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Origanum minutiflorum O. Schwarz et P. H. Davis essential oil: enzyme inhibitory activities and chemical composition

Yıl 2023, Cilt: 27 Sayı: 5, 2160 - 2169, 28.06.2025

Gülsüm Yıldız , Betül Demirci , Halide Edip Temel , Neşe Kırımer

Öz

The essential oil (EO) of Origanum minutiflorum O. Schwarz et P. H. Davis was obtained by the hydrodistillation method. The analysis of the EO was conducted using Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GC/MS). The yield of the EO was determined to be 3.9%. Fifty-six compounds were identified, constituting 97.8% of the EO. The EO was rich in carvacrol at a rate of 83.3%, and the other major compounds were p-cymene (3.0%), β-caryophyllene (1.3%), trans-sabinene hydrate (1.1%), γ-terpinene (1.1%), borneol (1.1%), and terpinene-4-ol (1.0%). While the EO (100 µg/mL) demonstrated the highest inhibition on cyclooxygenase-1 (COX-1) with 55.26%, the inhibitory activities on the other enzymes were as follows: cyclooxygenase-2 (COX-2); 33.10%, and matrix metalloproteinase-9 (MMP-9); 12.87%. The EO had no inhibition on lipoxygenase (LOX). In this research, inhibitory activity of the EO of O. minutiflorum on COXs and MMP-9 enzymes was reported for the first time.

Anahtar Kelimeler

Origanum minutiflorum Lamiaceae essential oil enzyme inhibitory activity

Kaynakça

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Yıl 2023, Cilt: 27 Sayı: 5, 2160 - 2169, 28.06.2025

Gülsüm Yıldız , Betül Demirci , Halide Edip Temel , Neşe Kırımer

Öz

Kaynakça

  • [1] Cinbilgel I, Kurt Y. Oregano and/or marjoram: Traditional oil production and ethnomedical utilization of Origanum species in southern Turkey. J Herb Med. 2019; 16: 100257. https://doi.org/10.1016/j.hermed.2019.100257
  • [2] Jun WJ, Han BK, Yu KW, Kim MS, Chang IS, Kim HY, Cho HY. Antioxidant effects of Origanum majorana L. on superoxide anion radicals. Food Chem. 2001; 75(4): 439-444. https://doi.org/10.1016/S0308-8146(01)00233-3
  • [3] Bağci Y, Kan Y, Doğu S, Çelik SA. The essential oil compositions of Origanum majorana L. cultivated in Konya and collected from Mersin-Turkey. Indian J Pharm Educ Res. 2017; 51: 463-469. https://doi.org/10.5530/ijper.51.3s.68
  • [4] Sharifi-Rad M, Berkay Yılmaz Y, Antika G, Salehi B, Tumer TB, Kulandaisamy Venil C, Sharifi-Rad J. Phytochemical constituents, biological activities, and health-promoting effects of the genus Origanum. Phytother Res. 2021; 35(1): 95-121. https://doi.org/10.1002/ptr.6785
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  • [6] Özkan A, Erdoğan A. A comparative evaluation of antioxidant and anticancer activity of essential oil from Origanum onites (Lamiaceae) and its two major phenolic components. Turk J Biol. 2011; 35(6): 735-742. https://doi.org/10.3906/biy-1011-170
  • [7] Becer E, Mutlu Altundag E, Başer KHC, Vatansever HS. Cytotoxic activity and antioxidant effects of Origanum onites essential oil and its two major contents, carvacrol and p-cymene on human colorectal (HCT116) and hepatocelluler carcinoma (HepG2) cell lines. J Essent Oil Res. 2022; 34(6): 514-523. https://doi.org/10.1080/10412905.2022.2107101
  • [8] Avola R, Granata G, Geraci C, Napoli E, Graziano ACE, Cardile V. Oregano (Origanum vulgare L.) essential oil provides anti-inflammatory activity and facilitates wound healing in a human keratinocytes cell model. Food Chem Toxicol. 2020; 144: 111586. https://doi.org/10.1016/j.fct.2020.111586
  • [9] Gormez O, Diler O. In vitro antifungal activity of essential oils from Tymbra, Origanum, Satureja species and some pure compounds on the fish pathogenic fungus, Saprolegnia parasitica. Aquac Res. 2014; 45(7): 1196-1201. https://doi.org/10.1111/are.12060
  • [10] Koca SB, Cevikbas M. Antifungal effect of Origanum onites essential oil as an alternative to formalin in the artificial incubation of narrow-clawed crayfish (Astacus leptodactylus Eschscholtz, 1823). Aquac Res. 2015; 46(9): 2204-2210. https://doi.org/10.1111/are.12374
  • [11] Sarıkürkçü C, Zengin G, Oskay M, Uysal S, Ceylan R, Aktümsek A. Composition, antioxidant, antimicrobial and enzyme inhibition activities of two Origanum vulgare subspecies (subsp. vulgare and subsp. hirtum) essential oils. Ind Crops Prod. 2015; 70: 178-184. https://doi.org/10.1016/j.indcrop.2015.03.030
  • [12] Tonk FA, Yüce S, Bayram E, Akçali Giachino RR, Sönmez Ç, Telci I, Furan MA. Chemical and genetic variability of selected Turkish oregano (Origanum onites L.) clones. Plant Syst Evol. 2010; 288: 157-165. https://doi.org/10.1007/s00606-010-0320-3
  • [13] Başer KHC. The Turkish Origanum species. In: Oregano, The genera Origanum and Lippia, ed. By Kintzios SE, Taylor and Francis, London, 2002. pp. 109-126. eBook ISBN 9780429218972
  • [14] Lukas B, Samuel R, Mader E, Başer KHC, Duman H, Novak J. Complex evolutionary relationships in Origanum section Majorana (Lamiaceae). Bot J Linn Soc. 2013; 171(4): 667-686. https://doi.org/10.1111/boj.12022
  • [15] Kaplan B, Uçar Sözmen E, Turgut K. Chemical diversity of essential oils within the population of Origanum dubium Boiss. Nat Volatiles Essent Oils. 2019; 6(4): 6-12
  • [16] Aslim B, Yucel N. In vitro antimicrobial activity of essential oil from endemic Origanum minutiflorum on ciprofloxacin-resistant Campylobacter spp. Food Chem. 2008; 107(2): 602-606. https://doi.org/10.1016/j.foodchem.2007.08.048
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  • [46] Özkum D, Kürkçüoğlu M, Tipirdamaz R, Başer KHC. Essential oils from wild and micropropagated plants of Origanum minutiflorum O. Schwarz et Davis. J Essent Oil Res. 2010; 22: 135-137. https://doi.org/10.1080/10412905.2010.9700284
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Toplam 69 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmakognozi
Bölüm Articles
Yazarlar

Gülsüm Yıldız 0000-0002-1697-7380

Betül Demirci 0000-0003-2343-746X

Halide Edip Temel 0000-0002-5233-1165

Neşe Kırımer 0000-0001-7866-7719

Yayımlanma Tarihi 28 Haziran 2025
Yayımlandığı Sayı Yıl 2023 Cilt: 27 Sayı: 5

Kaynak Göster

APA Yıldız, G., Demirci, B., Temel, H. E., Kırımer, N. (2025). Origanum minutiflorum O. Schwarz et P. H. Davis essential oil: enzyme inhibitory activities and chemical composition. Journal of Research in Pharmacy, 27(5), 2160-2169.
AMA Yıldız G, Demirci B, Temel HE, Kırımer N. Origanum minutiflorum O. Schwarz et P. H. Davis essential oil: enzyme inhibitory activities and chemical composition. J. Res. Pharm. Temmuz 2025;27(5):2160-2169.
Chicago Yıldız, Gülsüm, Betül Demirci, Halide Edip Temel, ve Neşe Kırımer. “Origanum Minutiflorum O. Schwarz Et P. H. Davis Essential Oil: Enzyme Inhibitory Activities and Chemical Composition”. Journal of Research in Pharmacy 27, sy. 5 (Temmuz 2025): 2160-69.
EndNote Yıldız G, Demirci B, Temel HE, Kırımer N (01 Temmuz 2025) Origanum minutiflorum O. Schwarz et P. H. Davis essential oil: enzyme inhibitory activities and chemical composition. Journal of Research in Pharmacy 27 5 2160–2169.
IEEE G. Yıldız, B. Demirci, H. E. Temel, ve N. Kırımer, “Origanum minutiflorum O. Schwarz et P. H. Davis essential oil: enzyme inhibitory activities and chemical composition”, J. Res. Pharm., c. 27, sy. 5, ss. 2160–2169, 2025.
ISNAD Yıldız, Gülsüm vd. “Origanum Minutiflorum O. Schwarz Et P. H. Davis Essential Oil: Enzyme Inhibitory Activities and Chemical Composition”. Journal of Research in Pharmacy 27/5 (Temmuz 2025), 2160-2169.
JAMA Yıldız G, Demirci B, Temel HE, Kırımer N. Origanum minutiflorum O. Schwarz et P. H. Davis essential oil: enzyme inhibitory activities and chemical composition. J. Res. Pharm. 2025;27:2160–2169.
MLA Yıldız, Gülsüm vd. “Origanum Minutiflorum O. Schwarz Et P. H. Davis Essential Oil: Enzyme Inhibitory Activities and Chemical Composition”. Journal of Research in Pharmacy, c. 27, sy. 5, 2025, ss. 2160-9.
Vancouver Yıldız G, Demirci B, Temel HE, Kırımer N. Origanum minutiflorum O. Schwarz et P. H. Davis essential oil: enzyme inhibitory activities and chemical composition. J. Res. Pharm. 2025;27(5):2160-9.