Araştırma Makalesi
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Yıl 2022, Cilt: 26 Sayı: 6, 1752 - 1757, 28.06.2025

Ebrar İnal Şeyma Ulusoy , Evren Algın Yapar , Eda Sönmez Gürer , Şule Yalçın Murat Kartal

https://doi.org/10.29228/jrp.265
Cited By: 1

Öz

Kaynakça

  • [1] EMA Assessment report on Polygonum aviculare L., herba. https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-polygonum-aviculare-lherba_en.pdf (accessed on 28 August 2022).
  • [2] Keskin M. Polygonum. 2012. Bizimbitkiler (2013). http://www.bizimbitkiler.org.tr (accessed on 28 August 2022).
  • [3] Coode MJE, Cullen J. Polygonum L. In: Davis PH (Ed). Flora of Turkey and the East Aegean Islands. University of Edinburgh, Edinburgh, 1967, pp. 269–281.
  • [4] Tuzlacı E, Tolon E. Turkish folk medicinal plants, part III: Şile (İstanbul). Fitoterapia. 2000;71(6):673–685. [CrossRef]
  • [5] Yeşilada E, Sezik E, Honda G, Takaishi Y, Takeda Y, Tanaka T. Traditional medicine in Turkey IX: Folk medicine in north-west Anatolia. J Ethnopharmacol. 1999;64(3):195–210. [CrossRef]
  • [6] Dereli FTG, Ilhan M, Kozan E, Akkol EK. Effective eradication of pinworms (Syphacia obvelata and Aspiculuris tetraptera) with Polygonum cognatum Meissn. Exp Parasitol. 2019;196:63–67. [CrossRef]
  • [7] Coban F, Tosun M, Güneş A, Öztürk E, Atsan E, Polat T. Antioxidant activity and mineral nutrient composition of Polygonum cognatum—a potential source of wild edible plant. Indian J Tradit Knowl. 2021;20(1):221–229.
  • [8] Yücel E, Güney F, Şengün İY. The wild plants consumed as a food in Mihalıççık district (Eskişehir/Turkey) and consumption forms of these plants. 2010;3(3):158–175.
  • [9] Yörelere Göre Türkülerimiz – Sivas. https://www.turkuler.com/nota/tumyoreler.asp?yoresi=sivas&s=9 (accessed on 6 September 2022).
  • [10] Cakilcioglu U, Turkoglu I. An ethnobotanical survey of medicinal plants in Sivrice (Elazığ-Turkey). J Ethnopharmacol. 2010;132(1):165–175. [CrossRef]
  • [11] Yıldırım A, Mavi A, Kara AA. Antioxidant and antimicrobial activities of Polygonum cognatum Meissn extracts. J Sci Food Agric. 2003;83(1):64–69. [CrossRef]
  • [12] Hussain F, Ahmad B, Hameed I, Dastagir G, Sanaullah P, Azam S. Antibacterial, antifungal and insecticidal activities of some selected medicinal plants of Polygonaceae. Afr J Biotechnol. 2010;9(31):5032–5036.
  • [13] Cevik Ö, Sener A, Kumral ZÖ, Cetinel S, Altıntas A, Oba R, Yegen BC, Yarat A. Protective and therapeutic effects of Polygonum cognatum Meissn aqueous extract in experimental colitis. Marmara Pharm J. 2014;18(3):126–134. [CrossRef]
  • [14] Gumuscu A, Dinc S, Kara M, Akkus M, Gumuscu G. Phenolic compounds of natural knotweed (Polygonum cognatum Meissn.) populations from Turkey. Int J Plant Based Pharm. 2022;2(1):37–41.
  • [15] Singh AP, Singh R, Verma SS, Rai V, Kaschula CH, Maiti P, Gupta SC. Health benefits of resveratrol: Evidence from clinical studies. Med Res Rev. 2019;39(5):1851–1891. [CrossRef]
  • [16] Ratz-Łyko A, Arct J. Resveratrol as an active ingredient for cosmetic and dermatological applications: A review. J Cosmet Laser Ther. 2019;21(2):84–90. [CrossRef]
  • [17] Wang DG, Liu WY, Chen GT. A simple method for the isolation and purification of resveratrol from Polygonum cuspidatum. J Pharm Anal. 2013;3(4):241–247. [CrossRef]
  • [18] de Araújo FF, de Paulo Farias D, Neri-Numa IA, Pastore GM. Polyphenols and their applications: An approach in food chemistry and innovation potential. Food Chem. 2021;338:127535. [CrossRef]
  • [19] Miao M, Xiang L. Pharmacological action and potential targets of chlorogenic acid. In: Du G (Ed). Advances in Pharmacology. Elsevier Science, China, 2020, pp. 71–88. [CrossRef]
  • [20] Atanassova M, Bagdassarian V. Rutin content in plant products. J Univ Chem Technol Metall. 2009;44(2):201–203.
  • [21] Ku SK, Kwak S, Kwon OJ, Bae JS. Hyperoside inhibits high-glucose-induced vascular inflammation in vitro and in vivo. Inflammation. 2014;37(5):1389–1400. [CrossRef]
  • [22] Musial C, Kuban-Jankowska A, Gorska-Ponikowska M. Beneficial properties of green tea catechins. Int J Mol Sci. 2020;21(5):1744. [CrossRef]
  • [23] Reygaert WC. Green tea catechins: Their use in treating and preventing infectious diseases. Biomed Res Int. 2018;2018:9. [CrossRef]
  • [24] Koch W, Zagórska J, Marzec Z, Kukula-Koch W. Applications of tea (Camellia sinensis) and its active constituents in cosmetics. Molecules. 2019;24(23):4277. [CrossRef]
  • [25] Yang ST, Zhang K, Zhang B, Huang H. Fumaric acid. In: Murray MY (Ed). Comprehensive Biotechnology, 2nd ed. Academic Press, Burlington, 2011, pp. 163–177. [CrossRef]
  • [26] Smith D. Fumaric acid esters for psoriasis: a systematic review. Ir J Med Sci. 2017;186(1):161–177. [CrossRef]
  • [27] Council of Europe. European Pharmacopoeia, 10th ed. Fleeceflower root 01/2014:2433; pp. 1437–1438. Strasbourg: Council of Europe; 2019.
  • [28] Kiziltas H, Goren AC, Bingol Z, Alwasel SH, Gulcin I. Anticholinergic, antidiabetic and antioxidant activities of Ferula orientalis L.: determination of its polyphenol contents by LC-HRMS. Rec Nat Prod. 2021;15(6):513–528. [CrossRef]

Investigation of resveratrol and phenolic compounds of ethnomedicinal plant Polygonum cognatum Meissn. collected from Sivas

Yıl 2022, Cilt: 26 Sayı: 6, 1752 - 1757, 28.06.2025

Ebrar İnal Şeyma Ulusoy , Evren Algın Yapar , Eda Sönmez Gürer , Şule Yalçın Murat Kartal

https://doi.org/10.29228/jrp.265
Cited By: 1

Öz

Polygonum cognatum Meissn., which is also known as “madımak, solucanotu” has been used in the Turkish folk medicine for the treatment of various diseases and has also been consumed in the dishes and salads by local people. It has even been the subject of a folk song, sung among the people in Sivas. In this study, it was aimed to examine the resveratrol and phenolic compounds that are valuable for health industry, in leaf and root extracts obtained from P. cognatum, which is widely distrubuted in Sivas. While resveratrol was investigated by using HPLCPDA, the phenolic compounds were determined by using LC-HRMS. Results of analyses showed that resveratrol could not be detected in both leaf and root extracts, but both root and leaf extracts were quite rich in following phenolic compounds. While chlorogenic acid, hyperoside, rutin, and fumaric acid were the most abundant phenolic compounds detected from the leaf extract, the (+)-catechin, fumaric acid, chlorogenic acid and p-coumaric acid were the most abundant phenolic compounds in the root extract. As a conclusion, P. cognatum with its rich phenolic compounds content of the root and leaf parts are good candidates in terms of using in dietary supplements, health care and cosmetic products

Anahtar Kelimeler

Polygonum cognatum Meissn. phytochemicals resveratrol phenolic compounds HPLC LC-MS

Kaynakça

  • [1] EMA Assessment report on Polygonum aviculare L., herba. https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-polygonum-aviculare-lherba_en.pdf (accessed on 28 August 2022).
  • [2] Keskin M. Polygonum. 2012. Bizimbitkiler (2013). http://www.bizimbitkiler.org.tr (accessed on 28 August 2022).
  • [3] Coode MJE, Cullen J. Polygonum L. In: Davis PH (Ed). Flora of Turkey and the East Aegean Islands. University of Edinburgh, Edinburgh, 1967, pp. 269–281.
  • [4] Tuzlacı E, Tolon E. Turkish folk medicinal plants, part III: Şile (İstanbul). Fitoterapia. 2000;71(6):673–685. [CrossRef]
  • [5] Yeşilada E, Sezik E, Honda G, Takaishi Y, Takeda Y, Tanaka T. Traditional medicine in Turkey IX: Folk medicine in north-west Anatolia. J Ethnopharmacol. 1999;64(3):195–210. [CrossRef]
  • [6] Dereli FTG, Ilhan M, Kozan E, Akkol EK. Effective eradication of pinworms (Syphacia obvelata and Aspiculuris tetraptera) with Polygonum cognatum Meissn. Exp Parasitol. 2019;196:63–67. [CrossRef]
  • [7] Coban F, Tosun M, Güneş A, Öztürk E, Atsan E, Polat T. Antioxidant activity and mineral nutrient composition of Polygonum cognatum—a potential source of wild edible plant. Indian J Tradit Knowl. 2021;20(1):221–229.
  • [8] Yücel E, Güney F, Şengün İY. The wild plants consumed as a food in Mihalıççık district (Eskişehir/Turkey) and consumption forms of these plants. 2010;3(3):158–175.
  • [9] Yörelere Göre Türkülerimiz – Sivas. https://www.turkuler.com/nota/tumyoreler.asp?yoresi=sivas&s=9 (accessed on 6 September 2022).
  • [10] Cakilcioglu U, Turkoglu I. An ethnobotanical survey of medicinal plants in Sivrice (Elazığ-Turkey). J Ethnopharmacol. 2010;132(1):165–175. [CrossRef]
  • [11] Yıldırım A, Mavi A, Kara AA. Antioxidant and antimicrobial activities of Polygonum cognatum Meissn extracts. J Sci Food Agric. 2003;83(1):64–69. [CrossRef]
  • [12] Hussain F, Ahmad B, Hameed I, Dastagir G, Sanaullah P, Azam S. Antibacterial, antifungal and insecticidal activities of some selected medicinal plants of Polygonaceae. Afr J Biotechnol. 2010;9(31):5032–5036.
  • [13] Cevik Ö, Sener A, Kumral ZÖ, Cetinel S, Altıntas A, Oba R, Yegen BC, Yarat A. Protective and therapeutic effects of Polygonum cognatum Meissn aqueous extract in experimental colitis. Marmara Pharm J. 2014;18(3):126–134. [CrossRef]
  • [14] Gumuscu A, Dinc S, Kara M, Akkus M, Gumuscu G. Phenolic compounds of natural knotweed (Polygonum cognatum Meissn.) populations from Turkey. Int J Plant Based Pharm. 2022;2(1):37–41.
  • [15] Singh AP, Singh R, Verma SS, Rai V, Kaschula CH, Maiti P, Gupta SC. Health benefits of resveratrol: Evidence from clinical studies. Med Res Rev. 2019;39(5):1851–1891. [CrossRef]
  • [16] Ratz-Łyko A, Arct J. Resveratrol as an active ingredient for cosmetic and dermatological applications: A review. J Cosmet Laser Ther. 2019;21(2):84–90. [CrossRef]
  • [17] Wang DG, Liu WY, Chen GT. A simple method for the isolation and purification of resveratrol from Polygonum cuspidatum. J Pharm Anal. 2013;3(4):241–247. [CrossRef]
  • [18] de Araújo FF, de Paulo Farias D, Neri-Numa IA, Pastore GM. Polyphenols and their applications: An approach in food chemistry and innovation potential. Food Chem. 2021;338:127535. [CrossRef]
  • [19] Miao M, Xiang L. Pharmacological action and potential targets of chlorogenic acid. In: Du G (Ed). Advances in Pharmacology. Elsevier Science, China, 2020, pp. 71–88. [CrossRef]
  • [20] Atanassova M, Bagdassarian V. Rutin content in plant products. J Univ Chem Technol Metall. 2009;44(2):201–203.
  • [21] Ku SK, Kwak S, Kwon OJ, Bae JS. Hyperoside inhibits high-glucose-induced vascular inflammation in vitro and in vivo. Inflammation. 2014;37(5):1389–1400. [CrossRef]
  • [22] Musial C, Kuban-Jankowska A, Gorska-Ponikowska M. Beneficial properties of green tea catechins. Int J Mol Sci. 2020;21(5):1744. [CrossRef]
  • [23] Reygaert WC. Green tea catechins: Their use in treating and preventing infectious diseases. Biomed Res Int. 2018;2018:9. [CrossRef]
  • [24] Koch W, Zagórska J, Marzec Z, Kukula-Koch W. Applications of tea (Camellia sinensis) and its active constituents in cosmetics. Molecules. 2019;24(23):4277. [CrossRef]
  • [25] Yang ST, Zhang K, Zhang B, Huang H. Fumaric acid. In: Murray MY (Ed). Comprehensive Biotechnology, 2nd ed. Academic Press, Burlington, 2011, pp. 163–177. [CrossRef]
  • [26] Smith D. Fumaric acid esters for psoriasis: a systematic review. Ir J Med Sci. 2017;186(1):161–177. [CrossRef]
  • [27] Council of Europe. European Pharmacopoeia, 10th ed. Fleeceflower root 01/2014:2433; pp. 1437–1438. Strasbourg: Council of Europe; 2019.
  • [28] Kiziltas H, Goren AC, Bingol Z, Alwasel SH, Gulcin I. Anticholinergic, antidiabetic and antioxidant activities of Ferula orientalis L.: determination of its polyphenol contents by LC-HRMS. Rec Nat Prod. 2021;15(6):513–528. [CrossRef]
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmakognozi
Bölüm Articles
Yazarlar

Ebrar İnal

Şeyma Ulusoy

Evren Algın Yapar

Eda Sönmez Gürer

Şule Yalçın

Murat Kartal

Yayımlanma Tarihi 28 Haziran 2025
Yayımlandığı Sayı Yıl 2022 Cilt: 26 Sayı: 6

Kaynak Göster

APA İnal, E., Ulusoy, Ş., Algın Yapar, E., Sönmez Gürer, E., vd. (2025). Investigation of resveratrol and phenolic compounds of ethnomedicinal plant Polygonum cognatum Meissn. collected from Sivas. Journal of Research in Pharmacy, 26(6), 1752-1757. https://doi.org/10.29228/jrp.265
AMA İnal E, Ulusoy Ş, Algın Yapar E, Sönmez Gürer E, Yalçın Ş, Kartal M. Investigation of resveratrol and phenolic compounds of ethnomedicinal plant Polygonum cognatum Meissn. collected from Sivas. J. Res. Pharm. Haziran 2025;26(6):1752-1757. doi:10.29228/jrp.265
Chicago İnal, Ebrar, Şeyma Ulusoy, Evren Algın Yapar, Eda Sönmez Gürer, Şule Yalçın, ve Murat Kartal. “Investigation of Resveratrol and Phenolic Compounds of Ethnomedicinal Plant Polygonum Cognatum Meissn. Collected from Sivas”. Journal of Research in Pharmacy 26, sy. 6 (Haziran 2025): 1752-57. https://doi.org/10.29228/jrp.265.
EndNote İnal E, Ulusoy Ş, Algın Yapar E, Sönmez Gürer E, Yalçın Ş, Kartal M (01 Haziran 2025) Investigation of resveratrol and phenolic compounds of ethnomedicinal plant Polygonum cognatum Meissn. collected from Sivas. Journal of Research in Pharmacy 26 6 1752–1757.
IEEE E. İnal, Ş. Ulusoy, E. Algın Yapar, E. Sönmez Gürer, Ş. Yalçın, ve M. Kartal, “Investigation of resveratrol and phenolic compounds of ethnomedicinal plant Polygonum cognatum Meissn. collected from Sivas”, J. Res. Pharm., c. 26, sy. 6, ss. 1752–1757, 2025, doi: 10.29228/jrp.265.
ISNAD İnal, Ebrar vd. “Investigation of Resveratrol and Phenolic Compounds of Ethnomedicinal Plant Polygonum Cognatum Meissn. Collected from Sivas”. Journal of Research in Pharmacy 26/6 (Haziran 2025), 1752-1757. https://doi.org/10.29228/jrp.265.
JAMA İnal E, Ulusoy Ş, Algın Yapar E, Sönmez Gürer E, Yalçın Ş, Kartal M. Investigation of resveratrol and phenolic compounds of ethnomedicinal plant Polygonum cognatum Meissn. collected from Sivas. J. Res. Pharm. 2025;26:1752–1757.
MLA İnal, Ebrar vd. “Investigation of Resveratrol and Phenolic Compounds of Ethnomedicinal Plant Polygonum Cognatum Meissn. Collected from Sivas”. Journal of Research in Pharmacy, c. 26, sy. 6, 2025, ss. 1752-7, doi:10.29228/jrp.265.
Vancouver İnal E, Ulusoy Ş, Algın Yapar E, Sönmez Gürer E, Yalçın Ş, Kartal M. Investigation of resveratrol and phenolic compounds of ethnomedicinal plant Polygonum cognatum Meissn. collected from Sivas. J. Res. Pharm. 2025;26(6):1752-7.

Cited By

Assessment of antimicrobial, anti-diabetic, anti-Alzheimer and anti-cancer properties, along with bioaccessibility and bioactive potential of Polygonum cognatum Meissn extracts from various cities in Türkiye
Food Bioscience
https://doi.org/10.1016/j.fbio.2024.105669