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Yıl 2022, Cilt: 26 Sayı: 6, 1771 - 1779, 28.06.2025

Eda Türker , Hamide Gübbük , Gözde Öztürk , Betül Demirci

https://doi.org/10.29228/jrp.267

Öz

Kaynakça

  • [1] Bamisaye FA, Ajani EO, Minari JB. Prospects of ethnobotanical uses of pawpaw (Carica papaya). J Med Plants Stud. 2013; 1(4): 171-177. [CrossRef]
  • [2] Anitha B, Raghu N, Gopenath TS, Karthikeyan M, Gnanasekaran A, Chandrashekrappa GK, Basalingappa KM. Medicinal uses of Carica papaya. J Nat Ayurvedic Med. 2018; 2(6): 2-11. [CrossRef]
  • [3] Barroso PT, de Carvalho PP, Rocha TB, Pessoa FL, Azeanddo DA, Mendes MF. Evaluation of the composition of Carica papaya L. seed oil extracted with supercritical CO₂. Biotechnol Rep. 2016; 11: 110-116. [CrossRef]
  • [4] He X, Ma Y, Yi G, Wu J, Zhou L, Guo H. Chemical composition and antifungal activity of Carica papaya Linn. seed essential oil against Candida spp. Lett Appl Microbiol. 2017; 64(5): 350-354. [CrossRef]
  • [5] Moy JH. Papayas, second ed., American Press, USA, 2003.
  • [6] Ulrich D, Wijaya CH. Volatile patterns of different papaya (Carica papaya L.) varieties. J Appl Bot Food Qual. 2010; 83: 128-132. [CrossRef]
  • [7] Pino JA. Odour-active compounds in papaya fruit cv. Red Maradol. Food Chem. 2014; 146: 120-126. [CrossRef]
  • [8] Kelebek H, Selli S, Gubbuk H, Gunes E. Comparative evaluation of volatiles, phenolics, sugars, organic acids and antioxidant properties of Sel-42 and Tainung papaya varieties. Food Chem. 2015; 173: 912-919. [CrossRef]
  • [9] Melariri P, Campbell W, Etusim P, Smith P. Antiplasmodial properties and bioassay-guided fractionation of ethyl acetate extracts from Carica papaya leaves. J Parasitol Res. 2011; 2011: 1-7. [CrossRef]
  • [10] Gao Z, Zheng L, Wu W, Fu Y. Analysis of essential oils from leaf of Carica papaya with GC-MS. J Fruit Sci. 2010; 27(2): 307-311.
  • [11] Vij T, Prashar Y. A review on medicinal properties of Carica papaya Linn. Asian Pac J Trop Dis. 2015; 5(1): 1-6. [CrossRef]
  • [12] Singh O, Ali M. Phytochemical and antifungal profiles of the seeds of Carica papaya L. Indian J Pharm Sci. 2011; 4: 447-451. [CrossRef]
  • [13] Li ZY, Wang Y, Shen WT, Zhou P. Content determination of benzyl glucosinolate and anticancer activity of its hydrolysis product in Carica papaya L. Asian Pac J Trop Med. 2012; 3: 231-233. [CrossRef]
  • [14] Julaeha E, Permatasari Y, Mayanti T, Diantini A. Antifertility compound from the seeds of Carica papaya. Procedia Chem. 2015; 17: 66-69. [CrossRef]
  • [15] Asghar N, Naqvi SAR, Hussain Z, Rasool N, Khan ZA, Shahzad SA, Sherazi TA, Janjua MRSA, Nagra SA, Zia-Ul-Haq M, Jaafar HZ. Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents. Chem Cent J. 2016; 10: 1-11. [CrossRef]
  • [16] Lee WJ, Lee MH, Su NW. Characteristics of papaya seed oils obtained by extrusion–expelling processes. J Sci Food Agric. 2011; 91(13): 2348-2354. [CrossRef]
  • [17] Viana GM. Avaliação do isotiocianato de benzila natural como inseticida e precursor sintético de tiouréias e derivados. Rio de Janeiro Federal University, Brasil, 2009.
  • [18] Samaram S, Mirhosseini H, Tan CP, Ghazali HM. Ultrasound-assisted extraction (UAE) and solvent extraction of papaya seed oil: yield, fatty acid composition and triacylglycerol profile. Molecules. 2013; 18(10): 12474-12487. [CrossRef]
  • [19] Gomes BL, Fabi JP, Purgatto E. Cold storage affects the volatile profile and expression of a putative linalool synthase of papaya fruit. Food Res Int. 2016; 89: 654-660. [CrossRef]
  • [20] Puangsri T, Abdulkarim SM, Ghazali HM. Properties of Carica papaya L. (papaya) seed oil following extractions using solvent and aqueous enzymatic methods. J Food Lipids. 2005; 12(1): 62-76. [CrossRef]
  • [21] Malacrida CR, Kmura M, Jorge N. Characterization of a high oleic oil extracted from papaya (Carica papaya L.) seeds. Cienc Tecnol Aliment. 2011; 31(4): 929-934. [CrossRef]
  • [22] Zakaria ZA, Mat Jais AM, Sulaiman MR, Mohamed Isa SSP, Riffin S. The in vitro antibacterial activity of methanol and ethanol extracts of Carica papaya flowers and Mangifera indica leaves. J Pharmacol Toxicol. 2006; 1: 278-283. [CrossRef]
  • [23] Doughari JH, Elmahmood AM, Manzara S. Studies on the antibacterial activity of root extracts of Carica papaya L. Afr J Microbiol Res. 2007; 1(3): 37-41. [CrossRef]
  • [24] Oladimeji HO, Nia R, Kalu N, Attih EE. In vitro biological activities of Carica papaya. Res J Med Plant. 2007; 1: 92-99. [CrossRef]
  • [25] Eke ON, Augustin AU, Ibrahim HF. Qualitative analysis of phytochemicals and antibacterial screening of extracts of Carica papaya fruits and seeds. Int J Modern Chem. 2014; 6(1): 48-56. [CrossRef]
  • [26] Ozturk G, Demirci B, Çelik M, Başer KHC. Chemical characterization of Bunium allioides and B. brachyactis. Chem Nat Compd. 2020; 56: 1146-1147. [CrossRef]
  • [27] Levent S, Kaya Çavuşoğlu B, Sağlık B, Osmaniye D, Acar Çevik U, Atlı Ö, Özkay Y, Kaplancıklı Z. Synthesis of oxadiazole-thiadiazole hybrids and their anticandidal activity. Molecules. 2017; 22(11): 1-13. [CrossRef]
  • [28] CLSI. Method for Antifungal Disk Susceptibility Tests; Susceptibility Testing of Yeasts; Approved Standard, M44-A2. Clinical and Laboratory Standards Institute, 2009.
  • [29] CLSI. Method for Antimicrobial Disk Susceptibility Tests; Approved Standard, M02-A1. Clinical and Laboratory Standards Institute, 2012.

Chemical Characterizations and Biological Evaluation of Papaya (Carica papaya L.) Essential Oils and Fatty Acids

Yıl 2022, Cilt: 26 Sayı: 6, 1771 - 1779, 28.06.2025

Eda Türker , Hamide Gübbük , Gözde Öztürk , Betül Demirci

https://doi.org/10.29228/jrp.267

Öz

The genus Carica L. (Caricaceae) is presented by 22 species where C. papaya L. is the most widely cultivated and best-known species. It is native in Middle and South America, and consumed for its nutritional values. Also, its medicinal uses such as antimicrobial, antihelmintic, antifungal, hepatoprotective and diuretic among others are known. In this present study, it was aimed to analyse the chemical compositions of C. papaya (cv. Sel 42) essential and fatty oils from Antalya cultivars. Essential oils (EOs) from leaf, ripe and unripe fruits of C. papaya were obtained by hydrodistillation using a Clevenger type apparatus. The essential oils were subsequently analysed by both Gas chromatography (GC) and Gas chromatography-Mass spectrometry (GC-MS). Benzyl isothiocyanate (86.3; 100; 94.4%) was found as the main constituent of the EOs of C. papaya leaf, ripe and unripe fruits, respectively. Dried and fresh seeds of C. papaya fatty acids (FAs) were extracted with n-hexane in a Soxhlet apparatus, and after the methylation the chemical compositions were determined by GC and GC-MS systems. The major FAs of both dried and fresh seeds of C. papaya were oleic acid (72; 70%), palmitic acid (15%; 16.4%), linoleic acid (5.3%; 5.1%), respectively. The C. papaya EOs and FAs were evaluated also for their in vitro antimicrobial properties against different microbial strains by the agar disk well diffusion method. The EOs and FAs showed relatively weak antimicrobial activity against the tested Escherichia coli NRRL B-3008, Bacillus subtilis NRRL B-4378, and Candida albicans ATCC 10231, respectively. Further biological evaluations are ongoing.

Anahtar Kelimeler

Carica papaya L. Caricaceae essential oil fatty oil antimicrobial activity

Kaynakça

  • [1] Bamisaye FA, Ajani EO, Minari JB. Prospects of ethnobotanical uses of pawpaw (Carica papaya). J Med Plants Stud. 2013; 1(4): 171-177. [CrossRef]
  • [2] Anitha B, Raghu N, Gopenath TS, Karthikeyan M, Gnanasekaran A, Chandrashekrappa GK, Basalingappa KM. Medicinal uses of Carica papaya. J Nat Ayurvedic Med. 2018; 2(6): 2-11. [CrossRef]
  • [3] Barroso PT, de Carvalho PP, Rocha TB, Pessoa FL, Azeanddo DA, Mendes MF. Evaluation of the composition of Carica papaya L. seed oil extracted with supercritical CO₂. Biotechnol Rep. 2016; 11: 110-116. [CrossRef]
  • [4] He X, Ma Y, Yi G, Wu J, Zhou L, Guo H. Chemical composition and antifungal activity of Carica papaya Linn. seed essential oil against Candida spp. Lett Appl Microbiol. 2017; 64(5): 350-354. [CrossRef]
  • [5] Moy JH. Papayas, second ed., American Press, USA, 2003.
  • [6] Ulrich D, Wijaya CH. Volatile patterns of different papaya (Carica papaya L.) varieties. J Appl Bot Food Qual. 2010; 83: 128-132. [CrossRef]
  • [7] Pino JA. Odour-active compounds in papaya fruit cv. Red Maradol. Food Chem. 2014; 146: 120-126. [CrossRef]
  • [8] Kelebek H, Selli S, Gubbuk H, Gunes E. Comparative evaluation of volatiles, phenolics, sugars, organic acids and antioxidant properties of Sel-42 and Tainung papaya varieties. Food Chem. 2015; 173: 912-919. [CrossRef]
  • [9] Melariri P, Campbell W, Etusim P, Smith P. Antiplasmodial properties and bioassay-guided fractionation of ethyl acetate extracts from Carica papaya leaves. J Parasitol Res. 2011; 2011: 1-7. [CrossRef]
  • [10] Gao Z, Zheng L, Wu W, Fu Y. Analysis of essential oils from leaf of Carica papaya with GC-MS. J Fruit Sci. 2010; 27(2): 307-311.
  • [11] Vij T, Prashar Y. A review on medicinal properties of Carica papaya Linn. Asian Pac J Trop Dis. 2015; 5(1): 1-6. [CrossRef]
  • [12] Singh O, Ali M. Phytochemical and antifungal profiles of the seeds of Carica papaya L. Indian J Pharm Sci. 2011; 4: 447-451. [CrossRef]
  • [13] Li ZY, Wang Y, Shen WT, Zhou P. Content determination of benzyl glucosinolate and anticancer activity of its hydrolysis product in Carica papaya L. Asian Pac J Trop Med. 2012; 3: 231-233. [CrossRef]
  • [14] Julaeha E, Permatasari Y, Mayanti T, Diantini A. Antifertility compound from the seeds of Carica papaya. Procedia Chem. 2015; 17: 66-69. [CrossRef]
  • [15] Asghar N, Naqvi SAR, Hussain Z, Rasool N, Khan ZA, Shahzad SA, Sherazi TA, Janjua MRSA, Nagra SA, Zia-Ul-Haq M, Jaafar HZ. Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents. Chem Cent J. 2016; 10: 1-11. [CrossRef]
  • [16] Lee WJ, Lee MH, Su NW. Characteristics of papaya seed oils obtained by extrusion–expelling processes. J Sci Food Agric. 2011; 91(13): 2348-2354. [CrossRef]
  • [17] Viana GM. Avaliação do isotiocianato de benzila natural como inseticida e precursor sintético de tiouréias e derivados. Rio de Janeiro Federal University, Brasil, 2009.
  • [18] Samaram S, Mirhosseini H, Tan CP, Ghazali HM. Ultrasound-assisted extraction (UAE) and solvent extraction of papaya seed oil: yield, fatty acid composition and triacylglycerol profile. Molecules. 2013; 18(10): 12474-12487. [CrossRef]
  • [19] Gomes BL, Fabi JP, Purgatto E. Cold storage affects the volatile profile and expression of a putative linalool synthase of papaya fruit. Food Res Int. 2016; 89: 654-660. [CrossRef]
  • [20] Puangsri T, Abdulkarim SM, Ghazali HM. Properties of Carica papaya L. (papaya) seed oil following extractions using solvent and aqueous enzymatic methods. J Food Lipids. 2005; 12(1): 62-76. [CrossRef]
  • [21] Malacrida CR, Kmura M, Jorge N. Characterization of a high oleic oil extracted from papaya (Carica papaya L.) seeds. Cienc Tecnol Aliment. 2011; 31(4): 929-934. [CrossRef]
  • [22] Zakaria ZA, Mat Jais AM, Sulaiman MR, Mohamed Isa SSP, Riffin S. The in vitro antibacterial activity of methanol and ethanol extracts of Carica papaya flowers and Mangifera indica leaves. J Pharmacol Toxicol. 2006; 1: 278-283. [CrossRef]
  • [23] Doughari JH, Elmahmood AM, Manzara S. Studies on the antibacterial activity of root extracts of Carica papaya L. Afr J Microbiol Res. 2007; 1(3): 37-41. [CrossRef]
  • [24] Oladimeji HO, Nia R, Kalu N, Attih EE. In vitro biological activities of Carica papaya. Res J Med Plant. 2007; 1: 92-99. [CrossRef]
  • [25] Eke ON, Augustin AU, Ibrahim HF. Qualitative analysis of phytochemicals and antibacterial screening of extracts of Carica papaya fruits and seeds. Int J Modern Chem. 2014; 6(1): 48-56. [CrossRef]
  • [26] Ozturk G, Demirci B, Çelik M, Başer KHC. Chemical characterization of Bunium allioides and B. brachyactis. Chem Nat Compd. 2020; 56: 1146-1147. [CrossRef]
  • [27] Levent S, Kaya Çavuşoğlu B, Sağlık B, Osmaniye D, Acar Çevik U, Atlı Ö, Özkay Y, Kaplancıklı Z. Synthesis of oxadiazole-thiadiazole hybrids and their anticandidal activity. Molecules. 2017; 22(11): 1-13. [CrossRef]
  • [28] CLSI. Method for Antifungal Disk Susceptibility Tests; Susceptibility Testing of Yeasts; Approved Standard, M44-A2. Clinical and Laboratory Standards Institute, 2009.
  • [29] CLSI. Method for Antimicrobial Disk Susceptibility Tests; Approved Standard, M02-A1. Clinical and Laboratory Standards Institute, 2012.
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmakognozi
Bölüm Articles
Yazarlar

Eda Türker

Hamide Gübbük

Gözde Öztürk

Betül Demirci

Yayımlanma Tarihi 28 Haziran 2025
Yayımlandığı Sayı Yıl 2022 Cilt: 26 Sayı: 6

Kaynak Göster

APA Türker, E., Gübbük, H., Öztürk, G., Demirci, B. (2025). Chemical Characterizations and Biological Evaluation of Papaya (Carica papaya L.) Essential Oils and Fatty Acids. Journal of Research in Pharmacy, 26(6), 1771-1779. https://doi.org/10.29228/jrp.267
AMA Türker E, Gübbük H, Öztürk G, Demirci B. Chemical Characterizations and Biological Evaluation of Papaya (Carica papaya L.) Essential Oils and Fatty Acids. J. Res. Pharm. Haziran 2025;26(6):1771-1779. doi:10.29228/jrp.267
Chicago Türker, Eda, Hamide Gübbük, Gözde Öztürk, ve Betül Demirci. “Chemical Characterizations and Biological Evaluation of Papaya (Carica Papaya L.) Essential Oils and Fatty Acids”. Journal of Research in Pharmacy 26, sy. 6 (Haziran 2025): 1771-79. https://doi.org/10.29228/jrp.267.
EndNote Türker E, Gübbük H, Öztürk G, Demirci B (01 Haziran 2025) Chemical Characterizations and Biological Evaluation of Papaya (Carica papaya L.) Essential Oils and Fatty Acids. Journal of Research in Pharmacy 26 6 1771–1779.
IEEE E. Türker, H. Gübbük, G. Öztürk, ve B. Demirci, “Chemical Characterizations and Biological Evaluation of Papaya (Carica papaya L.) Essential Oils and Fatty Acids”, J. Res. Pharm., c. 26, sy. 6, ss. 1771–1779, 2025, doi: 10.29228/jrp.267.
ISNAD Türker, Eda vd. “Chemical Characterizations and Biological Evaluation of Papaya (Carica Papaya L.) Essential Oils and Fatty Acids”. Journal of Research in Pharmacy 26/6 (Haziran 2025), 1771-1779. https://doi.org/10.29228/jrp.267.
JAMA Türker E, Gübbük H, Öztürk G, Demirci B. Chemical Characterizations and Biological Evaluation of Papaya (Carica papaya L.) Essential Oils and Fatty Acids. J. Res. Pharm. 2025;26:1771–1779.
MLA Türker, Eda vd. “Chemical Characterizations and Biological Evaluation of Papaya (Carica Papaya L.) Essential Oils and Fatty Acids”. Journal of Research in Pharmacy, c. 26, sy. 6, 2025, ss. 1771-9, doi:10.29228/jrp.267.
Vancouver Türker E, Gübbük H, Öztürk G, Demirci B. Chemical Characterizations and Biological Evaluation of Papaya (Carica papaya L.) Essential Oils and Fatty Acids. J. Res. Pharm. 2025;26(6):1771-9.