and three 1, 10-seco-guaianolide derivatives from Achillea ligustica. Tetrahedron. 2003; 59(21): 3729-3735. https://doi.org/10.1016/S0040-4020(03)00572-6.
  • [30] Hegazy MEF, Mohamed AEHH, El-Sayed MA, Ohta S. A new chlorine-containing sesquiterpene lactone from Achillea ligustica. Z Naturforsch B J Chem Sci. 2008; 63(1): 105-107. https://doi.org/10.1515/znb-2008-0116.
  • [31] Mahmoud AA, Al-Shihry SS, Hegazy MEF. A new epimeric sesquiterpene lactone from Achillea ligustica. Rec Nat Prod. 2012; 6: 21-27.
  • [32] Cecchini C, Silvi S, Cresci A, Piciotti A, Caprioli G, Papa F, Sagratini G, Vittori S, Maggi F. Antimicrobial efficacy of Achillea ligustica All. (Asteraceae) essential oils against reference and isolated oral microorganisms. Chem Biodivers. 2012; 9(1): 12–24. https://doi.org/10.1002/cbdv.201100249.
  • [33] Tzakou O, Loukis A, Verykokidou E, Roussis V. Chemical constituents of the essential oil of Achillea ligustica All. from Greece. J Essent Oil Res, 1995; 7(5): 549-550. https://doi.org/10.1080/10412905.1995.9698583.
  • [34] Benilli G, Pavela R, Giordani C, Casettari L, Curzi G, Cappellacci L, Petrelli R, Maggi, F. Acute and sub-lethal toxicity of eight essential oils of commercial interest against the filariasis mosquito Culex quinque fasciatus and the housefly Musca domestica. Ind Crops Prod. 2018; 112: 668–680. https://doi.org/10.1016/j.indcrop.2017.12.062.
  • [35] Giamperi L, Bucchini AEA, Ricci D, Papa F, Maggi F. Essential oil of Achillea ligustica (Asteraceae) as an antifungal agent against phytopathogenic fungi. Nat Prod Commun. 2018; 13(19): 1171-1174. https://doi.org/10.1177/1934578X1801300918.
  • [36] Maffei M, Germano F, Doglia G, Chialva F. Essential oils, chromosome numbers and karyotypes from Italian Achillea species. Part II. J Essent Oil Res. 1993; 5(1): 61-70. https://dx.doi.org/10.1080/10412905.1993.9698171.
  • [37] Tuberoso CIG, Kowalczyk A, Coroneo V, Russo MT, Dessì S, Cabras P. Chemical composition and antioxidant, antimicrobial, and antifungal activities of the essential oil of Achillea ligustica All. J Agric Food Chem. 2005; 53(26): 10148-10153. https://doi.org/10.1021/jf0518913.
  • [38] Greger H, Zdero C, Bohlmann F. Pyrrolidine and piperidine amides from Achillea. Phytochemistry. 1984; 23(7): 1503-1505. https://doi.org/10.1016/S0031-9422(00)80494-.
  • [39] Freires IA, Denny C, Benso B, de Alencar SM, Rosalen PL. Antibacterial activity of essential oils and their isolated constituents against cariogenic bacteria: A systematic review. Molecules. 2015; 20(4): 7329-7358. https://doi.org/10.3390/molecules20047329.

Yıl 2024, Cilt: 28 Sayı: 1, 313 - 325, 28.06.2025

Azza Bouteche Ahmed Touil , Segueni Narimane

Öz

Kaynakça

  • [1] Ghasemi A. Medicinal and fragrant plants, identification and evalaution of their effects, Islamic Azad University, Shahrekord Press, Shahrekord, Iran.
  • [2] Appelquist WL, Moerman DE. Yarrow (Achillea millefolium L.): A neglected panacea? A review of ethnobotany, bioactivity, and biomedical research. Econ Bot. 2011; 65(2): 209-225. https://doi.org/10.1007/s12231-011-9154-3.
  • [3] World Health Organization. Avialable online: www.who.int (accessed on 1 July 2023).
  • [4] European Medicines Agency. Avialable online: www.ema.europa.eu (accessed on 1 July 2023).
  • [5] Quezel P, Santa S. Nouvelle Flore de l’Algérie et des régions désertiques et méridionales, CNRS, Paris, France 1962.
  • [6] Bader A, Martini F, Schinella GR, Rios JL, Prieto JM. Modulation of Cox-1, 5-,12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases. Phytother Res. 2015; 29(1): 108- 113. https://doi.org/10.1002/ptr.5234.
  • [7] Filippi JJ, Lanfranchi DA, Prado S, Baldovini N, Meierhenrich UJ. Composition, enantiomeric distribution and antibacterial activity of the essential oil of Achillea ligustica All. from Corsica. J Agric Food Chem. 2006; 54(17): 6308-6313. https://doi.org/10.1021/jf060752y.
  • [8] Muselli A, Pau M, Desjobert JM, Foddai M, Usai M, Costa J. Volatile constituents of Achillea ligustica All. by HS-SPME/GC/GC-MS comparison with essential oils obtained by hydrodistillation from Corsica and Sardinia. Chromatographia. 2009 ; 69: 575-585. https://doi.org/10.1365/s10337-008-0939-1.
  • [9] Ben Jemia M, Rouis Z, Maggio A, Venditti A, Bruno M, Senatore F. Chemical composition and free radical scavenging activity of the essential oil of Achillea ligustica growing wild in Lipari (Aeolian Islands, Sicily). Nat Prod Commun. 2013; 8(11): 1629-1632. https://doi.org/10.1177/1934578X1300801132.
  • [10] Conforti F, Loizzo MR, Statti GA, Menichini F. Comparative radical scavenging and antidiabetic activities of methanolic extract and fractions from Achillea ligustica All. Biol Pharm Bull. 2005; 28(9): 1791-1794. https://doi.org/10.1248/bpb.28.1791.
  • [11] Maggi F, Bramucci M, Cecchini C, Coman MM, Cresci A, Cristalli G, Lupidi G, Papa F, Quassinti L, Sagratini G, Vittori S. Composition and biological activity of essential oil of Achillea ligustica All. (Asteraceae) naturalized in central Italy: Ideal candidate for anti-cariogenic formulations. Fitoterapia. 2009; 80(6): 313-319. https://doi.org/10.1016/j.fitote.2009.04.004.
  • [12] Tuberoso CIG, Montoro P, Piacente S, Corona G, Deiana M, Dessì MA, Pizza C, Cabras P. Flavonoid characterization and antioxidant activity of hydroalcoholic extracts from Achillea ligustica All. J Pharm Biomed Anal. 2009; 50(3): 440-448. https://doi.org/10.1016/j.jpba.2009.05.032.
  • [13] Barda C, Grafakou ME,Tomou EM, Skaltsa H. Phytochemistry and evidence-based traditional uses of the genus Achillea L.: An update (2011-2021). Sci Pharm. 2021; 89(4): 1-36. https://doi.org/10.3390/scipharm89040050.
  • [14] Mahammadhosseini M, Sarker DS, Akbarzadeh A. Chemical composition of the essential oils and extracts of Achillea species and their biological activities: A review. J Ethnopharmacol. 2017; 199: 257–315. https://doi.org/10.1016/j.jep.2017.02.010.
  • [15] Radulovic N, Zlatkovic B, Palic R, Gordana Stojanovic G. Chemotaxonomic significance of the Balkan Achillea volatiles. Nat Prod Commun. 2007; 2(4): 453-474. https://doi.org/10.1177/1934578X0700200417.
  • [16] Saeidnia S, Gohari AR, Mokhber-Dezfuli N, Kiuchi F. A review on phytochemistry and medicinal properties of the genus Achillea. Daru. 2011; 19(3): 173-186.
  • [17] Salehi B, Selamoglu Z, Sevindik M, Fahmy NM, Al-sayed E, El-Shazly M, Csupor-Loffler B, Csupor D, Yazdi SE, Shrifi-Rad J, Arserim-Uçar DK, Arserim EH, Karazhan N, Jahani A, Dey A, Azadi H, Vakili SA, Sharopov F, Martins N, Busselberg D. Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications. Cell Mol Biol. 2020; 66(4): 78-103. https://doi.org/10.14715/cmb/2020.66.4.13.
  • [18] Si XT, Zhang ML, Shi QW, Kiyota H. Chemical constituents of the plants in the genus Achillea. Chem Biodivers. 2006; 3(11): 1163-1180. https://doi.org/10.1002/cbdv.200690119.
  • [19] Figueiredo AC, Pais MSS, Scheffer JJC. Achillea millefolium L. ssp. Millefolium (Yarrow): in vitro culture and production of essential oils. Biotechnology in agriculture and forestry. In Medicinal and Aromatic Plants VIII. Bajaj YDS. (Ed.) Berlin: Springer-Verlag, 1995; pp. 1–20.
  • [20] Venditti A, Guarcini L, Bianco A, Rosselli S, Bruno M, Senatore F. Phytochemical analysis of Achillea ligustica All. from Lipari Island (Aeolian Islands). Nat Prod Res. 2016; 30(8): 912-919. https://doi.org/10.1080/14786419.2015.1079188.
  • [21] Bader A, Panizzi L, Cioni PL, Flamini G. Achillea ligustica: Composition and antimicrobial activity of essential oils from the leaves, flowers, and some pure constituents. Open Life Sci. 2007; 2(2): 206-212. https://doi.org/10.2478/s11535-007-0020-3.
  • [22] Bruni A, Ballero M, Poli F. Quantitative ethnopharmacological study of the Campidano Valley and Urzulei district, Sardinia, Italy. J Ethnopharmacol. 1997 ; 57(2): 97-124. https://doi.org/10.1016/s0378-8741(97)00055-X.
  • [23] Viegi L, Pieroni A, Guarrera PM, Vangelisti R. A review of plants used in folk veterinary medicine in Italy as basis for a databank. J Ethnopharmacol. 2003; 89(2-3): 221–244. https://doi.org/10.1016/j.jep.2003.08.003.
  • [24] Cornara L, La Rocca A, Terrizzano L, Dente F, Mariotti MG. Ethnobotanical and phytomedical knowledge in the North-Western Ligurian Alps. J Ethnopharmacol. 2014 ; 155(1): 463-484. https://doi.org/10.1016/j.jep.2014.05.046.
  • [25] Boudjerda A, Zaiter H, Benayache S, Chalchat JC, Gonzàlez Platas J, Leon F, Brouard I, Bermejo J, Benayache F. A new guaianolide and other constituents from Achillea ligustica. Biochem Syst Ecol. 2008; 36(5-6): 461-466. https://doi.org/10.1016/j.bse.2007.11.006.
  • [26] Bruno M, Herz W. Guaianolides and other constituents of Achillea ligustica. Phytochemistry. 1988; 27(6): 1871-1872. https://doi.org/10.1016/0031-9422(88)80466-7.
  • [27] Tzakou O, Couladis M, Evmorfia V, Loukis A. Leaf flavonoids of Achillea ligustica and Achillea holosericea. Biochem Syst Ecol. 1995; 23(5): 569-570. https://doi.org/10.1016/0305-1978(95)00044-U.
  • [28] Valant-Vetschera KM. Flavonoid glycoside accumulation trends of Achillea nobilis L. and related species. Biochem Syst Ecol. 1987; 15: 45-52. https://doi.org/10.1016/0305-1978(87)90078-0.
  • [29] Ahmed AA, Gàti T, Hussein TA, Ali AT, Tzakou O, Couladis MA, Mabry TJ. Ligustolide A and B two novel sesquiterpenes with rare skeletons and three 1, 10-seco-guaianolide derivatives from Achillea ligustica. Tetrahedron. 2003; 59(21): 3729-3735. https://doi.org/10.1016/S0040-4020(03)00572-6.
  • [30] Hegazy MEF, Mohamed AEHH, El-Sayed MA, Ohta S. A new chlorine-containing sesquiterpene lactone from Achillea ligustica. Z Naturforsch B J Chem Sci. 2008; 63(1): 105-107. https://doi.org/10.1515/znb-2008-0116.
  • [31] Mahmoud AA, Al-Shihry SS, Hegazy MEF. A new epimeric sesquiterpene lactone from Achillea ligustica. Rec Nat Prod. 2012; 6: 21-27.
  • [32] Cecchini C, Silvi S, Cresci A, Piciotti A, Caprioli G, Papa F, Sagratini G, Vittori S, Maggi F. Antimicrobial efficacy of Achillea ligustica All. (Asteraceae) essential oils against reference and isolated oral microorganisms. Chem Biodivers. 2012; 9(1): 12–24. https://doi.org/10.1002/cbdv.201100249.
  • [33] Tzakou O, Loukis A, Verykokidou E, Roussis V. Chemical constituents of the essential oil of Achillea ligustica All. from Greece. J Essent Oil Res, 1995; 7(5): 549-550. https://doi.org/10.1080/10412905.1995.9698583.
  • [34] Benilli G, Pavela R, Giordani C, Casettari L, Curzi G, Cappellacci L, Petrelli R, Maggi, F. Acute and sub-lethal toxicity of eight essential oils of commercial interest against the filariasis mosquito Culex quinque fasciatus and the housefly Musca domestica. Ind Crops Prod. 2018; 112: 668–680. https://doi.org/10.1016/j.indcrop.2017.12.062.
  • [35] Giamperi L, Bucchini AEA, Ricci D, Papa F, Maggi F. Essential oil of Achillea ligustica (Asteraceae) as an antifungal agent against phytopathogenic fungi. Nat Prod Commun. 2018; 13(19): 1171-1174. https://doi.org/10.1177/1934578X1801300918.
  • [36] Maffei M, Germano F, Doglia G, Chialva F. Essential oils, chromosome numbers and karyotypes from Italian Achillea species. Part II. J Essent Oil Res. 1993; 5(1): 61-70. https://dx.doi.org/10.1080/10412905.1993.9698171.
  • [37] Tuberoso CIG, Kowalczyk A, Coroneo V, Russo MT, Dessì S, Cabras P. Chemical composition and antioxidant, antimicrobial, and antifungal activities of the essential oil of Achillea ligustica All. J Agric Food Chem. 2005; 53(26): 10148-10153. https://doi.org/10.1021/jf0518913.
  • [38] Greger H, Zdero C, Bohlmann F. Pyrrolidine and piperidine amides from Achillea. Phytochemistry. 1984; 23(7): 1503-1505. https://doi.org/10.1016/S0031-9422(00)80494-.
  • [39] Freires IA, Denny C, Benso B, de Alencar SM, Rosalen PL. Antibacterial activity of essential oils and their isolated constituents against cariogenic bacteria: A systematic review. Molecules. 2015; 20(4): 7329-7358. https://doi.org/10.3390/molecules20047329.
Toplam 39 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri (Diğer)
Bölüm Reviews
Yazarlar

Azza Bouteche 0009-0000-7883-5508

Ahmed Touil 0000-0001-6098-904X

Segueni Narimane 0000-0001-5804-5998

Yayımlanma Tarihi 28 Haziran 2025
Yayımlandığı Sayı Yıl 2024 Cilt: 28 Sayı: 1

Kaynak Göster

APA Bouteche, A., Touil, A., & Narimane, S. (2025). Phytochemical composition, ethnomedicinal uses, and pharmacological properties of Achillea ligustica All.: A review. Journal of Research in Pharmacy, 28(1), 313-325.
AMA Bouteche A, Touil A, Narimane S. Phytochemical composition, ethnomedicinal uses, and pharmacological properties of Achillea ligustica All.: A review. J. Res. Pharm. Haziran 2025;28(1):313-325.
Chicago Bouteche, Azza, Ahmed Touil, ve Segueni Narimane. “Phytochemical Composition, Ethnomedicinal Uses, and Pharmacological Properties of Achillea Ligustica All.: A Review”. Journal of Research in Pharmacy 28, sy. 1 (Haziran 2025): 313-25.
EndNote Bouteche A, Touil A, Narimane S (01 Haziran 2025) Phytochemical composition, ethnomedicinal uses, and pharmacological properties of Achillea ligustica All.: A review. Journal of Research in Pharmacy 28 1 313–325.
IEEE A. Bouteche, A. Touil, ve S. Narimane, “Phytochemical composition, ethnomedicinal uses, and pharmacological properties of Achillea ligustica All.: A review”, J. Res. Pharm., c. 28, sy. 1, ss. 313–325, 2025.
ISNAD Bouteche, Azza vd. “Phytochemical Composition, Ethnomedicinal Uses, and Pharmacological Properties of Achillea Ligustica All.: A Review”. Journal of Research in Pharmacy 28/1 (Haziran 2025), 313-325.
JAMA Bouteche A, Touil A, Narimane S. Phytochemical composition, ethnomedicinal uses, and pharmacological properties of Achillea ligustica All.: A review. J. Res. Pharm. 2025;28:313–325.
MLA Bouteche, Azza vd. “Phytochemical Composition, Ethnomedicinal Uses, and Pharmacological Properties of Achillea Ligustica All.: A Review”. Journal of Research in Pharmacy, c. 28, sy. 1, 2025, ss. 313-25.
Vancouver Bouteche A, Touil A, Narimane S. Phytochemical composition, ethnomedicinal uses, and pharmacological properties of Achillea ligustica All.: A review. J. Res. Pharm. 2025;28(1):313-25.