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Antioxidant, Antityrosinase Activities and Composition of Essential Oils Obtained from Roots and Fruits of Ferulago longistylis Boiss.

Yıl 2022, Cilt: 26 Sayı: 4, 790 - 798, 28.06.2025

Mine Kürkçüoğlu , Hale Gamze Ağalar Burak Temiz , Ahmet Duran , Mehmet Yavuz Paksoy , Kemal Hüsnü Can Başer

Öz

This study was aimed to evaluate the potential uses of Ferulago longistylis Boiss. essential oils in cosmetic
applications. The air dried roots and fruits were subjected to water distillation by using a Clevenger apparatus for 3 h.
Both essential oils were analyzed by gas chromatography (GC-FID) and gas chromatography-mass spectrometry
(GC/MS) systems, simultaneously. The essential oil yields of the fruits and roots were calculated as 4% and 0.91%,
respectively. The major compounds were identified as 2,3,6-trimethylbenzaldehyde (29.5%), cis-chrysanthenyl acetate
(15.2%), (Z)-β-ocimene (12.4%), α-pinene (12.0%) and myrcene (11.4%) in the fruit essential oil while the root essential
oil was characterized with high content of α-pinene (90.5%). Both essential oils were evaluated for their potential
antioxidant and antityrosinase activities. The both essential oils showed weak Trolox equivalent antioxidant capacity
and DPPH radical scavenging activity. The fruit essential oil showed weak antityrosinase (%25 inhibition, 1 mg/mL)
activity while the root essential oil was inactive. The results concluded that both essential oils were not promising in
cosmetic applications.

Anahtar Kelimeler

Ferulago longistylis α-pinene; 2 3 6-trimethylbenzaldehyde antioxidant antityrosinase

Kaynakça

  • [1] Gonzalez-Minero FJ, Bravo-Diaz L. The use of plants in skin-care products, cosmetics and fragrances: Past and present. Cosmetics. 2018; 5(3): 50. [crossref]
  • [2]Choi I, Park Y, Ryu IY, Jung HJ, Ullah S, Choi H, Park C, Kang D, Lee S, Chun P, Chung HY, Moon HR. In silico and in vitro insights into tyrosinase inhibitors with a 2-thioxooxazoline-4-one template. Comput Struct Biotechnol J. 2021; 19: 37-50. [crossref]
  • [3] Saeedi M, Eslamifar M, Khezri K. Kojic acid applications in cosmetic and pharmaceutical preparations. Biomed Pharmacother. 2019; 110: 582-593. [crossref]
  • [4] Mukherjee PK, Bahadur S, Chaudhary SK, Harwansh RK, Nema NK. In: Mukherjee PK (Ed.). Validation of Medicinal Herbs for Skin Aging. Elsevier. Kolkata, India, 2015, pp. 119-147.
  • [5]Spinozzi E, Maggi F, Bonacucina G, Pavela R, Boukouvala MC, Kavallieratos NG, Canale A, Romano D, Desneux N, Wilke ABB, Beier JC, Benelli G. Apiaceae essential oils and their constituents as insecticides against mosquitoes—A review. Ind Crop Prod. 2021; 171: 113892. [crossref]
  • [6] Acimovic MG, Kostadinovic LM, Popovic SJ, Dojcinovic NS. Apiaceae seeds as functional food. J Agric Sci. 2015; 60(3): 237-246. [crossref]
  • [7] Sayed-Ahmad B, Talou T, Saad Z, Hijazi A, Merah O. The Apiaceae: Ethnomedicinal family as source for industrial uses. Ind Crop Prod. 2017; 109: 661-671. [crossref]
  • [8] Badalamenti N, Ilardi V, Rosselli S, Bruno M. The ethnobotany, phytochemistry and biological properties of genus Ferulago – a review. J Ethnopharmacol. 2021; 274: 114050. [crossref]
  • [9] Süzgeç-Selçuk S, Dikpınar T. Phytochemical evaluation of the Ferulago genus and the pharmacological activities of its coumarin constituents. J Herb Med. 2021; 25: 100415. [crossref]
  • [10] Gençler Özkan AM, Demirci B, Demirci F, Başer KHC. Composition and antimicrobial activity of essential oil of Ferulago longistylis Boiss. fruits. J Essent Oil Res. 2008; 20: 569-573.
  • [11] Kiliç CS, Özkan AMG, Demirci B, Coşkun M, Başer KHC. Essential oil composition of four endemic Ferulago species growing in Turkey. Nat Prod Commun. 2010; 5: 1951-1954.
  • [12] Küçükboyacı N, Ayaz F, Adigüzel N, Bani B, Gören AC. Fatty acid methyl ester composition of some Turkish Apiaceae seed oils: new sources for petroselinic acid. Nat Prod Commun. 2016; 11(11): 1697-1700.
  • [13] Demirci B, Dilmaç E, Kırcı D, Demirci F, Kılıç CS, Duman H, Gürbüz İ. Chemical and antimicrobial characterization of essential oils obtained from aerial part, root and fruit of Ferulago longistylis Boiss., an endemic species. Nat Volatiles Essent Oils. 2020; 7(1): 18-25. [crossref]
  • [14] Babushok VI, Linstrom PJ, Zenkevich IG. Retention indices for frequently reported 9 compounds of plant essential oils. J Phys Chem Ref Data. 2011; 40 (4): 043101. [crossref]
  • [15] Kıvçak B, Akay S, Demirci B, Başer K. Chemical composition of essential oils from leaves and twigs of Pistacia lentiscus, Pistacia lentiscus var. chia, and Pistacia terebinthus from Turkey. Pharm Biol. 2004; 42 (4-5): 360-366. [crossref]
  • [16] Formisano C, Senatore F, Bancheva S, Bruno M, Rosselli S. Volatile components from aerial parts of Centaurea spinosociliata Seenus ssp. cristata (Bartl.) Dostal and Centaurea spinosociliata Seenus ssp. spinosociliata growing wild in Croatia. Croat Chem Acta. 2010; 83(4): 403-408.
  • [17] Abdelwahed A, Hayder N, Kilani S, Mahmoud A, Chibani J, Hammami M, Chekir-Ghedira L, Ghedira K. Chemical composition and antimicrobial activity of essential oils from Tunisian Pituranthos tortuosus (Cross.) Maire. Flavour Fragr J. 2006; 21: 129-133. [crossref]
  • [18] Polatoğlu K, Karakoç ÖC, Demirci B, Gören N, Başer KHC. Sitophilus granarius L. (Coleoptera) toxicity and biological activities of the essential oils of Tanacetum macrophyllum (Waldst. & Kit.) Schultz Bip. J Oleo Sci. 2015; 64 (8): 881-893. [crossref]
  • [19] Maggio A, Bruno M, Formisano C, Rigano D, Senatore F. Chemical composition of the essential oils of three species of Apiaceae growing wild in Sicily: Bonannia graeca, Eryngium maritimum and Opopanax chironium. Nat Prod Commun. 2013; 8 (6): 841-844.
  • [20] Erdurak CS, Coşkun M, Demirci B, Başer KHC. Composition of the essential oil of fruits and roots of Ferulago isaurica Peşmen and F. syriaca Boiss. (Umbelliferae) from Turkey. Flavour Fragr J. 2006; 21: 118-121. [crossref]
  • [21] Demirci F, Işcan G, Güven K, Kirimer N, Demirci B, Baser KHC. Antimicrobial activities of Ferulago essential oils. Z Naturforsch C J Biosci. 2000; 55(11-12): 886-889. [crossref] [22] Baser KHC, Demirci B, Duman H. Composition of the essential oil of Ferulago asparagifolia Boiss. from Turkey. J Essent Oil Res. 2001; 13(2): 134-135. [crossref]
  • [23] Karakaya S, Göger G, Kılıç CS, Demirci B. Composition of volatile oil of the aerial parts, flowers and roots of Ferulago blancheana Post. (Apiaceae) growing in Turkey and determination of their antimicrobial activities by bioautography method. Turk J Pharm Sci. 2016; 13(2): 173-180.
  • [24] Karakaya S, Simsek D, Göger G, Demirci B, Duman H, Altanlar N, Kiliç CS. Comparison of essential oils of Ferulago pachyloba (Fenzl) Boiss., F. trachycarpa Boiss. and F. bracteata Boiss. & Hausskn. species (Apiaceae) growing in Turkey and determination of their antimicrobial activities. J Essen Oil Bearing Plant. 2019; 22(1): 200-213. [crossref]
  • [25] Sanli A, Karadogan T, Tosun B, Erbas S. Variation of chemical composition of essential oils in wild populations of Ferulago cassia Boiss. from Turkey. J Essent Oil Bearing Plant 2020; 23(6): 1386-1394. [crossref]
  • [26] Celik A, Arslan I, Herken EN, Ermis A. Constituents, oxidant-antioxidant profile, and antimicrobial capacity of the essential oil obtained from Ferulago sandrasica Peşmen and Quézel. Int J Food Prop. 2013; 16(8): 1655-1662. [crossref]
  • [27] Sucu M, Kırcı D, Demirci B, Duman H, Kılıç CS, Gürbüz İ. In vitro antimicrobial evaluation of Ferulago sandrasica Peşmen & Quezel herba and root essential oil. Nat Volatiles Essent Oils. 2019; 6(4): 13-20.
  • [28] Polat T, Özer H, Mete E, Çakir A, Kandemir A, Özturk E. Essential oil composition of Ferulago setifolia C. Koch growing wild in Eastern Anatolia, Turkey. J Essent Oil Bearing Plant. 2010; 13(1): 20-24. [crossref]
  • [29] Başer KHC, Demirci B, Demirci F, Hashimoto T, Asakawa Y, Noma Y. Ferulagone: a new monoterpene ester from Ferulago thirkeana essential oil. Planta Med. 2002; 68(6): 564-567. [crossref]
  • [30] Baser KHC, Koyuncu M, Vural M. Composition of the essential oil of Ferulago trachycarpa (Fenzl) Boiss. J Essent Oil Res. 1998; 10(6); 665-666. [crossref]
  • [31] Kurkcuoglu M, Sen A, Bitis L, Birteksoz Tan S, Doğan A, Baser KHC. Chemical composition, anti-Inflammatory, antioxidant and antimicrobial activity of essential oil from aerial parts of Chaerophyllum aromaticum L. from Turkey. 2018; 21(2): 563-569. [crossref]
  • [32] Ağalar HG, Temiz B. HPTLC-DPPH• and HPTLC-tyrosinase methods for hot water-soluble contents of kumquat, limequat and Mexican lime fruit powders. J Res Pharm. 2021; 25(5), 569-580. [crossref]
  • [33] Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999; 26(9-10): 1231-1237. [crossref]

Yıl 2022, Cilt: 26 Sayı: 4, 790 - 798, 28.06.2025

Mine Kürkçüoğlu , Hale Gamze Ağalar Burak Temiz , Ahmet Duran , Mehmet Yavuz Paksoy , Kemal Hüsnü Can Başer

Öz

Kaynakça

  • [1] Gonzalez-Minero FJ, Bravo-Diaz L. The use of plants in skin-care products, cosmetics and fragrances: Past and present. Cosmetics. 2018; 5(3): 50. [crossref]
  • [2]Choi I, Park Y, Ryu IY, Jung HJ, Ullah S, Choi H, Park C, Kang D, Lee S, Chun P, Chung HY, Moon HR. In silico and in vitro insights into tyrosinase inhibitors with a 2-thioxooxazoline-4-one template. Comput Struct Biotechnol J. 2021; 19: 37-50. [crossref]
  • [3] Saeedi M, Eslamifar M, Khezri K. Kojic acid applications in cosmetic and pharmaceutical preparations. Biomed Pharmacother. 2019; 110: 582-593. [crossref]
  • [4] Mukherjee PK, Bahadur S, Chaudhary SK, Harwansh RK, Nema NK. In: Mukherjee PK (Ed.). Validation of Medicinal Herbs for Skin Aging. Elsevier. Kolkata, India, 2015, pp. 119-147.
  • [5]Spinozzi E, Maggi F, Bonacucina G, Pavela R, Boukouvala MC, Kavallieratos NG, Canale A, Romano D, Desneux N, Wilke ABB, Beier JC, Benelli G. Apiaceae essential oils and their constituents as insecticides against mosquitoes—A review. Ind Crop Prod. 2021; 171: 113892. [crossref]
  • [6] Acimovic MG, Kostadinovic LM, Popovic SJ, Dojcinovic NS. Apiaceae seeds as functional food. J Agric Sci. 2015; 60(3): 237-246. [crossref]
  • [7] Sayed-Ahmad B, Talou T, Saad Z, Hijazi A, Merah O. The Apiaceae: Ethnomedicinal family as source for industrial uses. Ind Crop Prod. 2017; 109: 661-671. [crossref]
  • [8] Badalamenti N, Ilardi V, Rosselli S, Bruno M. The ethnobotany, phytochemistry and biological properties of genus Ferulago – a review. J Ethnopharmacol. 2021; 274: 114050. [crossref]
  • [9] Süzgeç-Selçuk S, Dikpınar T. Phytochemical evaluation of the Ferulago genus and the pharmacological activities of its coumarin constituents. J Herb Med. 2021; 25: 100415. [crossref]
  • [10] Gençler Özkan AM, Demirci B, Demirci F, Başer KHC. Composition and antimicrobial activity of essential oil of Ferulago longistylis Boiss. fruits. J Essent Oil Res. 2008; 20: 569-573.
  • [11] Kiliç CS, Özkan AMG, Demirci B, Coşkun M, Başer KHC. Essential oil composition of four endemic Ferulago species growing in Turkey. Nat Prod Commun. 2010; 5: 1951-1954.
  • [12] Küçükboyacı N, Ayaz F, Adigüzel N, Bani B, Gören AC. Fatty acid methyl ester composition of some Turkish Apiaceae seed oils: new sources for petroselinic acid. Nat Prod Commun. 2016; 11(11): 1697-1700.
  • [13] Demirci B, Dilmaç E, Kırcı D, Demirci F, Kılıç CS, Duman H, Gürbüz İ. Chemical and antimicrobial characterization of essential oils obtained from aerial part, root and fruit of Ferulago longistylis Boiss., an endemic species. Nat Volatiles Essent Oils. 2020; 7(1): 18-25. [crossref]
  • [14] Babushok VI, Linstrom PJ, Zenkevich IG. Retention indices for frequently reported 9 compounds of plant essential oils. J Phys Chem Ref Data. 2011; 40 (4): 043101. [crossref]
  • [15] Kıvçak B, Akay S, Demirci B, Başer K. Chemical composition of essential oils from leaves and twigs of Pistacia lentiscus, Pistacia lentiscus var. chia, and Pistacia terebinthus from Turkey. Pharm Biol. 2004; 42 (4-5): 360-366. [crossref]
  • [16] Formisano C, Senatore F, Bancheva S, Bruno M, Rosselli S. Volatile components from aerial parts of Centaurea spinosociliata Seenus ssp. cristata (Bartl.) Dostal and Centaurea spinosociliata Seenus ssp. spinosociliata growing wild in Croatia. Croat Chem Acta. 2010; 83(4): 403-408.
  • [17] Abdelwahed A, Hayder N, Kilani S, Mahmoud A, Chibani J, Hammami M, Chekir-Ghedira L, Ghedira K. Chemical composition and antimicrobial activity of essential oils from Tunisian Pituranthos tortuosus (Cross.) Maire. Flavour Fragr J. 2006; 21: 129-133. [crossref]
  • [18] Polatoğlu K, Karakoç ÖC, Demirci B, Gören N, Başer KHC. Sitophilus granarius L. (Coleoptera) toxicity and biological activities of the essential oils of Tanacetum macrophyllum (Waldst. & Kit.) Schultz Bip. J Oleo Sci. 2015; 64 (8): 881-893. [crossref]
  • [19] Maggio A, Bruno M, Formisano C, Rigano D, Senatore F. Chemical composition of the essential oils of three species of Apiaceae growing wild in Sicily: Bonannia graeca, Eryngium maritimum and Opopanax chironium. Nat Prod Commun. 2013; 8 (6): 841-844.
  • [20] Erdurak CS, Coşkun M, Demirci B, Başer KHC. Composition of the essential oil of fruits and roots of Ferulago isaurica Peşmen and F. syriaca Boiss. (Umbelliferae) from Turkey. Flavour Fragr J. 2006; 21: 118-121. [crossref]
  • [21] Demirci F, Işcan G, Güven K, Kirimer N, Demirci B, Baser KHC. Antimicrobial activities of Ferulago essential oils. Z Naturforsch C J Biosci. 2000; 55(11-12): 886-889. [crossref] [22] Baser KHC, Demirci B, Duman H. Composition of the essential oil of Ferulago asparagifolia Boiss. from Turkey. J Essent Oil Res. 2001; 13(2): 134-135. [crossref]
  • [23] Karakaya S, Göger G, Kılıç CS, Demirci B. Composition of volatile oil of the aerial parts, flowers and roots of Ferulago blancheana Post. (Apiaceae) growing in Turkey and determination of their antimicrobial activities by bioautography method. Turk J Pharm Sci. 2016; 13(2): 173-180.
  • [24] Karakaya S, Simsek D, Göger G, Demirci B, Duman H, Altanlar N, Kiliç CS. Comparison of essential oils of Ferulago pachyloba (Fenzl) Boiss., F. trachycarpa Boiss. and F. bracteata Boiss. & Hausskn. species (Apiaceae) growing in Turkey and determination of their antimicrobial activities. J Essen Oil Bearing Plant. 2019; 22(1): 200-213. [crossref]
  • [25] Sanli A, Karadogan T, Tosun B, Erbas S. Variation of chemical composition of essential oils in wild populations of Ferulago cassia Boiss. from Turkey. J Essent Oil Bearing Plant 2020; 23(6): 1386-1394. [crossref]
  • [26] Celik A, Arslan I, Herken EN, Ermis A. Constituents, oxidant-antioxidant profile, and antimicrobial capacity of the essential oil obtained from Ferulago sandrasica Peşmen and Quézel. Int J Food Prop. 2013; 16(8): 1655-1662. [crossref]
  • [27] Sucu M, Kırcı D, Demirci B, Duman H, Kılıç CS, Gürbüz İ. In vitro antimicrobial evaluation of Ferulago sandrasica Peşmen & Quezel herba and root essential oil. Nat Volatiles Essent Oils. 2019; 6(4): 13-20.
  • [28] Polat T, Özer H, Mete E, Çakir A, Kandemir A, Özturk E. Essential oil composition of Ferulago setifolia C. Koch growing wild in Eastern Anatolia, Turkey. J Essent Oil Bearing Plant. 2010; 13(1): 20-24. [crossref]
  • [29] Başer KHC, Demirci B, Demirci F, Hashimoto T, Asakawa Y, Noma Y. Ferulagone: a new monoterpene ester from Ferulago thirkeana essential oil. Planta Med. 2002; 68(6): 564-567. [crossref]
  • [30] Baser KHC, Koyuncu M, Vural M. Composition of the essential oil of Ferulago trachycarpa (Fenzl) Boiss. J Essent Oil Res. 1998; 10(6); 665-666. [crossref]
  • [31] Kurkcuoglu M, Sen A, Bitis L, Birteksoz Tan S, Doğan A, Baser KHC. Chemical composition, anti-Inflammatory, antioxidant and antimicrobial activity of essential oil from aerial parts of Chaerophyllum aromaticum L. from Turkey. 2018; 21(2): 563-569. [crossref]
  • [32] Ağalar HG, Temiz B. HPTLC-DPPH• and HPTLC-tyrosinase methods for hot water-soluble contents of kumquat, limequat and Mexican lime fruit powders. J Res Pharm. 2021; 25(5), 569-580. [crossref]
  • [33] Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999; 26(9-10): 1231-1237. [crossref]
Toplam 32 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmakognozi
Bölüm Articles
Yazarlar

Mine Kürkçüoğlu 0000-0002-9375-0294

Hale Gamze Ağalar

Burak Temiz 0000-0002-8743-7234

Ahmet Duran 0000-0002-3675-1450

Mehmet Yavuz Paksoy 0000-0001-9581-4514

Kemal Hüsnü Can Başer 0000-0003-2710-0231

Yayımlanma Tarihi 28 Haziran 2025
Yayımlandığı Sayı Yıl 2022 Cilt: 26 Sayı: 4

Kaynak Göster

APA Kürkçüoğlu, M., Ağalar, H. G., Temiz, B., Duran, A., vd. (2025). Antioxidant, Antityrosinase Activities and Composition of Essential Oils Obtained from Roots and Fruits of Ferulago longistylis Boiss. Journal of Research in Pharmacy, 26(4), 790-798.
AMA Kürkçüoğlu M, Ağalar HG, Temiz B, Duran A, Paksoy MY, Başer KHC. Antioxidant, Antityrosinase Activities and Composition of Essential Oils Obtained from Roots and Fruits of Ferulago longistylis Boiss. J. Res. Pharm. Haziran 2025;26(4):790-798.
Chicago Kürkçüoğlu, Mine, Hale Gamze Ağalar, Burak Temiz, Ahmet Duran, Mehmet Yavuz Paksoy, ve Kemal Hüsnü Can Başer. “ Antityrosinase Activities and Composition of Essential Oils Obtained from Roots and Fruits of Ferulago Longistylis Boiss”. Journal of Research in Pharmacy 26, sy. 4 (Haziran 2025): 790-98.
EndNote Kürkçüoğlu M, Ağalar HG, Temiz B, Duran A, Paksoy MY, Başer KHC (01 Haziran 2025) Antioxidant, Antityrosinase Activities and Composition of Essential Oils Obtained from Roots and Fruits of Ferulago longistylis Boiss. Journal of Research in Pharmacy 26 4 790–798.
IEEE M. Kürkçüoğlu, H. G. Ağalar, B. Temiz, A. Duran, M. Y. Paksoy, ve K. H. C. Başer, “ Antityrosinase Activities and Composition of Essential Oils Obtained from Roots and Fruits of Ferulago longistylis Boiss”., J. Res. Pharm., c. 26, sy. 4, ss. 790–798, 2025.
ISNAD Kürkçüoğlu, Mine vd. “ Antityrosinase Activities and Composition of Essential Oils Obtained from Roots and Fruits of Ferulago Longistylis Boiss”. Journal of Research in Pharmacy 26/4 (Haziran 2025), 790-798.
JAMA Kürkçüoğlu M, Ağalar HG, Temiz B, Duran A, Paksoy MY, Başer KHC. Antioxidant, Antityrosinase Activities and Composition of Essential Oils Obtained from Roots and Fruits of Ferulago longistylis Boiss. J. Res. Pharm. 2025;26:790–798.
MLA Kürkçüoğlu, Mine vd. “ Antityrosinase Activities and Composition of Essential Oils Obtained from Roots and Fruits of Ferulago Longistylis Boiss”. Journal of Research in Pharmacy, c. 26, sy. 4, 2025, ss. 790-8.
Vancouver Kürkçüoğlu M, Ağalar HG, Temiz B, Duran A, Paksoy MY, Başer KHC. Antioxidant, Antityrosinase Activities and Composition of Essential Oils Obtained from Roots and Fruits of Ferulago longistylis Boiss. J. Res. Pharm. 2025;26(4):790-8.