Araştırma Makalesi
BibTex RIS Kaynak Göster

Analgesic, anti-inflammatory and anti-pyretic activities of methanolic extract of Cordyline fruticosa (L.) A. Chev. leaves

Yıl 2019, Cilt: 23 Sayı: 2, 198 - 207, 27.06.2025

Sharmin Naher Md Abdullah Aziz Mst. Irin Akter S M Mushiur Rahman Sadiur Rahman Sajon

Öz

Traditionally Cordyline fruticosa (L.) A. Chev. is being used for the treatment of various disorders, such as fever, headache, diarrhea, coughs, haemoptysis, small pox, madness, skin eruptions, joint pains, rheumatic bone pains, swelling pain and it is also used for abortion. The aim of our study wast o evaluate analgesic, anti-inflammatory and anti-pyretic activities of methanolic extract of C. Fruticosa leaves (MCFL). Analgesic effect of MCFL was investigated by using acetic acid induced writhing test, formalin-induced paw licking test, tail immersion test and hot plate test. The anti-inflammatory activity was assessed by using xylene induced ear edema test and cotton pellet induced granuloma test, whereas antipyretic effect was observed by utilizing Brewer’s yeast-induced pyrexia test. In analgesic test, MCFL significantly (∗p< 0.05, vs. control) reduced paw licking and abdominal writhing of mice in a dose dependent manner. MCFL at a dose of 800 mg/kg body weight, significantly increased pain threshold in tail immersion test and hot plate test. Significant anti-inflammatory effect was produced by MCFL by reducing xylene induced air edema and cotton pellet induced granuloma in a dose dependent manner. In anti-pyretic test, after 4th hour of respective treatment, MCFL at all doses exhibited anti-pyretic activity, when compared with control (∗p < 0.05, vs. control). The results obtained demonstrate that C. fruticosa may provide a source of plant compounds with analgesic, anti-inflammatory and antipyretic activities

Anahtar Kelimeler

Cordyline fruticosa analgesic anti-inflammatory anti-pyretic

Kaynakça

  • [1] Rafieian-Kopaei M, Shakiba A, Sedighi M, Bahmani M. The analgesic and anti-inflammatory activity of Linum usitatissimum in Balb/c mice. J Evid Based Complementary Altern Med. 2017;22(4):892–896. [CrossRef]
  • [2] Ishola IO, Agbaje EO, Adeyemi OO, Shukla R. Analgesic and anti-inflammatory effects of the methanol root extracts of some selected Nigerian medicinal plants. Pharm Biol. 2014;52(9):1208–1216. [CrossRef]
  • [3] Cheng J, Yi X, Wang Y, Huang X, He X. Phenolics from the roots of hairy fig (Ficus hirta Vahl.) exert prominent anti-inflammatory activity. J Funct Foods. 2017;31:79–88. [CrossRef]
  • [4] Sajid M, Khan MR, Shah SA, Majid M, Ismail H, Maryam S, Batool R, Younis T. Investigations on anti-inflammatory and analgesic activities of Alnus nitida Spach (Endl.) stem bark in Sprague Dawley rats. J Ethnopharmacol. 2017;198:408–416. [CrossRef]
  • [5] Huo X, Zhang L, Gao L, Guo Y, Zhang L, Li L, Si J, Cao L. Anti-inflammatory and analgesic activities of ethanol extract and isolated compounds from Millettia pulchra. Biol Pharm Bull. 2015;38:1328–1336. [CrossRef]
  • [6] Sengar N, Joshi A, Prasad SK, Hemalatha S. Anti-inflammatory, analgesic and anti-pyretic activities of standardized root extract of Jasminum sambac. J Ethnopharmacol. 2015;160:140–148. [CrossRef]
  • [7] Gupta S, Singh A. Antimicrobial, analgesic and anti-inflammatory activity reported on Tamarindus indica Linn root extract. Pharmacogn J. 2017;9(3):410–416. [CrossRef]
  • [8] Eidi A, Oryan S, Zaringhalam J, Rad M. Antinociceptive and anti-inflammatory effects of the aerial parts of Artemisia dracunculus in mice. Pharm Biol. 2016;54(3):549–554. [CrossRef]
  • [9] Paliwal SK, Sati B, Faujdar S, Sharma S. Studies on analgesic, anti-inflammatory activities of stem and roots of Inula cuspidata C.B Clarke. J Tradit Complement Med. 2017;7(4):532–537. [CrossRef]
  • [10] da Costa Oliveira C, de Matos NA, de Carvalho Veloso C, Lage GA, Pimenta LPS, Duarte IDG, Romero TRL, Klein A, de Castro Perez A. Anti-inflammatory and antinociceptive properties of the hydroalcoholic fractions from the leaves of Annona crassiflora Mart. in mice. Inflammopharmacol. 2018;1–12. [CrossRef]
  • [11] Yokosuka A, Suzuki T, Mimaki Y. New cholestane glycosides from the leaves of Cordyline terminalis. Chem Pharm Bull. 2012;60(2):275–279.
  • [12] Lim TK. Cordyline fruticosa. In: Edible Medicinal and Non Medicinal Plants. Springer, Dordrecht, New York, 2015, pp.627–632. [CrossRef]
  • [13] Fouedjoua RT, Teponno RB, Quassinti L. Steroidal saponins from the leaves of Cordyline fruticosa (L.) A. Chev. and their cytotoxic and antimicrobial activity. Phytochem Lett. 2014;7:62–68. [CrossRef]
  • [14] Dahlia AA, Ahmad AR, Wahid M. Extraction of color pigment and determination of flavonoid content of andong leaves (Cordyline fruticosa L.) source Makassar city. J Biol Sci Opin. 2013;1(4):294–296. [CrossRef]
  • [15] Fouedjou RT, Nguelefack-Mbuyo EP, Ponou BK. Antioxidant activities and chemical constituents of extracts from Cordyline fruticosa (L.) A. Chev. (Agavaceae) and Eriobotrya japonica (Thunb) Lindl. (Rosaceae). Pharmacologia. 2016;7:103–113. [CrossRef]
  • [16] Ahmed F, Das PK, Islam MA, Rahman KM, Rahman MM, Selim MST. Antibacterial activity of Cordyline terminalis Kunth. leaves. J Med Sci. 2003;3(5):418–422. [CrossRef]
  • [17] Liu S, Cao D, Xiao Z, Liu F, Wang X, Zhao L, Tian L, Shen S. A comparative study of anti-gastric cancer activity between aqueous extract and ethanol extract of Folium Cordylines Fruticosae. Afr J Tradit Complement Altern Med. 2013;10(4):78–82.
  • [18] Reddy BC, Noor A, Sabareesh V, Vijayalakshmi MA. Preliminary screening of potential flavonoid-subclasses in Myristica fragrans and Cordyline terminalis by LC-ESI-MS. J Pharmacogn Phytochem. 2016;5(6):437–450.
  • [19] Aziz MA. Qualitative phytochemical screening and evaluation of anti-inflammatory, analgesic and antipyretic activities of Microcos paniculata barks and fruits. J Integr Med. 2015;13(3):173–184. [CrossRef]
  • [20] Zhang L, Hu JJ, Lin JW, Fang WS, Du GH. Anti-inflammatory and analgesic effects of ethanol and aqueous extracts of Pterocephalus hookeri (C.B. Clarke) Höeck. J Ethnopharmacol. 2009;123(3):510–514. [CrossRef]
  • [21] Ma KJ, Zhu ZZ, Yu CH, Zhang H, Liu J, Qin LP. Analgesic, anti-inflammatory, and antipyretic activities of the ethanol extract from Desmodium caudatum. Pharm Biol. 2011;49(4):403–407. [CrossRef]
  • [22] Lee KH, Choi EM. Analgesic and anti-inflammatory effects of Ligularia fischeri leaves in experimental animals. J Ethnopharmacol. 2008;120:103–107. [CrossRef]
  • [23] Zhao J, Fang F, Yu L, Wang G, Yang L. Anti-nociceptive and anti-inflammatory effects of Croton crassifolius ethanol extract. J Ethnopharmacol. 2012;142:367–373. [CrossRef]
  • [24] Zhou M, Wang H, Suolangjiba, Kou J, Yu B. Antinociceptive and anti-inflammatory activities of Aquilaria sinensis (Lour.) Gilg. leaves extract. J Ethnopharmacol. 2008;117(2):345–350. [CrossRef]
  • [25] Pingsusaen P, Kunanusorn P, Khonsung P, Chiranthanut N, Panthong A, Rujjanawate C. Investigation of anti-inflammatory, antinociceptive and antipyretic activities of Stahlianthus involucratus rhizome ethanol extract. J Ethnopharmacol. 2015;162:199–206. [CrossRef]
  • [26] Panthong A, Kanjanapothi D, Taesotikul T, Phankummoon A, Panthong K, Reutrakul V. Anti-inflammatory activity of methanolic extracts from Ventilago harmandiana Pierre. J Ethnopharmacol. 2004;91(2–3):237–242. [CrossRef]
  • [27] Antonisamy P, Duraipandiyan V, Ignacimuthu S. Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models. J Pharm Pharmacol. 2011;63(8):1070–1077. [CrossRef]
  • [28] Koster R, Anderson M, De-Beer EJ. Acetic acid analgesic screening. Fed Proc. 1959;18:412–417.
  • [29] Hunskaar S, Hole K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain. 1987;30(1):103–114.
  • [30] Toma W, Graciosa JS, Hiruma-Lima CA, Andrade CDP, Vilegas W, Souza Brito ARM. Evaluation of analgesic and antiedematogenic activities of Quassia amara bark extract. J Ethnopharmacol. 2003;85:19–23. [CrossRef]
  • [31] Turner RA. Analgesics. In: Screening Methods in Pharmacology. Academic Press, New York & London, 1965, pp.100–117.
  • [32] Dai Y, Liu LH. Anti-inflammatory effect of aqueous extract of Wu-Hu-Tang. J China Pharm Uni. 1995;6:362–364.
  • [33] Swingle KF, Shideman FE. Phases of the inflammatory response to subcutaneous implantation of cotton pellet and their modification by certain anti-inflammatory agents. J Pharm Exp Ther. 1972;183(1):226–234.

Yıl 2019, Cilt: 23 Sayı: 2, 198 - 207, 27.06.2025

Sharmin Naher Md Abdullah Aziz Mst. Irin Akter S M Mushiur Rahman Sadiur Rahman Sajon

Öz

Kaynakça

  • [1] Rafieian-Kopaei M, Shakiba A, Sedighi M, Bahmani M. The analgesic and anti-inflammatory activity of Linum usitatissimum in Balb/c mice. J Evid Based Complementary Altern Med. 2017;22(4):892–896. [CrossRef]
  • [2] Ishola IO, Agbaje EO, Adeyemi OO, Shukla R. Analgesic and anti-inflammatory effects of the methanol root extracts of some selected Nigerian medicinal plants. Pharm Biol. 2014;52(9):1208–1216. [CrossRef]
  • [3] Cheng J, Yi X, Wang Y, Huang X, He X. Phenolics from the roots of hairy fig (Ficus hirta Vahl.) exert prominent anti-inflammatory activity. J Funct Foods. 2017;31:79–88. [CrossRef]
  • [4] Sajid M, Khan MR, Shah SA, Majid M, Ismail H, Maryam S, Batool R, Younis T. Investigations on anti-inflammatory and analgesic activities of Alnus nitida Spach (Endl.) stem bark in Sprague Dawley rats. J Ethnopharmacol. 2017;198:408–416. [CrossRef]
  • [5] Huo X, Zhang L, Gao L, Guo Y, Zhang L, Li L, Si J, Cao L. Anti-inflammatory and analgesic activities of ethanol extract and isolated compounds from Millettia pulchra. Biol Pharm Bull. 2015;38:1328–1336. [CrossRef]
  • [6] Sengar N, Joshi A, Prasad SK, Hemalatha S. Anti-inflammatory, analgesic and anti-pyretic activities of standardized root extract of Jasminum sambac. J Ethnopharmacol. 2015;160:140–148. [CrossRef]
  • [7] Gupta S, Singh A. Antimicrobial, analgesic and anti-inflammatory activity reported on Tamarindus indica Linn root extract. Pharmacogn J. 2017;9(3):410–416. [CrossRef]
  • [8] Eidi A, Oryan S, Zaringhalam J, Rad M. Antinociceptive and anti-inflammatory effects of the aerial parts of Artemisia dracunculus in mice. Pharm Biol. 2016;54(3):549–554. [CrossRef]
  • [9] Paliwal SK, Sati B, Faujdar S, Sharma S. Studies on analgesic, anti-inflammatory activities of stem and roots of Inula cuspidata C.B Clarke. J Tradit Complement Med. 2017;7(4):532–537. [CrossRef]
  • [10] da Costa Oliveira C, de Matos NA, de Carvalho Veloso C, Lage GA, Pimenta LPS, Duarte IDG, Romero TRL, Klein A, de Castro Perez A. Anti-inflammatory and antinociceptive properties of the hydroalcoholic fractions from the leaves of Annona crassiflora Mart. in mice. Inflammopharmacol. 2018;1–12. [CrossRef]
  • [11] Yokosuka A, Suzuki T, Mimaki Y. New cholestane glycosides from the leaves of Cordyline terminalis. Chem Pharm Bull. 2012;60(2):275–279.
  • [12] Lim TK. Cordyline fruticosa. In: Edible Medicinal and Non Medicinal Plants. Springer, Dordrecht, New York, 2015, pp.627–632. [CrossRef]
  • [13] Fouedjoua RT, Teponno RB, Quassinti L. Steroidal saponins from the leaves of Cordyline fruticosa (L.) A. Chev. and their cytotoxic and antimicrobial activity. Phytochem Lett. 2014;7:62–68. [CrossRef]
  • [14] Dahlia AA, Ahmad AR, Wahid M. Extraction of color pigment and determination of flavonoid content of andong leaves (Cordyline fruticosa L.) source Makassar city. J Biol Sci Opin. 2013;1(4):294–296. [CrossRef]
  • [15] Fouedjou RT, Nguelefack-Mbuyo EP, Ponou BK. Antioxidant activities and chemical constituents of extracts from Cordyline fruticosa (L.) A. Chev. (Agavaceae) and Eriobotrya japonica (Thunb) Lindl. (Rosaceae). Pharmacologia. 2016;7:103–113. [CrossRef]
  • [16] Ahmed F, Das PK, Islam MA, Rahman KM, Rahman MM, Selim MST. Antibacterial activity of Cordyline terminalis Kunth. leaves. J Med Sci. 2003;3(5):418–422. [CrossRef]
  • [17] Liu S, Cao D, Xiao Z, Liu F, Wang X, Zhao L, Tian L, Shen S. A comparative study of anti-gastric cancer activity between aqueous extract and ethanol extract of Folium Cordylines Fruticosae. Afr J Tradit Complement Altern Med. 2013;10(4):78–82.
  • [18] Reddy BC, Noor A, Sabareesh V, Vijayalakshmi MA. Preliminary screening of potential flavonoid-subclasses in Myristica fragrans and Cordyline terminalis by LC-ESI-MS. J Pharmacogn Phytochem. 2016;5(6):437–450.
  • [19] Aziz MA. Qualitative phytochemical screening and evaluation of anti-inflammatory, analgesic and antipyretic activities of Microcos paniculata barks and fruits. J Integr Med. 2015;13(3):173–184. [CrossRef]
  • [20] Zhang L, Hu JJ, Lin JW, Fang WS, Du GH. Anti-inflammatory and analgesic effects of ethanol and aqueous extracts of Pterocephalus hookeri (C.B. Clarke) Höeck. J Ethnopharmacol. 2009;123(3):510–514. [CrossRef]
  • [21] Ma KJ, Zhu ZZ, Yu CH, Zhang H, Liu J, Qin LP. Analgesic, anti-inflammatory, and antipyretic activities of the ethanol extract from Desmodium caudatum. Pharm Biol. 2011;49(4):403–407. [CrossRef]
  • [22] Lee KH, Choi EM. Analgesic and anti-inflammatory effects of Ligularia fischeri leaves in experimental animals. J Ethnopharmacol. 2008;120:103–107. [CrossRef]
  • [23] Zhao J, Fang F, Yu L, Wang G, Yang L. Anti-nociceptive and anti-inflammatory effects of Croton crassifolius ethanol extract. J Ethnopharmacol. 2012;142:367–373. [CrossRef]
  • [24] Zhou M, Wang H, Suolangjiba, Kou J, Yu B. Antinociceptive and anti-inflammatory activities of Aquilaria sinensis (Lour.) Gilg. leaves extract. J Ethnopharmacol. 2008;117(2):345–350. [CrossRef]
  • [25] Pingsusaen P, Kunanusorn P, Khonsung P, Chiranthanut N, Panthong A, Rujjanawate C. Investigation of anti-inflammatory, antinociceptive and antipyretic activities of Stahlianthus involucratus rhizome ethanol extract. J Ethnopharmacol. 2015;162:199–206. [CrossRef]
  • [26] Panthong A, Kanjanapothi D, Taesotikul T, Phankummoon A, Panthong K, Reutrakul V. Anti-inflammatory activity of methanolic extracts from Ventilago harmandiana Pierre. J Ethnopharmacol. 2004;91(2–3):237–242. [CrossRef]
  • [27] Antonisamy P, Duraipandiyan V, Ignacimuthu S. Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models. J Pharm Pharmacol. 2011;63(8):1070–1077. [CrossRef]
  • [28] Koster R, Anderson M, De-Beer EJ. Acetic acid analgesic screening. Fed Proc. 1959;18:412–417.
  • [29] Hunskaar S, Hole K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain. 1987;30(1):103–114.
  • [30] Toma W, Graciosa JS, Hiruma-Lima CA, Andrade CDP, Vilegas W, Souza Brito ARM. Evaluation of analgesic and antiedematogenic activities of Quassia amara bark extract. J Ethnopharmacol. 2003;85:19–23. [CrossRef]
  • [31] Turner RA. Analgesics. In: Screening Methods in Pharmacology. Academic Press, New York & London, 1965, pp.100–117.
  • [32] Dai Y, Liu LH. Anti-inflammatory effect of aqueous extract of Wu-Hu-Tang. J China Pharm Uni. 1995;6:362–364.
  • [33] Swingle KF, Shideman FE. Phases of the inflammatory response to subcutaneous implantation of cotton pellet and their modification by certain anti-inflammatory agents. J Pharm Exp Ther. 1972;183(1):226–234.
Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmasotik Biyoteknoloji
Bölüm Articles
Yazarlar

Sharmin Naher

Md Abdullah Aziz

Mst. Irin Akter

S M Mushiur Rahman

Sadiur Rahman Sajon

Yayımlanma Tarihi 27 Haziran 2025
Yayımlandığı Sayı Yıl 2019 Cilt: 23 Sayı: 2

Kaynak Göster

APA Naher, S., Aziz, M. A., Akter, M. I., Rahman, S. M. M., vd. (2025). Analgesic, anti-inflammatory and anti-pyretic activities of methanolic extract of Cordyline fruticosa (L.) A. Chev. leaves. Journal of Research in Pharmacy, 23(2), 198-207.
AMA Naher S, Aziz MA, Akter MI, Rahman SMM, Sajon SR. Analgesic, anti-inflammatory and anti-pyretic activities of methanolic extract of Cordyline fruticosa (L.) A. Chev. leaves. J. Res. Pharm. Haziran 2025;23(2):198-207.
Chicago Naher, Sharmin, Md Abdullah Aziz, Mst. Irin Akter, S M Mushiur Rahman, ve Sadiur Rahman Sajon. “Analgesic, Anti-Inflammatory and Anti-Pyretic Activities of Methanolic Extract of Cordyline Fruticosa (L.) A. Chev. Leaves”. Journal of Research in Pharmacy 23, sy. 2 (Haziran 2025): 198-207.
EndNote Naher S, Aziz MA, Akter MI, Rahman SMM, Sajon SR (01 Haziran 2025) Analgesic, anti-inflammatory and anti-pyretic activities of methanolic extract of Cordyline fruticosa (L.) A. Chev. leaves. Journal of Research in Pharmacy 23 2 198–207.
IEEE S. Naher, M. A. Aziz, M. I. Akter, S. M. M. Rahman, ve S. R. Sajon, “Analgesic, anti-inflammatory and anti-pyretic activities of methanolic extract of Cordyline fruticosa (L.) A. Chev. leaves”, J. Res. Pharm., c. 23, sy. 2, ss. 198–207, 2025.
ISNAD Naher, Sharmin vd. “Analgesic, Anti-Inflammatory and Anti-Pyretic Activities of Methanolic Extract of Cordyline Fruticosa (L.) A. Chev. Leaves”. Journal of Research in Pharmacy 23/2 (Haziran 2025), 198-207.
JAMA Naher S, Aziz MA, Akter MI, Rahman SMM, Sajon SR. Analgesic, anti-inflammatory and anti-pyretic activities of methanolic extract of Cordyline fruticosa (L.) A. Chev. leaves. J. Res. Pharm. 2025;23:198–207.
MLA Naher, Sharmin vd. “Analgesic, Anti-Inflammatory and Anti-Pyretic Activities of Methanolic Extract of Cordyline Fruticosa (L.) A. Chev. Leaves”. Journal of Research in Pharmacy, c. 23, sy. 2, 2025, ss. 198-07.
Vancouver Naher S, Aziz MA, Akter MI, Rahman SMM, Sajon SR. Analgesic, anti-inflammatory and anti-pyretic activities of methanolic extract of Cordyline fruticosa (L.) A. Chev. leaves. J. Res. Pharm. 2025;23(2):198-207.