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Nasal in situ gels as a drug delivery system: An overview of literature and clinical studies

Yıl 2023, Cilt: 27 Sayı: 5, 1875 - 1888, 28.06.2025

Yavuz Selim Çelik Büşra Örenli Mazen Al-mohaya Burcu Mesut Yıldız Özsoy

Öz

There are various ways to deliver drugs and each one has its ups and downs depending on the purpose of use and the patients themselves. And among these drug delivery systems, the intranasal path stands out as one of the more exciting and challenging ones. Despite being perhaps the most commonly used path of delivery, the oral route is subject to facing various roadblocks in terms of efficacy and bioavailability, requiring a certain amount of dosage and synergy from the active pharmaceutical ingredient that is being used to be effective. When said active pharmaceutical ingredient is ineffective via the oral route, has to be given in small doses, or has to enter circulation quickly to manifest its effects, it inevitably falls out of favor. In its place, the intranasal route can act as a viable substitute. Although there are several methods to formulate intranasal drugs, naturally, the intranasal route possesses advantages and disadvantages of its own. Thus, in situ gel systems have emerged as a favorable preference among these formulation methods. Possessing the upsides of not only gels but solutions as well, the in situ gel systems effectively address and solve some of the disadvantages posed by intranasal drug delivery systems. This review article aims to provide a general understanding of intranasal drug delivery systems and in situ gels, both separately and together as a combination, while underlining the importance of each and also providing examples from existing literature to display their range of applications.

Anahtar Kelimeler

Drug delivery system in situ gel intranasal nasal pharmaceutical polymer.

Kaynakça

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Yıl 2023, Cilt: 27 Sayı: 5, 1875 - 1888, 28.06.2025

Yavuz Selim Çelik Büşra Örenli Mazen Al-mohaya Burcu Mesut Yıldız Özsoy

Öz

Kaynakça

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  • [84] Aref AA, Refaat A, El Meshad AN, El-Dahmy RM. Chitosan-coated mixed polymeric micelles incorporated in thermosensitive in situ gel for brain targeting of piperine via intranasal route. Int. J. Pharm. 2020; 590: 119915. https://doi.org/10.1016/j.ijpharm.2020.119915
  • [85] Shaikh U, Kumbhar M, Jagdale S. A review on nasal drug delivery system. Int. J. Pharm. Sci. Rev. Res. 2020; 60(1): 17-24. https://doi.org/10.5530/ijper.54.3.124
  • [86] Asasutjarit R, Sorrachatanon P, Sukma M, Ritthidej GC. Physicochemical properties and stability of ascorbyl palmitate-loaded nanoparticles in poloxamer-based gels for vaginal administration. AAPS PharmSciTech. 2012; 13: 1186-98. https://doi.org/10.1208/s12249-012-9843-7
  • [87] Saeed AO, Abdulrasool AA, Abdulameer SA. Development and in-vitro evaluation of thermoreversible mucoadhesive in situ nasal gel formulations of pseudoephedrine hydrochloride. Int. J. Appl. Pharm. 2019; 11(5): 95-102. https://doi.org/10.22159/ijap.2019.v11s5.33540
  • [88] Saindane NG, Vavia PR. Glucose sensitive dual responsive in situ gel for enhanced ocular retention. Int. J. Pharm. 2021; 596: 120222. https://doi.org/10.1016/j.ijpharm.2021.120222
  • [89] Almeida H, Amaral MH, Lobão P, Lobo JM. In situ gelling systems: a strategy to improve the bioavailability of ophthalmic pharmaceutical formulations. Drug Discov. Today. 2014; 19(4): 400-12. https://doi.org/10.1016/j.drudis.2013.10.002
  • [90] Chavda HV, Patel MS, Anand IS. Biodegradable in situ gel for subcutaneous administration of simvastatin for prolonged drug delivery. J. Drug Deliv. Sci. Technol. 2020; 59: 101911. https://doi.org/10.1016/j.jddst.2020.101911
  • [91] He W, Lu Y, Qi J, Chen L, Yin L, Wu W. Bioavailability improvement of an antiepileptic drug via oral administration of nanocrystals prepared by a wet milling method. Drug Deliv. 2011; 18(3): 179-87. https://doi.org/10.3109/10717544.2010.532506
  • [92] Upadhyay P, Gautam A, Singh D. Formulation and characterization of in-situ nasal gel of lamotrigine for the treatment of epilepsy. Int. J. Curr. Pharm. Res. 2018; 10(1): 24-9. https://doi.org/10.22159/ijcpr.2018.v10i1.22704
  • [93] Agrawal M, Saraf S, Saraf S, Dubey SK, Puri A, Kurundkar SB, Alexander A. Stimuli-responsive in situ gelling system for nose-to-brain drug delivery. J. Control. Release. 2020; 327: 235-65. https://doi.org/10.1016/j.jconrel.2020.08.024
  • [94] Song Y, Wang P, Wang X, Wang D, Guo C, Kang W. Synthesis and evaluation of a novel chitosan-based thermosensitive hydrogel for the sustained and efficient delivery of donepezil. Carbohydr. Polym. 2021; 251: 117108. https://doi.org/10.1016/j.carbpol.2020.117108
  • [95] Singh RM, Kumar A, Pathak K. Mucoadhesive in situ nasal gel of loratadine: Design, development, optimization and evaluation. Int. J. Appl. Pharm. 2011; 3(2): 12-7.
  • [96] Gavini E, Hegge AB, Rassu G, Sanna V, Testa C, Pirisino G, Karlsen J, Giunchedi P. Nasal administration of carbamazepine using chitosan microspheres: In vitro/in vivo studies. Int. J. Pharm. 2006; 307(1): 9-15. https://doi.org/10.1016/j.ijpharm.2005.10.003
  • [97] Gratieri T, Gelfuso GM, Rocha EM, Sarmento VH, de Freitas O, Lopez RF. A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery. Eur. J. Pharm. Biopharm. 2010; 75(2): 186-93. https://doi.org/10.1016/j.ejpb.2010.02.017
Toplam 97 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri (Diğer)
Bölüm Articles
Yazarlar

Yavuz Selim Çelik 0000-0001-9601-4615

Büşra Örenli 0000-0001-7013-1872

Mazen Al-mohaya 0000-0003-4176-0308

Burcu Mesut

Yıldız Özsoy 0000-0002-9110-3704

Yayımlanma Tarihi 28 Haziran 2025
Yayımlandığı Sayı Yıl 2023 Cilt: 27 Sayı: 5

Kaynak Göster

APA Çelik, Y. S., Örenli, B., Al-mohaya, M., Mesut, B., vd. (2025). Nasal in situ gels as a drug delivery system: An overview of literature and clinical studies. Journal of Research in Pharmacy, 27(5), 1875-1888.
AMA Çelik YS, Örenli B, Al-mohaya M, Mesut B, Özsoy Y. Nasal in situ gels as a drug delivery system: An overview of literature and clinical studies. J. Res. Pharm. Temmuz 2025;27(5):1875-1888.
Chicago Çelik, Yavuz Selim, Büşra Örenli, Mazen Al-mohaya, Burcu Mesut, ve Yıldız Özsoy. “Nasal in Situ Gels As a Drug Delivery System: An Overview of Literature and Clinical Studies”. Journal of Research in Pharmacy 27, sy. 5 (Temmuz 2025): 1875-88.
EndNote Çelik YS, Örenli B, Al-mohaya M, Mesut B, Özsoy Y (01 Temmuz 2025) Nasal in situ gels as a drug delivery system: An overview of literature and clinical studies. Journal of Research in Pharmacy 27 5 1875–1888.
IEEE Y. S. Çelik, B. Örenli, M. Al-mohaya, B. Mesut, ve Y. Özsoy, “Nasal in situ gels as a drug delivery system: An overview of literature and clinical studies”, J. Res. Pharm., c. 27, sy. 5, ss. 1875–1888, 2025.
ISNAD Çelik, Yavuz Selim vd. “Nasal in Situ Gels As a Drug Delivery System: An Overview of Literature and Clinical Studies”. Journal of Research in Pharmacy 27/5 (Temmuz 2025), 1875-1888.
JAMA Çelik YS, Örenli B, Al-mohaya M, Mesut B, Özsoy Y. Nasal in situ gels as a drug delivery system: An overview of literature and clinical studies. J. Res. Pharm. 2025;27:1875–1888.
MLA Çelik, Yavuz Selim vd. “Nasal in Situ Gels As a Drug Delivery System: An Overview of Literature and Clinical Studies”. Journal of Research in Pharmacy, c. 27, sy. 5, 2025, ss. 1875-88.
Vancouver Çelik YS, Örenli B, Al-mohaya M, Mesut B, Özsoy Y. Nasal in situ gels as a drug delivery system: An overview of literature and clinical studies. J. Res. Pharm. 2025;27(5):1875-88.