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Formulation and evaluation of herbal antioxidant face cream using extract of the marine seaweed Sargassum spp. (Phaeophyceae)

Yıl 2022, Cilt: 26 Sayı: 4, 828 - 833, 28.06.2025

Rana M. Al-momani Zeinab H. Arabeyyat Esra E. Malkawi Mohammad K. Alzibdah

Öz

The present study develops a formulation of face cream which is made by the ethanol extract of Sargassum spp. (Phaeophyceae) from the Jordanian Gulf of Aqaba. A different type of formulations (from F1 to F8), such as oil in water were discovered to obtain the best formula of a cosmetic cream of marine herbal origin. The evaluation of all formulations (F1 to F6) has been done by the analysis of different parameters like viscosity, spread ability and stability. An ethanol fraction analyzed from a sample of Sargassum spp. showed that F2, F3, F6 and F7 were of the best homogeneity. These formulas were the subject of further evaluation tests. By implementing the dye test to formulas F2, F3, F6 and F7, all were showed a O/W feature of emulsion. The evaluation of formulations of F3, F4, F6 and F7 was conducted by using an accelerated test. Parameters including homogeneity, appearance, type of smear and removal were tested and showed acceptable stability. Among the eight formulations (F1-F8), only F2 and F6 showed the best results in terms of stability, texture and evaluation test. F2 and F6 are held intact with good appearance and consistency that continues until day 15 after preparation. Hence, the study suggests that the composition of extract and the base of the cream F2 and F6 are more stable and safer.

Anahtar Kelimeler

Herbal cosmetics emulsions formulation Sargassum spp. phaeophyceae Gulf of Aqaba

Kaynakça

  • [1] Desai P, Patlolla R, Singh M. Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery. Mol. Membr. Biol. 2010; 27(7): 247-259. [CrossRef]
  • [2] Ali HS, Hanafy AF. Glibenclamide nanocrystals in a biodegradable chitosan patch for transdermal delivery:engineering, formulation, and evaluation. J. Pharm. Sci. 2017; 106(1): 402-10. [CrossRef]
  • [3] Kottner J, Lichterfeld A, Blume-Peytavi U. Maintaining skin integrity in the aged: a systematic review. Br. J. Dermatol.2013; 169(3): 528-542. [CrossRef]
  • [4] Eichler O, Sies H, Stahl W. Divergent Optimum Levels of Lycopene, β‐Carotene and Lutein Protecting Against UVB Irradiation in Human Fibroblasts. Photochem. Photobiol. 2002; 75(5): 503-506. [CrossRef]
  • [5] Wrona M, Korytowski W, Różanowska, M, Sarna T, Truscott TG. Cooperation of antioxidants in protection against photosensitized oxidation. Free Radic. Biol. Med. 2003; 35(10): 1319-1329. [CrossRef]
  • [6] Mosquera TT, Noriega RP, Cornejo JC, Pardo ML. Biological activity of Cymbopogon citratus (DC) Stapf and its potential cosmetic activities. Int J Phytocosmetics Nat Ingred. 2016; 3(1): 7. [CrossRef]
  • [7] Idha K, and Indrayanto G. Chapter 15 - Natural Antioxidants in Cosmetics. Vol. 40. Elsevier., 2013. 485-505. [CrossRef]
  • [8] Mora C, Tittensor DP, Adl S, Simpson AG, Worm B. How many species are there on Earth and in the ocean?. PLoS Biol. 2011; 9(8). [CrossRef]
  • [9] Corinaldesi C, Barone G, Marcellini F, Dell’Anno A, Danovaro R. Marine microbial-derived molecules and their potential use in cosmeceutical and cosmetic products. Mar. Drugs. 2017; 15(4): 118. [CrossRef]
  • [10] Danovaro R, Snelgrove P, Tyler P. Challenging the paradigms of deep-sea ecology. Trends Ecol. Evol. 2014; 29(8): 465- 475. [CrossRef]
  • [11] Panno L, Bruno M, Voyron S, Anastasi A, Gnavi G, Miserere L, Varese GC. Diversity, ecological role and potential biotechnological applications of marine fungi associated to the seagrass Posidonia oceanica. New Biotechnol. 2013; 30(6): 685-694. [CrossRef]
  • [12] Blunt JW, Carroll AR, Copp BR, Davis RA, Keyzers RA, Prinsep MR. Marine natural products. Nat. Prod. Rep. 2016; 33(3): 382-431. [CrossRef]
  • [13] Imhoff JF, Labes A, Wiese J. Bio-mining the microbial treasures of the ocean: New natural products. Biotechnol. Adv. 2011; 29: 468-482. [CrossRef]
  • [14] Jin L, Quan C, Hou X, Fan S. Potential Pharmacological Resources: Natural Bioactive Compounds from Marine- Derived Fungi. Mar. Drugs. 2016; 14. [CrossRef]
  • [15] Smit AJ. Medicinal and pharmaceutical uses of seaweed natural products: a review. J. Appl. Phycol. 2004; 16(4): 245- 262. [CrossRef]
  • [16] Cornish ML, Garbary DJ. Antioxidants from macroalgae: Potential applications in human health and nutrition. Algae. 2010; 25:155-171. [CrossRef]
  • [17] Zubia M, Robledo D, Freile-Pelegrin Y. Antioxidant activities in tropical marine macroalgae from the Yucatan Peninsula, Mexico. J. Appl. Phycol. 2007; 19: 449-458. [CrossRef]
  • [18] Lim SN, Cheung PCK, Ooi VEC, Ang PO. Evaluation of antioxidative activity of extracts from a brown seaweed, Sargassum siliquastrum. J. Agric. Food Chem. 2002; 50(13): 3862-3866. [CrossRef]
  • [19] Zubia, M, Payri C, Deslandes E. Alginate, mannitol, phenolic compounds and biological activities of two rangeextending brown algae, Sargassum mangarevense and Turbinaria ornata (Phaeophyta: Fucales), from Tahiti (French Polynesia). J. Appl. Phycol. 2008; 20(6): 1033-1043. [CrossRef]
  • [20] Aswal A, Kalara M, Rout A. Preparation and evaluation of polyherbal cosmetic cream. Der Pharm. Lett. 2013; 5(1): 83- 88. http:// www.scholarsresearchlibrary.com (accessed on 19 April 2022).
  • [21] Gupta S, Abu-Ghannam N. Bioactive potential and possible health effects of edible brown seaweeds. Trends Food Sci. Technol. 2011; 22(6): 315-326. [CrossRef]
  • [22] Garza ARM, Tapia-Salazar M, Maldonado-Muñiz M, Rosa-Millán J, Gutiérrez-Uribe JA, Santos-Zea L, Barba-Dávila BA, Ricque-Marie D, Cruz-Suárez LE. Nutraceutical potential of five Mexican brown seaweeds. Biomed Res. Int. 2019 (2019). [CrossRef]
  • [23] Peñalver R, Lorenzo JM, Ros G, Amarowicz R, Pateiro M, Nieto G. Seaweeds as a functional ingredient for a healthydiet. Mar. Drugs. 2020; 18(6): 301. [CrossRef]
  • [24] Gomez-Zavaglia A, Prieto Lage MA, Jimenez-Lopez C, Mejuto JC, Simal-Gandara J. The potential of seaweeds as asource of functional ingredients of prebiotic and antioxidant value. Antioxidants. 2019; 8(9): 406. [CrossRef]
  • [25] Wang J, Jin W, Hou Y, Niu X, Zhang H, Zhang Q. Chemical composition and moisture-absorption/retention ability of polysaccharides extracted from five algae. Int. J. Biol. Macromol. 2013; 57: 26-29. [CrossRef]
  • [26] Heo S-Jin, Ko S-Chun, Cha S-Heui, Kang D-Hyung, Park H-Sik, Choi Y-Ung, Kim D, Jung W-Kyo, Jeon Y-Jin. Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation. Toxicol In Vitro. 2009; 23(6): 1123-1130. [CrossRef]
  • [27] Pereira L, Ribeiro-Claro P. Analysis by vibrational spectroscopy of seaweed with potential use in food, pharmaceutical and cosmetic industries. Marine Algae: Biodiversity, Taxonomy, Environmental Assessment, and Biotechnology; Pereira, L., Neto, JM, Eds. 2014; 228-250. [CrossRef]
  • [28] Pereira L. Seaweeds as source of bioactive substances and skin care therapy—cosmeceuticals, algotheraphy, and thalassotherapy. Cosmetics. 2018; 5(4): 68. [CrossRef]
  • [29] Kelman D, Posner EK, McDermid KJ, Tabandera NK, Wright PR, Wright AD. Antioxidant activity of Hawaiian marine algae. Mar. Drugs. 2012; 10(2): 403-416. [CrossRef]
  • [30] Liu J, Luthuli S, Wu Q, Wu M, Choi J-il, Tong H. Pharmaceutical and nutraceutical potential applications of Sargassum fulvellum. Biomed Res. Int. 2020 14; 2020. [CrossRef]
  • [31] Al-Zibdah M, Damhoureyeh S. Spatial and Temporal Distribution of Macroalgae Along the Jordanian Coast of Gulf of Aqaba, Red Sea. Dirasat. 2006; 33: 35-47. https://journals.ju.edu.jo/DirasatSci/article/view/643 (accessed on 19 April 2022).
  • [32] Al-Rousan S. Skeletal extension rate of the reef building coral Porites species from Aqaba and their environmental variables. Natural Science. 2012; 4(9): 731-739. [CrossRef]

Yıl 2022, Cilt: 26 Sayı: 4, 828 - 833, 28.06.2025

Rana M. Al-momani Zeinab H. Arabeyyat Esra E. Malkawi Mohammad K. Alzibdah

Öz

Kaynakça

  • [1] Desai P, Patlolla R, Singh M. Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery. Mol. Membr. Biol. 2010; 27(7): 247-259. [CrossRef]
  • [2] Ali HS, Hanafy AF. Glibenclamide nanocrystals in a biodegradable chitosan patch for transdermal delivery:engineering, formulation, and evaluation. J. Pharm. Sci. 2017; 106(1): 402-10. [CrossRef]
  • [3] Kottner J, Lichterfeld A, Blume-Peytavi U. Maintaining skin integrity in the aged: a systematic review. Br. J. Dermatol.2013; 169(3): 528-542. [CrossRef]
  • [4] Eichler O, Sies H, Stahl W. Divergent Optimum Levels of Lycopene, β‐Carotene and Lutein Protecting Against UVB Irradiation in Human Fibroblasts. Photochem. Photobiol. 2002; 75(5): 503-506. [CrossRef]
  • [5] Wrona M, Korytowski W, Różanowska, M, Sarna T, Truscott TG. Cooperation of antioxidants in protection against photosensitized oxidation. Free Radic. Biol. Med. 2003; 35(10): 1319-1329. [CrossRef]
  • [6] Mosquera TT, Noriega RP, Cornejo JC, Pardo ML. Biological activity of Cymbopogon citratus (DC) Stapf and its potential cosmetic activities. Int J Phytocosmetics Nat Ingred. 2016; 3(1): 7. [CrossRef]
  • [7] Idha K, and Indrayanto G. Chapter 15 - Natural Antioxidants in Cosmetics. Vol. 40. Elsevier., 2013. 485-505. [CrossRef]
  • [8] Mora C, Tittensor DP, Adl S, Simpson AG, Worm B. How many species are there on Earth and in the ocean?. PLoS Biol. 2011; 9(8). [CrossRef]
  • [9] Corinaldesi C, Barone G, Marcellini F, Dell’Anno A, Danovaro R. Marine microbial-derived molecules and their potential use in cosmeceutical and cosmetic products. Mar. Drugs. 2017; 15(4): 118. [CrossRef]
  • [10] Danovaro R, Snelgrove P, Tyler P. Challenging the paradigms of deep-sea ecology. Trends Ecol. Evol. 2014; 29(8): 465- 475. [CrossRef]
  • [11] Panno L, Bruno M, Voyron S, Anastasi A, Gnavi G, Miserere L, Varese GC. Diversity, ecological role and potential biotechnological applications of marine fungi associated to the seagrass Posidonia oceanica. New Biotechnol. 2013; 30(6): 685-694. [CrossRef]
  • [12] Blunt JW, Carroll AR, Copp BR, Davis RA, Keyzers RA, Prinsep MR. Marine natural products. Nat. Prod. Rep. 2016; 33(3): 382-431. [CrossRef]
  • [13] Imhoff JF, Labes A, Wiese J. Bio-mining the microbial treasures of the ocean: New natural products. Biotechnol. Adv. 2011; 29: 468-482. [CrossRef]
  • [14] Jin L, Quan C, Hou X, Fan S. Potential Pharmacological Resources: Natural Bioactive Compounds from Marine- Derived Fungi. Mar. Drugs. 2016; 14. [CrossRef]
  • [15] Smit AJ. Medicinal and pharmaceutical uses of seaweed natural products: a review. J. Appl. Phycol. 2004; 16(4): 245- 262. [CrossRef]
  • [16] Cornish ML, Garbary DJ. Antioxidants from macroalgae: Potential applications in human health and nutrition. Algae. 2010; 25:155-171. [CrossRef]
  • [17] Zubia M, Robledo D, Freile-Pelegrin Y. Antioxidant activities in tropical marine macroalgae from the Yucatan Peninsula, Mexico. J. Appl. Phycol. 2007; 19: 449-458. [CrossRef]
  • [18] Lim SN, Cheung PCK, Ooi VEC, Ang PO. Evaluation of antioxidative activity of extracts from a brown seaweed, Sargassum siliquastrum. J. Agric. Food Chem. 2002; 50(13): 3862-3866. [CrossRef]
  • [19] Zubia, M, Payri C, Deslandes E. Alginate, mannitol, phenolic compounds and biological activities of two rangeextending brown algae, Sargassum mangarevense and Turbinaria ornata (Phaeophyta: Fucales), from Tahiti (French Polynesia). J. Appl. Phycol. 2008; 20(6): 1033-1043. [CrossRef]
  • [20] Aswal A, Kalara M, Rout A. Preparation and evaluation of polyherbal cosmetic cream. Der Pharm. Lett. 2013; 5(1): 83- 88. http:// www.scholarsresearchlibrary.com (accessed on 19 April 2022).
  • [21] Gupta S, Abu-Ghannam N. Bioactive potential and possible health effects of edible brown seaweeds. Trends Food Sci. Technol. 2011; 22(6): 315-326. [CrossRef]
  • [22] Garza ARM, Tapia-Salazar M, Maldonado-Muñiz M, Rosa-Millán J, Gutiérrez-Uribe JA, Santos-Zea L, Barba-Dávila BA, Ricque-Marie D, Cruz-Suárez LE. Nutraceutical potential of five Mexican brown seaweeds. Biomed Res. Int. 2019 (2019). [CrossRef]
  • [23] Peñalver R, Lorenzo JM, Ros G, Amarowicz R, Pateiro M, Nieto G. Seaweeds as a functional ingredient for a healthydiet. Mar. Drugs. 2020; 18(6): 301. [CrossRef]
  • [24] Gomez-Zavaglia A, Prieto Lage MA, Jimenez-Lopez C, Mejuto JC, Simal-Gandara J. The potential of seaweeds as asource of functional ingredients of prebiotic and antioxidant value. Antioxidants. 2019; 8(9): 406. [CrossRef]
  • [25] Wang J, Jin W, Hou Y, Niu X, Zhang H, Zhang Q. Chemical composition and moisture-absorption/retention ability of polysaccharides extracted from five algae. Int. J. Biol. Macromol. 2013; 57: 26-29. [CrossRef]
  • [26] Heo S-Jin, Ko S-Chun, Cha S-Heui, Kang D-Hyung, Park H-Sik, Choi Y-Ung, Kim D, Jung W-Kyo, Jeon Y-Jin. Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation. Toxicol In Vitro. 2009; 23(6): 1123-1130. [CrossRef]
  • [27] Pereira L, Ribeiro-Claro P. Analysis by vibrational spectroscopy of seaweed with potential use in food, pharmaceutical and cosmetic industries. Marine Algae: Biodiversity, Taxonomy, Environmental Assessment, and Biotechnology; Pereira, L., Neto, JM, Eds. 2014; 228-250. [CrossRef]
  • [28] Pereira L. Seaweeds as source of bioactive substances and skin care therapy—cosmeceuticals, algotheraphy, and thalassotherapy. Cosmetics. 2018; 5(4): 68. [CrossRef]
  • [29] Kelman D, Posner EK, McDermid KJ, Tabandera NK, Wright PR, Wright AD. Antioxidant activity of Hawaiian marine algae. Mar. Drugs. 2012; 10(2): 403-416. [CrossRef]
  • [30] Liu J, Luthuli S, Wu Q, Wu M, Choi J-il, Tong H. Pharmaceutical and nutraceutical potential applications of Sargassum fulvellum. Biomed Res. Int. 2020 14; 2020. [CrossRef]
  • [31] Al-Zibdah M, Damhoureyeh S. Spatial and Temporal Distribution of Macroalgae Along the Jordanian Coast of Gulf of Aqaba, Red Sea. Dirasat. 2006; 33: 35-47. https://journals.ju.edu.jo/DirasatSci/article/view/643 (accessed on 19 April 2022).
  • [32] Al-Rousan S. Skeletal extension rate of the reef building coral Porites species from Aqaba and their environmental variables. Natural Science. 2012; 4(9): 731-739. [CrossRef]
Toplam 32 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık Bilimleri
Bölüm Articles
Yazarlar

Rana M. Al-momani 0000-0001-9073-6203

Zeinab H. Arabeyyat 0000-0003-4109-3453

Esra E. Malkawi 0000-0003-2291-9010

Mohammad K. Alzibdah 0000-0002-8108-5178

Yayımlanma Tarihi 28 Haziran 2025
Yayımlandığı Sayı Yıl 2022 Cilt: 26 Sayı: 4

Kaynak Göster

APA Al-momani, R. M., H. Arabeyyat, Z., Malkawi, E. E., Alzibdah, M. K. (2025). Formulation and evaluation of herbal antioxidant face cream using extract of the marine seaweed Sargassum spp. (Phaeophyceae). Journal of Research in Pharmacy, 26(4), 828-833.
AMA Al-momani RM, H. Arabeyyat Z, Malkawi EE, Alzibdah MK. Formulation and evaluation of herbal antioxidant face cream using extract of the marine seaweed Sargassum spp. (Phaeophyceae). J. Res. Pharm. Haziran 2025;26(4):828-833.
Chicago Al-momani, Rana M., Zeinab H. Arabeyyat, Esra E. Malkawi, ve Mohammad K. Alzibdah. “Formulation and Evaluation of Herbal Antioxidant Face Cream Using Extract of the Marine Seaweed Sargassum Spp. (Phaeophyceae)”. Journal of Research in Pharmacy 26, sy. 4 (Haziran 2025): 828-33.
EndNote Al-momani RM, H. Arabeyyat Z, Malkawi EE, Alzibdah MK (01 Haziran 2025) Formulation and evaluation of herbal antioxidant face cream using extract of the marine seaweed Sargassum spp. (Phaeophyceae). Journal of Research in Pharmacy 26 4 828–833.
IEEE R. M. Al-momani, Z. H. Arabeyyat, E. E. Malkawi, ve M. K. Alzibdah, “Formulation and evaluation of herbal antioxidant face cream using extract of the marine seaweed Sargassum spp. (Phaeophyceae)”, J. Res. Pharm., c. 26, sy. 4, ss. 828–833, 2025.
ISNAD Al-momani, Rana M. vd. “Formulation and Evaluation of Herbal Antioxidant Face Cream Using Extract of the Marine Seaweed Sargassum Spp. (Phaeophyceae)”. Journal of Research in Pharmacy 26/4 (Haziran 2025), 828-833.
JAMA Al-momani RM, H. Arabeyyat Z, Malkawi EE, Alzibdah MK. Formulation and evaluation of herbal antioxidant face cream using extract of the marine seaweed Sargassum spp. (Phaeophyceae). J. Res. Pharm. 2025;26:828–833.
MLA Al-momani, Rana M. vd. “Formulation and Evaluation of Herbal Antioxidant Face Cream Using Extract of the Marine Seaweed Sargassum Spp. (Phaeophyceae)”. Journal of Research in Pharmacy, c. 26, sy. 4, 2025, ss. 828-33.
Vancouver Al-momani RM, H. Arabeyyat Z, Malkawi EE, Alzibdah MK. Formulation and evaluation of herbal antioxidant face cream using extract of the marine seaweed Sargassum spp. (Phaeophyceae). J. Res. Pharm. 2025;26(4):828-33.