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Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac

Yıl 2024, Cilt: 28 Sayı: 5, 1562 - 1571, 28.06.2025

Sariye İrem Kaya , Göksu Özçelikay Akyıldız

Öz

This study aimed to develop an electrochemical method for the electrochemical determination of bufexamac (BUF), an important anti-inflammatory drug. For this purpose, the electrochemical properties of BUF were elucidated using a glassy carbon electrode (GCE) and cyclic voltammetry. The electrochemical performance of BUF was examined by the differential pulse voltammetry (DPV) method. It was observed that the response of GCE to DBT was linear in the concentration range of 6.0 × 10–6 M and 1.0 × 10–4 M. The limit of detection (LOD) was found to be 2.64 × 10−8 M; The limit of quantification (LOQ) was calculated as 8.79 × 10−8 M. The dexketoprofen tromethamine (DEX), diclofenac (DIC), and ibuprofen (IBU) were used as model active compounds to illustrate the oxidation mechanism of BUF. A simple, rapid, and sensitive electrochemical method for quantitatively determining BUF in a commercial sample of human serum was developed and validated. The calibration curve was linear in the 8.0 × 10–6 – 1.0 × 10–4 M in the biological media. The LOD for the commercial sample of human serum was set at 1.59 × 10−7 M. The electrochemical response of BUF in the presence of interferent was evaluated. The data obtained from the study showed that the developed method can be used in sensitive and selective BUF determination.

Anahtar Kelimeler

Bufexamac determination electrochemical sensor glassy carbon electrode validation

Kaynakça

  • [1] Buer JK. Origins and impact of the term ‘NSAID.’ Inflammopharmacology. 2014;22:263–267. https://doi.org/10.1007/s10787-014-0211-2.
  • [2] Sohail R, Mathew M, Patel KK, Reddy SA, Haider Z, Naria M, Habib A, Abdin ZU, Razzaq Chaudhry W, Akbar A. Effects of non-steroidal anti-inflammatory drugs (NSAIDs) and gastroprotective NSAIDs on the gastrointestinal tract: A narrative review. Cureus. 2023;15(4):e37080. https://doi.org/10.7759/cureus.37080.
  • [3] Ozleyen A, Yilmaz YB, Donmez S, Atalay HN, Antika G, Tumer TB. Looking at NSAIDs from a historical perspective and their current status in drug repurposing for cancer treatment and prevention. J Cancer Res Clin Oncol. 2023;149:2095–2113. https://doi.org/10.1007/s00432-022-04187-8.
  • [4] Ren L, Yi J, Yang J, Li P, Cheng X, Mao P. Nonsteroidal anti-inflammatory drugs use and risk of Parkinson disease: A dose–response meta-analysis. Medicine (United States). https://doi.org/10.1097/MD.0000000000012172.
  • [5] Ray Bettley F, Skin diseases in general practice, Eyre & Spottiswoode, London, UK, 1949.
  • [6] 2018;97:e12172. Brogden RN, Pinder RM, Sawyer PR, Speight TM, Avery GS. Evaluations on new drugs bufexamac: A review of its pharmacological properties and therapeutic efficacy in ınflammatory dermatoses. Drugs. 1975;10:351-356.
  • [7] Kamata K, Akiyama K. Note Determination of bufexamac in cream and ointment by high-performance liquid chromatography. J Chromatogr A. 1986;370:344-347. https://doi.org/10.1016/S0021-9673(00)94706-X.
  • [8] Woo IS, Kim JH, Kim YK, Kim H Il, Shin DW, Kim JH, Baek SY. Development and validation of a simultaneous analytical method for non-steroidal therapeutic compounds in cosmetics using liquid chromatography–tandem mass spectrometry. J Sep Sci. 2021;44:2371–2381. https://doi.org/10.1002/jssc.202001267.
  • [9] Saputra HA. Electrochemical sensors: basic principles, engineering, and state of the art. Monatsh Chem. 2023;154:1083–1100. https://doi.org/10.1007/s00706-023-03113-z.
  • [10] Omar FS, Duraisamy N, Ramesh K, Ramesh S. Conducting polymer and its composite materials based electrochemical sensor for Nicotinamide Adenine Dinucleotide (NADH). Biosens Bioelectron. 2016;79:763–75. https://doi.org/10.1016/j.bios.2016.01.013.
  • [11] Brett CMA, Brett AM Oliveira, Electrochemistry: Principles, Methods, and Applications, Oxford Science Publications, Oxford, UK, 1993.
  • [12] Wang J. Analytical Electrochemistry. Third Edit. John Wiley & Sons, Inc.; 2006.
  • [13] Bard AJ, Faulkner LR. Electrochemical Methods Fundamentals and Applications. Second Edi. John Wiley & Sons, Inc.; 2001.
  • [14] Laviron E. Surface linear potential sweep voltammetry. Equation of the peaks for a reversible reaction when interactions between the adsorbed molecules are taken into account. J Electroanal Chem. 1974;52:395–402. https://doi.org/10.1016/S0022-0728(74)80449-3.
  • [15] Mekassa B, Tessema M, Chandravanshi BS, Tefera M. Square wave voltammetric determination of ibuprofen at poly(L-Aspartic Acid) modified glassy carbon electrode. IEEE Sens J. 2018;18:37–44. https://doi.org/10.1109/JSEN.2017.2769137.
  • [16] Ferreira M, Güney S, Kuźniarska-Biernacka I, Soares OSGP, Figueiredo JL, Pereira MFR, Neves IC, Fonseca AM, Parpot P. Electrochemical oxidation of diclofenac on CNT and M/CNT modified electrodes. New J Chem. 2021;45:12622–12633. https://doi.org/10.1039/d1nj01117k.
  • [17] Švorc Ľ, Strežová I, Kianičková K, Stanković DM, Otřísal P, Samphao A. An advanced approach for electrochemical sensing of ibuprofen in pharmaceuticals and human urine samples using a bare boron-doped diamond electrode. J Electroanal Chem. 2018;822:144–152. https://doi.org/10.1016/j.jelechem.2018.05.026.7
  • [18] Cid-Cerón MM, Guzmán-Hernández DS, Ramírez-Silva MT, Galano A, Romero-Romo M, Palomar-Pardavé M. New insigths on the kinetics and mechanism of the electrochemical oxidation of diclofenac in neutral aqueous medium. Electrochim Acta. 2016;199:92–98. https://doi.org/10.1016/j.electacta.2016.03.094
  • [19] European Medicines Agency. Validation of Analytical Procedures: Text and Methodology. International Conference on Harmonisation (ICH) Guideline 1995;ICH Topic Q2 (R1).

Yıl 2024, Cilt: 28 Sayı: 5, 1562 - 1571, 28.06.2025

Sariye İrem Kaya , Göksu Özçelikay Akyıldız

Öz

Kaynakça

  • [1] Buer JK. Origins and impact of the term ‘NSAID.’ Inflammopharmacology. 2014;22:263–267. https://doi.org/10.1007/s10787-014-0211-2.
  • [2] Sohail R, Mathew M, Patel KK, Reddy SA, Haider Z, Naria M, Habib A, Abdin ZU, Razzaq Chaudhry W, Akbar A. Effects of non-steroidal anti-inflammatory drugs (NSAIDs) and gastroprotective NSAIDs on the gastrointestinal tract: A narrative review. Cureus. 2023;15(4):e37080. https://doi.org/10.7759/cureus.37080.
  • [3] Ozleyen A, Yilmaz YB, Donmez S, Atalay HN, Antika G, Tumer TB. Looking at NSAIDs from a historical perspective and their current status in drug repurposing for cancer treatment and prevention. J Cancer Res Clin Oncol. 2023;149:2095–2113. https://doi.org/10.1007/s00432-022-04187-8.
  • [4] Ren L, Yi J, Yang J, Li P, Cheng X, Mao P. Nonsteroidal anti-inflammatory drugs use and risk of Parkinson disease: A dose–response meta-analysis. Medicine (United States). https://doi.org/10.1097/MD.0000000000012172.
  • [5] Ray Bettley F, Skin diseases in general practice, Eyre & Spottiswoode, London, UK, 1949.
  • [6] 2018;97:e12172. Brogden RN, Pinder RM, Sawyer PR, Speight TM, Avery GS. Evaluations on new drugs bufexamac: A review of its pharmacological properties and therapeutic efficacy in ınflammatory dermatoses. Drugs. 1975;10:351-356.
  • [7] Kamata K, Akiyama K. Note Determination of bufexamac in cream and ointment by high-performance liquid chromatography. J Chromatogr A. 1986;370:344-347. https://doi.org/10.1016/S0021-9673(00)94706-X.
  • [8] Woo IS, Kim JH, Kim YK, Kim H Il, Shin DW, Kim JH, Baek SY. Development and validation of a simultaneous analytical method for non-steroidal therapeutic compounds in cosmetics using liquid chromatography–tandem mass spectrometry. J Sep Sci. 2021;44:2371–2381. https://doi.org/10.1002/jssc.202001267.
  • [9] Saputra HA. Electrochemical sensors: basic principles, engineering, and state of the art. Monatsh Chem. 2023;154:1083–1100. https://doi.org/10.1007/s00706-023-03113-z.
  • [10] Omar FS, Duraisamy N, Ramesh K, Ramesh S. Conducting polymer and its composite materials based electrochemical sensor for Nicotinamide Adenine Dinucleotide (NADH). Biosens Bioelectron. 2016;79:763–75. https://doi.org/10.1016/j.bios.2016.01.013.
  • [11] Brett CMA, Brett AM Oliveira, Electrochemistry: Principles, Methods, and Applications, Oxford Science Publications, Oxford, UK, 1993.
  • [12] Wang J. Analytical Electrochemistry. Third Edit. John Wiley & Sons, Inc.; 2006.
  • [13] Bard AJ, Faulkner LR. Electrochemical Methods Fundamentals and Applications. Second Edi. John Wiley & Sons, Inc.; 2001.
  • [14] Laviron E. Surface linear potential sweep voltammetry. Equation of the peaks for a reversible reaction when interactions between the adsorbed molecules are taken into account. J Electroanal Chem. 1974;52:395–402. https://doi.org/10.1016/S0022-0728(74)80449-3.
  • [15] Mekassa B, Tessema M, Chandravanshi BS, Tefera M. Square wave voltammetric determination of ibuprofen at poly(L-Aspartic Acid) modified glassy carbon electrode. IEEE Sens J. 2018;18:37–44. https://doi.org/10.1109/JSEN.2017.2769137.
  • [16] Ferreira M, Güney S, Kuźniarska-Biernacka I, Soares OSGP, Figueiredo JL, Pereira MFR, Neves IC, Fonseca AM, Parpot P. Electrochemical oxidation of diclofenac on CNT and M/CNT modified electrodes. New J Chem. 2021;45:12622–12633. https://doi.org/10.1039/d1nj01117k.
  • [17] Švorc Ľ, Strežová I, Kianičková K, Stanković DM, Otřísal P, Samphao A. An advanced approach for electrochemical sensing of ibuprofen in pharmaceuticals and human urine samples using a bare boron-doped diamond electrode. J Electroanal Chem. 2018;822:144–152. https://doi.org/10.1016/j.jelechem.2018.05.026.7
  • [18] Cid-Cerón MM, Guzmán-Hernández DS, Ramírez-Silva MT, Galano A, Romero-Romo M, Palomar-Pardavé M. New insigths on the kinetics and mechanism of the electrochemical oxidation of diclofenac in neutral aqueous medium. Electrochim Acta. 2016;199:92–98. https://doi.org/10.1016/j.electacta.2016.03.094
  • [19] European Medicines Agency. Validation of Analytical Procedures: Text and Methodology. International Conference on Harmonisation (ICH) Guideline 1995;ICH Topic Q2 (R1).
Toplam 19 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılıkta Analitik Kimya
Bölüm Articles
Yazarlar

Sariye İrem Kaya 0000-0003-0578-5399

Göksu Özçelikay Akyıldız 0000-0001-7919-3236

Yayımlanma Tarihi 28 Haziran 2025
Gönderilme Tarihi 3 Temmuz 2024
Kabul Tarihi 31 Temmuz 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 28 Sayı: 5

Kaynak Göster

APA Kaya, S. İ., & Özçelikay Akyıldız, G. (2025). Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac. Journal of Research in Pharmacy, 28(5), 1562-1571.
AMA Kaya Sİ, Özçelikay Akyıldız G. Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac. J. Res. Pharm. Temmuz 2025;28(5):1562-1571.
Chicago Kaya, Sariye İrem, ve Göksu Özçelikay Akyıldız. “Investigation of Electrochemical Behavior and Voltammetric Determination of the Anti-Inflammatory Agent Bufexamac”. Journal of Research in Pharmacy 28, sy. 5 (Temmuz 2025): 1562-71.
EndNote Kaya Sİ, Özçelikay Akyıldız G (01 Temmuz 2025) Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac. Journal of Research in Pharmacy 28 5 1562–1571.
IEEE S. İ. Kaya ve G. Özçelikay Akyıldız, “Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac”, J. Res. Pharm., c. 28, sy. 5, ss. 1562–1571, 2025.
ISNAD Kaya, Sariye İrem - Özçelikay Akyıldız, Göksu. “Investigation of Electrochemical Behavior and Voltammetric Determination of the Anti-Inflammatory Agent Bufexamac”. Journal of Research in Pharmacy 28/5 (Temmuz 2025), 1562-1571.
JAMA Kaya Sİ, Özçelikay Akyıldız G. Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac. J. Res. Pharm. 2025;28:1562–1571.
MLA Kaya, Sariye İrem ve Göksu Özçelikay Akyıldız. “Investigation of Electrochemical Behavior and Voltammetric Determination of the Anti-Inflammatory Agent Bufexamac”. Journal of Research in Pharmacy, c. 28, sy. 5, 2025, ss. 1562-71.
Vancouver Kaya Sİ, Özçelikay Akyıldız G. Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac. J. Res. Pharm. 2025;28(5):1562-71.