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Yıl 2022, Cilt: 26 Sayı: 6, 1842 - 1856, 28.06.2025

Ramachandran Valavan Harsha Kharkwal Satyendra Kumar Rajput Robert Hoerr Subhash Chander

https://doi.org/10.29228/jrp.274

Öz

Kaynakça

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Aqueous-ethanolic extracts of Curcuma longa and Withania somnifera improve memory in the dementia model

Yıl 2022, Cilt: 26 Sayı: 6, 1842 - 1856, 28.06.2025

Ramachandran Valavan Harsha Kharkwal Satyendra Kumar Rajput Robert Hoerr Subhash Chander

https://doi.org/10.29228/jrp.274

Öz

Dementia involves impairment in cognitive and behavioral abilities, which leads to disability and dependency, particularly among older people. Alzheimer's disease is the most common form of dementia. Currently, available synthetic drugs against dementia have several side effects and only give symptomatic relief without curing or reversing the pathophysiology of the disease. So, herbal drugs can be good alternatives with a good safety profile. Curcuma longa (CL) and Withania somnifera (WS) have been reported for neurological activities with individual extracts and select phytoconstituents. However, their aqueous-ethanolic extracts have not been studied in dementia models. This study aimed to find the effect of aqueous-ethanol extracts of CL rhizomes and WS roots in scopolamine-induced dementia in Swiss albino mice using behavior models; Elevated Plus Maze (EPM), Morris Water Maze (MWM) and Spontaneous Alternation (Y Maze). Further, their antioxidant activity was also studied. The findings of the study revealed that both extracts effectively antagonized the detrimental effects of Scopolamine. Comparatively, WS in the dose of 40 mg/kg exhibited more efficacy in EPM and MWM models, while CL at 40 mg/kg was found to be more effective in the Y Maze. Furthermore, both extracts showed higher effects at the dose of 40 mg/kg than 20 mg/kg. They have also exhibited antioxidant activity. It is concluded that the aqueous-ethanolic extracts of CL and WS possess antidementia and antioxidant potential like other extracts earlier reported. Their pathophysiology, synergistic effects in different combinations, and influence on the neurotransmitters need further exploration.

Anahtar Kelimeler

dementia Alzheimer's disease Curcuma longa Curcumin Withania somnifera Withanolides

Kaynakça

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  • [18] Jivad N, Rabiei Z. A review study on medicinal plants used in the treatment of learning and memory impairments. Asian Pac J Trop Biomed. 2014; 4(10): 780–789. [CrossRef]
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Toplam 87 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmakognozi
Bölüm Articles
Yazarlar

Ramachandran Valavan

Harsha Kharkwal

Satyendra Kumar Rajput

Robert Hoerr

Subhash Chander

Yayımlanma Tarihi 28 Haziran 2025
Yayımlandığı Sayı Yıl 2022 Cilt: 26 Sayı: 6

Kaynak Göster

APA Valavan, R., Kharkwal, H., Rajput, S. K., Hoerr, R., vd. (2025). Aqueous-ethanolic extracts of Curcuma longa and Withania somnifera improve memory in the dementia model. Journal of Research in Pharmacy, 26(6), 1842-1856. https://doi.org/10.29228/jrp.274
AMA Valavan R, Kharkwal H, Rajput SK, Hoerr R, Chander S. Aqueous-ethanolic extracts of Curcuma longa and Withania somnifera improve memory in the dementia model. J. Res. Pharm. Haziran 2025;26(6):1842-1856. doi:10.29228/jrp.274
Chicago Valavan, Ramachandran, Harsha Kharkwal, Satyendra Kumar Rajput, Robert Hoerr, ve Subhash Chander. “Aqueous-Ethanolic Extracts of Curcuma Longa and Withania Somnifera Improve Memory in the Dementia Model”. Journal of Research in Pharmacy 26, sy. 6 (Haziran 2025): 1842-56. https://doi.org/10.29228/jrp.274.
EndNote Valavan R, Kharkwal H, Rajput SK, Hoerr R, Chander S (01 Haziran 2025) Aqueous-ethanolic extracts of Curcuma longa and Withania somnifera improve memory in the dementia model. Journal of Research in Pharmacy 26 6 1842–1856.
IEEE R. Valavan, H. Kharkwal, S. K. Rajput, R. Hoerr, ve S. Chander, “Aqueous-ethanolic extracts of Curcuma longa and Withania somnifera improve memory in the dementia model”, J. Res. Pharm., c. 26, sy. 6, ss. 1842–1856, 2025, doi: 10.29228/jrp.274.
ISNAD Valavan, Ramachandran vd. “Aqueous-Ethanolic Extracts of Curcuma Longa and Withania Somnifera Improve Memory in the Dementia Model”. Journal of Research in Pharmacy 26/6 (Haziran 2025), 1842-1856. https://doi.org/10.29228/jrp.274.
JAMA Valavan R, Kharkwal H, Rajput SK, Hoerr R, Chander S. Aqueous-ethanolic extracts of Curcuma longa and Withania somnifera improve memory in the dementia model. J. Res. Pharm. 2025;26:1842–1856.
MLA Valavan, Ramachandran vd. “Aqueous-Ethanolic Extracts of Curcuma Longa and Withania Somnifera Improve Memory in the Dementia Model”. Journal of Research in Pharmacy, c. 26, sy. 6, 2025, ss. 1842-56, doi:10.29228/jrp.274.
Vancouver Valavan R, Kharkwal H, Rajput SK, Hoerr R, Chander S. Aqueous-ethanolic extracts of Curcuma longa and Withania somnifera improve memory in the dementia model. J. Res. Pharm. 2025;26(6):1842-56.