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Development and evaluation of gastro retentive drug delivery system of monoammonium glycyrrhizinate for the management of gastric ulcer

Yıl 2023, Cilt: 27 Sayı: 5, 1889 - 1910, 28.06.2025

Vinita Patole Harshad Kapare Jayashri Mahore Rachana Bhimanwar Devyani Awar Pranali Jadhav

Öz

Monoammonium glycyrrhizinate (MAG), a salt of glycyrrhizin, is reported for effective treatment of gastric disorders. The work was aimed to design and develop a gastro-retentive drug delivery system for MAG to delay its release in stomach by developing a stable raft with sufficient strength and acid-neutralizing potential. Preliminary, in-silico molecular docking study of MAG with the native ligand (Vonoprazan, a potential proton pump inhibitor) present in the gastric proton pump was performed. Docking studies predicted that MAG could bind to Vonoprazan binding site, indicating its ability to inhibit the gastric proton pump. The most desirable optimal formulation of raft forming tablets of MAG was anticipated with the desirability (0.819). The optimized formulation showed raft strength (8.61 ± 0.06 g), acid neutralizing capacity (11.19 ± 0.03 mEq) and in vitro release of MAG (69.11 ± 0.61% over 8h) indicating its suitability as a potential Gastro-retentive raft forming delivery system. The optimized formulation decreased gastric acid production and elevated gastric pH (p< 0.001.) in pylorus ligation induced gastric ulcers in animal model and demonstrated significant decrease in ulcer index (p< 0.001.) The developed raft-forming tablet of MAG could be a promising alternative to the existing synthetic agents to treat gastric ulcers.

Anahtar Kelimeler

Gastric ulcers Gastro retentive drug delivery system Monoammonium glycyrrhizinate Raft forming tablets pylorus ligation induced gastric ulcers

Kaynakça

  • [1] Woolf A, Rehman RB, Rose R. Gastric Ulcer In: Stat Pearls. Treasure Island (FL): Stat Pearls Publishing 2022. https://www.ncbi.nlm.nih.gov/books/NBK537128/ (accessed on 20 February, 2023).
  • [2] Kuna L, Jakab J, Smolic R, Raguz-Lucic N, Vcev A, Smolic M. Peptic ulcer disease: A brief review of conventional therapy and herbal treatment options. J Clin Med. 2019; 8(2): 179 1-19. https://doi.org/10.3390/jcm8020179
  • [3] Kangwan N, Park J, Kim E, Hahm KB, Kangwan N, Park J, et al. Quality of healing of gastric ulcers: Natural products beyond acid suppression. 2014; 5(1): 40–47. https://doi.org/10.4291%2Fwjgp.v5.i1.40
  • [4] Bi W, Man H, Man M. Efficacy and safety of herbal medicines in treating gastric ulcer: A review. World J Gastroenterol. 2014; 20(45): 17020–17028. https://doi.org/10.3748/wjg.v20.i45.17020
  • [5] Wahab S, Annadurai S, Abullais SS, et al. Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology. Plants (Basel). 2021; 10(12): 2751 1-36. https://doi.org/10.3390/plants10122751
  • [6] Pastorino G, Cornara L, Soares S, Rodrigues F, Oliveira M. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytother. Res. 2018; 32(12): 2323–2339. https://doi.org/10.1002/ptr.6178
  • [7] Rahnama M, Mehrabani D, Japoni S, Edjtehadi M, Saberi Firoozi M. The healing effect of licorice. J. Res. Med. Sci. 2013; 18(6): 532–533. https://pubmed.ncbi.nlm.nih.gov/24250708
  • [8] Mukhopadhyay M, Panja PA. Novel process for extraction of natural sweetener from licorice (Glycyrrhiza glabra) roots. Sep. Purif. Technol. 2008; 63(3): 539–545. https://doi.org/10.1016/j.seppur.2008.06.013
  • [9] Hani U, Rahamathulla M, Osmani RAM, Begum Y, Wahab S, Ghazwani M, et al. Development and characterization of oral raft forming in situ gelling system of neratinib anticancer drug using 32 factorial design. Polymers. 2022; 14(13): 1-19. https://doi.org/10.3390/polym14132520
  • [10] Batiha GE, Beshbishy AM, El-mleeh A. Traditional uses, bioactive chemical constituents, and pharmacological and toxicological activities of Glycyrrhiza glabra L. (Fabaceae). Biomolecules 2020; 10(352): 1–19. https://doi.org/10.3390/biom10030352
  • [11] Ferreira LG, Dos Santos RN, Oliva G, Andricopulo AD. Molecular docking and structure-based drug design strategies. Molecules. 2015; 20(7): 13384–13421. https://doi.org/10.3390/molecules200713384
  • [12] Kawai D, Takenaka R, Ishiguro M, Okanoue S, Gotoda T, Kono Y. Vonoprazan versus lansoprazole in the treatment of artificial gastric ulcers after endoscopic submucossal dissection: a randomized, open label trial. BMC Gastroenterol. 2021; 21(1): 236: 1-6. https://doi.org/10.1186/s12876-021-01822-5
  • [13] Tripathi J, Thapa P, Maharjan R, Jeong SH. Current state and future perspectives on gastroretentive drug delivery systems. Pharmaceutics. 2019; 11(193): 1-22. https://doi.org/10.3390/pharmaceutics11040193
  • [14] Mandal UK, Chatterjee B, Senjoti FG. Gastro-retentive drug delivery systems and their in vivo success: A recent update. Asian J. Pharm. Sci. 2016; 11(5): 575–84. https://doi.org/10.1016/j.ajps.2016.04.007
  • [15] Prajapati VD, Jani GK, Khutliwala TA, Zala BS. Raft forming system - An upcoming approach of gastroretentive drug delivery system. J Control Release. 2013; 168(2): 151–65. https://doi.org/10.1016/j.jconrel.2013.02.028
  • [16] Matchanov AD, Esanov RS, Renkawitz T, Soliev AB, Kunisch E, Gonzalo de Juan I, et al. Synthesis, structure–property evaluation and biological assessment of supramolecular assemblies of bioactive glass with glycyrrhizic acid and its monoammonium salt. Materials (Basel). 2022; 15(12): 4197. https://doi.org/10.3390/ma15124197
  • [17] Kesavan K, Nath G, Pandit JK. Sodium alginate based mucoadhesive system for gatifloxacin and its in vitro antibacterial activity. Sci Pharm. 2010; 78(4): 941–957. https://doi.org/10.3797/scipharm.1004-24
  • [18] Jana S, Kumar Trivedi M, Tallapragada RM. Characterization of Physicochemical and Thermal Properties of Chitosan and Sodium Alginate after Biofield Treatment. Pharm. Anal. Acta. 2015; 6(10): 1-10. http://dx.doi.org/10.4172/2153-2435.1000430
  • [19] Darwish MKM, Abu El-Enin ASM, Mohammed KHA. Formulation, optimization, and evaluation of raft-forming formulations containing Nizatidine. Drug Dev Ind Pharm. 2019; 45(4): 651–63. https://doi.org/10.1080/03639045.2019.1569033
  • [20] Marta S, Agata P, Emilia S, Patrycja C, Katarzyna W. Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications. Int. J. Polym. Sci. 2016; 2016: 1-17. https://doi.org/10.1155/2016/7697031
  • [21] Ishak NA. Buoyancy-generating agents for stomach-specific drug delivery: an overview with special emphasis on floating behavior. J Pharm Pharm Sci. 2015; 18(1): 77-100. https://doi.org/10.18433/J3602K
  • [22] Dettmar PW, Gil-Gonzalez D, Fisher J, Flint L, Rainforth D, Moreno-Herrera A, et al. A comparative study on the raft chemical properties of various alginate antacid raft-forming products. Drug Dev Ind Pharm. 2018; 44(1): 30–39. https://doi.org/10.1080/03639045.2017.1371737
  • [23] Hariyadi DM, Islam N. Current Status of Alginate in Drug Delivery. Adv Pharmacol Pharm Sci. 2020; 2020: 8886095 1-6. https://doi.org/10.1155%2F2020%2F8886095
  • [24] Deshkar SS, Pawara AS, Shirolkar SV. Formulation and optimization of floating tablets of clopidogrel bisulphate using design of experiments. Int J Appl Pharm. 2018; 10(6): 94–102. https://doi.org/10.22159/ijap.2018v10i6.27873
  • [25] Ranade AN, Wankhede SS, Ranpise NS, Mundada MS. Development of bilayer floating tablet of amoxicillin and aloe vera gel powder for treatment of gastric ulcers. AAPS PharmSciTech. 2012; 13(4): 1518–23. https://doi.org/10.1208/s12249-012-9882-4
  • [26] El Kalawy S, Abd Elkader D, Ibrahim E, Swifi S. Comparative histological and immunohistochemical study on the effect of curcumin and wild honey versus omeprazole on a rat model of gastric ulcer. J Med Histol. 2019; 2(2): 103–14. https://dx.doi.org/10.21608/jmh.2019.6357.1044
  • [27] Sahoo SK, Sahoo HB, Priyadarshini D, Soundarya G, Kumar CK, Rani KU. Antiulcer Activity of Ethanolic Extract of Salvadora indica (W.) Leaves on Albino Rats. J Clin Diagn Res. 2016; 10(9): 7-10. https://doi.org/10.7860%2FJCDR%2F2016%2F20384.8470
  • [28] El-Ashmawy NE, Khedr EG, El-Bahrawy HA, Selim HM. Nebivolol prevents indomethacin-induced gastric ulcer in rats. J Immunotoxicol. 2016; 13(4): 580–589. https://doi.org/10.3109/1547691x.2016.1142488
  • [29] Laloo D, Sinha SK, Prasad SK, Hemalatha S. Gastric H+, K+-ATPase inhibitory effects of the active constituent isolated from Potentilla fulgens roots: An in vivo and in silico molecular docking studies. Phytomedicine Plus. 2021; 1(3): 100037 1-10. https://doi.org/10.1016/j.phyplu.2021.100037
  • [30] Trott O, Olson AJ. Software news and update AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput. Chem. 2010; 31(2): 455-461. https://doi.org/10.1002/jcc.21334
  • [31] Prajapati S, Mehta A, Modhia I, Patel C. Formulation and optimisation of raft-forming chewable tablets containing H2 antagonist. Int J Pharm Investig. 2012; 2(4): 176. https://doi.org/10.4103%2F2230-973X.106988
  • [32] Bunlung S, Nualnoi T, Issarachot O, Wiwattanapatapee R. Development of raft-forming liquid and chewable tablet formulations incorporating quercetin solid dispersions for treatment of gastric ulcers. Saudi Pharm J. 2021; 29(10): 1143-1154. https://doi.org/10.1016/j.jsps.2021.08.005
  • [33] Fahelelbom KMS, Al-tabakha MMM, Eissa NAM. Evaluation of certain pharmaceutical quality attributes of lisinopril split tablets. Sci. Pharm. 2016; 84(4): 646–653. https://doi.org/10.3390/scipharm84040646
  • [34] Shah S, Hanif M, Abbas G, Rasul A, Zaman M, Ullah H, et al. Prompt drug delivery of rabeprazole through raft formation: In vitro and in vivo evaluation. J. Drug. Deliv. Sci. Technol. 2020; 60: 1-9. https://doi.org/10.1016/j.jddst.2020.101932
  • [35] Abbas G, Hanif M. Development and pharmacokinetic evaluation of alginate-pectin polymeric rafts forming tablets using box behnken design. Drug Dev Ind Pharm. 2018; 44(12): 2026-2037. https://doi.org/10.1080/03639045.2018.1508221
  • [36] Aseel N, Wedad A. Preparation and in-Vitro Evaluation of Cinnarizine Raft Forming Chewable Tablets. AJPS 2019; 19(3): 42-53. https://doi.org/10.32947/ajps.v19i3.623
  • [37] Umre R, Ganeshpurkar A, Ganeshpurkar A, Pandey S, Pandey V, Shrivastava A, et al. In vitro, in vivo and in silico antiulcer activity of ferulic acid. Future J. Pharm. Sci. 2018; 4(2): 248–253. https://doi.org/10.1016/j.fjps.2018.08.001

Yıl 2023, Cilt: 27 Sayı: 5, 1889 - 1910, 28.06.2025

Vinita Patole Harshad Kapare Jayashri Mahore Rachana Bhimanwar Devyani Awar Pranali Jadhav

Öz

Kaynakça

  • [1] Woolf A, Rehman RB, Rose R. Gastric Ulcer In: Stat Pearls. Treasure Island (FL): Stat Pearls Publishing 2022. https://www.ncbi.nlm.nih.gov/books/NBK537128/ (accessed on 20 February, 2023).
  • [2] Kuna L, Jakab J, Smolic R, Raguz-Lucic N, Vcev A, Smolic M. Peptic ulcer disease: A brief review of conventional therapy and herbal treatment options. J Clin Med. 2019; 8(2): 179 1-19. https://doi.org/10.3390/jcm8020179
  • [3] Kangwan N, Park J, Kim E, Hahm KB, Kangwan N, Park J, et al. Quality of healing of gastric ulcers: Natural products beyond acid suppression. 2014; 5(1): 40–47. https://doi.org/10.4291%2Fwjgp.v5.i1.40
  • [4] Bi W, Man H, Man M. Efficacy and safety of herbal medicines in treating gastric ulcer: A review. World J Gastroenterol. 2014; 20(45): 17020–17028. https://doi.org/10.3748/wjg.v20.i45.17020
  • [5] Wahab S, Annadurai S, Abullais SS, et al. Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology. Plants (Basel). 2021; 10(12): 2751 1-36. https://doi.org/10.3390/plants10122751
  • [6] Pastorino G, Cornara L, Soares S, Rodrigues F, Oliveira M. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytother. Res. 2018; 32(12): 2323–2339. https://doi.org/10.1002/ptr.6178
  • [7] Rahnama M, Mehrabani D, Japoni S, Edjtehadi M, Saberi Firoozi M. The healing effect of licorice. J. Res. Med. Sci. 2013; 18(6): 532–533. https://pubmed.ncbi.nlm.nih.gov/24250708
  • [8] Mukhopadhyay M, Panja PA. Novel process for extraction of natural sweetener from licorice (Glycyrrhiza glabra) roots. Sep. Purif. Technol. 2008; 63(3): 539–545. https://doi.org/10.1016/j.seppur.2008.06.013
  • [9] Hani U, Rahamathulla M, Osmani RAM, Begum Y, Wahab S, Ghazwani M, et al. Development and characterization of oral raft forming in situ gelling system of neratinib anticancer drug using 32 factorial design. Polymers. 2022; 14(13): 1-19. https://doi.org/10.3390/polym14132520
  • [10] Batiha GE, Beshbishy AM, El-mleeh A. Traditional uses, bioactive chemical constituents, and pharmacological and toxicological activities of Glycyrrhiza glabra L. (Fabaceae). Biomolecules 2020; 10(352): 1–19. https://doi.org/10.3390/biom10030352
  • [11] Ferreira LG, Dos Santos RN, Oliva G, Andricopulo AD. Molecular docking and structure-based drug design strategies. Molecules. 2015; 20(7): 13384–13421. https://doi.org/10.3390/molecules200713384
  • [12] Kawai D, Takenaka R, Ishiguro M, Okanoue S, Gotoda T, Kono Y. Vonoprazan versus lansoprazole in the treatment of artificial gastric ulcers after endoscopic submucossal dissection: a randomized, open label trial. BMC Gastroenterol. 2021; 21(1): 236: 1-6. https://doi.org/10.1186/s12876-021-01822-5
  • [13] Tripathi J, Thapa P, Maharjan R, Jeong SH. Current state and future perspectives on gastroretentive drug delivery systems. Pharmaceutics. 2019; 11(193): 1-22. https://doi.org/10.3390/pharmaceutics11040193
  • [14] Mandal UK, Chatterjee B, Senjoti FG. Gastro-retentive drug delivery systems and their in vivo success: A recent update. Asian J. Pharm. Sci. 2016; 11(5): 575–84. https://doi.org/10.1016/j.ajps.2016.04.007
  • [15] Prajapati VD, Jani GK, Khutliwala TA, Zala BS. Raft forming system - An upcoming approach of gastroretentive drug delivery system. J Control Release. 2013; 168(2): 151–65. https://doi.org/10.1016/j.jconrel.2013.02.028
  • [16] Matchanov AD, Esanov RS, Renkawitz T, Soliev AB, Kunisch E, Gonzalo de Juan I, et al. Synthesis, structure–property evaluation and biological assessment of supramolecular assemblies of bioactive glass with glycyrrhizic acid and its monoammonium salt. Materials (Basel). 2022; 15(12): 4197. https://doi.org/10.3390/ma15124197
  • [17] Kesavan K, Nath G, Pandit JK. Sodium alginate based mucoadhesive system for gatifloxacin and its in vitro antibacterial activity. Sci Pharm. 2010; 78(4): 941–957. https://doi.org/10.3797/scipharm.1004-24
  • [18] Jana S, Kumar Trivedi M, Tallapragada RM. Characterization of Physicochemical and Thermal Properties of Chitosan and Sodium Alginate after Biofield Treatment. Pharm. Anal. Acta. 2015; 6(10): 1-10. http://dx.doi.org/10.4172/2153-2435.1000430
  • [19] Darwish MKM, Abu El-Enin ASM, Mohammed KHA. Formulation, optimization, and evaluation of raft-forming formulations containing Nizatidine. Drug Dev Ind Pharm. 2019; 45(4): 651–63. https://doi.org/10.1080/03639045.2019.1569033
  • [20] Marta S, Agata P, Emilia S, Patrycja C, Katarzyna W. Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications. Int. J. Polym. Sci. 2016; 2016: 1-17. https://doi.org/10.1155/2016/7697031
  • [21] Ishak NA. Buoyancy-generating agents for stomach-specific drug delivery: an overview with special emphasis on floating behavior. J Pharm Pharm Sci. 2015; 18(1): 77-100. https://doi.org/10.18433/J3602K
  • [22] Dettmar PW, Gil-Gonzalez D, Fisher J, Flint L, Rainforth D, Moreno-Herrera A, et al. A comparative study on the raft chemical properties of various alginate antacid raft-forming products. Drug Dev Ind Pharm. 2018; 44(1): 30–39. https://doi.org/10.1080/03639045.2017.1371737
  • [23] Hariyadi DM, Islam N. Current Status of Alginate in Drug Delivery. Adv Pharmacol Pharm Sci. 2020; 2020: 8886095 1-6. https://doi.org/10.1155%2F2020%2F8886095
  • [24] Deshkar SS, Pawara AS, Shirolkar SV. Formulation and optimization of floating tablets of clopidogrel bisulphate using design of experiments. Int J Appl Pharm. 2018; 10(6): 94–102. https://doi.org/10.22159/ijap.2018v10i6.27873
  • [25] Ranade AN, Wankhede SS, Ranpise NS, Mundada MS. Development of bilayer floating tablet of amoxicillin and aloe vera gel powder for treatment of gastric ulcers. AAPS PharmSciTech. 2012; 13(4): 1518–23. https://doi.org/10.1208/s12249-012-9882-4
  • [26] El Kalawy S, Abd Elkader D, Ibrahim E, Swifi S. Comparative histological and immunohistochemical study on the effect of curcumin and wild honey versus omeprazole on a rat model of gastric ulcer. J Med Histol. 2019; 2(2): 103–14. https://dx.doi.org/10.21608/jmh.2019.6357.1044
  • [27] Sahoo SK, Sahoo HB, Priyadarshini D, Soundarya G, Kumar CK, Rani KU. Antiulcer Activity of Ethanolic Extract of Salvadora indica (W.) Leaves on Albino Rats. J Clin Diagn Res. 2016; 10(9): 7-10. https://doi.org/10.7860%2FJCDR%2F2016%2F20384.8470
  • [28] El-Ashmawy NE, Khedr EG, El-Bahrawy HA, Selim HM. Nebivolol prevents indomethacin-induced gastric ulcer in rats. J Immunotoxicol. 2016; 13(4): 580–589. https://doi.org/10.3109/1547691x.2016.1142488
  • [29] Laloo D, Sinha SK, Prasad SK, Hemalatha S. Gastric H+, K+-ATPase inhibitory effects of the active constituent isolated from Potentilla fulgens roots: An in vivo and in silico molecular docking studies. Phytomedicine Plus. 2021; 1(3): 100037 1-10. https://doi.org/10.1016/j.phyplu.2021.100037
  • [30] Trott O, Olson AJ. Software news and update AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput. Chem. 2010; 31(2): 455-461. https://doi.org/10.1002/jcc.21334
  • [31] Prajapati S, Mehta A, Modhia I, Patel C. Formulation and optimisation of raft-forming chewable tablets containing H2 antagonist. Int J Pharm Investig. 2012; 2(4): 176. https://doi.org/10.4103%2F2230-973X.106988
  • [32] Bunlung S, Nualnoi T, Issarachot O, Wiwattanapatapee R. Development of raft-forming liquid and chewable tablet formulations incorporating quercetin solid dispersions for treatment of gastric ulcers. Saudi Pharm J. 2021; 29(10): 1143-1154. https://doi.org/10.1016/j.jsps.2021.08.005
  • [33] Fahelelbom KMS, Al-tabakha MMM, Eissa NAM. Evaluation of certain pharmaceutical quality attributes of lisinopril split tablets. Sci. Pharm. 2016; 84(4): 646–653. https://doi.org/10.3390/scipharm84040646
  • [34] Shah S, Hanif M, Abbas G, Rasul A, Zaman M, Ullah H, et al. Prompt drug delivery of rabeprazole through raft formation: In vitro and in vivo evaluation. J. Drug. Deliv. Sci. Technol. 2020; 60: 1-9. https://doi.org/10.1016/j.jddst.2020.101932
  • [35] Abbas G, Hanif M. Development and pharmacokinetic evaluation of alginate-pectin polymeric rafts forming tablets using box behnken design. Drug Dev Ind Pharm. 2018; 44(12): 2026-2037. https://doi.org/10.1080/03639045.2018.1508221
  • [36] Aseel N, Wedad A. Preparation and in-Vitro Evaluation of Cinnarizine Raft Forming Chewable Tablets. AJPS 2019; 19(3): 42-53. https://doi.org/10.32947/ajps.v19i3.623
  • [37] Umre R, Ganeshpurkar A, Ganeshpurkar A, Pandey S, Pandey V, Shrivastava A, et al. In vitro, in vivo and in silico antiulcer activity of ferulic acid. Future J. Pharm. Sci. 2018; 4(2): 248–253. https://doi.org/10.1016/j.fjps.2018.08.001
Toplam 37 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri (Diğer)
Bölüm Articles
Yazarlar

Vinita Patole 0000-0001-9544-4074

Harshad Kapare 0000-0003-2991-7413

Jayashri Mahore 0000-0002-5356-9466

Rachana Bhimanwar 0000-0001-6392-1526

Devyani Awar 0000-0002-6445-0700

Pranali Jadhav 0000-0001-7956-3268

Yayımlanma Tarihi 28 Haziran 2025
Yayımlandığı Sayı Yıl 2023 Cilt: 27 Sayı: 5

Kaynak Göster

APA Patole, V., Kapare, H., Mahore, J., Bhimanwar, R., vd. (2025). Development and evaluation of gastro retentive drug delivery system of monoammonium glycyrrhizinate for the management of gastric ulcer. Journal of Research in Pharmacy, 27(5), 1889-1910.
AMA Patole V, Kapare H, Mahore J, Bhimanwar R, Awar D, Jadhav P. Development and evaluation of gastro retentive drug delivery system of monoammonium glycyrrhizinate for the management of gastric ulcer. J. Res. Pharm. Temmuz 2025;27(5):1889-1910.
Chicago Patole, Vinita, Harshad Kapare, Jayashri Mahore, Rachana Bhimanwar, Devyani Awar, ve Pranali Jadhav. “Development and Evaluation of Gastro Retentive Drug Delivery System of Monoammonium Glycyrrhizinate for the Management of Gastric Ulcer”. Journal of Research in Pharmacy 27, sy. 5 (Temmuz 2025): 1889-1910.
EndNote Patole V, Kapare H, Mahore J, Bhimanwar R, Awar D, Jadhav P (01 Temmuz 2025) Development and evaluation of gastro retentive drug delivery system of monoammonium glycyrrhizinate for the management of gastric ulcer. Journal of Research in Pharmacy 27 5 1889–1910.
IEEE V. Patole, H. Kapare, J. Mahore, R. Bhimanwar, D. Awar, ve P. Jadhav, “Development and evaluation of gastro retentive drug delivery system of monoammonium glycyrrhizinate for the management of gastric ulcer”, J. Res. Pharm., c. 27, sy. 5, ss. 1889–1910, 2025.
ISNAD Patole, Vinita vd. “Development and Evaluation of Gastro Retentive Drug Delivery System of Monoammonium Glycyrrhizinate for the Management of Gastric Ulcer”. Journal of Research in Pharmacy 27/5 (Temmuz 2025), 1889-1910.
JAMA Patole V, Kapare H, Mahore J, Bhimanwar R, Awar D, Jadhav P. Development and evaluation of gastro retentive drug delivery system of monoammonium glycyrrhizinate for the management of gastric ulcer. J. Res. Pharm. 2025;27:1889–1910.
MLA Patole, Vinita vd. “Development and Evaluation of Gastro Retentive Drug Delivery System of Monoammonium Glycyrrhizinate for the Management of Gastric Ulcer”. Journal of Research in Pharmacy, c. 27, sy. 5, 2025, ss. 1889-10.
Vancouver Patole V, Kapare H, Mahore J, Bhimanwar R, Awar D, Jadhav P. Development and evaluation of gastro retentive drug delivery system of monoammonium glycyrrhizinate for the management of gastric ulcer. J. Res. Pharm. 2025;27(5):1889-910.