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Yıl 2022, Cilt: 26 Sayı: 6, 1789 - 1795, 28.06.2025

Burcu Sümer Tüzün , Tuğçe Fafal , Evren Tileklioglu , Hatice Ertabaklar , Bijen Kıvçak

https://doi.org/10.29228/jrp.269

Öz

Kaynakça

  • [1] WHO. Global Incidence and Prevalence of Selected Curable Sexually Transmitted Infections (2008): World Health Organization, Geneva, Switzerland, 2012.
  • [2] World Health Organization. WHO, 2012. Global Incidence and Prevalence of Selected Curable Sexually Transmitted Infections-2008. World Health Organization, Geneva, Switzerland.
  • [3] Wood BA, Monro AM. Pharmacokinetics of tinidazole and metronidazole in women after single large oral doses. Br J Vener Dis. 1975; 51: 51-53. [CrossRef]
  • [4] Derda M, Hadas E. The use of phytotherapy in diseases caused by parasitic protozoa. Acta Parasitol. 2015; 60(1): 1-8. [CrossRef]
  • [5] Davis PH. Flora of Turkey and East Aegean Islands. University Press, Edinburgh, 1975, pp. 5, 193.
  • [6] Kozlowska M, Laudy AE, Przybyl J, Ziarno M, Majewska E. Chemical composition and antibacterial activity of some medicinal plants from Lamiaceae family. Drug Res. 2015; 72(4): 757-767.
  • [7] Williams CA, Greenham J, Harborne JB. The role of lipophilic and polar flavonoids in the classification of temperate members of the Anthemideae. Syst Ecol. 2001; 29: 929. [CrossRef]
  • [8] Davis PH. Flora of Turkey and the East Aegean Islands. Vol. 7, University Press, Edinburgh, 1982.
  • [9] Davis PH. Flora of Turkey and the East Aegean Islands. Vol. 10, University Press, Edinburgh, 1988.
  • [10] Belaqziz R, Harrak R, Romane A, Oufdou K, El Alaoui ElFels MA. Antimicrobial and insecticidal activities of the endemic Thymus broussonetti Boiss. and Thymus maroccanus Ball. Rec Nat Prod. 2010; 4: 230-237.
  • [11] Nazemiyeh H, Lotfipoor F, Delazar A, Razavi SM, Asnaashari S, Kasebi N, Talebpour AH, Nahar L, Sarker SD. Chemical composition, and antibacterial and free-radical scavenging activities of the essential oils of a citronellol-producing new chemotype of Thymus pubescens Boiss. & Kotschy ex Celak. Rec Nat Prod. 2011; 5: 184-192.
  • [12] Celen S, Azaz AD, Kucukbay FZ. Chemical composition, antimicrobial and antioxidant properties of Thymus haussknechtii Velen. essential oil. J Appl Biol Sci. 2012; 6: 13-18.
  • [13] Baricevic D, Bartol D. The biological/pharmacological activity of the Salvia genus. In: The genus Salvia, Kintzios SE (Ed.). Harwood Academic Publishers, Abingdon, Marston, 2001.
  • [14] Zupko I, Hohmann J, Redei D, Falkay G, Janicsak G, Mathe I. Antioxidant activity of leaves of Salvia species in enzyme-dependent and enzyme-independent systems of lipid peroxidation and their phenolic constituents. Planta Med. 2001; 67: 366-368. [CrossRef]
  • [15] Gokturk BN, Ozkan G, Sagdic O. Total phenolic contents and antibacterial activities of grape (Vitis vinifera L.) extracts. Food Cont. 2004; 15: 169-172.
  • [16] Llurba-Montesino N, Schmidt TJ. Salvia species as sources of natural products with antiprotozoal activity. Int J Mol Sci. 2018; 19: 264-296. [CrossRef]
  • [17] Topcu G. Bioactive triterpenoids from Salvia species. J Nat Prod. 2006; 69: 482-487. [CrossRef]
  • [18] Mehriardestani M, Aliahmadi A, Toliat T, Rahi R. Medicinal plants and their isolated compounds showing anti-Trichomonas vaginalis activity. Biomed Pharmacother. 2017; 88: 885-893. [CrossRef]
  • [19] Hashemi N, Ommi D, Kheyri P, Khamesipour F, Setzer WN, Benchimol M. A review study on the anti-Trichomonas activities of medicinal plants. Int J Pharm. 2021; 15: 92-104. [CrossRef]
  • [20] Zgorka G, Głowniak K. Variation of free phenolic acids in medicinal plants belonging to the Lamiaceae family. J Pharm Biomed Anal. 2001; 26: 79-87. [CrossRef]
  • [21] Garza-Gonzalez JN, Vargas-Villarreal J, Verde-Star MJ, Rivas-Morales C, Oranday-Cardenas C, Oranday-Cardenas A, Hernandez-Garcia ME, Garza-Salinas LDL, Gonzalez-Salazar FG. Antiprotozoal activity of Thymus vulgaris methanol extract and its fractions. Health. 2017; 9: 1081-1094.
  • [22] Behnia M, Haghighi A, Komeylizadeh H, Seyyed Tabaei SJ, Abadi A. Inhibitory effects of Iranian Thymus vulgaris extracts on in vitro growth of Entamoeba histolytica. Korean J Parasitol. 2008; 46(3): 153-156. [CrossRef]
  • [23] Ezz Eldin HM, Badawy AF. In vitro anti-Trichomonas vaginalis activity of Pistacia lentiscus mastic and Ocimum basilicum essential oil. J Parasit Dis. 2015; 39: 465–473.
  • [24] Yousefi M, Taghipur S, Arefkhah N, Rahimian R, Davoudian A, Rafeiean M, Darani HY. In-vitro effect of Mentha piperita and Salvia officinalis extracts on Trichomonas vaginalis. J Isfahan Med Sch. 2013; 31: 811–818.
  • [25] Moon T, Wilkinson JM, Cavanagh HM. Antiparasitic activity of two Lavandula essential oils against Giardia duodenalis, Trichomonas vaginalis and Hexamita inflata. Parasitol Res. 2006; 99: 722–728.
  • [26] Zheng LL, Cui Y, Qin YH, Ren YX, Liu X, Tao L, Dai XD. Effect of Mosla chinensis Maxim on Trichomonas vaginalis in vitro. J Dalian Med Univ. 2009; 3: 282–285.
  • [27] Camacho-Corona MD, Garcia A, Mata-Cardenas BD, Garza-Gonzalez E, Ibarra-Alvarado C, Rojas-Molina A, Rojas-Molina I, Bah M, Sanchez MAZ, Gutierrez SP. Screening for antibacterial and antiprotozoal activities of crude extracts derived from Mexican medicinal plants. Afr J Tradit Complement Alt Med. 2015; 12: 104–112.
  • [28] Ozbilgin A, Durmuşkahya C, Kayalar H, Ertabaklar H, Gunduz C, Ostan Ural I, Zeyrek F, Kurt O, Çavuş İ, Balcıoğlu C, Toz SO, Ozbel Y. Antileishmanial activity of selected Turkish medicinal plants. Trop J Pharm Res. 2014; 13(12): 2047–2055.
  • [29] Calzada F, Yepez-Mulia L, Tapia-Contreras A, Bautista E, Maldonado E, Ortega A. Evaluation of the antiprotozoal activity of neo-clerodane type diterpenes from Salvia polystachya against Entamoeba histolytica and Giardia lamblia. Phytother Res. 2010; 24: 662–665.
  • [30] Tabefam M, Farimani MM, Danton O, Ramseyer J, Ebrahimi SN, Neuburger M, Kaise M, Salehi P, Potterat O, Hamburger M. Antiprotozoal isoprenoids from Salvia hydrangea. J Nat Prod. 2018; 81: 2682–2691. [CrossRef]
  • [31] Ebrahimi SN, Zimmermann S, Zaugg J, Smiesko M, Brun R, Hamburger M. Abietane diterpenoids from Salvia sahendica – Antiprotozoal activity and determination of their absolute configurations. Planta Med. 2013; 79: 150–156.
  • [32] Tasdemir D, Brun R, Perozzo R, Dönmez AA. Evaluation of antiprotozoal and plasmodial enoyl-ACP reductase inhibition potential of Turkish medicinal plants. Phytother Res. 2005; 19: 162–166.
  • [33] Ozbilgin A, Çavus I, Yıldırım A, Kaya T, Ertabaklar H. Evaluation of in vitro and in vivo drug efficacy over Leishmania tropica: A pilot study. Türkiye Parazitol Derg. 2018; 42(1): 11–19.

Anti-Trichomonas vaginalis activities of some Lamiaceae plants

Yıl 2022, Cilt: 26 Sayı: 6, 1789 - 1795, 28.06.2025

Burcu Sümer Tüzün , Tuğçe Fafal , Evren Tileklioglu , Hatice Ertabaklar , Bijen Kıvçak

https://doi.org/10.29228/jrp.269

Öz

Trichomoniasis is a sexually transmitted infection caused by the Trichomonas vaginalis, non-viral protozoan, affecting the world. Metronidazole is one of the effective treatments approved by the FDA. Natural alternative approaches are required due to developed of resistance and drug intolerance in long-term treatment. The Lamiaceae, with 250 genera and 3000 species, are one of the largest family based on the taxon numbers. Thymus, Salvia, and Phlomis are also the largest genus of the family. The most distinctive feature of the species is active compounds of antiprotozoal activities. In present study Phlomis armeniaca Willd., Phlomis pungens Willd. var. pungens, Phlomis sieheana Rech. Fil., Thymus haussknechtii Velen., Thymus kotschyanus Boiss. & Hohen. var. kotschyanus, Stachys lavandulifolia Vahl subsp. lavandulifolia and Salvia verticillata L. subsp. verticillata L. had investigated anti-Trichomonas vaginalis activity. Results indicated that Thymus haussknetchtii was found anti-trichomonal activity in 250 and 125 μg/ml concentrations at the end of 16 hours. The inhibition of Salvia verticillata subsp. verticillata and Phlomis sieheana. were started after 24 hours, and anti-trichomonal activity was detected 70% and 90% at the end of 48 hours, respectively.

Anahtar Kelimeler

Lamiaceae Phlomis Salvia Thymus Trichomonas vaginalis

Kaynakça

  • [1] WHO. Global Incidence and Prevalence of Selected Curable Sexually Transmitted Infections (2008): World Health Organization, Geneva, Switzerland, 2012.
  • [2] World Health Organization. WHO, 2012. Global Incidence and Prevalence of Selected Curable Sexually Transmitted Infections-2008. World Health Organization, Geneva, Switzerland.
  • [3] Wood BA, Monro AM. Pharmacokinetics of tinidazole and metronidazole in women after single large oral doses. Br J Vener Dis. 1975; 51: 51-53. [CrossRef]
  • [4] Derda M, Hadas E. The use of phytotherapy in diseases caused by parasitic protozoa. Acta Parasitol. 2015; 60(1): 1-8. [CrossRef]
  • [5] Davis PH. Flora of Turkey and East Aegean Islands. University Press, Edinburgh, 1975, pp. 5, 193.
  • [6] Kozlowska M, Laudy AE, Przybyl J, Ziarno M, Majewska E. Chemical composition and antibacterial activity of some medicinal plants from Lamiaceae family. Drug Res. 2015; 72(4): 757-767.
  • [7] Williams CA, Greenham J, Harborne JB. The role of lipophilic and polar flavonoids in the classification of temperate members of the Anthemideae. Syst Ecol. 2001; 29: 929. [CrossRef]
  • [8] Davis PH. Flora of Turkey and the East Aegean Islands. Vol. 7, University Press, Edinburgh, 1982.
  • [9] Davis PH. Flora of Turkey and the East Aegean Islands. Vol. 10, University Press, Edinburgh, 1988.
  • [10] Belaqziz R, Harrak R, Romane A, Oufdou K, El Alaoui ElFels MA. Antimicrobial and insecticidal activities of the endemic Thymus broussonetti Boiss. and Thymus maroccanus Ball. Rec Nat Prod. 2010; 4: 230-237.
  • [11] Nazemiyeh H, Lotfipoor F, Delazar A, Razavi SM, Asnaashari S, Kasebi N, Talebpour AH, Nahar L, Sarker SD. Chemical composition, and antibacterial and free-radical scavenging activities of the essential oils of a citronellol-producing new chemotype of Thymus pubescens Boiss. & Kotschy ex Celak. Rec Nat Prod. 2011; 5: 184-192.
  • [12] Celen S, Azaz AD, Kucukbay FZ. Chemical composition, antimicrobial and antioxidant properties of Thymus haussknechtii Velen. essential oil. J Appl Biol Sci. 2012; 6: 13-18.
  • [13] Baricevic D, Bartol D. The biological/pharmacological activity of the Salvia genus. In: The genus Salvia, Kintzios SE (Ed.). Harwood Academic Publishers, Abingdon, Marston, 2001.
  • [14] Zupko I, Hohmann J, Redei D, Falkay G, Janicsak G, Mathe I. Antioxidant activity of leaves of Salvia species in enzyme-dependent and enzyme-independent systems of lipid peroxidation and their phenolic constituents. Planta Med. 2001; 67: 366-368. [CrossRef]
  • [15] Gokturk BN, Ozkan G, Sagdic O. Total phenolic contents and antibacterial activities of grape (Vitis vinifera L.) extracts. Food Cont. 2004; 15: 169-172.
  • [16] Llurba-Montesino N, Schmidt TJ. Salvia species as sources of natural products with antiprotozoal activity. Int J Mol Sci. 2018; 19: 264-296. [CrossRef]
  • [17] Topcu G. Bioactive triterpenoids from Salvia species. J Nat Prod. 2006; 69: 482-487. [CrossRef]
  • [18] Mehriardestani M, Aliahmadi A, Toliat T, Rahi R. Medicinal plants and their isolated compounds showing anti-Trichomonas vaginalis activity. Biomed Pharmacother. 2017; 88: 885-893. [CrossRef]
  • [19] Hashemi N, Ommi D, Kheyri P, Khamesipour F, Setzer WN, Benchimol M. A review study on the anti-Trichomonas activities of medicinal plants. Int J Pharm. 2021; 15: 92-104. [CrossRef]
  • [20] Zgorka G, Głowniak K. Variation of free phenolic acids in medicinal plants belonging to the Lamiaceae family. J Pharm Biomed Anal. 2001; 26: 79-87. [CrossRef]
  • [21] Garza-Gonzalez JN, Vargas-Villarreal J, Verde-Star MJ, Rivas-Morales C, Oranday-Cardenas C, Oranday-Cardenas A, Hernandez-Garcia ME, Garza-Salinas LDL, Gonzalez-Salazar FG. Antiprotozoal activity of Thymus vulgaris methanol extract and its fractions. Health. 2017; 9: 1081-1094.
  • [22] Behnia M, Haghighi A, Komeylizadeh H, Seyyed Tabaei SJ, Abadi A. Inhibitory effects of Iranian Thymus vulgaris extracts on in vitro growth of Entamoeba histolytica. Korean J Parasitol. 2008; 46(3): 153-156. [CrossRef]
  • [23] Ezz Eldin HM, Badawy AF. In vitro anti-Trichomonas vaginalis activity of Pistacia lentiscus mastic and Ocimum basilicum essential oil. J Parasit Dis. 2015; 39: 465–473.
  • [24] Yousefi M, Taghipur S, Arefkhah N, Rahimian R, Davoudian A, Rafeiean M, Darani HY. In-vitro effect of Mentha piperita and Salvia officinalis extracts on Trichomonas vaginalis. J Isfahan Med Sch. 2013; 31: 811–818.
  • [25] Moon T, Wilkinson JM, Cavanagh HM. Antiparasitic activity of two Lavandula essential oils against Giardia duodenalis, Trichomonas vaginalis and Hexamita inflata. Parasitol Res. 2006; 99: 722–728.
  • [26] Zheng LL, Cui Y, Qin YH, Ren YX, Liu X, Tao L, Dai XD. Effect of Mosla chinensis Maxim on Trichomonas vaginalis in vitro. J Dalian Med Univ. 2009; 3: 282–285.
  • [27] Camacho-Corona MD, Garcia A, Mata-Cardenas BD, Garza-Gonzalez E, Ibarra-Alvarado C, Rojas-Molina A, Rojas-Molina I, Bah M, Sanchez MAZ, Gutierrez SP. Screening for antibacterial and antiprotozoal activities of crude extracts derived from Mexican medicinal plants. Afr J Tradit Complement Alt Med. 2015; 12: 104–112.
  • [28] Ozbilgin A, Durmuşkahya C, Kayalar H, Ertabaklar H, Gunduz C, Ostan Ural I, Zeyrek F, Kurt O, Çavuş İ, Balcıoğlu C, Toz SO, Ozbel Y. Antileishmanial activity of selected Turkish medicinal plants. Trop J Pharm Res. 2014; 13(12): 2047–2055.
  • [29] Calzada F, Yepez-Mulia L, Tapia-Contreras A, Bautista E, Maldonado E, Ortega A. Evaluation of the antiprotozoal activity of neo-clerodane type diterpenes from Salvia polystachya against Entamoeba histolytica and Giardia lamblia. Phytother Res. 2010; 24: 662–665.
  • [30] Tabefam M, Farimani MM, Danton O, Ramseyer J, Ebrahimi SN, Neuburger M, Kaise M, Salehi P, Potterat O, Hamburger M. Antiprotozoal isoprenoids from Salvia hydrangea. J Nat Prod. 2018; 81: 2682–2691. [CrossRef]
  • [31] Ebrahimi SN, Zimmermann S, Zaugg J, Smiesko M, Brun R, Hamburger M. Abietane diterpenoids from Salvia sahendica – Antiprotozoal activity and determination of their absolute configurations. Planta Med. 2013; 79: 150–156.
  • [32] Tasdemir D, Brun R, Perozzo R, Dönmez AA. Evaluation of antiprotozoal and plasmodial enoyl-ACP reductase inhibition potential of Turkish medicinal plants. Phytother Res. 2005; 19: 162–166.
  • [33] Ozbilgin A, Çavus I, Yıldırım A, Kaya T, Ertabaklar H. Evaluation of in vitro and in vivo drug efficacy over Leishmania tropica: A pilot study. Türkiye Parazitol Derg. 2018; 42(1): 11–19.
Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmakognozi
Bölüm Articles
Yazarlar

Burcu Sümer Tüzün

Tuğçe Fafal

Evren Tileklioglu

Hatice Ertabaklar

Bijen Kıvçak

Yayımlanma Tarihi 28 Haziran 2025
Yayımlandığı Sayı Yıl 2022 Cilt: 26 Sayı: 6

Kaynak Göster

APA Sümer Tüzün, B., Fafal, T., Tileklioglu, E., Ertabaklar, H., vd. (2025). Anti-Trichomonas vaginalis activities of some Lamiaceae plants. Journal of Research in Pharmacy, 26(6), 1789-1795. https://doi.org/10.29228/jrp.269
AMA Sümer Tüzün B, Fafal T, Tileklioglu E, Ertabaklar H, Kıvçak B. Anti-Trichomonas vaginalis activities of some Lamiaceae plants. J. Res. Pharm. Haziran 2025;26(6):1789-1795. doi:10.29228/jrp.269
Chicago Sümer Tüzün, Burcu, Tuğçe Fafal, Evren Tileklioglu, Hatice Ertabaklar, ve Bijen Kıvçak. “Anti-Trichomonas Vaginalis Activities of Some Lamiaceae Plants”. Journal of Research in Pharmacy 26, sy. 6 (Haziran 2025): 1789-95. https://doi.org/10.29228/jrp.269.
EndNote Sümer Tüzün B, Fafal T, Tileklioglu E, Ertabaklar H, Kıvçak B (01 Haziran 2025) Anti-Trichomonas vaginalis activities of some Lamiaceae plants. Journal of Research in Pharmacy 26 6 1789–1795.
IEEE B. Sümer Tüzün, T. Fafal, E. Tileklioglu, H. Ertabaklar, ve B. Kıvçak, “Anti-Trichomonas vaginalis activities of some Lamiaceae plants”, J. Res. Pharm., c. 26, sy. 6, ss. 1789–1795, 2025, doi: 10.29228/jrp.269.
ISNAD Sümer Tüzün, Burcu vd. “Anti-Trichomonas Vaginalis Activities of Some Lamiaceae Plants”. Journal of Research in Pharmacy 26/6 (Haziran 2025), 1789-1795. https://doi.org/10.29228/jrp.269.
JAMA Sümer Tüzün B, Fafal T, Tileklioglu E, Ertabaklar H, Kıvçak B. Anti-Trichomonas vaginalis activities of some Lamiaceae plants. J. Res. Pharm. 2025;26:1789–1795.
MLA Sümer Tüzün, Burcu vd. “Anti-Trichomonas Vaginalis Activities of Some Lamiaceae Plants”. Journal of Research in Pharmacy, c. 26, sy. 6, 2025, ss. 1789-95, doi:10.29228/jrp.269.
Vancouver Sümer Tüzün B, Fafal T, Tileklioglu E, Ertabaklar H, Kıvçak B. Anti-Trichomonas vaginalis activities of some Lamiaceae plants. J. Res. Pharm. 2025;26(6):1789-95.