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Determination and comparison of metal contents in simulated body fluid medium conditions of the plant species by flame atomic absorption spectrometry (FAAS)

Yıl 2022, Cilt: 26 Sayı: 5, 1281 - 1294, 28.06.2025

Adil Umaz , Fırat Aydın , Özge Tokul Ölmez Mehmet Fırat , Mehmet Öztürk , Abdulselam Ertaş , Işıl Aydın

Öz

The importance of plants in folk medicine and scientific studies is increasing day by day. In this context, the plants pose a danger to human health when they are eaten by the public, consumed as herbal tea or used as medicinal plants especially the toxic metals in their composition. For this reason, determining the macro, micro and toxic element content in the plants is important for health. In this study; the metal contents of root and aerial parts of nine different Salvia species were determined and the chemometric evaluation of the obtained results was made. In the principal component analysis (PCA) made with 20 elements of Salvia species, it was determined that the first two principal components explained 62.60% of the variance and the first six principal components explained 92.70%. When PCA and hierarchical cluster analysis (HCA) results are evaluated; the parts of Salvia species root and aerial parts were determined that were not clearly separated and there was no regional grouping. In addition, Salvia species prepared as herbal tea was left to different simulated body fluid medium conditions, and the changes in metal contents were examined. It was determined that were taken up Cr, Cd, Pb, Cu, Zn metals in the simulated saliva fluid (SSF), Ni, Mn metals in the simulated gastric fluid (SGF), and Na, K metals in the simulated intestinal fluid (SIF). It was determined that Fe metal in almost all Salvia species was not taken from three simulated body fluid mediums. Thus, elements determined which were taken up in body fluid mediums.

Anahtar Kelimeler

Salvia chemometry SSF SGF SIF FAAS

Kaynakça

  • [1] Celep F, Dirmenci T. Systematic and Biogeographic Overview of Lamiaceae in Turkey. Nat Volatiles Essent Oils. 2017; 4(4): 14-27.
  • [2] Yılar M, Bayar Y, Onaran A. Chemical Composition and Allelopathic Effect of Origanum onites L. Essential Oil. Plant Prot Bull. 2019; 59(3): 71-78. [CrossRef]
  • [3] Gedik O, Kiran Y, Emre I, Kursat M. Karyological Notes for Seven Salvia L. Taxa Grown in Turkey. Cytologia. 2016; 81(4): 395-402. [CrossRef]
  • [4] Nickavar B, Rezaee J, Nickavar A. Effect-directed Analysis for the Antioxidant Compound in Salvia verticillata. Iran J Pharm Res. 2016; 15(1): 241–246. [CrossRef]
  • [5] Asadi-Samani M, Khaledi M, Khaledi F, Samarghandian S, Gholipour A. Phytochemical Properties and Antibacterial Effects of Salvia multicaulis vahl., euphorbia microsciadia Boiss., and Reseda Lutea on Staphylococcus aureus and Acinetobacter Baumanii. Jundishapur J Nat Pharm Prod. 2019; 14(3): 63640. [CrossRef]
  • [6] Coşge Şenkal B. The effect of Cuttings Stages on Components and Content of Essential Oils from Salvia viridis L. KSU J Agric Nat. 2019; 22(1): 71-77. [CrossRef]
  • [7] Güzel S, Özay Y, Kumaş M, Uzun C, Özkorkmaz EG, Yıldırım Z, Ülger M, Güler G, Çelik A, Çamlıca Y, Kahraman A. Wound Healing Properties, Antimicrobial and Antioxidant Activities of Salvia kronenburgii Rech. f. and Salvia euphratica Montbret, Aucher & Rech. f. var. euphratica on Excision and Incision Wound Models in Diabetic Rats. Biomed Pharmacother. 201; 111: 1260-1276. [CrossRef]
  • [8] Moridi Farimani M, Miran M, Ebrahimi SN. New Diterpenoids from the Aerial Parts of Salvia reuterana. Iran J Pharm Res. 2019; 18(1): 406-411. [CrossRef]
  • [9] Firat M. An Addition to the Flora of Turkey : Salvia reuteriana (Lamiaceae), with Contributions To Its Taxonomy. Iran J Bot. 2020; 26(2): 137-140. [CrossRef]
  • [10] Senatore F, Arnold NA, Piozzi F, Formisano C. Chemical Composition of the Essential Oil of Salvia microstegia Boiss. et Balansa Growing wild in Lebanon. J Chromatogr A. 2006; 1108(2): 276-278. [CrossRef]
  • [11] Tosun M, Ercisli S, Sengul M, Ozer H, Polat T, Ozturk E. Antioxidant Properties and Total Phenolic Content of Eight Salvia Species from Turkey. Biolog Res. 2009; 42(2): 175–181. [CrossRef]
  • [12] Kahraman A, Doǧan M, Celep F. Salvia siirtica sp. nov. (Lamiaceae) from Turkey. Nord J Bot. 2011; 29(4): 397-401. [CrossRef]
  • [13] Kahnamoei MB, Tabefam M, Ebrahimi SN, Danton O, Hamburger M, Farimani MM. Chemical Constituents from the Ethyl Acetate Extract of Salvia hydrangea. Nat Prod Commun. 2019; 14(6): 1-4. [CrossRef]
  • [14] Lv H, Zhang Y, Sun Y, Duan Y. Multielement Patterns of Danshen (Salvia miltiorrhiza) from Origins in China. Microchem J. 2019; 145: 273–279. [CrossRef]
  • [15] Naidu GRK, Denschlag HO, Mauerhofer E, Porte N, Balaji T. Determination of Macro, Micro Nutrient and Trace Element Concentrations in Indian Medicinal and Vegetable Leaves Using Instrumental Neutron Activation Analysis. Appl Radiat Isot. 1999; 50(5): 947-953.
  • [16] Pytlakowska K, Kita A, Janoska P, Połowniak M, Kozik V. Multi-element Analysis of Mineral and Trace Elements in Medicinal Herbs and Their Infusions. Food Chem. 2012; 135(2): 494-501. [CrossRef]
  • [17] Szymczycha-Madeja A, Welna M, Zyrnicki W. Multi-element Analysis, Bioavailability and Fractionation of Herbal Tea Products. J Braz Chem Soc. 2013; 24(5): 777-787. [CrossRef]
  • [18] Zhang X, Ding W, Li J, Liu F, Zhou X, Tian S. Multi-elemental Analysis of Ziziphora Clinopodioides from Different Regions, Periods and Parts Using Atomic Absorption Spectrometry and Chemometric Approaches. Braz J of Farmacogn. 2015; 25(5): 465-472. [CrossRef]
  • [19] Targan S, Yelboga EG, Cittan M. Macro and Trace Element Contents of Some Wild Plants Consumed as Vegetable in Manisa District, Turkey. J of the Turk Chem Soc Sec A: Chem. 2018; 5(2): 751-762. [CrossRef]
  • [20] Umaz A, Aydin F, Firat M, Ertas A. Bazı Geofitlerin İndüktif Eşleşmiş Plazmalı Kütle Spektrometresi (ICP-MS) ile Makro ve Mikro Element Analizi. DU Fen Bilim Ens Der. 2021; 10(1): 47-58.
  • [21] Tunay Z, Yener İ, Varhan Oral E, Barla Demirkoz A, Tokul-Ölmez Ö, Firat M, Öztürk M, Aydin I, Aydin F, Ertas, A. Trace Element Analysis in Some Salvia Species by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) and Chemometric Approach. J of Res in Pharm. 2020; 24(2): 297-309. [CrossRef]
  • [22] Shannon I. L. Fluoride Treatmentprograms for High-Caries-Risk Patients. Clin Prevent Dent. 1982; 4: 11-20.
  • [23] Stefaniak AB, Abbas Virji M, Harvey CJ, Sbarra DC, Day GA, Hoover MD. Influence of Artificial Gastric Juice Composition on Bioaccessibility of Cobalt-and Tungsten-Containing Powders. Int J Hyg Environ Health. 2010; 213(2): 107-115. [CrossRef]
  • [24] Stippler E, Kopp S, Dressman JB. Comparison of US Pharmacopeia Simulated Intestinal Fluid TS (without pancreatin) and Phosphate Standard Buffer pH 6.8, TS of the International Pharmacopoeia with Respect to Their Use in Vitro Dissolution Testing. Dissolut Technol. 2004; 11(2): 6-10. [CrossRef]

Yıl 2022, Cilt: 26 Sayı: 5, 1281 - 1294, 28.06.2025

Adil Umaz , Fırat Aydın , Özge Tokul Ölmez Mehmet Fırat , Mehmet Öztürk , Abdulselam Ertaş , Işıl Aydın

Öz

Kaynakça

  • [1] Celep F, Dirmenci T. Systematic and Biogeographic Overview of Lamiaceae in Turkey. Nat Volatiles Essent Oils. 2017; 4(4): 14-27.
  • [2] Yılar M, Bayar Y, Onaran A. Chemical Composition and Allelopathic Effect of Origanum onites L. Essential Oil. Plant Prot Bull. 2019; 59(3): 71-78. [CrossRef]
  • [3] Gedik O, Kiran Y, Emre I, Kursat M. Karyological Notes for Seven Salvia L. Taxa Grown in Turkey. Cytologia. 2016; 81(4): 395-402. [CrossRef]
  • [4] Nickavar B, Rezaee J, Nickavar A. Effect-directed Analysis for the Antioxidant Compound in Salvia verticillata. Iran J Pharm Res. 2016; 15(1): 241–246. [CrossRef]
  • [5] Asadi-Samani M, Khaledi M, Khaledi F, Samarghandian S, Gholipour A. Phytochemical Properties and Antibacterial Effects of Salvia multicaulis vahl., euphorbia microsciadia Boiss., and Reseda Lutea on Staphylococcus aureus and Acinetobacter Baumanii. Jundishapur J Nat Pharm Prod. 2019; 14(3): 63640. [CrossRef]
  • [6] Coşge Şenkal B. The effect of Cuttings Stages on Components and Content of Essential Oils from Salvia viridis L. KSU J Agric Nat. 2019; 22(1): 71-77. [CrossRef]
  • [7] Güzel S, Özay Y, Kumaş M, Uzun C, Özkorkmaz EG, Yıldırım Z, Ülger M, Güler G, Çelik A, Çamlıca Y, Kahraman A. Wound Healing Properties, Antimicrobial and Antioxidant Activities of Salvia kronenburgii Rech. f. and Salvia euphratica Montbret, Aucher & Rech. f. var. euphratica on Excision and Incision Wound Models in Diabetic Rats. Biomed Pharmacother. 201; 111: 1260-1276. [CrossRef]
  • [8] Moridi Farimani M, Miran M, Ebrahimi SN. New Diterpenoids from the Aerial Parts of Salvia reuterana. Iran J Pharm Res. 2019; 18(1): 406-411. [CrossRef]
  • [9] Firat M. An Addition to the Flora of Turkey : Salvia reuteriana (Lamiaceae), with Contributions To Its Taxonomy. Iran J Bot. 2020; 26(2): 137-140. [CrossRef]
  • [10] Senatore F, Arnold NA, Piozzi F, Formisano C. Chemical Composition of the Essential Oil of Salvia microstegia Boiss. et Balansa Growing wild in Lebanon. J Chromatogr A. 2006; 1108(2): 276-278. [CrossRef]
  • [11] Tosun M, Ercisli S, Sengul M, Ozer H, Polat T, Ozturk E. Antioxidant Properties and Total Phenolic Content of Eight Salvia Species from Turkey. Biolog Res. 2009; 42(2): 175–181. [CrossRef]
  • [12] Kahraman A, Doǧan M, Celep F. Salvia siirtica sp. nov. (Lamiaceae) from Turkey. Nord J Bot. 2011; 29(4): 397-401. [CrossRef]
  • [13] Kahnamoei MB, Tabefam M, Ebrahimi SN, Danton O, Hamburger M, Farimani MM. Chemical Constituents from the Ethyl Acetate Extract of Salvia hydrangea. Nat Prod Commun. 2019; 14(6): 1-4. [CrossRef]
  • [14] Lv H, Zhang Y, Sun Y, Duan Y. Multielement Patterns of Danshen (Salvia miltiorrhiza) from Origins in China. Microchem J. 2019; 145: 273–279. [CrossRef]
  • [15] Naidu GRK, Denschlag HO, Mauerhofer E, Porte N, Balaji T. Determination of Macro, Micro Nutrient and Trace Element Concentrations in Indian Medicinal and Vegetable Leaves Using Instrumental Neutron Activation Analysis. Appl Radiat Isot. 1999; 50(5): 947-953.
  • [16] Pytlakowska K, Kita A, Janoska P, Połowniak M, Kozik V. Multi-element Analysis of Mineral and Trace Elements in Medicinal Herbs and Their Infusions. Food Chem. 2012; 135(2): 494-501. [CrossRef]
  • [17] Szymczycha-Madeja A, Welna M, Zyrnicki W. Multi-element Analysis, Bioavailability and Fractionation of Herbal Tea Products. J Braz Chem Soc. 2013; 24(5): 777-787. [CrossRef]
  • [18] Zhang X, Ding W, Li J, Liu F, Zhou X, Tian S. Multi-elemental Analysis of Ziziphora Clinopodioides from Different Regions, Periods and Parts Using Atomic Absorption Spectrometry and Chemometric Approaches. Braz J of Farmacogn. 2015; 25(5): 465-472. [CrossRef]
  • [19] Targan S, Yelboga EG, Cittan M. Macro and Trace Element Contents of Some Wild Plants Consumed as Vegetable in Manisa District, Turkey. J of the Turk Chem Soc Sec A: Chem. 2018; 5(2): 751-762. [CrossRef]
  • [20] Umaz A, Aydin F, Firat M, Ertas A. Bazı Geofitlerin İndüktif Eşleşmiş Plazmalı Kütle Spektrometresi (ICP-MS) ile Makro ve Mikro Element Analizi. DU Fen Bilim Ens Der. 2021; 10(1): 47-58.
  • [21] Tunay Z, Yener İ, Varhan Oral E, Barla Demirkoz A, Tokul-Ölmez Ö, Firat M, Öztürk M, Aydin I, Aydin F, Ertas, A. Trace Element Analysis in Some Salvia Species by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) and Chemometric Approach. J of Res in Pharm. 2020; 24(2): 297-309. [CrossRef]
  • [22] Shannon I. L. Fluoride Treatmentprograms for High-Caries-Risk Patients. Clin Prevent Dent. 1982; 4: 11-20.
  • [23] Stefaniak AB, Abbas Virji M, Harvey CJ, Sbarra DC, Day GA, Hoover MD. Influence of Artificial Gastric Juice Composition on Bioaccessibility of Cobalt-and Tungsten-Containing Powders. Int J Hyg Environ Health. 2010; 213(2): 107-115. [CrossRef]
  • [24] Stippler E, Kopp S, Dressman JB. Comparison of US Pharmacopeia Simulated Intestinal Fluid TS (without pancreatin) and Phosphate Standard Buffer pH 6.8, TS of the International Pharmacopoeia with Respect to Their Use in Vitro Dissolution Testing. Dissolut Technol. 2004; 11(2): 6-10. [CrossRef]
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmakognozi, Farmasotik Kimya
Bölüm Articles
Yazarlar

Adil Umaz 0000-0003-2438-5454

Fırat Aydın 0000-0002-0868-2769

Özge Tokul Ölmez 0000-0002-2093-4949

Mehmet Fırat 0000-0001-5814-614X

Mehmet Öztürk 0000-0001-8932-4535

Abdulselam Ertaş 0000-0002-2193-8386

Işıl Aydın

Yayımlanma Tarihi 28 Haziran 2025
Yayımlandığı Sayı Yıl 2022 Cilt: 26 Sayı: 5

Kaynak Göster

APA Umaz, A., Aydın, F., Ölmez, Ö. T., Fırat, M., vd. (2025). Determination and comparison of metal contents in simulated body fluid medium conditions of the plant species by flame atomic absorption spectrometry (FAAS). Journal of Research in Pharmacy, 26(5), 1281-1294.
AMA Umaz A, Aydın F, Ölmez ÖT, Fırat M, Öztürk M, Ertaş A, Aydın I. Determination and comparison of metal contents in simulated body fluid medium conditions of the plant species by flame atomic absorption spectrometry (FAAS). J. Res. Pharm. Haziran 2025;26(5):1281-1294.
Chicago Umaz, Adil, Fırat Aydın, Özge Tokul Ölmez, Mehmet Fırat, Mehmet Öztürk, Abdulselam Ertaş, ve Işıl Aydın. “Determination and Comparison of Metal Contents in Simulated Body Fluid Medium Conditions of the Plant Species by Flame Atomic Absorption Spectrometry (FAAS)”. Journal of Research in Pharmacy 26, sy. 5 (Haziran 2025): 1281-94.
EndNote Umaz A, Aydın F, Ölmez ÖT, Fırat M, Öztürk M, Ertaş A, Aydın I (01 Haziran 2025) Determination and comparison of metal contents in simulated body fluid medium conditions of the plant species by flame atomic absorption spectrometry (FAAS). Journal of Research in Pharmacy 26 5 1281–1294.
IEEE A. Umaz, F. Aydın, Ö. T. Ölmez, M. Fırat, M. Öztürk, A. Ertaş, ve I. Aydın, “Determination and comparison of metal contents in simulated body fluid medium conditions of the plant species by flame atomic absorption spectrometry (FAAS)”, J. Res. Pharm., c. 26, sy. 5, ss. 1281–1294, 2025.
ISNAD Umaz, Adil vd. “Determination and Comparison of Metal Contents in Simulated Body Fluid Medium Conditions of the Plant Species by Flame Atomic Absorption Spectrometry (FAAS)”. Journal of Research in Pharmacy 26/5 (Haziran 2025), 1281-1294.
JAMA Umaz A, Aydın F, Ölmez ÖT, Fırat M, Öztürk M, Ertaş A, Aydın I. Determination and comparison of metal contents in simulated body fluid medium conditions of the plant species by flame atomic absorption spectrometry (FAAS). J. Res. Pharm. 2025;26:1281–1294.
MLA Umaz, Adil vd. “Determination and Comparison of Metal Contents in Simulated Body Fluid Medium Conditions of the Plant Species by Flame Atomic Absorption Spectrometry (FAAS)”. Journal of Research in Pharmacy, c. 26, sy. 5, 2025, ss. 1281-94.
Vancouver Umaz A, Aydın F, Ölmez ÖT, Fırat M, Öztürk M, Ertaş A, Aydın I. Determination and comparison of metal contents in simulated body fluid medium conditions of the plant species by flame atomic absorption spectrometry (FAAS). J. Res. Pharm. 2025;26(5):1281-94.