Araştırma Makalesi
BibTex RIS Kaynak Göster

Antimicrobial activity of three Scutellaria L. species from Turkey

Yıl 2019, Cilt: 23 Sayı: 3, 552 - 558, 27.06.2025

Zekiye Ceren Arıtuluk , Ceren Özkul , Gülin Renda , Melike Ekizoğlu Nurten Ezer

Öz

Plant-sourced antimicrobials are known for their therapeutic potency against multi-drug-resistant pathogens. The members of Scutellaria L. have been used to cure several diseases in East Asia, Europe, and North America. The genus Scutellaria belonging to Lamiaceae family is composed of around 360 species worldwide and 18 species in Turkey. In this study, 36 extracts prepared with different solvents from aerial parts and roots of S. salviifolia Benth., S. diffusa Benth. and S. pontica C. Koch were investigated for their antimicrobial activity against four bacteria (Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 29213) and three yeasts (Candida albicans ATCC 90028, C. krusei ATCC 6258, C. parapsilosis ATCC 90018) by using the broth microdilution method. Gentamicin, vancomycin and fluconazole were used as positive control. According to our results, all of the tested extracts showed stronger antimicrobial activity against yeasts than bacteria. The chloroform extract of S. salviifolia root showed the highest antifungal effect against C. krusei with 32 μg/ml MIC value compared with all the tested extracts and the positive control fluconazole (64 μg/ml MIC value).

Anahtar Kelimeler

Scutellaria Lamiaceae plant extract antimicrobial activity minimum inhibitory concentration.

Kaynakça

  • [1] Subramani R, Narayanasamy M, Feussner K-D. Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens. 3 Biotech. 2017; 7(3): 172. [CrossRef]
  • [2] Rios J, Recio M. Medicinal plants and antimicrobial activity. J Ethnopharmacol. 2005; 100(1-2): 80-84. [CrossRef]
  • [3] Paton A. A global taxonomic investigation of Scutellaria (Labiatae). Kew Bull. 1990; 45(3): 399-450. [CrossRef]
  • [4] Shang X, He X, He X, Li M, Zhang R, Fan P, Zhang Q, Jia Z. The genus Scutellaria an ethnopharmacological and phytochemical review. J Ethnopharmacol. 2010; 128(2): 279-313. [CrossRef]
  • [5] Joshee N, Patrick TS, Mentreddy RS, Yadav AK. Skullcap: Potential medicinal crop. In: Janick J, Whipkey A (Eds). Trends in New Crops and New Uses. ASHS Press, Alexandria, VA, 2002, pp.580-586.
  • [6] Çiçek M, Yaprak AE. Scutellaria yildirimlii (Lamiaceae), a new species from Turkey. Phytotaxa. 2013; 132(1): 53-58. [CrossRef]
  • [7] Güner A, Aslan S, Ekim T, Vural M, Babaç M. Türkiye Bitkileri Listesi (Damarlı Bitkiler), Flora Dizisi 1., ANG Vakfi, Nezahat Gökyiğit Botanik Bahçesi Yayınları, İstanbul, 2012.
  • [8] Tuzlacı E, Türkiye Bitkileri Geleneksel İlaç Rehberi, İstanbul Tıp Kitabevi, İstanbul, 2016.
  • [9] Altundag E, Ozturk M. Ethnomedicinal studies on the plant resources of east Anatolia, Turkey. Procedia Soc Behav Sci. 2011; 19: 756-777. [CrossRef]
  • [10] Cakilcioglu U, Turkoglu I. An ethnobotanical survey of medicinal plants in Sivrice (Elazığ-Turkey). J Ethnopharmacol. 2010; 132(1): 165-175. [CrossRef]
  • [11] Mükemre M, Behçet L, Çakılcıoğlu U. Ethnobotanical study on medicinal plants in villages of Çatak (Van-Turkey). J Ethnopharmacol. 2015; 166: 361-374. [CrossRef]
  • [12] Edmondson JR. Scutellaria L. In: Davis PH. (Eds). Flora of Turkey and the East Aegean Islands, Vol. 7, Edinburgh University Press, Edinburgh, 1982, pp. 78.
  • [13] Ersöz T, Harput ÜŞ, Saracoğlu İ, Çalış İ, Ogihara Y. Phenolic compounds from Scutellaria pontica. Turk J Chem. 2002; 26(4): 581-588.
  • [14] Rodríguez B, de la Torre MC, Jimeno M-L, Bruno M, Vassallo N, Bondì M, Piozzi F, Servettaz O. Neoclerodane diterpenoids from Scutellaria pontica. J Nat Prod. 1997; 60(4): 348-355.
  • [15] Cicek M, Demirci B, Yilmaz G, Baser KHC. Essential oil composition of three species of Scutellaria from Turkey. Nat Prod Res. 2011; 25(18): 1720-1726. [CrossRef]
  • [16] Saracoglu I, Inoue M, Calıs I, Ogihara Y. Studies on constituents with cytotoxic and cytostatic activity of two Turkish medicinal plants Phlomis armeniaca and Scutellaria salviifolia. Biol Pharm Bull. 1995; 18(10): 1396-1400. [CrossRef]
  • [17] Şenol FS, Orhan I, Yilmaz G, Cicek M, Şener B. Acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibition studies and antioxidant activities of 33 Scutellaria L. taxa from Turkey. Food Chem Toxicol. 2010; 48(3): 781-788. [CrossRef]
  • [18] Yavuz C, Dereli Kılıç DD, Ayar A, Yıldırım T. Antibacterial effects of methanol extracts of some plant species belonging to Lamiaceae family. Int J Sec Metabolite. 2017; 4(3): 429-433. [CrossRef]
  • [19] Clinical and Laboratory Standards Institute, Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, Approved Standard 8th ed., M 07-A8, Clinical and Laboratory Standards Institute, Wayne, PA, 2008.
  • [20] Clinical and Laboratory Standards Institute, Reference method for broth dilution antifungal susceptibility testing of yeasts: approved Standard 3rd ed., M 27-A3, Clinical and Laboratory Standards Institute, Wayne, PA, 2008.
  • [21] Yang Z-C, Wang B-C, Yang X-S, Wang Q, Ran L. The synergistic activity of antibiotics combined with eight traditional Chinese medicines against two different strains of Staphylococcus aureus. Colloids Surf B Biointerfaces. 2005; 41(2-3): 79-81. [CrossRef]
  • [22] Trinh H, Yoo Y, Won K-H, Ngo HT, Yang J-E, Cho J-G, Lee S-W, Kim K-Y, Yi T-H. Evaluation of in-vitro antimicrobial activity of Artemisia apiacea H. and Scutellaria baicalensis G. extracts. J Med Microbiol. 2018; 67(4): 489-495. [CrossRef]
  • [23] Shan B, Cai Y-Z, Brooks JD, Corke H. The in vitro antibacterial activity of dietary spice and medicinal herb extracts. Int J Food Microbiol. 2007; 117(1): 112-119. [CrossRef]
  • [24] Lu Y, Joerger R, Wu C. Study of the chemical composition and antimicrobial activities of ethanolic extracts from roots of Scutellaria baicalensis Georgi. J Agric Food Chem. 2011; 59(20): 10934-10942. [CrossRef]

Yıl 2019, Cilt: 23 Sayı: 3, 552 - 558, 27.06.2025

Zekiye Ceren Arıtuluk , Ceren Özkul , Gülin Renda , Melike Ekizoğlu Nurten Ezer

Öz

Kaynakça

  • [1] Subramani R, Narayanasamy M, Feussner K-D. Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens. 3 Biotech. 2017; 7(3): 172. [CrossRef]
  • [2] Rios J, Recio M. Medicinal plants and antimicrobial activity. J Ethnopharmacol. 2005; 100(1-2): 80-84. [CrossRef]
  • [3] Paton A. A global taxonomic investigation of Scutellaria (Labiatae). Kew Bull. 1990; 45(3): 399-450. [CrossRef]
  • [4] Shang X, He X, He X, Li M, Zhang R, Fan P, Zhang Q, Jia Z. The genus Scutellaria an ethnopharmacological and phytochemical review. J Ethnopharmacol. 2010; 128(2): 279-313. [CrossRef]
  • [5] Joshee N, Patrick TS, Mentreddy RS, Yadav AK. Skullcap: Potential medicinal crop. In: Janick J, Whipkey A (Eds). Trends in New Crops and New Uses. ASHS Press, Alexandria, VA, 2002, pp.580-586.
  • [6] Çiçek M, Yaprak AE. Scutellaria yildirimlii (Lamiaceae), a new species from Turkey. Phytotaxa. 2013; 132(1): 53-58. [CrossRef]
  • [7] Güner A, Aslan S, Ekim T, Vural M, Babaç M. Türkiye Bitkileri Listesi (Damarlı Bitkiler), Flora Dizisi 1., ANG Vakfi, Nezahat Gökyiğit Botanik Bahçesi Yayınları, İstanbul, 2012.
  • [8] Tuzlacı E, Türkiye Bitkileri Geleneksel İlaç Rehberi, İstanbul Tıp Kitabevi, İstanbul, 2016.
  • [9] Altundag E, Ozturk M. Ethnomedicinal studies on the plant resources of east Anatolia, Turkey. Procedia Soc Behav Sci. 2011; 19: 756-777. [CrossRef]
  • [10] Cakilcioglu U, Turkoglu I. An ethnobotanical survey of medicinal plants in Sivrice (Elazığ-Turkey). J Ethnopharmacol. 2010; 132(1): 165-175. [CrossRef]
  • [11] Mükemre M, Behçet L, Çakılcıoğlu U. Ethnobotanical study on medicinal plants in villages of Çatak (Van-Turkey). J Ethnopharmacol. 2015; 166: 361-374. [CrossRef]
  • [12] Edmondson JR. Scutellaria L. In: Davis PH. (Eds). Flora of Turkey and the East Aegean Islands, Vol. 7, Edinburgh University Press, Edinburgh, 1982, pp. 78.
  • [13] Ersöz T, Harput ÜŞ, Saracoğlu İ, Çalış İ, Ogihara Y. Phenolic compounds from Scutellaria pontica. Turk J Chem. 2002; 26(4): 581-588.
  • [14] Rodríguez B, de la Torre MC, Jimeno M-L, Bruno M, Vassallo N, Bondì M, Piozzi F, Servettaz O. Neoclerodane diterpenoids from Scutellaria pontica. J Nat Prod. 1997; 60(4): 348-355.
  • [15] Cicek M, Demirci B, Yilmaz G, Baser KHC. Essential oil composition of three species of Scutellaria from Turkey. Nat Prod Res. 2011; 25(18): 1720-1726. [CrossRef]
  • [16] Saracoglu I, Inoue M, Calıs I, Ogihara Y. Studies on constituents with cytotoxic and cytostatic activity of two Turkish medicinal plants Phlomis armeniaca and Scutellaria salviifolia. Biol Pharm Bull. 1995; 18(10): 1396-1400. [CrossRef]
  • [17] Şenol FS, Orhan I, Yilmaz G, Cicek M, Şener B. Acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibition studies and antioxidant activities of 33 Scutellaria L. taxa from Turkey. Food Chem Toxicol. 2010; 48(3): 781-788. [CrossRef]
  • [18] Yavuz C, Dereli Kılıç DD, Ayar A, Yıldırım T. Antibacterial effects of methanol extracts of some plant species belonging to Lamiaceae family. Int J Sec Metabolite. 2017; 4(3): 429-433. [CrossRef]
  • [19] Clinical and Laboratory Standards Institute, Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, Approved Standard 8th ed., M 07-A8, Clinical and Laboratory Standards Institute, Wayne, PA, 2008.
  • [20] Clinical and Laboratory Standards Institute, Reference method for broth dilution antifungal susceptibility testing of yeasts: approved Standard 3rd ed., M 27-A3, Clinical and Laboratory Standards Institute, Wayne, PA, 2008.
  • [21] Yang Z-C, Wang B-C, Yang X-S, Wang Q, Ran L. The synergistic activity of antibiotics combined with eight traditional Chinese medicines against two different strains of Staphylococcus aureus. Colloids Surf B Biointerfaces. 2005; 41(2-3): 79-81. [CrossRef]
  • [22] Trinh H, Yoo Y, Won K-H, Ngo HT, Yang J-E, Cho J-G, Lee S-W, Kim K-Y, Yi T-H. Evaluation of in-vitro antimicrobial activity of Artemisia apiacea H. and Scutellaria baicalensis G. extracts. J Med Microbiol. 2018; 67(4): 489-495. [CrossRef]
  • [23] Shan B, Cai Y-Z, Brooks JD, Corke H. The in vitro antibacterial activity of dietary spice and medicinal herb extracts. Int J Food Microbiol. 2007; 117(1): 112-119. [CrossRef]
  • [24] Lu Y, Joerger R, Wu C. Study of the chemical composition and antimicrobial activities of ethanolic extracts from roots of Scutellaria baicalensis Georgi. J Agric Food Chem. 2011; 59(20): 10934-10942. [CrossRef]
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmasotik Botanik
Bölüm Articles
Yazarlar

Zekiye Ceren Arıtuluk

Ceren Özkul

Gülin Renda

Melike Ekizoğlu

Nurten Ezer

Yayımlanma Tarihi 27 Haziran 2025
Yayımlandığı Sayı Yıl 2019 Cilt: 23 Sayı: 3

Kaynak Göster

APA Arıtuluk, Z. C., Özkul, C., Renda, G., Ekizoğlu, M., vd. (2025). Antimicrobial activity of three Scutellaria L. species from Turkey. Journal of Research in Pharmacy, 23(3), 552-558.
AMA Arıtuluk ZC, Özkul C, Renda G, Ekizoğlu M, Ezer N. Antimicrobial activity of three Scutellaria L. species from Turkey. J. Res. Pharm. Haziran 2025;23(3):552-558.
Chicago Arıtuluk, Zekiye Ceren, Ceren Özkul, Gülin Renda, Melike Ekizoğlu, ve Nurten Ezer. “Antimicrobial Activity of Three Scutellaria L. Species from Turkey”. Journal of Research in Pharmacy 23, sy. 3 (Haziran 2025): 552-58.
EndNote Arıtuluk ZC, Özkul C, Renda G, Ekizoğlu M, Ezer N (01 Haziran 2025) Antimicrobial activity of three Scutellaria L. species from Turkey. Journal of Research in Pharmacy 23 3 552–558.
IEEE Z. C. Arıtuluk, C. Özkul, G. Renda, M. Ekizoğlu, ve N. Ezer, “Antimicrobial activity of three Scutellaria L. species from Turkey”, J. Res. Pharm., c. 23, sy. 3, ss. 552–558, 2025.
ISNAD Arıtuluk, Zekiye Ceren vd. “Antimicrobial Activity of Three Scutellaria L. Species from Turkey”. Journal of Research in Pharmacy 23/3 (Haziran 2025), 552-558.
JAMA Arıtuluk ZC, Özkul C, Renda G, Ekizoğlu M, Ezer N. Antimicrobial activity of three Scutellaria L. species from Turkey. J. Res. Pharm. 2025;23:552–558.
MLA Arıtuluk, Zekiye Ceren vd. “Antimicrobial Activity of Three Scutellaria L. Species from Turkey”. Journal of Research in Pharmacy, c. 23, sy. 3, 2025, ss. 552-8.
Vancouver Arıtuluk ZC, Özkul C, Renda G, Ekizoğlu M, Ezer N. Antimicrobial activity of three Scutellaria L. species from Turkey. J. Res. Pharm. 2025;23(3):552-8.