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Yıl 2022, Cilt: 26 Sayı: 6, 1857 - 1867, 28.06.2025

Dicki Bakhtiar Purkon Mimin Kusmiyati Elvi Trinovani Faizah Min Fadhlillah Widyastiwi Widyastiwi Mohammad Roseno , Erick Khristian Ainun Nadhifah

https://doi.org/10.29228/jrp.275

Öz

Kaynakça

  • [1] Zulkarnain Z, Novianto F, Saryanto S. Phase II clinical trial of jamu for hepatoprotector (article in Indonesian with an abstract in English). Buletin Penelitian Kesehatan. 2017; 45: 125–136. [CrossRef]
  • [2] Yuvaraja KR, Santhiagu A, Jasemine S, Gopalasatheeskumar K. Hepatoprotective activity of Ehretia microphylla on paracetamol-induced liver toxic rats. Marmara Pharm J. 2021; 25(1): 89–98. [CrossRef]
  • [3] Asrani SK, Devarbhavi H, Eaton J, Kamath PS. Burden of liver diseases in the world. J Hepatol. 2019; 70(1): 151–171. [CrossRef]
  • [4] WHO. WHO methods and data sources for country-level causes of death 2000–2016. Department of Information, Evidence, and Research WHO, Geneva, 2018.
  • [5] Amarapurkar DN, Hashimoto E, Lesmana LA, Sollano JD, Chen PJ, Goh KL. How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences? J Gastroenterol Hepatol. 2007; 22: 788–793. [CrossRef]
  • [6] Uroko R, Nwuke C, Agbafor A, Okwor J. Evaluation of in vitro antioxidants activities, hepatoprotective and haematological effects of ethanol extract of Anthocleista vogelii stem bark (AVSB) on carbon tetrachloride (CCl4)-induced rats. Marmara Pharm J. 2021; 25(3): 258–270. [CrossRef]
  • [7] Indahsari NK, Masfufatun M, Devi EDR. Potensi ekstrak daun kelor (Moringa oleifera) sebagai hepatoprotektor pada tikus putih (Rattus novergicus) yang diinduksi parasetamol dosis toksik. Jurnal Ilmiah Kedokteran Wijaya Kusuma. 2018; 5: 58–66. [CrossRef]
  • [8] Toklu H, Şehirli Ö, Şahin H, Çetinel Ş, Yeǧen BC, Şener G. Resveratrol supplementation protects against chronic nicotine-induced oxidative damage and organ dysfunction in the rat urogenital system. Marmara Pharm J. 2010; 14(1): 29–40. [CrossRef]
  • [9] Adewusi EA, Afolayan AJ. A review of natural products with hepatoprotective activity. J Med Plants Res. 2010; 4: 1318–1334.
  • [10] Susilawati E, Lister INE, Fachrial E. The protective effect of Phyllanthus emblica Linn. extract against doxorubicin-induced hepatotoxicity in rats. Pharmaciana. 2021; 11(1): 153–162. [CrossRef]
  • [11] Yayintas OT, İrkin LC. Bryophytes as hidden treasure. Journal of Scientific Perspectives. 2018; 2(1): 71–83. [CrossRef]
  • [12] Fadhilla R, Iskandar EA, Kusumaningrum D. Antibacterial activity of liverwort (Marchantia paleacea) extract on pathogenic and food spoilage bacteria (article in Indonesian with an abstract in English). Jurnal Teknologi dan Industri Pangan. 2012; 23(2): 126–131. [CrossRef]
  • [13] Zhang K, Cao H, Gao Y, et al. Marchantia polymorpha L. flavonoids protect liver from CCl4-induced injury by antioxidant and gene-regulatory effects. Altern Ther Health Med. 2022; 28: 34–41.
  • [14] Jian-bo X, Feng-lian R, Xu M. Anti-hepatitis B virus activity of flavonoids from Marchantia convoluta. Iranian Journal of Pharmacology and Therapeutics. 2005; 4(2): 128–131.
  • [15] Hasballah K, Sarong M, Rusly R, et al. Acute toxicity and hepatotoxicity evaluation of methanol extract of root bark of Calotropis gigantea in rats. Dhaka Univ J Pharm Sci. 2018; 17(2): 243–250. [CrossRef]
  • [16] Handayani S, Wirasutisna KR, Insanu M. Penapisan fitokimia dan karakterisasi simplisia daun jambu mawar (Syzygium jambos Alston). Jurnal Farmasi UIN Alauddin Makassar. 2017; 5(3): 174–179.
  • [17] Kurniawan JC, Suryanto E, Yudistira A. Analisis fitokimia dan uji aktivitas antioksidan dari getah kulit buah pisang goroho (Musa acuminate (L.)). Pharmacon. 2013; 2(3): 34–39.
  • [18] Wang L, Wang LN, Zhao Y, Lou HX, Cheng AX. Secondary metabolites from Marchantia paleacea calluses and their allelopathic effects on Arabidopsis seed growth. Nat Prod Res. 2013; 27(3): 274–276. [CrossRef]
  • [19] Asakawa Y. Liverworts—potential source of medicinal compounds. Curr Pharm Des. 2008; 14: 3067–3088. [CrossRef]
  • [20] Xiao J, Jiang X, Chen X. Antibacterial, anti-inflammatory, and diuretic effect of flavonoids from Marchantia convoluta. Afr J Tradit Complement Altern Med. 2005; 2(3): 244–252.
  • [21] Novianto A. Hepatoprotector activity ethyl acetate fraction of kenikir (Cosmos caudatus) on rat induced by paracetamol (article in Indonesian with an abstract in English). Indonesian Journal on Medical Science. 2016; 3(1): 35–41.
  • [22] Food and Drug Administration of Indonesia. Description of Curcuma FCT drug product. https://cekbpom.pom.go.id//home/produk/kdfq3nls24aa7v9vfqkld51ft7/all/row/10/page/1/order/4/DESC/search/1/Curcuma%20FCT (accessed June 9, 2022).
  • [23] Asri M, Kalsum K. Hepatoprotector test of fruit (Solanum muricatum) ethanol extract against male white rats induced by CCl4 (article in Indonesian with an abstract in English). Media Kesehatan Politeknik Kesehatan Makassar. 2021; 16(1): 167–172.
  • [24] Hariyanti LPD, Wardhana AANW, Indriyani NKS, Putri IAPY. Pengaruh pemberian ekstrak etanol daun binahong (Anredera scandens (L.) Moq.) terhadap histopatologi hati mencit jantan galur Balb/c yang diinduksi dengan karbon tetraklorida. Jurnal Farmasi Udayana. 2017; 6(1): 39–42. [CrossRef]
  • [25] Suriani S, Firawati F, Pertiwi S. Uji aktivitas hepatoprotektor ekstrak kubis ungu (Brassica oleracea var. Capitata L.) terhadap hewan uji kelinci (Oryctolagus cuniculus) yang diinduksi karbon tetraklorida (CCl4). Jurnal Farmasi UIN Alauddin Makassar. 2013; 7(1): 17–25.
  • [26] Liem S, Levita J. Review of hepatoprotector of rosela (Hibiscus sabdariffa): activity, mechanism of action, and toxicity. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy). 2017; 3(2): 103–117. [CrossRef]
  • [27] Freitag AF, Cardia GFE, Da Rocha BA, Aguiar RP, Silva-Comar FMDS, Spironello RA, Grespan R, Caparros-Assef SM, Bersani-Amado CA, Cuman RKN. Hepatoprotective effect of silymarin (Silybum marianum) on hepatotoxicity induced by acetaminophen in spontaneously hypertensive rats. Evid Based Complement Alternat Med. 2015; 2015: 1–8. [CrossRef]
  • [28] Olaleye MT, Akinmoladun AC, Ogunboye AA, Akindahunsi AA. Antioxidant activity and hepatoprotective property of leaf extracts of Boerhaavia diffusa Linn against acetaminophen-induced liver damage in rats. Food Chem Toxicol. 2010; 48(8-9): 2200–2205. [CrossRef]
  • [29] Seif HSA. Physiological changes due to hepatotoxicity and the protective role of some medicinal plants. Beni Suef Univ J Basic Appl Sci. 2016; 2016: 1–13. [CrossRef]
  • [30] Chaphalkar R, Apte KG, Talekar Y, Ojha SK, Nandave M. Antioxidants of Phyllanthus emblica L. bark extract provide hepatoprotection against ethanol-induced hepatic damage: A comparison with silymarin. Oxid Med Cell Longev. 2017; 2017: 1–10. [CrossRef]
  • [31] Sabri E, Ilyas S, Prasetiawan E. The effect of n-hexane extract of andaliman (Zanthoxylum acanthopodium DC.) fruit in the liver tissues of mice during post implantation of pregnancy. J Phys Conf Ser. 2018; 1116(5): 1–5. [CrossRef]
  • [32] Ilyas S, Tanjung M, Nurwahyuni I, Pasaribu FY. Effect of Phaleria macrocarpa ethanolic extracts to hepar histology of female rat (Rattus norvegicus) in preeclampsia. IOP Conf Ser Earth Environ Sci. 2019; 305(1): 1–8. [CrossRef]
  • [33] Luedde T, Kaplowitz N, Schwabe RF. Cell death and cell death responses in liver disease: Mechanisms and clinical relevance. Gastroenterology. 2014; 147(4): 765–783. [CrossRef]
  • [34] Gökbulut A, Satilmiş B, Batçioğlu K, Çetin B, Şarer E. Antioxidant activity and luteolin content of Marchantia polymorpha L. Turk J Biol. 2012; 36: 381–385. [CrossRef]
  • [35] Sinam G, Sahu V, Pandey N, Asthana AK. Effect of arsenic on biochemical and antioxidant enzymes in two species of Marchantia L. (Marchantiophyta): Role of enzymes in stress acclimatization. J Environ Agric Sci. 2016; 8: 79–85.
  • [36] Qian D, Florenly F, Liena L, Purba DR. Effectiveness of ethanol extract of mangosteen peel (Garcinia mangostana L.) in accelerating post-tooth extraction healing in Wistar rats. Budapest Int Res Exact Sci (BirEx) J. 2021; 4(1): 22–30. [CrossRef]
  • [37] Şehirli Ö, Şener G. Protective effect of erdosteine against naphthalene-induced oxidative stress in rats. Marmara Pharm J. 2010; 14(2): 67–73. [CrossRef]
  • [38] Oktavia S, Ifora I, Suhatri S, Susanti M. Uji aktivitas hepatoprotektor ekstrak daun sirih hijau (Piper betle Linn.) terhadap kerusakan hati yang diinduksi parasetamol. Jurnal Farmasi Higea. 2017; 9(2): 109–117.
  • [39] Adyttia A, Untari EK, Wahdaningsih S. Efek ekstrak etanol daun Premna cordifolia terhadap malondialdehida tikus yang dipapar asap rokok. Pharm Sci Res. 2014; 1(2): 104–115. [CrossRef]
  • [40] Sebayang R, Idawati Y, Sinaga H. Analisis lactat dehydrogenase dalam serum darah menggunakan sentrifugasi. J Keperawatan Silampari. 2020; 4(1): 274–280.
  • [41] Rahman S, Kosman R, Siamea AC. Efek hepatoprotektor dari ekstrak etanol daun johar (Cassia siamea Lamk.) pada tikus (Rattus norvegicus). J Ilmiah As-Syifaa. 2017; 9(2): 131–136.
  • [42] Wahidah LK, Triyandi R, Indriani R. Fraksi air daun ubi jalar (Ipomea batatas (L.) Lam.) sebagai hepatoprotektor terhadap tikus putih jantan yang diinduksi paracetamol. Jurnal Farmasi Lampung. 2019; 8(1): 39–46. [CrossRef]

The hepatoprotective effect of Marchantia paleacea bertol. extract against acetaminophen-induced liver damage in rat: biochemical and histological evidence

Yıl 2022, Cilt: 26 Sayı: 6, 1857 - 1867, 28.06.2025

Dicki Bakhtiar Purkon Mimin Kusmiyati Elvi Trinovani Faizah Min Fadhlillah Widyastiwi Widyastiwi Mohammad Roseno , Erick Khristian Ainun Nadhifah

https://doi.org/10.29228/jrp.275

Öz

Hepatoprotectors are compounds or substances that have efficacy to protect liver cells against toxic substances result in liver damage. Liver damage caused by various factors, such as: viruses, bacteria, drugs that directly damage liver cells (such as acetaminophen, etc.), hypersensitivity reactions, hepatotoxic chemicals, toxins in food and pollution. Therefore, the development of the drug is still being tested to obtain more satisfactory results in terms of efficacy and the minimal side effects it causes. Until now, there has been no research on the hepatoprotector effect of the liverwort herbs ethanol extract of Marchantia paleacea Bertol. in a hepatotoxic-induced test animal model, especially with acetaminophen in rats. This study aimed to examine the potential hepatoprotector of the herbal liverworts extract of Marchantia paleacea Bertol. compare to Curcuma FCT®. The hepatoprotector effect was determined by examining the biochemical levels of SGPT and SGOT, the percentage of liver index (% w/w) and histopathological feature of the liver. The increase in SGPT and SGOT levels in the liver tissue induced by acetaminophen to prove the toxicity of the liver tissue caused by acetaminophen. Marchantia paleacea Bertol ethanol extract with doses of 26 and 104 mg/kg bw in the measurement of serum levels of SGPT, SGOT, and liver index (% w/w) has shown decreased serum levels of SGPT, SGOT, and liver index (% w/w). In addition, the histological examination for scoring liver cell repair using the Manja Roenigk Histopathology Scoring Model method has shown a repair score for acetaminophen-induced liver tissue damage at both doses of the test extract (26 and 104 mg/kg bw). These findings suggest that 26 and 104 mg/kg bw have a potential protective effect on liver function against hepatotoxicity in rat livers. Thus, Marchantia paleacea Bertol. liverwort herb has great potential as a nutraceutical product, supplement, or traditional medicine that has hepatoprotective therapeutic efficacy.

Anahtar Kelimeler

Marchantia paleacea Bertol. acetaminophen-induced hepatoprotective SGPT and SGOT liver histology

Kaynakça

  • [1] Zulkarnain Z, Novianto F, Saryanto S. Phase II clinical trial of jamu for hepatoprotector (article in Indonesian with an abstract in English). Buletin Penelitian Kesehatan. 2017; 45: 125–136. [CrossRef]
  • [2] Yuvaraja KR, Santhiagu A, Jasemine S, Gopalasatheeskumar K. Hepatoprotective activity of Ehretia microphylla on paracetamol-induced liver toxic rats. Marmara Pharm J. 2021; 25(1): 89–98. [CrossRef]
  • [3] Asrani SK, Devarbhavi H, Eaton J, Kamath PS. Burden of liver diseases in the world. J Hepatol. 2019; 70(1): 151–171. [CrossRef]
  • [4] WHO. WHO methods and data sources for country-level causes of death 2000–2016. Department of Information, Evidence, and Research WHO, Geneva, 2018.
  • [5] Amarapurkar DN, Hashimoto E, Lesmana LA, Sollano JD, Chen PJ, Goh KL. How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences? J Gastroenterol Hepatol. 2007; 22: 788–793. [CrossRef]
  • [6] Uroko R, Nwuke C, Agbafor A, Okwor J. Evaluation of in vitro antioxidants activities, hepatoprotective and haematological effects of ethanol extract of Anthocleista vogelii stem bark (AVSB) on carbon tetrachloride (CCl4)-induced rats. Marmara Pharm J. 2021; 25(3): 258–270. [CrossRef]
  • [7] Indahsari NK, Masfufatun M, Devi EDR. Potensi ekstrak daun kelor (Moringa oleifera) sebagai hepatoprotektor pada tikus putih (Rattus novergicus) yang diinduksi parasetamol dosis toksik. Jurnal Ilmiah Kedokteran Wijaya Kusuma. 2018; 5: 58–66. [CrossRef]
  • [8] Toklu H, Şehirli Ö, Şahin H, Çetinel Ş, Yeǧen BC, Şener G. Resveratrol supplementation protects against chronic nicotine-induced oxidative damage and organ dysfunction in the rat urogenital system. Marmara Pharm J. 2010; 14(1): 29–40. [CrossRef]
  • [9] Adewusi EA, Afolayan AJ. A review of natural products with hepatoprotective activity. J Med Plants Res. 2010; 4: 1318–1334.
  • [10] Susilawati E, Lister INE, Fachrial E. The protective effect of Phyllanthus emblica Linn. extract against doxorubicin-induced hepatotoxicity in rats. Pharmaciana. 2021; 11(1): 153–162. [CrossRef]
  • [11] Yayintas OT, İrkin LC. Bryophytes as hidden treasure. Journal of Scientific Perspectives. 2018; 2(1): 71–83. [CrossRef]
  • [12] Fadhilla R, Iskandar EA, Kusumaningrum D. Antibacterial activity of liverwort (Marchantia paleacea) extract on pathogenic and food spoilage bacteria (article in Indonesian with an abstract in English). Jurnal Teknologi dan Industri Pangan. 2012; 23(2): 126–131. [CrossRef]
  • [13] Zhang K, Cao H, Gao Y, et al. Marchantia polymorpha L. flavonoids protect liver from CCl4-induced injury by antioxidant and gene-regulatory effects. Altern Ther Health Med. 2022; 28: 34–41.
  • [14] Jian-bo X, Feng-lian R, Xu M. Anti-hepatitis B virus activity of flavonoids from Marchantia convoluta. Iranian Journal of Pharmacology and Therapeutics. 2005; 4(2): 128–131.
  • [15] Hasballah K, Sarong M, Rusly R, et al. Acute toxicity and hepatotoxicity evaluation of methanol extract of root bark of Calotropis gigantea in rats. Dhaka Univ J Pharm Sci. 2018; 17(2): 243–250. [CrossRef]
  • [16] Handayani S, Wirasutisna KR, Insanu M. Penapisan fitokimia dan karakterisasi simplisia daun jambu mawar (Syzygium jambos Alston). Jurnal Farmasi UIN Alauddin Makassar. 2017; 5(3): 174–179.
  • [17] Kurniawan JC, Suryanto E, Yudistira A. Analisis fitokimia dan uji aktivitas antioksidan dari getah kulit buah pisang goroho (Musa acuminate (L.)). Pharmacon. 2013; 2(3): 34–39.
  • [18] Wang L, Wang LN, Zhao Y, Lou HX, Cheng AX. Secondary metabolites from Marchantia paleacea calluses and their allelopathic effects on Arabidopsis seed growth. Nat Prod Res. 2013; 27(3): 274–276. [CrossRef]
  • [19] Asakawa Y. Liverworts—potential source of medicinal compounds. Curr Pharm Des. 2008; 14: 3067–3088. [CrossRef]
  • [20] Xiao J, Jiang X, Chen X. Antibacterial, anti-inflammatory, and diuretic effect of flavonoids from Marchantia convoluta. Afr J Tradit Complement Altern Med. 2005; 2(3): 244–252.
  • [21] Novianto A. Hepatoprotector activity ethyl acetate fraction of kenikir (Cosmos caudatus) on rat induced by paracetamol (article in Indonesian with an abstract in English). Indonesian Journal on Medical Science. 2016; 3(1): 35–41.
  • [22] Food and Drug Administration of Indonesia. Description of Curcuma FCT drug product. https://cekbpom.pom.go.id//home/produk/kdfq3nls24aa7v9vfqkld51ft7/all/row/10/page/1/order/4/DESC/search/1/Curcuma%20FCT (accessed June 9, 2022).
  • [23] Asri M, Kalsum K. Hepatoprotector test of fruit (Solanum muricatum) ethanol extract against male white rats induced by CCl4 (article in Indonesian with an abstract in English). Media Kesehatan Politeknik Kesehatan Makassar. 2021; 16(1): 167–172.
  • [24] Hariyanti LPD, Wardhana AANW, Indriyani NKS, Putri IAPY. Pengaruh pemberian ekstrak etanol daun binahong (Anredera scandens (L.) Moq.) terhadap histopatologi hati mencit jantan galur Balb/c yang diinduksi dengan karbon tetraklorida. Jurnal Farmasi Udayana. 2017; 6(1): 39–42. [CrossRef]
  • [25] Suriani S, Firawati F, Pertiwi S. Uji aktivitas hepatoprotektor ekstrak kubis ungu (Brassica oleracea var. Capitata L.) terhadap hewan uji kelinci (Oryctolagus cuniculus) yang diinduksi karbon tetraklorida (CCl4). Jurnal Farmasi UIN Alauddin Makassar. 2013; 7(1): 17–25.
  • [26] Liem S, Levita J. Review of hepatoprotector of rosela (Hibiscus sabdariffa): activity, mechanism of action, and toxicity. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy). 2017; 3(2): 103–117. [CrossRef]
  • [27] Freitag AF, Cardia GFE, Da Rocha BA, Aguiar RP, Silva-Comar FMDS, Spironello RA, Grespan R, Caparros-Assef SM, Bersani-Amado CA, Cuman RKN. Hepatoprotective effect of silymarin (Silybum marianum) on hepatotoxicity induced by acetaminophen in spontaneously hypertensive rats. Evid Based Complement Alternat Med. 2015; 2015: 1–8. [CrossRef]
  • [28] Olaleye MT, Akinmoladun AC, Ogunboye AA, Akindahunsi AA. Antioxidant activity and hepatoprotective property of leaf extracts of Boerhaavia diffusa Linn against acetaminophen-induced liver damage in rats. Food Chem Toxicol. 2010; 48(8-9): 2200–2205. [CrossRef]
  • [29] Seif HSA. Physiological changes due to hepatotoxicity and the protective role of some medicinal plants. Beni Suef Univ J Basic Appl Sci. 2016; 2016: 1–13. [CrossRef]
  • [30] Chaphalkar R, Apte KG, Talekar Y, Ojha SK, Nandave M. Antioxidants of Phyllanthus emblica L. bark extract provide hepatoprotection against ethanol-induced hepatic damage: A comparison with silymarin. Oxid Med Cell Longev. 2017; 2017: 1–10. [CrossRef]
  • [31] Sabri E, Ilyas S, Prasetiawan E. The effect of n-hexane extract of andaliman (Zanthoxylum acanthopodium DC.) fruit in the liver tissues of mice during post implantation of pregnancy. J Phys Conf Ser. 2018; 1116(5): 1–5. [CrossRef]
  • [32] Ilyas S, Tanjung M, Nurwahyuni I, Pasaribu FY. Effect of Phaleria macrocarpa ethanolic extracts to hepar histology of female rat (Rattus norvegicus) in preeclampsia. IOP Conf Ser Earth Environ Sci. 2019; 305(1): 1–8. [CrossRef]
  • [33] Luedde T, Kaplowitz N, Schwabe RF. Cell death and cell death responses in liver disease: Mechanisms and clinical relevance. Gastroenterology. 2014; 147(4): 765–783. [CrossRef]
  • [34] Gökbulut A, Satilmiş B, Batçioğlu K, Çetin B, Şarer E. Antioxidant activity and luteolin content of Marchantia polymorpha L. Turk J Biol. 2012; 36: 381–385. [CrossRef]
  • [35] Sinam G, Sahu V, Pandey N, Asthana AK. Effect of arsenic on biochemical and antioxidant enzymes in two species of Marchantia L. (Marchantiophyta): Role of enzymes in stress acclimatization. J Environ Agric Sci. 2016; 8: 79–85.
  • [36] Qian D, Florenly F, Liena L, Purba DR. Effectiveness of ethanol extract of mangosteen peel (Garcinia mangostana L.) in accelerating post-tooth extraction healing in Wistar rats. Budapest Int Res Exact Sci (BirEx) J. 2021; 4(1): 22–30. [CrossRef]
  • [37] Şehirli Ö, Şener G. Protective effect of erdosteine against naphthalene-induced oxidative stress in rats. Marmara Pharm J. 2010; 14(2): 67–73. [CrossRef]
  • [38] Oktavia S, Ifora I, Suhatri S, Susanti M. Uji aktivitas hepatoprotektor ekstrak daun sirih hijau (Piper betle Linn.) terhadap kerusakan hati yang diinduksi parasetamol. Jurnal Farmasi Higea. 2017; 9(2): 109–117.
  • [39] Adyttia A, Untari EK, Wahdaningsih S. Efek ekstrak etanol daun Premna cordifolia terhadap malondialdehida tikus yang dipapar asap rokok. Pharm Sci Res. 2014; 1(2): 104–115. [CrossRef]
  • [40] Sebayang R, Idawati Y, Sinaga H. Analisis lactat dehydrogenase dalam serum darah menggunakan sentrifugasi. J Keperawatan Silampari. 2020; 4(1): 274–280.
  • [41] Rahman S, Kosman R, Siamea AC. Efek hepatoprotektor dari ekstrak etanol daun johar (Cassia siamea Lamk.) pada tikus (Rattus norvegicus). J Ilmiah As-Syifaa. 2017; 9(2): 131–136.
  • [42] Wahidah LK, Triyandi R, Indriani R. Fraksi air daun ubi jalar (Ipomea batatas (L.) Lam.) sebagai hepatoprotektor terhadap tikus putih jantan yang diinduksi paracetamol. Jurnal Farmasi Lampung. 2019; 8(1): 39–46. [CrossRef]
Toplam 42 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmakognozi
Bölüm Articles
Yazarlar

Dicki Bakhtiar Purkon

Mimin Kusmiyati

Elvi Trinovani

Faizah Min Fadhlillah

Widyastiwi Widyastiwi

Mohammad Roseno

Erick Khristian

Ainun Nadhifah

Yayımlanma Tarihi 28 Haziran 2025
Yayımlandığı Sayı Yıl 2022 Cilt: 26 Sayı: 6

Kaynak Göster

APA Purkon, D. B., Kusmiyati, M., Trinovani, E., Fadhlillah, F. M., vd. (2025). The hepatoprotective effect of Marchantia paleacea bertol. extract against acetaminophen-induced liver damage in rat: biochemical and histological evidence. Journal of Research in Pharmacy, 26(6), 1857-1867. https://doi.org/10.29228/jrp.275
AMA Purkon DB, Kusmiyati M, Trinovani E, Fadhlillah FM, Widyastiwi W, Roseno M, Khristian E, Nadhifah A. The hepatoprotective effect of Marchantia paleacea bertol. extract against acetaminophen-induced liver damage in rat: biochemical and histological evidence. J. Res. Pharm. Haziran 2025;26(6):1857-1867. doi:10.29228/jrp.275
Chicago Purkon, Dicki Bakhtiar, Mimin Kusmiyati, Elvi Trinovani, Faizah Min Fadhlillah, Widyastiwi Widyastiwi, Mohammad Roseno, Erick Khristian, ve Ainun Nadhifah. “The Hepatoprotective Effect of Marchantia Paleacea Bertol. Extract Against Acetaminophen-Induced Liver Damage in Rat: Biochemical and Histological Evidence”. Journal of Research in Pharmacy 26, sy. 6 (Haziran 2025): 1857-67. https://doi.org/10.29228/jrp.275.
EndNote Purkon DB, Kusmiyati M, Trinovani E, Fadhlillah FM, Widyastiwi W, Roseno M, Khristian E, Nadhifah A (01 Haziran 2025) The hepatoprotective effect of Marchantia paleacea bertol. extract against acetaminophen-induced liver damage in rat: biochemical and histological evidence. Journal of Research in Pharmacy 26 6 1857–1867.
IEEE D. B. Purkon, M. Kusmiyati, E. Trinovani, F. M. Fadhlillah, W. Widyastiwi, M. Roseno, E. Khristian, ve A. Nadhifah, “The hepatoprotective effect of Marchantia paleacea bertol. extract against acetaminophen-induced liver damage in rat: biochemical and histological evidence”, J. Res. Pharm., c. 26, sy. 6, ss. 1857–1867, 2025, doi: 10.29228/jrp.275.
ISNAD Purkon, Dicki Bakhtiar vd. “The Hepatoprotective Effect of Marchantia Paleacea Bertol. Extract Against Acetaminophen-Induced Liver Damage in Rat: Biochemical and Histological Evidence”. Journal of Research in Pharmacy 26/6 (Haziran 2025), 1857-1867. https://doi.org/10.29228/jrp.275.
JAMA Purkon DB, Kusmiyati M, Trinovani E, Fadhlillah FM, Widyastiwi W, Roseno M, Khristian E, Nadhifah A. The hepatoprotective effect of Marchantia paleacea bertol. extract against acetaminophen-induced liver damage in rat: biochemical and histological evidence. J. Res. Pharm. 2025;26:1857–1867.
MLA Purkon, Dicki Bakhtiar vd. “The Hepatoprotective Effect of Marchantia Paleacea Bertol. Extract Against Acetaminophen-Induced Liver Damage in Rat: Biochemical and Histological Evidence”. Journal of Research in Pharmacy, c. 26, sy. 6, 2025, ss. 1857-6, doi:10.29228/jrp.275.
Vancouver Purkon DB, Kusmiyati M, Trinovani E, Fadhlillah FM, Widyastiwi W, Roseno M, Khristian E, Nadhifah A. The hepatoprotective effect of Marchantia paleacea bertol. extract against acetaminophen-induced liver damage in rat: biochemical and histological evidence. J. Res. Pharm. 2025;26(6):1857-6.