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Investigation of vehicle-induced whole-body vibration with experimental rat models

Yıl 2023, Cilt: 27 Sayı: 6, 2310 - 2329, 28.06.2025

Ayşe Nur Hazar-yavuz , Akif Yavuz

Öz

This comprehensive study delves into the profound impact of low frequency whole-body vibrations (WBV) on health, focusing on the utilization of rat models for understanding this complex phenomenon. It highlights the adverse effects of low frequency vehicle vibrations on human health, encompassing musculoskeletal discomfort, fatigue, concentration deficits, potential gastrointestinal issues, hearing impairment, and psychological stress. WBV's influence extends to physiological and cognitive consequences, affecting multiple systems. Prolonged WBV exposure, particularly in the lumbar region, is associated with spinal disorders. To navigate ethical challenges in studying WBV in humans, rat models are crucial tools. These models, with customized parameters, offer insights into various health aspects, including bone density, muscle strength, hormonal responses, cardiovascular parameters, and more. Advantages and disadvantages of using low-frequency vibrations in rat models are discussed. While demonstrating WBV's potential effect in research, further exploration is essential to optimize parameters and applications, always prioritizing ethical considerations and regulations. The article concludes by proposing measures to mitigate vehicle vibration impacts on drivers, emphasizing the collaboration of manufacturers, drivers, and regulators for safer and healthier driving experiences.

Anahtar Kelimeler

Whole-body vibration WBV low-frequency vibration vehicle vibrations rat experiments

Kaynakça

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Yıl 2023, Cilt: 27 Sayı: 6, 2310 - 2329, 28.06.2025

Ayşe Nur Hazar-yavuz , Akif Yavuz

Öz

Kaynakça

  • [1] Tiemessen IJ, Hulshof CT, Frings-Dresen MH. An overview of strategies to reduce whole-body vibration exposure on drivers: A systematic review. International Journal of Industrial Ergonomics. 2007; 37(3): 245-256. https://orcid.org/10.1016/j.ergon.2006.10.021
  • [2] Abercromby AF, Amonette WE, Layne CS, McFarlin BK, Hinman MR, Paloski WH. Vibration exposure and biodynamic responses during whole-body vibration training. Med Sci Sports Exerc. 2007 Oct;39(10):1794-800. https://orcid.org/10.1249/mss.0b013e3181238a0f
  • [3] Ozkaya N, Willems B, Goldsheyder D. Whole-body vibration exposure: a comprehensive field study. Am Ind Hyg Assoc J. 1994 Dec;55(12):1164-71. https://orcid.org/10.1080/15428119491018240
  • [4] Dong Y, Wang W, Zheng J, Chen S, Qiao J, Wang X. Whole Body Vibration Exercise for Chronic Musculoskeletal Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Arch Phys Med Rehabil. 2019 Nov;100(11):2167-2178. https://orcid.org/10.1016/j.apmr.2019.03.011
  • [5] Mandal BB, Srivastava AK. Musculoskeletal disorders in dumper operators exposed to whole body vibration at Indian mines. International Journal of Mining, Reclamation and Environment. 2010; 24(3): 233-243. https://orcid.org/10.1080/17480930903526227
  • [6] Grenier SG, Eger TR, Dickey JP. Predicting discomfort scores reported by LHD operators using whole-body vibration exposure values and musculoskeletal pain scores. Work. 2010;35(1):49-62. https://orcid.org/10.3233/WOR-2010-0957
  • [7] Rittweger J, Beller G, Felsenberg D. Acute physiological effects of exhaustive whole-body vibration exercise in man. Clin Physiol. 2000 Mar;20(2):134-42. https://orcid.org/10.1046/j.1365-2281.2000.00238.x
  • [8] Saucier M. Effects of vertical whole-body vibration parameters on rate of muscle fatigue in submaximal isometric contraction: a pilot study (Doctoral dissertation, Concordia University). 2010
  • [9] Torvinen S, Sievänen H, Järvinen TA, Pasanen M, Kontulainen S, Kannus P. Effect of 4-min vertical whole body vibration on muscle performance and body balance: a randomized cross-over study. Int J Sports Med. 2002 Jul;23(5):374-9. https://orcid.org/10.1055/s-2002-33148
  • [10] Miyashita K, Morioka I, Tanabe T, Iwata H, Takeda S. Symptoms of construction workers exposed to whole body vibration and local vibration. Int Arch Occup Environ Health. 1992;64(5):347-51. https://orcid.org/10.1007/BF00379545
  • [11] Dupuis H, Zerlett G. The effects of whole-body vibration. Springer Science & Business Media. 2012
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  • [13] Hamernik RP, Henderson D, Coling D, Slepecky N. The interaction of whole body vibration and impulse noise. J Acoust Soc Am. 1980 Mar;67(3):928-34. https://orcid.org/10.1121/1.383942
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  • [59] Minematsu A, Nishii Y, Imagita H, Sakata S. Whole body vibration at low-frequency can increase trabecular thickness and width in adult rats. J Musculoskelet Neuronal Interact. 2019 Jun 1;19(2):169-177.
  • [60] Maddalozzo GF, Iwaniec UT, Turner RT, Rosen CJ, Widrick JJ. Whole-body vibration slows the acquisition of fat in mature female rats. Int J Obes (Lond). 2008 Sep;32(9):1348-54. https://orcid.org/10.1038/ijo.2008.111
  • [61] Lin CI, Huang WC, Chen WC, Kan NW, Wei L, Chiu YS, Huang CC. Effect of whole-body vibration training on body composition, exercise performance and biochemical responses in middle-aged mice. Metabolism. 2015 Sep;64(9):1146-56. https://orcid.org/10.1016/j.metabol.2015.05.007
  • [62] Sandhu E, Miles JD, Dahners LE, Keller BV, Weinhold PS. Whole body vibration increases area and stiffness of the flexor carpi ulnaris tendon in the rat. J Biomech. 2011 Apr 7;44(6):1189-91. https://orcid.org/10.1016/j.jbiomech.2011.02.017
  • [63] Hoffmann DB, Sehmisch S, Hofmann AM, Eimer C, Komrakova M, Saul D, Wassmann M, Stürmer KM, Tezval M. Comparison of parathyroid hormone and strontium ranelate in combination with whole-body vibration in a rat model of osteoporosis. J Bone Miner Metab. 2017 Jan;35(1):31-39. https://orcid.org/10.1007/s00774-016-0736-0
  • [64] Luan H, Huang Y, Li J, Sun L, Fan Y. Effect of Local Vibration and Passive Exercise on the Hormones and Neurotransmitters of Hypothalamic–Pituitary–Adrenal Axis in Hindlimb Unloading Rats. Microgravity Science and Technology. 2018; 30: 483-489. https://orcid.org/10.1007/s12217-018-9609-6
  • [65] Pawlak M, Kaczmarek D, Nowak A, Krutki P. Low-volume whole-body vibration lasting 3 or 6 months does not affect biomarkers in blood serum of rats. Acta Physiol Hung. 2013 Mar;100(1):48-53. https://orcid.org/10.1556/APhysiol.99.2012.003
  • [66] Nakamura H, Ohsu W, Nagase H, Okazawa T, Yoshida M, Okada A. Uterine circulatory dysfunction induced by whole-body vibration and its endocrine pathogenesis in the pregnant rat. Eur J Appl Physiol Occup Physiol. 1996;72(4):292-6. https://orcid.org/10.1007/BF00599687
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  • [68] Shekarforoush S, Naghii MR. Whole-Body Vibration Training Increases Myocardial Salvage Against Acute Ischemia in Adult Male Rats. Arq Bras Cardiol. 2019 Jan;112(1):32-37. https://orcid.org/10.5935/abc.20180252
  • [69] Tóth K, Oroszi T, Nyakas C, van der Zee EA, Schoemaker RG. Whole-body vibration as a passive alternative to exercise after myocardial damage in middle-aged female rats: Effects on the heart, the brain, and behavior. Front Aging Neurosci. 2023 Mar 7;15:1034474. https://orcid.org/10.3389/fnagi.2023.1034474
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  • [76] Eisenberg RM. Sound vibration, a non-invasive stress: antagonism by diazepam. Psychopharmacology (Berl). 1993;110(4):467-70. https://orcid.org/10.1007/BF02244654 [77] Dolkas CB, Leon HA, Chackerian M. Short term response of insulin, glucose, growth hormone and corticosterone to acute vibration in rats. Aerosp Med. 1971 Jul;42(7):723-6. [78] Bovenzi M. Health effects of mechanical vibration. G Ital Med Lav Ergon. 2005 Jan-Mar;27(1):58-64.
  • [79] Cardinale M, Pope MH. The effects of whole body vibration on humans: dangerous or advantageous? Acta Physiol Hung. 2003;90(3):195-206. https://orcid.org/10.1556/APhysiol.90.2003.3.2
  • [80] Jensen A, Jepsen JR. Vibration on board and health effects. Int Marit Health. 2014;65(2):58-60. https://orcid.org/10.5603/IMH.2014.0013
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  • [84] da Costa JRG, Tavares ALDF, Bertolini GRF, Wutzke MLS, Boaro CDT, Rodriguez DFS, ... Ribeiro LDFC. Histological aspects of whole-body vibration in the knee remobilization of Wistar rats. European Journal of Clinical and Experimental Medicine. 2022; (2): 159-166. https://orcid.org/10.15584/ejcem.2022.2.4
  • [85] Yavuz A. Msc Thesis. Evaluation of vehicle seats for the vibration comfort. Department of Mechanical Engineering, Istanbul Technical University, Istanbul, Türkiye, 2017.
Toplam 81 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri (Diğer)
Bölüm Reviews
Yazarlar

Ayşe Nur Hazar-yavuz 0000-0003-0784-8779

Akif Yavuz 0000-0002-9447-7306

Yayımlanma Tarihi 28 Haziran 2025
Gönderilme Tarihi 4 Kasım 2023
Kabul Tarihi 18 Kasım 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 27 Sayı: 6

Kaynak Göster

APA Hazar-yavuz, A. N., & Yavuz, A. (2025). Investigation of vehicle-induced whole-body vibration with experimental rat models. Journal of Research in Pharmacy, 27(6), 2310-2329. https://doi.org/10.29228/jrp.519
AMA Hazar-yavuz AN, Yavuz A. Investigation of vehicle-induced whole-body vibration with experimental rat models. J. Res. Pharm. Temmuz 2025;27(6):2310-2329. doi:10.29228/jrp.519
Chicago Hazar-yavuz, Ayşe Nur, ve Akif Yavuz. “Investigation of Vehicle-Induced Whole-Body Vibration With Experimental Rat Models”. Journal of Research in Pharmacy 27, sy. 6 (Temmuz 2025): 2310-29. https://doi.org/10.29228/jrp.519.
EndNote Hazar-yavuz AN, Yavuz A (01 Temmuz 2025) Investigation of vehicle-induced whole-body vibration with experimental rat models. Journal of Research in Pharmacy 27 6 2310–2329.
IEEE A. N. Hazar-yavuz ve A. Yavuz, “Investigation of vehicle-induced whole-body vibration with experimental rat models”, J. Res. Pharm., c. 27, sy. 6, ss. 2310–2329, 2025, doi: 10.29228/jrp.519.
ISNAD Hazar-yavuz, Ayşe Nur - Yavuz, Akif. “Investigation of Vehicle-Induced Whole-Body Vibration With Experimental Rat Models”. Journal of Research in Pharmacy 27/6 (Temmuz 2025), 2310-2329. https://doi.org/10.29228/jrp.519.
JAMA Hazar-yavuz AN, Yavuz A. Investigation of vehicle-induced whole-body vibration with experimental rat models. J. Res. Pharm. 2025;27:2310–2329.
MLA Hazar-yavuz, Ayşe Nur ve Akif Yavuz. “Investigation of Vehicle-Induced Whole-Body Vibration With Experimental Rat Models”. Journal of Research in Pharmacy, c. 27, sy. 6, 2025, ss. 2310-29, doi:10.29228/jrp.519.
Vancouver Hazar-yavuz AN, Yavuz A. Investigation of vehicle-induced whole-body vibration with experimental rat models. J. Res. Pharm. 2025;27(6):2310-29.