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Yıl 2021, Cilt: 25 Sayı: 2, 164 - 172, 27.06.2025

Sıla Tümen Erden Ceyda Ekentok Atıcı , Birnur Cömez Ali Demir Sezer

https://doi.org/10.29228/jrp.7

Öz

Kaynakça

  • [1] Baroli B. Hydrogels for Tissue Engineering and Delivery of Tissue-Inducing Substances. J Pharm Sci. 2007; 96(9): 2197-2223. [CrossRef]
  • [2] Mahinroosta M, Farsangi ZJ, Allahverdi A, Shakoori Z. Hydrogels as intelligent materials: a brief review of synthesis, properties and applications. Materials Today Chemistry. 2018; 8: 42-55. [CrossRef]
  • [3] Abandansari HS, Aghaghafari E, Nabid MR, Niknejad H. Preparation of injectable and thermoresponsive hydrogel based on penta-block copolymer with improved sol stability and mechanical properties. Polymer. 2013; 54(4): 1329-1340. [CrossRef]
  • [4] He F, Zhang Y, Li J, Liu S, Chi Z, Xu J. Preparation and properties of multi-responsive semi-IPN hydrogel modified magnetic nanoparticles as drug carrier. J Control Release. 2011; 152(1): e119-e121. [CrossRef]
  • [5] Epstein-Barash H, Stefanescu CF, Kohane DS. An in situ cross-linking hybrid hydrogel for controlled release of proteins. Acta Biomaterialia. 2012; 8(5): 1703-1709. [CrossRef]
  • [6] Costache MC, Qu H, Ducheyne P, Devore DI. Polymer–xerogel composites for controlled release wound dressings. Biomaterials. 2010; 31(24): 6336-6343. [CrossRef]
  • [7] Miao HQ, Elkin M, Aingorn E, Ishai‐Michaeli R, Stein CA, Vlodavsky I. Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides. Int J Cancer. 1999; 83(3): 424-431. [CrossRef]
  • [8] O’Sullivan L, Murphy B, McLoughlin P, Duggan P, Lawlor PG, Hughes H, Gardiner GE. Prebiotics from marine macroalgae for human and animal health applications. Mar Drugs. 2010; 8(7): 2038-2064. [CrossRef]
  • [9] Choi Ji, Kim HJ, Lee JW. Structural feature and antioxidant activity of low molecular weight laminarin degraded by gamma irradiation. Food Chem. 2011; 129(2): 520-523. [CrossRef]
  • [10] Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol. 2002; 60(3): 258-274. [CrossRef]
  • [11] Yadav M, Rhee KY, Jung IH, Park SJ. Eco-friendly synthesis, characterization and properties of a sodium carboxymethyl cellulose/graphene oxide nanocomposite film. Cellulose. 2013; 20: 687-698. [CrossRef]
  • [12] Sannino A, Madaghiele M, Conversano F, Mele G, Maffezzoli A, Netti P, Nicolais L Cellulose derivative-hyaluronic acid-based microporous hydrogels cross-linked through divinyl sulfone (DVS) to modulate equilibrium sorption capacity and network stability. Biomacromolecules. 2004; 5(1): 92-96. [CrossRef]
  • [13] Raith K, Kühn AV, Rosche F, Wolf R, Neubert RH Characterization of Povidone Products by Means of 13C-NMR, MALDI-TOF, and Electrospray Mass Spectrometry. Pharm Res. 2002; 19(4): 556-560. [CrossRef]
  • [14] Zhao L, Xu L, Mitomo H, Yoshii F. Synthesis of pH-sensitive PVP/CM-chitosan hydrogels with improved surface property by irradiation. Carbohydr Polym. 2006; 64(3): 473-480. [CrossRef]
  • [15] Roy N, Saha N, Kitano T, Saha P. Novel hydrogels of PVP–CMC and their swelling effect on viscoelastic properties. J Appl Polym Sci 2010; 117(3): 1703-1710. [CrossRef]
  • [16] Kamaruddin, Edikresnha D, Sriyanti I, Munir MM, Khairurrijal. Synthesis of Polyvinylpyrrolidone (PVP)-Green Tea Extract Composite Nanostructures using Electrohydrodynamic Spraying Technique. IOP Conf. Ser.: Mater. Sci.Eng. 2017; 202 (012043):1-7. [CrossRef]
  • [17] Safo A, Werheid M, Dosche C, Oezaslan M. The role of polyvinylpyrrolidone (PVP) as a capping and structure-directing agent in the formation of Pt nanocubes. Nanoscale Adv. 2019; 1: 3095-3106. [CrossRef]
  • [18] Sunardi, Febriani NM, Junaidi AB. Preparation of carboxymethyl cellulose produced from purun tikus (Eleocharis dulcis). AIP Conf Proc. 2017; 1868 (020008): 1-8. [CrossRef]
  • [19] Kadry G. Comparison between gelatin/carboxymethyl cellulose and gelatin/ carboxymethyl nanocellulose in tramadol drug loaded capsule. Heliyon. 2019; 5 (9): e02404 1-10. [CrossRef]
  • [20] Ji CF, Ji YB, Meng DY. Sulfated modification and anti-tumor activity of laminarin. Exp Ther Med. 2013; 6(5): 1259-1264. [CrossRef]
  • [21] Rajauria G, Ravindran R, Garcia-Vaquero M, Rai DK, Sweeney T, O’Doherty J. Molecular characteristics and antioxidant activity of laminarin extracted from the seaweed species Laminaria hyperborea, using hydrothermal-assisted extraction and a multi-step purification procedure. Food Hydrocoll. 2021; 112: 106332 1-10. [CrossRef]
  • [22] Caló E, Khutoryanskiy VV. Biomedical applications of hydrogels: a review of patents and commercial products. Eur Polym J. 2015; 65: 252-267. [CrossRef]
  • [23] Lay-Flurrie K. The properties of hydrogel dressings and their impact on wound healing. Prof Nurse. 2004; 19(5): 269-273.
  • [24] Thomas S, Hay P. Fluid handling properties of hydrogel dressings. Ostomy Wound Manage. 1995; 41(3), 54-6, 58-9.
  • [25] Fansler RF, Taheri P, Cullinane C, Sabates B, Flint LM. Polypropylene mesh closure of the complicated abdominal wound. Am J Surg. 1995; 170(1): 15-18. [CrossRef]
  • [26] Moroney NC, O'Grady MN, Lordan S, Stanton C, Kerry JP. Seaweed Polysaccharides (Laminarin and Fucoidan) as Functional Ingredients in Pork Meat: An Evaluation of Anti-Oxidative Potential, Thermal Stability and Bioaccessibility. Mar Drugs. 2015; 13(4): 2447-2464. [CrossRef]
  • [27] Kamel S, Ali N, Jahangir K, Shah S, El-Gendy A. Pharmaceutical significance of cellulose: a review. Express PolymLett. 2008; 2(11): 758-778. [CrossRef]
  • [28] Lü S, Liu M, Ni B, Gao C. A novel pH‐and thermo‐sensitive PVP/CMC semi‐IPN hydrogel: Swelling, phase behavior, and drug release study. J Polym Sci B Polym Phys. 2010; 48(15): 1749-1756. [CrossRef]

Preparation and in vitro characterization of laminarin based hydrogels

Yıl 2021, Cilt: 25 Sayı: 2, 164 - 172, 27.06.2025

Sıla Tümen Erden Ceyda Ekentok Atıcı , Birnur Cömez Ali Demir Sezer

https://doi.org/10.29228/jrp.7

Öz

Hydrogels are one of the most effective pharmaceutical forms because of several advantages in the treatment of burn and wound healings. Laminarin is a storage polysaccharide derived from brown algae and member of the 1-3-β-D-glucan family. It is a heparin-like molecule and plays role in hemostasis, regulation of cell growth and regeneration. Also, indirectly functional in neovascularization. In addition, accelerates the formation of fibroblast activity and re-epithelization. Aim of this study is prepare laminarin hydrogels and evaluate the in vitro characteristics of hydrogels for use in various wounds. For this purpose, different hydrogel formulations prepared and examined, and evaluated by water absorption capacity, viscosity, rheological and mechanical properties and bioadhesion. It was observed that hydrogels prepared with laminarin are an ideal wound dressing as expected.

Anahtar Kelimeler

Hydrogel laminarin carboxymethylcellulose polyvinylpyrrolidone wound healing.

Kaynakça

  • [1] Baroli B. Hydrogels for Tissue Engineering and Delivery of Tissue-Inducing Substances. J Pharm Sci. 2007; 96(9): 2197-2223. [CrossRef]
  • [2] Mahinroosta M, Farsangi ZJ, Allahverdi A, Shakoori Z. Hydrogels as intelligent materials: a brief review of synthesis, properties and applications. Materials Today Chemistry. 2018; 8: 42-55. [CrossRef]
  • [3] Abandansari HS, Aghaghafari E, Nabid MR, Niknejad H. Preparation of injectable and thermoresponsive hydrogel based on penta-block copolymer with improved sol stability and mechanical properties. Polymer. 2013; 54(4): 1329-1340. [CrossRef]
  • [4] He F, Zhang Y, Li J, Liu S, Chi Z, Xu J. Preparation and properties of multi-responsive semi-IPN hydrogel modified magnetic nanoparticles as drug carrier. J Control Release. 2011; 152(1): e119-e121. [CrossRef]
  • [5] Epstein-Barash H, Stefanescu CF, Kohane DS. An in situ cross-linking hybrid hydrogel for controlled release of proteins. Acta Biomaterialia. 2012; 8(5): 1703-1709. [CrossRef]
  • [6] Costache MC, Qu H, Ducheyne P, Devore DI. Polymer–xerogel composites for controlled release wound dressings. Biomaterials. 2010; 31(24): 6336-6343. [CrossRef]
  • [7] Miao HQ, Elkin M, Aingorn E, Ishai‐Michaeli R, Stein CA, Vlodavsky I. Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides. Int J Cancer. 1999; 83(3): 424-431. [CrossRef]
  • [8] O’Sullivan L, Murphy B, McLoughlin P, Duggan P, Lawlor PG, Hughes H, Gardiner GE. Prebiotics from marine macroalgae for human and animal health applications. Mar Drugs. 2010; 8(7): 2038-2064. [CrossRef]
  • [9] Choi Ji, Kim HJ, Lee JW. Structural feature and antioxidant activity of low molecular weight laminarin degraded by gamma irradiation. Food Chem. 2011; 129(2): 520-523. [CrossRef]
  • [10] Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol. 2002; 60(3): 258-274. [CrossRef]
  • [11] Yadav M, Rhee KY, Jung IH, Park SJ. Eco-friendly synthesis, characterization and properties of a sodium carboxymethyl cellulose/graphene oxide nanocomposite film. Cellulose. 2013; 20: 687-698. [CrossRef]
  • [12] Sannino A, Madaghiele M, Conversano F, Mele G, Maffezzoli A, Netti P, Nicolais L Cellulose derivative-hyaluronic acid-based microporous hydrogels cross-linked through divinyl sulfone (DVS) to modulate equilibrium sorption capacity and network stability. Biomacromolecules. 2004; 5(1): 92-96. [CrossRef]
  • [13] Raith K, Kühn AV, Rosche F, Wolf R, Neubert RH Characterization of Povidone Products by Means of 13C-NMR, MALDI-TOF, and Electrospray Mass Spectrometry. Pharm Res. 2002; 19(4): 556-560. [CrossRef]
  • [14] Zhao L, Xu L, Mitomo H, Yoshii F. Synthesis of pH-sensitive PVP/CM-chitosan hydrogels with improved surface property by irradiation. Carbohydr Polym. 2006; 64(3): 473-480. [CrossRef]
  • [15] Roy N, Saha N, Kitano T, Saha P. Novel hydrogels of PVP–CMC and their swelling effect on viscoelastic properties. J Appl Polym Sci 2010; 117(3): 1703-1710. [CrossRef]
  • [16] Kamaruddin, Edikresnha D, Sriyanti I, Munir MM, Khairurrijal. Synthesis of Polyvinylpyrrolidone (PVP)-Green Tea Extract Composite Nanostructures using Electrohydrodynamic Spraying Technique. IOP Conf. Ser.: Mater. Sci.Eng. 2017; 202 (012043):1-7. [CrossRef]
  • [17] Safo A, Werheid M, Dosche C, Oezaslan M. The role of polyvinylpyrrolidone (PVP) as a capping and structure-directing agent in the formation of Pt nanocubes. Nanoscale Adv. 2019; 1: 3095-3106. [CrossRef]
  • [18] Sunardi, Febriani NM, Junaidi AB. Preparation of carboxymethyl cellulose produced from purun tikus (Eleocharis dulcis). AIP Conf Proc. 2017; 1868 (020008): 1-8. [CrossRef]
  • [19] Kadry G. Comparison between gelatin/carboxymethyl cellulose and gelatin/ carboxymethyl nanocellulose in tramadol drug loaded capsule. Heliyon. 2019; 5 (9): e02404 1-10. [CrossRef]
  • [20] Ji CF, Ji YB, Meng DY. Sulfated modification and anti-tumor activity of laminarin. Exp Ther Med. 2013; 6(5): 1259-1264. [CrossRef]
  • [21] Rajauria G, Ravindran R, Garcia-Vaquero M, Rai DK, Sweeney T, O’Doherty J. Molecular characteristics and antioxidant activity of laminarin extracted from the seaweed species Laminaria hyperborea, using hydrothermal-assisted extraction and a multi-step purification procedure. Food Hydrocoll. 2021; 112: 106332 1-10. [CrossRef]
  • [22] Caló E, Khutoryanskiy VV. Biomedical applications of hydrogels: a review of patents and commercial products. Eur Polym J. 2015; 65: 252-267. [CrossRef]
  • [23] Lay-Flurrie K. The properties of hydrogel dressings and their impact on wound healing. Prof Nurse. 2004; 19(5): 269-273.
  • [24] Thomas S, Hay P. Fluid handling properties of hydrogel dressings. Ostomy Wound Manage. 1995; 41(3), 54-6, 58-9.
  • [25] Fansler RF, Taheri P, Cullinane C, Sabates B, Flint LM. Polypropylene mesh closure of the complicated abdominal wound. Am J Surg. 1995; 170(1): 15-18. [CrossRef]
  • [26] Moroney NC, O'Grady MN, Lordan S, Stanton C, Kerry JP. Seaweed Polysaccharides (Laminarin and Fucoidan) as Functional Ingredients in Pork Meat: An Evaluation of Anti-Oxidative Potential, Thermal Stability and Bioaccessibility. Mar Drugs. 2015; 13(4): 2447-2464. [CrossRef]
  • [27] Kamel S, Ali N, Jahangir K, Shah S, El-Gendy A. Pharmaceutical significance of cellulose: a review. Express PolymLett. 2008; 2(11): 758-778. [CrossRef]
  • [28] Lü S, Liu M, Ni B, Gao C. A novel pH‐and thermo‐sensitive PVP/CMC semi‐IPN hydrogel: Swelling, phase behavior, and drug release study. J Polym Sci B Polym Phys. 2010; 48(15): 1749-1756. [CrossRef]
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmasotik Biyoteknoloji, İlaç Dağıtım Teknolojileri
Bölüm Articles
Yazarlar

Sıla Tümen Erden

Ceyda Ekentok Atıcı

Birnur Cömez

Ali Demir Sezer

Yayımlanma Tarihi 27 Haziran 2025
Yayımlandığı Sayı Yıl 2021 Cilt: 25 Sayı: 2

Kaynak Göster

APA Tümen Erden, S., Atıcı, C. E., Cömez, B., Sezer, A. D. (2025). Preparation and in vitro characterization of laminarin based hydrogels. Journal of Research in Pharmacy, 25(2), 164-172. https://doi.org/10.29228/jrp.7
AMA Tümen Erden S, Atıcı CE, Cömez B, Sezer AD. Preparation and in vitro characterization of laminarin based hydrogels. J. Res. Pharm. Haziran 2025;25(2):164-172. doi:10.29228/jrp.7
Chicago Tümen Erden, Sıla, Ceyda Ekentok Atıcı, Birnur Cömez, ve Ali Demir Sezer. “Preparation and in Vitro Characterization of Laminarin Based Hydrogels”. Journal of Research in Pharmacy 25, sy. 2 (Haziran 2025): 164-72. https://doi.org/10.29228/jrp.7.
EndNote Tümen Erden S, Atıcı CE, Cömez B, Sezer AD (01 Haziran 2025) Preparation and in vitro characterization of laminarin based hydrogels. Journal of Research in Pharmacy 25 2 164–172.
IEEE S. Tümen Erden, C. E. Atıcı, B. Cömez, ve A. D. Sezer, “Preparation and in vitro characterization of laminarin based hydrogels”, J. Res. Pharm., c. 25, sy. 2, ss. 164–172, 2025, doi: 10.29228/jrp.7.
ISNAD Tümen Erden, Sıla vd. “Preparation and in Vitro Characterization of Laminarin Based Hydrogels”. Journal of Research in Pharmacy 25/2 (Haziran 2025), 164-172. https://doi.org/10.29228/jrp.7.
JAMA Tümen Erden S, Atıcı CE, Cömez B, Sezer AD. Preparation and in vitro characterization of laminarin based hydrogels. J. Res. Pharm. 2025;25:164–172.
MLA Tümen Erden, Sıla vd. “Preparation and in Vitro Characterization of Laminarin Based Hydrogels”. Journal of Research in Pharmacy, c. 25, sy. 2, 2025, ss. 164-72, doi:10.29228/jrp.7.
Vancouver Tümen Erden S, Atıcı CE, Cömez B, Sezer AD. Preparation and in vitro characterization of laminarin based hydrogels. J. Res. Pharm. 2025;25(2):164-72.