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Formulation and evaluation of Lornoxicam mucoadhesive buccal films

Yıl 2024, Cilt: 28 Sayı: 4, 1152 - 1165, 28.06.2025

Magdy Ibrahim Mohamed Khaled Fathey El-shaboury Mohamed Aly Abdallah

Öz

Lornoxicam (LN) is a non-steroidal anti-inflammatory and analgesic drug of the oxicam class. As with other non-steroidal anti-inflammatory drugs, it has the same side effects of this group of drugs if they are taken orally such as gastrointestinal, renal and hepatic disorders. Besides, it binds extensively to plasma albumin (99%), has a relatively short plasma half-life (3 to 5 hrs) and undergoes first pass hepatic metabolism and gastrointestinal degradation upon oral administration. These drawbacks render LN a good candidate for local delivery via sustained release dosage forms. Therefore, LN mucoadhesive buccal films were prepared by the solvent casting method using different polymers, that is sodium carboxymethyl cellulose (Na CMC), hydroxypropylmethyl cellulose (HPMC), hydroxypropyl cellulose (HPC), gelatin, polyethylene glycol (PEG) and polyvinyl pyrrolidone (PVP) K-30. Differential scanning calorimetry (DSC) and infrared spectroscopy (IR) studies indicated the absence of any physical or chemical interaction of the drug with any of the used polymers. The prepared films were evaluated for their weight uniformity, thickness uniformity, swelling index, surface pH, folding endurance, in vitro drug release as well as mucoadhesion force. On the basis of the results obtained, it was deduced that the best formula of LN mucoadhesive buccal films was that containing a mixture of Na CMC, HPC and PVP; since it exhibited a high bioadhesive strength, a high percentage of drug release, a good folding endurance and a high swelling index. It can be finally concluded that mucoadhesive buccal films can be one of the alternatives available for administration of LN in order to minimize its side effects and avoid the disadvantages of parenteral and oral routes of administration.

Anahtar Kelimeler

Lornoxicam mucoadhesive buccal films solvent casting method bioadhesive strength

Kaynakça

  • [1] Jacob S, Nair AB, Boddu SHS, Gorain B, Sreeharsha N, Shah J. An updated overview of the emerging role of patch and film-based buccal delivery systems. Pharmaceutics. 2021; 13(8): 1206. https://doi.org/10.3390/pharmaceutics13081206
  • [2] Alqahtani MS, Kazi M, Alsenaidy MA, Ahmad MZ. Advances in oral drug delivery. Front Pharmacol. 2021; 12: 618411. https://doi.org/10.3389/fphar.2021.618411
  • [3] Shipp L, Liu F, Kerai-Varsani L, Okwuosa TC. Buccal films: A review of therapeutic opportunities, formulations & relevant evaluation approaches. J Control Release. 2022; 352: 1071-1092. https://doi.org/10.1016/j.jconrel.2022.10.058
  • [4] Hua S. Advances in nanoparticulate drug delivery approaches for sublingual and buccal administration. Front Pharmacol. 2019; 10(5 Nov.): 1328. https://doi.org/10.3389/fphar.2019.01328
  • [5] Jagtap VD. Buccal film a review on novel drug delivery system. Int J Res Rev. 2020; 7(6): 17-28. https://doi.org/10.52403/ijrr
  • [6] Speer I, Preis M, Breitkreutz J. Dissolution testing of oral film preparations: experimental comparison of compendial and non-compendial methods. Int J Pharm. 2019; 561: 124–134. https://doi.org/10.1016/j.ijpharm.2019.02.042
  • [7] Ali J, Bong Lee J, Gittings S, Iachelini A, Bennett J, Cram A, Garnett M, Roberts CJ, Gershkovich P. Development and optimisation of simulated salivary fluid for biorelevant oral cavity dissolution. Eur J Pharm Biopharm. 2021; 160: 125–133. https://doi.org/10.1016/j.ejpb.2021.01.017
  • [8] Patel VF, Liu F, Brown MB. Advances in oral transmucosal drug delivery. J Control Release. 2011; 153(2): 106–116. https://doi.org/10.1016/j.jconrel.2011.01.027
  • [9] Subramanian P. Mucoadhesive delivery system: A smart way to improve bioavailability of nutraceuticals. Foods. 2021; 10: 1362. https://doi.org/10.3390/foods10061362
  • [10] Desu PK, Brahmaiah B, Nagalakshmi A, Neelima K, Nama S, Baburao C. An overview on rapid dissolving films. Asian J Pharm Res. 2013; 3(1): 15-23.
  • [11] Jovanović M, Petrović M, Cvijić S, Tomić N, Stojanović D, Ibrić S, Uskoković P. 3D Printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction. Pharmaceutics. 2021; 13(12): 2143. https://doi.org/10.3390/pharmaceutics13122143
  • [12] Patil H, Tiwari RV, Repka MA. Hot-melt extrusion: from theory to application in pharmaceutical formulation. AAPS PharmSciTech. 2016; 17(1): 20-42. https://doi.org/10.1208/s12249-015-0360-7
  • [13] Janigová N, Elbl J, Pavloková S, Gajdziok J. Effects of various drying times on the properties of 3D printed orodispersible films. Pharmaceutics. 2022; 14(2): 250. https://doi.org/10.3390/pharmaceutics14020250
  • [14] Morales JO, McConville JT. Manufacture and characterization of mucoadhesive buccal films. Eur J Pharm Biopharm. 2011; 77(2): 187–199. https://doi.org/10.1016/j.ejpb.2010.11.023
  • [15] Zewail MB, Asaad GF, Swellam SM, Abd-Allah SM, Hosny SK, Sallah SK, Eissa JE, Mohamed SS, El-Dakroury WA. Design, characterization and in vivo performance of solid lipid nanoparticles (SLNs)-loaded mucoadhesive buccal tablets for efficient delivery of Lornoxicam in experimental inflammation. Int J Pharm. 2022; 624: 122006. https://doi.org/10.1016/j.ijpharm.2022.122006
  • [16] Li L, Li J, Si S. Effect of formulation variables on in vitrorelease of a water-soluble drug from chitosan-sodium alginate matrix tablets. Asian J Pharma Sci. 2015; 10(4): 314–321. https://doi.org/10.1016/j.ajps.2014.09.002
  • [17] El Sharawy AM, Shukr MH, Elshafeey AH. Formulation and optimization of duloxetine hydrochloride buccal films: in vitro and in vivo evaluation. Drug Deliv. 2017; 24(1): 1762–1769. https://doi.org/10.1080/10717544.2017.1402216
  • [18] Gilhotra RM, Ikram M, Srivastava S, Gilhotra N. A clinical perspective on mucoadhesive buccal drug delivery systems. J Biomed Res. 2014; 28 (2): 81–97. https://doi.org/10.7555/JBR.27.20120136
  • [19] Singh R, Sharma D, Garg R. Review on mucoadhesive drug delivery system with special emphasis on buccal route: an important tool in designing of novel controlled drug delivery system for the effective delivery opharmaceuticals. J Dev Drugs. 2017; 6(1): 1–12. https://doi.org/10.4172/2329-6631.1000169
  • [20] Tongnuanchanm P, Benjakul S, Prodpran T. Properties and antioxidant activity of fish skin gelatin film incorporated with citrus essential oils. Food Chem. 2012; 134(3): 1571-1579. https://doi.org/10.1016/j.foodchem.2012.03.094
  • [21] Gaber DA, Alburaykan AI, Alruthea LM, Aldohan NS, Alharbi RF, Aljohani AR, Albilaihi HM, Adogim SS. Development, in vitro evaluation, and in vivo study of adhesive buccal films for the treatment of diabetic pediatrics via trans mucosal delivery of gliclazide. Drug Des Devel Ther. 2022; 16(Dec 13): 4235–4250. https://doi.org/10.2147/DDDT.S394523
  • [22] Baliga S, Muglikar S, Kale R. Salivary pH: A Diagnostic Biomarker. J Indian Soc Periodontol. 2013; 17(4): 461–465. https://doi.org/10.4103/0972-124X.118317
  • [23] Koland M, Charyulu RN, Vijayanarayana K, Prabhu P. In vitro and in vivo evaluation of chitosan buccal films of ondansetron hydrochloride. Int J Pharm Investig. 2011; 1(3): 164–171. https://doi.org/10.4103/2230-973X.85967.
  • [24] Pongjanyakul T, Suksri H. Alginate-magnesium aluminum silicate films for buccal delivery of nicotine. Colloids Surf B Biointerfaces. 2009; 74(1): 103-113. https://doi.org/10.1016/j.colsurfb.2009.06.033
  • [25] Shidhaye SS, Saindane NS, Sutar S, Kadam V. Mucoadhesive bilayered patches for administration of sumatriptan succinate. AAPS PharmSciTech. 2008; 9(3): 909-916. https://doi.org/10.1208/s12249-008-9125-x
  • [26] Perioli L, Ambrogi V, Angelici F, Ricci M, Giovagnoli S, Capuccell M, Rossi C. Development of mucoadhesive patches for buccal administration of ibuprofen. J Control Release. 2004; 99(1): 73–82. https://doi.org/10.1016/j.jconrel.2004.06.005
  • [27] Asfour MH, Amira M, Mohsen AM. Formulation and evaluation of pH-sensitive rutin nanospheres against colon carcinoma using HCT-116 cell line. J Adv Res. 2018; 9(Oct 12): 17-26. https://doi.org/10.1016/j.jare.2017.10.003
  • [28] Scarpa M, Paudel A, Kloprogge F, Hsiao WK, Bresciani M, Gaisford S, Orlu M. Key acceptability attributes of orodispersible films. Eur J Pharm Biopharm. 2018; 125: 131-140. https://doi.org/10.1016/j.ejpb.2018.01.003
  • [29] Speer I, Preis M, Breitkreutz J. Prolonged drug release properties for orodispersible films by combining hot-melt extrusion and solvent casting methods. Eur J Pharm Biopharm. 2018; 129: 66-73. https://doi.org/10.1016/j.ejpb.2018.05.023
  • [30] Elbi J, Gajdziok J, Kolarczyk J. 3D printing of multilayered orodispersible films with in-process drying. Int J Pharm. 2020; 575: 118883. https://doi.org/10.1016/j.ijpharm.2019.118883
  • [31] Pamlényi K, Kristó K, Sovány T, Regdon Jr G. Development and evaluation of bioadhesive buccal films based on sodium alginate for allergy therapy. Heliyon. 2022; 8(8): e10364. https://doi.org/10.1016/j.heliyon.2022.e10364
  • [32] Alanazi FK, Abdel Rahman AA, Mahrous GM, Alsarra IA. Formulation and physicochemical characterization of buccoadhesive films containing ketorolac. J Drug Deliv Sci Technol. 2007; 17(3): 183-192. https://doi.org/10.1016/S1773-2247(07)50034-1
  • [33] Parodi B, Russo E, Caviglioli G, Cafaggi S, Bignardi G. Development and characterization of a buccoadhesive dosage form of oxycodone hydrochloride. drug Dev Ind Pharm. 1996; 22(5): 445-450. https://doi.org/10.3109/03639049609069353
  • [34] Nakamura F, Ohta R, Machida Y, Nagai T. In vitro and in vivo nasal mucoadhesion of some water-soluble polymers. Int J Pharm. 1996; 134(1): 173-181. https://doi.org/10.1016/0378-5173(95)04416-7
  • [35] Giradkar KP, Channawar MA, Kajale AD, Sridhar E, Kamble RS, Chandewar AV, Wadhwani P. Design, development and in vitro evaluation of bioadhesive dosage form for buccal route. Int J Pharm Res Dev. 2010; 2(6): 1–20.
  • [36] Nirmala PN. Formulation and evaluation of fast dissolving oral films incorporated with ramipril and β-cyclodextrin complex. Int J Pharm Sci Drug Res. 2020; 12(4): 390-395. https://doi.org/10.25004/ijpsdr.2020.120412
  • [37] Abdella S, Afinjuomo F, Song Y, Upton R, Garg S. Mucoadhesive buccal film of estradiol for hormonal replacement therapy: Development and in-vivo performance prediction. Pharmaceutics. 2022; 14(3): 542. https://doi.org/10.3390/pharmaceutics14030542
  • [38] Dinte E, Muntean DM, Andrei V, Boșca BA, Dudescu CM, Barbu-Tudoran L, Borodi G, Andrei S, Gal AF, Rus V, Gherman LM, Cadar O, Barabas R, Niculae M, Ilea A. In vitro and in vivo characterisation of a mucoadhesive buccal film loaded with doxycycline hyclate for topical application in periodontitis. Pharmaceutics. 2023; 15(2): 580. https://doi.org/10.3390/pharmaceutics15020580
  • [39] Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm. 1983; 15(1): 25–35. https://doi.org/10.1016/0378-5173(83)90064-9
  • [40] Alshlash M, Kitaz A, Abdelwahed W. Qualitative phytochemical screening, antioxidant and wound healing of Pistacia palaestina boiss. extracts. Bull Pharm Sci Assiut University. 2023; 46(1): 83–96. https://dx.doi.org/10.21608/bfsa.2023.300765

Yıl 2024, Cilt: 28 Sayı: 4, 1152 - 1165, 28.06.2025

Magdy Ibrahim Mohamed Khaled Fathey El-shaboury Mohamed Aly Abdallah

Öz

Kaynakça

  • [1] Jacob S, Nair AB, Boddu SHS, Gorain B, Sreeharsha N, Shah J. An updated overview of the emerging role of patch and film-based buccal delivery systems. Pharmaceutics. 2021; 13(8): 1206. https://doi.org/10.3390/pharmaceutics13081206
  • [2] Alqahtani MS, Kazi M, Alsenaidy MA, Ahmad MZ. Advances in oral drug delivery. Front Pharmacol. 2021; 12: 618411. https://doi.org/10.3389/fphar.2021.618411
  • [3] Shipp L, Liu F, Kerai-Varsani L, Okwuosa TC. Buccal films: A review of therapeutic opportunities, formulations & relevant evaluation approaches. J Control Release. 2022; 352: 1071-1092. https://doi.org/10.1016/j.jconrel.2022.10.058
  • [4] Hua S. Advances in nanoparticulate drug delivery approaches for sublingual and buccal administration. Front Pharmacol. 2019; 10(5 Nov.): 1328. https://doi.org/10.3389/fphar.2019.01328
  • [5] Jagtap VD. Buccal film a review on novel drug delivery system. Int J Res Rev. 2020; 7(6): 17-28. https://doi.org/10.52403/ijrr
  • [6] Speer I, Preis M, Breitkreutz J. Dissolution testing of oral film preparations: experimental comparison of compendial and non-compendial methods. Int J Pharm. 2019; 561: 124–134. https://doi.org/10.1016/j.ijpharm.2019.02.042
  • [7] Ali J, Bong Lee J, Gittings S, Iachelini A, Bennett J, Cram A, Garnett M, Roberts CJ, Gershkovich P. Development and optimisation of simulated salivary fluid for biorelevant oral cavity dissolution. Eur J Pharm Biopharm. 2021; 160: 125–133. https://doi.org/10.1016/j.ejpb.2021.01.017
  • [8] Patel VF, Liu F, Brown MB. Advances in oral transmucosal drug delivery. J Control Release. 2011; 153(2): 106–116. https://doi.org/10.1016/j.jconrel.2011.01.027
  • [9] Subramanian P. Mucoadhesive delivery system: A smart way to improve bioavailability of nutraceuticals. Foods. 2021; 10: 1362. https://doi.org/10.3390/foods10061362
  • [10] Desu PK, Brahmaiah B, Nagalakshmi A, Neelima K, Nama S, Baburao C. An overview on rapid dissolving films. Asian J Pharm Res. 2013; 3(1): 15-23.
  • [11] Jovanović M, Petrović M, Cvijić S, Tomić N, Stojanović D, Ibrić S, Uskoković P. 3D Printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction. Pharmaceutics. 2021; 13(12): 2143. https://doi.org/10.3390/pharmaceutics13122143
  • [12] Patil H, Tiwari RV, Repka MA. Hot-melt extrusion: from theory to application in pharmaceutical formulation. AAPS PharmSciTech. 2016; 17(1): 20-42. https://doi.org/10.1208/s12249-015-0360-7
  • [13] Janigová N, Elbl J, Pavloková S, Gajdziok J. Effects of various drying times on the properties of 3D printed orodispersible films. Pharmaceutics. 2022; 14(2): 250. https://doi.org/10.3390/pharmaceutics14020250
  • [14] Morales JO, McConville JT. Manufacture and characterization of mucoadhesive buccal films. Eur J Pharm Biopharm. 2011; 77(2): 187–199. https://doi.org/10.1016/j.ejpb.2010.11.023
  • [15] Zewail MB, Asaad GF, Swellam SM, Abd-Allah SM, Hosny SK, Sallah SK, Eissa JE, Mohamed SS, El-Dakroury WA. Design, characterization and in vivo performance of solid lipid nanoparticles (SLNs)-loaded mucoadhesive buccal tablets for efficient delivery of Lornoxicam in experimental inflammation. Int J Pharm. 2022; 624: 122006. https://doi.org/10.1016/j.ijpharm.2022.122006
  • [16] Li L, Li J, Si S. Effect of formulation variables on in vitrorelease of a water-soluble drug from chitosan-sodium alginate matrix tablets. Asian J Pharma Sci. 2015; 10(4): 314–321. https://doi.org/10.1016/j.ajps.2014.09.002
  • [17] El Sharawy AM, Shukr MH, Elshafeey AH. Formulation and optimization of duloxetine hydrochloride buccal films: in vitro and in vivo evaluation. Drug Deliv. 2017; 24(1): 1762–1769. https://doi.org/10.1080/10717544.2017.1402216
  • [18] Gilhotra RM, Ikram M, Srivastava S, Gilhotra N. A clinical perspective on mucoadhesive buccal drug delivery systems. J Biomed Res. 2014; 28 (2): 81–97. https://doi.org/10.7555/JBR.27.20120136
  • [19] Singh R, Sharma D, Garg R. Review on mucoadhesive drug delivery system with special emphasis on buccal route: an important tool in designing of novel controlled drug delivery system for the effective delivery opharmaceuticals. J Dev Drugs. 2017; 6(1): 1–12. https://doi.org/10.4172/2329-6631.1000169
  • [20] Tongnuanchanm P, Benjakul S, Prodpran T. Properties and antioxidant activity of fish skin gelatin film incorporated with citrus essential oils. Food Chem. 2012; 134(3): 1571-1579. https://doi.org/10.1016/j.foodchem.2012.03.094
  • [21] Gaber DA, Alburaykan AI, Alruthea LM, Aldohan NS, Alharbi RF, Aljohani AR, Albilaihi HM, Adogim SS. Development, in vitro evaluation, and in vivo study of adhesive buccal films for the treatment of diabetic pediatrics via trans mucosal delivery of gliclazide. Drug Des Devel Ther. 2022; 16(Dec 13): 4235–4250. https://doi.org/10.2147/DDDT.S394523
  • [22] Baliga S, Muglikar S, Kale R. Salivary pH: A Diagnostic Biomarker. J Indian Soc Periodontol. 2013; 17(4): 461–465. https://doi.org/10.4103/0972-124X.118317
  • [23] Koland M, Charyulu RN, Vijayanarayana K, Prabhu P. In vitro and in vivo evaluation of chitosan buccal films of ondansetron hydrochloride. Int J Pharm Investig. 2011; 1(3): 164–171. https://doi.org/10.4103/2230-973X.85967.
  • [24] Pongjanyakul T, Suksri H. Alginate-magnesium aluminum silicate films for buccal delivery of nicotine. Colloids Surf B Biointerfaces. 2009; 74(1): 103-113. https://doi.org/10.1016/j.colsurfb.2009.06.033
  • [25] Shidhaye SS, Saindane NS, Sutar S, Kadam V. Mucoadhesive bilayered patches for administration of sumatriptan succinate. AAPS PharmSciTech. 2008; 9(3): 909-916. https://doi.org/10.1208/s12249-008-9125-x
  • [26] Perioli L, Ambrogi V, Angelici F, Ricci M, Giovagnoli S, Capuccell M, Rossi C. Development of mucoadhesive patches for buccal administration of ibuprofen. J Control Release. 2004; 99(1): 73–82. https://doi.org/10.1016/j.jconrel.2004.06.005
  • [27] Asfour MH, Amira M, Mohsen AM. Formulation and evaluation of pH-sensitive rutin nanospheres against colon carcinoma using HCT-116 cell line. J Adv Res. 2018; 9(Oct 12): 17-26. https://doi.org/10.1016/j.jare.2017.10.003
  • [28] Scarpa M, Paudel A, Kloprogge F, Hsiao WK, Bresciani M, Gaisford S, Orlu M. Key acceptability attributes of orodispersible films. Eur J Pharm Biopharm. 2018; 125: 131-140. https://doi.org/10.1016/j.ejpb.2018.01.003
  • [29] Speer I, Preis M, Breitkreutz J. Prolonged drug release properties for orodispersible films by combining hot-melt extrusion and solvent casting methods. Eur J Pharm Biopharm. 2018; 129: 66-73. https://doi.org/10.1016/j.ejpb.2018.05.023
  • [30] Elbi J, Gajdziok J, Kolarczyk J. 3D printing of multilayered orodispersible films with in-process drying. Int J Pharm. 2020; 575: 118883. https://doi.org/10.1016/j.ijpharm.2019.118883
  • [31] Pamlényi K, Kristó K, Sovány T, Regdon Jr G. Development and evaluation of bioadhesive buccal films based on sodium alginate for allergy therapy. Heliyon. 2022; 8(8): e10364. https://doi.org/10.1016/j.heliyon.2022.e10364
  • [32] Alanazi FK, Abdel Rahman AA, Mahrous GM, Alsarra IA. Formulation and physicochemical characterization of buccoadhesive films containing ketorolac. J Drug Deliv Sci Technol. 2007; 17(3): 183-192. https://doi.org/10.1016/S1773-2247(07)50034-1
  • [33] Parodi B, Russo E, Caviglioli G, Cafaggi S, Bignardi G. Development and characterization of a buccoadhesive dosage form of oxycodone hydrochloride. drug Dev Ind Pharm. 1996; 22(5): 445-450. https://doi.org/10.3109/03639049609069353
  • [34] Nakamura F, Ohta R, Machida Y, Nagai T. In vitro and in vivo nasal mucoadhesion of some water-soluble polymers. Int J Pharm. 1996; 134(1): 173-181. https://doi.org/10.1016/0378-5173(95)04416-7
  • [35] Giradkar KP, Channawar MA, Kajale AD, Sridhar E, Kamble RS, Chandewar AV, Wadhwani P. Design, development and in vitro evaluation of bioadhesive dosage form for buccal route. Int J Pharm Res Dev. 2010; 2(6): 1–20.
  • [36] Nirmala PN. Formulation and evaluation of fast dissolving oral films incorporated with ramipril and β-cyclodextrin complex. Int J Pharm Sci Drug Res. 2020; 12(4): 390-395. https://doi.org/10.25004/ijpsdr.2020.120412
  • [37] Abdella S, Afinjuomo F, Song Y, Upton R, Garg S. Mucoadhesive buccal film of estradiol for hormonal replacement therapy: Development and in-vivo performance prediction. Pharmaceutics. 2022; 14(3): 542. https://doi.org/10.3390/pharmaceutics14030542
  • [38] Dinte E, Muntean DM, Andrei V, Boșca BA, Dudescu CM, Barbu-Tudoran L, Borodi G, Andrei S, Gal AF, Rus V, Gherman LM, Cadar O, Barabas R, Niculae M, Ilea A. In vitro and in vivo characterisation of a mucoadhesive buccal film loaded with doxycycline hyclate for topical application in periodontitis. Pharmaceutics. 2023; 15(2): 580. https://doi.org/10.3390/pharmaceutics15020580
  • [39] Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm. 1983; 15(1): 25–35. https://doi.org/10.1016/0378-5173(83)90064-9
  • [40] Alshlash M, Kitaz A, Abdelwahed W. Qualitative phytochemical screening, antioxidant and wound healing of Pistacia palaestina boiss. extracts. Bull Pharm Sci Assiut University. 2023; 46(1): 83–96. https://dx.doi.org/10.21608/bfsa.2023.300765
Toplam 40 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular İlaç Dağıtım Teknolojileri
Bölüm Articles
Yazarlar

Magdy Ibrahim Mohamed 0000-0002-0480-7720

Khaled Fathey El-shaboury 0009-0008-2278-7381

Mohamed Aly Abdallah

Yayımlanma Tarihi 28 Haziran 2025
Gönderilme Tarihi 4 Nisan 2024
Kabul Tarihi 17 Mayıs 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 28 Sayı: 4

Kaynak Göster

APA Mohamed, M. I., El-shaboury, K. F., & Abdallah, M. A. (2025). Formulation and evaluation of Lornoxicam mucoadhesive buccal films. Journal of Research in Pharmacy, 28(4), 1152-1165.
AMA Mohamed MI, El-shaboury KF, Abdallah MA. Formulation and evaluation of Lornoxicam mucoadhesive buccal films. J. Res. Pharm. Temmuz 2025;28(4):1152-1165.
Chicago Mohamed, Magdy Ibrahim, Khaled Fathey El-shaboury, ve Mohamed Aly Abdallah. “Formulation and Evaluation of Lornoxicam Mucoadhesive Buccal Films”. Journal of Research in Pharmacy 28, sy. 4 (Temmuz 2025): 1152-65.
EndNote Mohamed MI, El-shaboury KF, Abdallah MA (01 Temmuz 2025) Formulation and evaluation of Lornoxicam mucoadhesive buccal films. Journal of Research in Pharmacy 28 4 1152–1165.
IEEE M. I. Mohamed, K. F. El-shaboury, ve M. A. Abdallah, “Formulation and evaluation of Lornoxicam mucoadhesive buccal films”, J. Res. Pharm., c. 28, sy. 4, ss. 1152–1165, 2025.
ISNAD Mohamed, Magdy Ibrahim vd. “Formulation and Evaluation of Lornoxicam Mucoadhesive Buccal Films”. Journal of Research in Pharmacy 28/4 (Temmuz 2025), 1152-1165.
JAMA Mohamed MI, El-shaboury KF, Abdallah MA. Formulation and evaluation of Lornoxicam mucoadhesive buccal films. J. Res. Pharm. 2025;28:1152–1165.
MLA Mohamed, Magdy Ibrahim vd. “Formulation and Evaluation of Lornoxicam Mucoadhesive Buccal Films”. Journal of Research in Pharmacy, c. 28, sy. 4, 2025, ss. 1152-65.
Vancouver Mohamed MI, El-shaboury KF, Abdallah MA. Formulation and evaluation of Lornoxicam mucoadhesive buccal films. J. Res. Pharm. 2025;28(4):1152-65.