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Anti-inflammatory properties of the ruthenium polypyridyl complex, K314, on the in vitro activated macrophages

Yıl 2019, Cilt: 23 Sayı: 2, 164 - 169, 27.06.2025

Furkan Ayaz

Öz

Ruthenium polypyridyl complex derivatives find applications in the solar cells. They are mostly used as photosensitizers in solar cells for energy production. In our study we examined their activities on the immune system cells. At cellular level metabolic activities are shaped by the electron transfer reactions and ruthenium polypyridyl complexes can very well interfere this process and alter the outcome. A change in the cell’s metabolism would lead to a change in the cell’s activity. Depending on the functional group types attached to the ruthenium complex there can be changes in their biological function. Therefore our group has been screening their different derivatives’ effects on the immune system cells inflammatory activity. We primarily focus on macrophages that are crucial cells of the innate immunity. In order to measure the activity of the macrophage cell line we detected the changes in the pro-inflammatory TNFα, IL1β and IL6 cytokine levels by ELISA. Our in vitro results support that K314 can be used as an anti-inflammatory drµg candidate in autoimmune diseases or inflammatory disorders. Furthermore, K314 can also be used as a surface coating material on the patches to prevent the inflammation in the area; as well as organ and tissue transplants, especially bone tissue, to suppress the inflammation mediated rejection of the transplant.

Anahtar Kelimeler

TNFα IL-6 IL-1β inflammation macrophage immunomodulation anti-inflammatory molecules innate immunity

Kaynakça

  • [1] Ocakoglu K, Okur S, Aydin H, Guloglu P, Emen FM. The effect of annealing temperature on the optical properties of a ruthenium complex thin film. Thin Solid Films. 2016; 612(2): 225-230. [CrossRef]
  • [2] Ocakoglu K, Zafer C, Cetinkaya B, Icli S. Synthesis, characterization, electrochemical and spectroscopic studies of two new heteroleptic Ru(II) polypyridyl complexes. Dyes Pigm. 2007; 75(1): 385–394. [CrossRef]
  • [3] Ocakoglu K, Harputlu E, Guloglu P, Erten-Ela S. The photovoltaic performance of new ruthenium complexes in DSSCs based on nanorod ZnO electrode. Synthetic Metals. 2012; 23(1): 2125-2133. [CrossRef]
  • [4] Buck MD, Sowell RT, Kaech SM, Pearce EL. Metabolic instruction of immunity. Cell. 2017; 1(1): 570-586. [CrossRef]
  • [5] Arango Duque G, Descoteaux A. Macrophage cytokines: Involvement in immunity and infectious diseases. Front Immunol. 2014; 5(1): 491. [CrossRef]
  • [6] Murray RZ, Stow JL. Cytokine secretion in macrophages: SNAREs, rabs, and membrane trafficking. Front Immunol. 2014; 5: 538. [CrossRef]
  • [7] Kawagishi C, Kurosaka K, Watanabe N, Kobayashi Y. Cytokine production by macrophages in association with phagocytosis of etoposide-treated P388 cells in vitro and in vivo. Biochim Biophys Acta (BBA) – Mol Cell Res. 2001; 1541(3): 221-230. [CrossRef]
  • [8] Cavaillon JM. Cytokines and macrophages. Biomed Pharmacother. 1994; 48(10): 445-453. [CrossRef]
  • [9] Scull CM, Hays WD, Fischer TH. Macrophage proinflammatory cytokine secretion is enhanced following interaction with autologous platelets. J Inflamm. 2010; 7: 53. [CrossRef]
  • [10] Berghaus LJ, Moore JN, Hurley DJ, Vandenplas ML, Fortes BP, Wolfert MA, Boons GJ. Innate immune responses of primary murine macrophage-lineage cells and RAW 264.7 cells to ligands of Toll-like receptors 2, 3, and 4. Comp Immunol Microbiol Infect Dis. 2010; 33(5): 443–454. [CrossRef]
  • [11] Schmitz F, Mages J, Heit A, Lang R, Wagner H. Transcriptional activation induced in macrophages by Toll-like receptor (TLR) ligands: from expression profiling to a model of TLR signaling. Eur J Immunol. 2004; 34(10): 2863-2873. [CrossRef]
  • [12] Soromou LW, Zhang Z, Li R, Chen N, Guo W, Huo M, Guan S, Lu J, Deng X. Regulation of inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 murine macrophage by 7-O-methyl-naringenin. Molecules. 2012; 17(3): 3574-3585. [CrossRef]
  • [13] Gasparini C, Foxwell BM, Feldmann M. RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages. Cytokine. 2013; 61(3): 736-740. [CrossRef]
  • [14] Parameswaran N, Patial S. Tumor Necrosis Factor-α Signaling in Macrophages. Crit Rev Eukaryot Gene Expr. 2010; 20(2): 87–103.
  • [15] Lopez-Castejon G, Brough D. Understanding the mechanism of IL-1β secretion. Cytokine Growth Factor Rev. 2011; 22(4): 189–195. [CrossRef]
  • [16] Manderson AP, Kay JG, Hammond LA, Brown DL, Stow JL. Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNFα. J Cell Biol. 2007; 178(1): 57. [CrossRef]
  • [17] Broide DH. Immunomodulation of allergic disease. Annu Rev Med. 2009; 60: 279-291. [CrossRef]
  • [18] Iwalewa EO, McGaw LJ, Naidoo V, Eloff JN. Inflammation: the foundation of diseases and disorders. A review of phytomedicines of South African origin used to treat pain and inflammatory conditions. Afr J Biotechnol. 2007; 6(25): 2868-2885.
  • [19] Hancock REW, Nijnik A, Philpott DJ. Modulating immunity as a therapy for bacterial infections. Nat Rev Microbiol. 2012; 10: 243-254. [CrossRef]
  • [20] Kaufmann T, Simon HU. Targeting disease by immunomodulation. Cell Death Differ. 2015; 22: 185–186.
  • [21] Julier Z, Park AJ, Briquez PS, Martino MM. Promoting tissue regeneration by modulating the immune system. Acta Biomaterialia. 2017: 1-42. [CrossRef]
  • [22] Khalil DN, Smith EL, Brentjens RJ, Wolchok JD. The future of cancer treatment: immunomodulation, CARs and combination immunotherapy. Nat Rev Clin Oncol. 2016; 13(5): 273–290. [CrossRef]
  • [23] Tan TT, Coussens LM. Humoral immunity, inflammation and cancer. Curr Opin Immunol. 2007; 19(2): 209-216. [CrossRef]
  • [24] Daniel CS, Ira M. Oncology meets immunity. Immunity. 2013; 39(1): 1-10. [CrossRef]
  • [25] Guevara-Patiño JA, Turk MJ, Wolchok JD, Houghton AN. Immunity to cancer through immune recognition of altered self: Studies with melanoma. Adv Cancer Res. 2003; 90: 157-177. [CrossRef]
  • [26] Valdés-Ramos R, Benítez-Arciniega A. Nutrition and immunity in cancer. Br J Nutr. 2007; 98(S1): S127-S132. [CrossRef]
  • [27] Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010; 140(6): 883–897. [CrossRef]
  • [28] Rakoff-Nahoum S. Why cancer and inflammation? Yale J Biol Med. 2006; 79(3-4): 123–130.
  • [29] Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002; 420(6917): 860–867. [CrossRef]

Yıl 2019, Cilt: 23 Sayı: 2, 164 - 169, 27.06.2025

Furkan Ayaz

Öz

Kaynakça

  • [1] Ocakoglu K, Okur S, Aydin H, Guloglu P, Emen FM. The effect of annealing temperature on the optical properties of a ruthenium complex thin film. Thin Solid Films. 2016; 612(2): 225-230. [CrossRef]
  • [2] Ocakoglu K, Zafer C, Cetinkaya B, Icli S. Synthesis, characterization, electrochemical and spectroscopic studies of two new heteroleptic Ru(II) polypyridyl complexes. Dyes Pigm. 2007; 75(1): 385–394. [CrossRef]
  • [3] Ocakoglu K, Harputlu E, Guloglu P, Erten-Ela S. The photovoltaic performance of new ruthenium complexes in DSSCs based on nanorod ZnO electrode. Synthetic Metals. 2012; 23(1): 2125-2133. [CrossRef]
  • [4] Buck MD, Sowell RT, Kaech SM, Pearce EL. Metabolic instruction of immunity. Cell. 2017; 1(1): 570-586. [CrossRef]
  • [5] Arango Duque G, Descoteaux A. Macrophage cytokines: Involvement in immunity and infectious diseases. Front Immunol. 2014; 5(1): 491. [CrossRef]
  • [6] Murray RZ, Stow JL. Cytokine secretion in macrophages: SNAREs, rabs, and membrane trafficking. Front Immunol. 2014; 5: 538. [CrossRef]
  • [7] Kawagishi C, Kurosaka K, Watanabe N, Kobayashi Y. Cytokine production by macrophages in association with phagocytosis of etoposide-treated P388 cells in vitro and in vivo. Biochim Biophys Acta (BBA) – Mol Cell Res. 2001; 1541(3): 221-230. [CrossRef]
  • [8] Cavaillon JM. Cytokines and macrophages. Biomed Pharmacother. 1994; 48(10): 445-453. [CrossRef]
  • [9] Scull CM, Hays WD, Fischer TH. Macrophage proinflammatory cytokine secretion is enhanced following interaction with autologous platelets. J Inflamm. 2010; 7: 53. [CrossRef]
  • [10] Berghaus LJ, Moore JN, Hurley DJ, Vandenplas ML, Fortes BP, Wolfert MA, Boons GJ. Innate immune responses of primary murine macrophage-lineage cells and RAW 264.7 cells to ligands of Toll-like receptors 2, 3, and 4. Comp Immunol Microbiol Infect Dis. 2010; 33(5): 443–454. [CrossRef]
  • [11] Schmitz F, Mages J, Heit A, Lang R, Wagner H. Transcriptional activation induced in macrophages by Toll-like receptor (TLR) ligands: from expression profiling to a model of TLR signaling. Eur J Immunol. 2004; 34(10): 2863-2873. [CrossRef]
  • [12] Soromou LW, Zhang Z, Li R, Chen N, Guo W, Huo M, Guan S, Lu J, Deng X. Regulation of inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 murine macrophage by 7-O-methyl-naringenin. Molecules. 2012; 17(3): 3574-3585. [CrossRef]
  • [13] Gasparini C, Foxwell BM, Feldmann M. RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages. Cytokine. 2013; 61(3): 736-740. [CrossRef]
  • [14] Parameswaran N, Patial S. Tumor Necrosis Factor-α Signaling in Macrophages. Crit Rev Eukaryot Gene Expr. 2010; 20(2): 87–103.
  • [15] Lopez-Castejon G, Brough D. Understanding the mechanism of IL-1β secretion. Cytokine Growth Factor Rev. 2011; 22(4): 189–195. [CrossRef]
  • [16] Manderson AP, Kay JG, Hammond LA, Brown DL, Stow JL. Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNFα. J Cell Biol. 2007; 178(1): 57. [CrossRef]
  • [17] Broide DH. Immunomodulation of allergic disease. Annu Rev Med. 2009; 60: 279-291. [CrossRef]
  • [18] Iwalewa EO, McGaw LJ, Naidoo V, Eloff JN. Inflammation: the foundation of diseases and disorders. A review of phytomedicines of South African origin used to treat pain and inflammatory conditions. Afr J Biotechnol. 2007; 6(25): 2868-2885.
  • [19] Hancock REW, Nijnik A, Philpott DJ. Modulating immunity as a therapy for bacterial infections. Nat Rev Microbiol. 2012; 10: 243-254. [CrossRef]
  • [20] Kaufmann T, Simon HU. Targeting disease by immunomodulation. Cell Death Differ. 2015; 22: 185–186.
  • [21] Julier Z, Park AJ, Briquez PS, Martino MM. Promoting tissue regeneration by modulating the immune system. Acta Biomaterialia. 2017: 1-42. [CrossRef]
  • [22] Khalil DN, Smith EL, Brentjens RJ, Wolchok JD. The future of cancer treatment: immunomodulation, CARs and combination immunotherapy. Nat Rev Clin Oncol. 2016; 13(5): 273–290. [CrossRef]
  • [23] Tan TT, Coussens LM. Humoral immunity, inflammation and cancer. Curr Opin Immunol. 2007; 19(2): 209-216. [CrossRef]
  • [24] Daniel CS, Ira M. Oncology meets immunity. Immunity. 2013; 39(1): 1-10. [CrossRef]
  • [25] Guevara-Patiño JA, Turk MJ, Wolchok JD, Houghton AN. Immunity to cancer through immune recognition of altered self: Studies with melanoma. Adv Cancer Res. 2003; 90: 157-177. [CrossRef]
  • [26] Valdés-Ramos R, Benítez-Arciniega A. Nutrition and immunity in cancer. Br J Nutr. 2007; 98(S1): S127-S132. [CrossRef]
  • [27] Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010; 140(6): 883–897. [CrossRef]
  • [28] Rakoff-Nahoum S. Why cancer and inflammation? Yale J Biol Med. 2006; 79(3-4): 123–130.
  • [29] Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002; 420(6917): 860–867. [CrossRef]
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmasotik Biyoteknoloji
Bölüm Articles
Yazarlar

Furkan Ayaz

Yayımlanma Tarihi 27 Haziran 2025
Yayımlandığı Sayı Yıl 2019 Cilt: 23 Sayı: 2

Kaynak Göster

APA Ayaz, F. (2025). Anti-inflammatory properties of the ruthenium polypyridyl complex, K314, on the in vitro activated macrophages. Journal of Research in Pharmacy, 23(2), 164-169.
AMA Ayaz F. Anti-inflammatory properties of the ruthenium polypyridyl complex, K314, on the in vitro activated macrophages. J. Res. Pharm. Haziran 2025;23(2):164-169.
Chicago Ayaz, Furkan. “Anti-Inflammatory Properties of the Ruthenium Polypyridyl Complex, K314, on the in Vitro Activated Macrophages”. Journal of Research in Pharmacy 23, sy. 2 (Haziran 2025): 164-69.
EndNote Ayaz F (01 Haziran 2025) Anti-inflammatory properties of the ruthenium polypyridyl complex, K314, on the in vitro activated macrophages. Journal of Research in Pharmacy 23 2 164–169.
IEEE F. Ayaz, “Anti-inflammatory properties of the ruthenium polypyridyl complex, K314, on the in vitro activated macrophages”, J. Res. Pharm., c. 23, sy. 2, ss. 164–169, 2025.
ISNAD Ayaz, Furkan. “Anti-Inflammatory Properties of the Ruthenium Polypyridyl Complex, K314, on the in Vitro Activated Macrophages”. Journal of Research in Pharmacy 23/2 (Haziran 2025), 164-169.
JAMA Ayaz F. Anti-inflammatory properties of the ruthenium polypyridyl complex, K314, on the in vitro activated macrophages. J. Res. Pharm. 2025;23:164–169.
MLA Ayaz, Furkan. “Anti-Inflammatory Properties of the Ruthenium Polypyridyl Complex, K314, on the in Vitro Activated Macrophages”. Journal of Research in Pharmacy, c. 23, sy. 2, 2025, ss. 164-9.
Vancouver Ayaz F. Anti-inflammatory properties of the ruthenium polypyridyl complex, K314, on the in vitro activated macrophages. J. Res. Pharm. 2025;23(2):164-9.