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Food, medicine or a poisonous plant: Arum maculatum L.

Yıl 2023, Cilt: 27 Sayı: 2, 1 - 16, 27.06.2025

Burçin Ergene , Melek Karaaslan

Öz

Arum maculatum L., which is known with various names such as cuckoo pint and sneakshead, is a
perennial, deciduous woodland plant distributed in Europe, East Ukraine and Anatolia. The phytochemical
studies revealed that the plant contains different groups of bioactive components, such as alkaloid, saponin,
cyanogenic glycosides, terpenic compounds, proanthocyanidins, carotenoids, volatile amines, lectin, mucilage,
gum and starch. Various traditional uses are recorded such as antihypertensive, antirheumatic,
antihemorrhoidal, analgesic, antidiabetic as well as its use against burns and wounds, Fasciola hepatica, sore
throat and cold. It is also consumed as vegetable in different cultures. In the Southeastern region of Turkey, a
traditional soup called “tirşik soup” is prepared from the leaves of A. maculatum and used for the treatment of
hemorrhoids, respiratory and gastrointestinal disorders and cancer. It is very crucial to apply a specific process
for the preparation of the dish or medicinal remedy, since all parts of the fresh plant are known to be toxic. The
toxic effect majorly rises from the oxalate crystals found in the content of plants, along with some other
components, such as cyanogenic glycosides, volatile amins, alkaloids etc. Although the bioactivity studies
showed antioxidant, antimicrobial, antiinflammatory, analgesic, antiangiogenic and insecticidal activities as well
as its protective activity against hemorrhoids; further research is needed on the bioactivity, cytotoxicity and
phytochemistry of the plant in order to clarify the mechanisms of action and provide the safe use of the drug.

Anahtar Kelimeler

Arum maculatum bioactivity cuckoo pint phytochemistry traditional medicine

Kaynakça

  • Ceylan F, Akar Sahingoz S. Using ethnobotanical plants in food preparation: Cuckoo pint (Arum maculatum L.). Int J Gastron Food Sci. 2022; 29. https://doi.org/10.1016/j.ijgfs.2022.100529
  • Comlekcioglu N, Çolak S, Aygan A. A study on the bioactivity of plant extracts obtained from Arum maculatum leaves by different extraction techniques. Croatian Journal of Food Technology, Biotechnology and Nutrition. 2021; 16(1-2): 41-46. https://doi.org/10.31895/hcptbn
  • Kozuharova E, Kochmarov V, Semerdjieva I, Mincheva I, Gibernau M. Potential of wild populations resources of Arum maculatum L. (Araceae) in Bulgaria – A prospective medicinal plant. Compt Rend Acad Bulg Sci. 2018; 71(2): 193-200. https://doi.org/10.7546/crabs.2018.02.06
  • Sowter FA. Arum maculatum L. J Ecol. 1949; 37(1): 207-219. https://doi.org/10.2307/2256754 Allen AK. Purification and characterization of an N-acetyllactosamine-specific lectin from tubers of Arum maculatum. BBA. 1995; 1244: 129-132. https://doi.org/10.1016/0304-4165(94)00210-O
  • Davis PH. Flora of Turkey: and the East Aegean Islands.(Supplement), Edinburgh University Press, 1982. Kianinia S, Farjam MH. Chemical and biological evolution of essential oil of Arum maculatum. Iran J Sci Technol Trans A Sci. 2018; 42(2): 395-399. https://doi.org/10.1007/s40995-016-0051-6
  • Dajdok ZK, Z. The distribution of Arum maculatum L. (Araceae) in Poland. Acta Soc Bot Pol. 2001; 70(2): 103- 106. https://doi.org/10.5586/asbp.2001.014
  • Tanker N, Koyuncu M, Coşkun M. Farmasötik Botanik, Ankara Üniversitesi Eczacılık Fakültesi Yayınları, Ankara 2014.
  • Erbil N, Arslan M, Murathan ZT. Antioxidant, antimicrobial, and antimutagenic effects and biochemical contents of Arum maculatum L. That is a medical plant from Turkish flora. Fresen Environ Bull. 2018; 27: 8709-8714.
  • Kochmarov V, Kozuharova E, Naychov Z, Momekov G, Mincheva I. Ethnobotany and ethnopharmacology of Arum maculatum L. (Araceae) in Bulgaria with an emphasis on its effect against haemorrhoids. International Journal of Pharmaceutical, Chemical and Biological Sciences. 2015; 5(2): 394-402.
  • Karaköse M. An ethnobotanical study of medicinal plants in Güce district, North-Eastern Turkey. Plant Divers. 2022; 44: 577-597. https://doi.org/10.1016/j.pld.2022.03.005
  • Kochmarov V, Kozuharova E, Naychov Z, Momekov G, Mincheva I. Ethnobotany and ethnopharmacology of Arum maculatum L. (Araceae) in Bulgaria with an emphasis on its effect against haemorrhoids. Int J Pharm Chem Sci. 2015; 5(2): 394-402.
  • Van Damme EJMG, K.; Smeets K.; Van Leuven F.V. ; Verhaert, P., Peumans The major tuber storage protein of Araceae. Characterization and moleculer cloning of the lection from Arum maculatum L. Plant Physiol. 1995; 107.
  • Çolak F, Savaroğlu F, İlhan S. Antibacterial and antifungal activities of Arum maculatum L. leaves extracts. J Appl Biol Sci. 2009; 3(3): 13-16.
  • Atalay T, Yildiz K. Arum maculatum (yılan yastığı) bitkisi ve antiparaziter özellikleri. Bull Vet Pharm Tox. 2020; 11(3): 126-133. https://doi.org/10.38137/vetfarmatoksbulten.753991
  • Dring JV, Kite GC, Nash RJ, Reynolds T. Chemicals in aroids: a survey, including new results for polyhydroxy alkaloids and alkylresorcinols. Bot J Linn Soc. 1995; 117(1): 1-12. https://doi.org/10.1111/j.1095-8339.1995.tb02373.x
  • Azab A. Arum: a plant genus with great medicinal potential. Eur Chem Bull. 2017; 6(2): 59-68. https://doi.org/10.17628/ecb.2017.6.59-68
  • Kozuharova E, Naychov Z, Kochmarov V, Benbassat N, Gibernau M, Momekov G. The potential of Arum spp. as a cure for hemorrhoids: Chemistry, bioactivities, and application. Adv Trad Med. 2020; 20(2): 133- 141. https://doi.org/10.1007/s13596-020-00425-x
  • Baytop T. Türkiye'de Bitkilerle Tedavi (Geçmişte ve Bugün), Nobel Tıp Kitabevleri, İstanbul 1999. Akpınar Ç. Osmaniye ili ve çevresinden toplanan tirşik (Arum maculatum L.) bitkisinin besin elementi konsantrasyonlarının değerlendirilmesi. Osmaniye Korkut Ata Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2021; 4(3): 211-216. https://doi.org/10.47495/okufbed.882195
  • Ceylan F. Master's Thesis. Yenilebilir otların yiyecek hazırlamada kullanımı: Tirşik otu (Arum maculatum L.). Ankara Hacıbayram Veli Üniversitesi, Gastronomi ve Mutfak Sanatları, Ankara, Turkey, 2019.
  • Koleva M, Gioreva D. A glucomannan isolated from the leaves of Arum maculatum L. Carbohydr Res. 1986; 155: 290-293. https://doi.org/10.1016/S0008-6215(00)90161-7
  • Mladenov IV, Haralambieva IH, Iankov ID, Mitov IG. Characterisation of 20-kDa lectin-spermagglutinin from Arum maculatum that prevents Chlamydia pneumoniae infection of L-929 fibroblast cells. FEMS Immunol Med Microbiol. 2002; 32(3): 249-254. https://doi.org/10.1111/j.1574-695X.2002.tb00561.x
  • Majumder P, Mondal HA, Das S. Insecticidal activity of Arum maculatum tuber lectin and its binding to the glycosylated insect gut receptors. J Agric Food Chem. 2005; 53(17): 6725-6729. https://doi.org/10.1021/jf051155z
  • Kochmarov V, Marinov L, Kozuharova E, Hristova-Avakumova N, Hadjimitova V, Traykov T, Biljali S, Nuhiu N, Benbassat N, Momekov G. Exploration of collagenase, cyclooxigenases, angiogenesis and free radical processes as the putative pharmacological targets of Arum maculatum L. Biotechnol Biotechnol Equip. 2020; 34 (1): 126-134. https://doi.org/10.1080/13102818.2020.1722239
  • Christie WW. 13‐Phenyltridec‐9‐enoic and 15‐phenylpentadec‐9‐enoic acids in Arum maculatum seed oil. Eur J Lipid Sci Technol. 2003; 105(12): 779-780. https://doi.org/10.1002/ejlt.200300865
  • Al-Shmgani HSA, Kadri ZHM, Al-Halbosiy MMF, Dewir YH. Phytochemical analysis, cytotoxicity and antioxidant activity of cuckoo pint (Arum maculatum) leaf extract. Acta Biol Szeged. 2020; 63(2): 119-124. https://doi.org/10.14232/abs.2019.2.119-124
  • Gras A, Garnatje T, Ibanez N, Lopez-Pujol J, Nualart N, Valles J. Medicinal plant uses and names from the herbarium of Francesc Bolos (1773-1844). J Ethnopharmacol. 2017; 204: 142-168. https://doi.org/10.1016/j.jep.2017.04.002
  • Mohammed ZH, Ibraheem RM. Antioxidant activity of methanol extracts of Arum maculatum L. and Physalis peruviana L. plants. Ibn Al-Haitham J Pure Appl Sci. 2015; 28(2): 1-7.
  • Ivancheva S, Stantcheva B. Ethnobotanical inventory of medicinal plants in Bulgaria. J Ethnopharmacol. 2000; 69(2): 165-172. https://doi.org/10.1016/S0378-8741(99)00129-4
  • Abu-Darwish MS, Efferth T. Medicinal plants from near east for cancer therapy. Front Pharmacol. 2018; 9: 56. https://doi.org/10.3389/fphar.2018.00056
  • Nabeel M, Abderrahman S, Papini A. Cytogenetic effect of Arum maculatum extract on the bone marrow cells of mice. Caryologia. 2008; 61(4): 383-387. https://doi.org/10.1080/00087114.2008.10589650
  • El-Hilaly J, Hmammouchi M, Lyoussi B. Ethnobotanical studies and economic evaluation of medicinal plants in Taounate province (Northern Morocco). J Ethnopharmacol. 2003; 86(2-3): 149-158. https://doi.org/10.1016/s0378-8741(03)00012-6
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  • Dayısoylu KS. Changes of antioxidant activity in different forms and meal of Arum maculatum in Kahramanmaras province from Turkey. Asian J Chem. 2010; 22(8): 6595-6599.
  • Tiğli Kaytanlioğlu EH, Fakir H. Onikişubat (Kahramanmaraş) yöresinde gıda olarak tüketilen bazı doğal bitki taksonlarına ait yöresel tarifler. Turk J Agric For. 2021: 83-90. https://doi.org/10.18182/tjf.875214
  • Berk Ş. Master's Thesis. Myrtus communis, Pistacia vera, Arum maculatum, Ceterach officinarum, Inula oculuschristi türlerinin antioksidan, anti-mikrobiyal ve DNA koruyucu aktivitelerinin araştırılması. Sivas Cumhuriyet Üniversitesi, Fen Bilimleri Enstitüsü Moleküler Biyoloji ve Genetik Sivas, Turkey, 2012.
  • Safari E, Amiri M, Bahador A, Amiri M, Esmaeili D. The study of antibacterial effects of alcoholic extracts of Arum maculatum, Allium hirtifolium and Teucrium polium against nosocomial resistance bacteria. Int J Curr Microbiol App Sci. 2014; 3(2): 601-605.
  • Mansour O, Salamma R, Abbas L. Screening of antibacterial activity in vitro of Arum maculatum L. leaves Extracts. Int. J. Pharm. Sci. Rev. Res. 2015; 31(2): 231-234.
  • Farahmandfar R, Esmaeilzadeh Kenari R, Asnaashari M, Shahrampour D, Bakhshandeh T. Bioactive compounds, antioxidant and antimicrobial activities of Arum maculatum leaves extracts as affected by various solvents and extraction methods. Food Sci Nutr. 2019; 7(2): 465-475. https://doi.org/10.1002/fsn3.815
  • Doğan G. Master's Thesis. Evaluation of protective effect of Arum maculatum against dextran sulfate sodium- induced experimental colitis in rats. Gaziantep University, Biochemistry Science and Technology, Gaziantep, Turkey, 2019.
  • Sakul AA, Okur ME, Ayla S, Daylan B, Karadag AE, Batur S, Ozdemir EM, Altinalan E, Gunal MY. Wound healing activity of Arum maculatum. Medeni Med J. 2023. https://doi.org/10.4274/MMJ.galenos.2022.73368
  • Kozuharova E. Distribution of Arum (Araceae) in Bulgaria. Flora Mediterr. 2014; 24: 51-62. https://doi.org/10.7320/FlMedit24.051
  • Alencar VB, Alencar NM, Assreuy AM, Mota ML, Brito GA, Aragao KS, Bittencourt FS, Pinto VP, Debray H, Ribeiro RA, Cavada BS. Pro-inflammatory effect of Arum maculatum lectin and role of resident cells. Int J Biochem Cell Biol. 2005; 37(9): 1805-1814. https://doi.org/10.1016/j.biocel.2005.02.027
  • Abbasi N, Vahid RK, Khairollah A, Masoumeh T, Abangah G, Morovat T, Asadollahi P. Analgesic effects of Arum maculatum plant extract in rats compared to other routine analgesics. J Med Plant Res. 2014; 8(31): 1025-1030. https://doi.org/10.5897/JMPR2013.5239
  • Zisis S, Giannakou K, Lavranos G, Lamnisos D. Alternative herbal medicine for hemorrhoids, effect of Arum maculatum on the quality of life of patients: A randomized controlled trial. J Appl Pharm Sci. 2019; 9(1): 040- 045. https://doi.org/10.7324/JAPS.2019.S105
  • Ibrahim ZH. Anti-obesity effects of Arum maculatum, Nasturtium officinale plant extracts and exercise in high fat diet-induced obese rats. KJAR. 2022: 190-198. https://doi.org/10.24017/science.2021.2.18
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  • Sorić I, Klanac A, Friganović-Huljev J. The cuckoopint (Arum maculatum)–unintentional plant poisoning in two children: Case report. Arh Zast. 2018; 62(3): 144-144.
  • Kadri ZHM, Ibrahim NA, Al-Shmgani HS. Hepatotoxicity evaluation of methanol leaves extract of Arum maculatum. A Journal of Multidisciplinary Science and Technology. 2016; 7: 435-440.
  • Cheung RCF, Wong JH, Ng TB, Naude R, Rolka K, Tse R, Tse TF, Chan H, Sze SCW. Tuber lectins with potentially exploitable bioactivities. Curr Med Chem. 2018; 25(42): 5986-6001. https://doi.org/10.2174/0929867325666180517095308
  • Dayısoylu KS, Yörükoğlu T, Ançel T. Kahramanmaraş'ın coğrafi işaretli ürünleri ve ilin potansiyel durumu. Ksu J Agric Nat. 2017; 20(1): 80-88. https://doi.org/10.18016/ksujns.14147
  • GKGM Risk Değerlendirme Daire Başkanlığı GOKBK. Division Arum sp.’nin Yaprak Kısımlarının Gıdalarda Kullanımının Güvenilirliğinin Değerlendirilmesi Hakkında Bilimsel Görüş, 2021.

Yıl 2023, Cilt: 27 Sayı: 2, 1 - 16, 27.06.2025

Burçin Ergene , Melek Karaaslan

Öz

Kaynakça

  • Ceylan F, Akar Sahingoz S. Using ethnobotanical plants in food preparation: Cuckoo pint (Arum maculatum L.). Int J Gastron Food Sci. 2022; 29. https://doi.org/10.1016/j.ijgfs.2022.100529
  • Comlekcioglu N, Çolak S, Aygan A. A study on the bioactivity of plant extracts obtained from Arum maculatum leaves by different extraction techniques. Croatian Journal of Food Technology, Biotechnology and Nutrition. 2021; 16(1-2): 41-46. https://doi.org/10.31895/hcptbn
  • Kozuharova E, Kochmarov V, Semerdjieva I, Mincheva I, Gibernau M. Potential of wild populations resources of Arum maculatum L. (Araceae) in Bulgaria – A prospective medicinal plant. Compt Rend Acad Bulg Sci. 2018; 71(2): 193-200. https://doi.org/10.7546/crabs.2018.02.06
  • Sowter FA. Arum maculatum L. J Ecol. 1949; 37(1): 207-219. https://doi.org/10.2307/2256754 Allen AK. Purification and characterization of an N-acetyllactosamine-specific lectin from tubers of Arum maculatum. BBA. 1995; 1244: 129-132. https://doi.org/10.1016/0304-4165(94)00210-O
  • Davis PH. Flora of Turkey: and the East Aegean Islands.(Supplement), Edinburgh University Press, 1982. Kianinia S, Farjam MH. Chemical and biological evolution of essential oil of Arum maculatum. Iran J Sci Technol Trans A Sci. 2018; 42(2): 395-399. https://doi.org/10.1007/s40995-016-0051-6
  • Dajdok ZK, Z. The distribution of Arum maculatum L. (Araceae) in Poland. Acta Soc Bot Pol. 2001; 70(2): 103- 106. https://doi.org/10.5586/asbp.2001.014
  • Tanker N, Koyuncu M, Coşkun M. Farmasötik Botanik, Ankara Üniversitesi Eczacılık Fakültesi Yayınları, Ankara 2014.
  • Erbil N, Arslan M, Murathan ZT. Antioxidant, antimicrobial, and antimutagenic effects and biochemical contents of Arum maculatum L. That is a medical plant from Turkish flora. Fresen Environ Bull. 2018; 27: 8709-8714.
  • Kochmarov V, Kozuharova E, Naychov Z, Momekov G, Mincheva I. Ethnobotany and ethnopharmacology of Arum maculatum L. (Araceae) in Bulgaria with an emphasis on its effect against haemorrhoids. International Journal of Pharmaceutical, Chemical and Biological Sciences. 2015; 5(2): 394-402.
  • Karaköse M. An ethnobotanical study of medicinal plants in Güce district, North-Eastern Turkey. Plant Divers. 2022; 44: 577-597. https://doi.org/10.1016/j.pld.2022.03.005
  • Kochmarov V, Kozuharova E, Naychov Z, Momekov G, Mincheva I. Ethnobotany and ethnopharmacology of Arum maculatum L. (Araceae) in Bulgaria with an emphasis on its effect against haemorrhoids. Int J Pharm Chem Sci. 2015; 5(2): 394-402.
  • Van Damme EJMG, K.; Smeets K.; Van Leuven F.V. ; Verhaert, P., Peumans The major tuber storage protein of Araceae. Characterization and moleculer cloning of the lection from Arum maculatum L. Plant Physiol. 1995; 107.
  • Çolak F, Savaroğlu F, İlhan S. Antibacterial and antifungal activities of Arum maculatum L. leaves extracts. J Appl Biol Sci. 2009; 3(3): 13-16.
  • Atalay T, Yildiz K. Arum maculatum (yılan yastığı) bitkisi ve antiparaziter özellikleri. Bull Vet Pharm Tox. 2020; 11(3): 126-133. https://doi.org/10.38137/vetfarmatoksbulten.753991
  • Dring JV, Kite GC, Nash RJ, Reynolds T. Chemicals in aroids: a survey, including new results for polyhydroxy alkaloids and alkylresorcinols. Bot J Linn Soc. 1995; 117(1): 1-12. https://doi.org/10.1111/j.1095-8339.1995.tb02373.x
  • Azab A. Arum: a plant genus with great medicinal potential. Eur Chem Bull. 2017; 6(2): 59-68. https://doi.org/10.17628/ecb.2017.6.59-68
  • Kozuharova E, Naychov Z, Kochmarov V, Benbassat N, Gibernau M, Momekov G. The potential of Arum spp. as a cure for hemorrhoids: Chemistry, bioactivities, and application. Adv Trad Med. 2020; 20(2): 133- 141. https://doi.org/10.1007/s13596-020-00425-x
  • Baytop T. Türkiye'de Bitkilerle Tedavi (Geçmişte ve Bugün), Nobel Tıp Kitabevleri, İstanbul 1999. Akpınar Ç. Osmaniye ili ve çevresinden toplanan tirşik (Arum maculatum L.) bitkisinin besin elementi konsantrasyonlarının değerlendirilmesi. Osmaniye Korkut Ata Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2021; 4(3): 211-216. https://doi.org/10.47495/okufbed.882195
  • Ceylan F. Master's Thesis. Yenilebilir otların yiyecek hazırlamada kullanımı: Tirşik otu (Arum maculatum L.). Ankara Hacıbayram Veli Üniversitesi, Gastronomi ve Mutfak Sanatları, Ankara, Turkey, 2019.
  • Koleva M, Gioreva D. A glucomannan isolated from the leaves of Arum maculatum L. Carbohydr Res. 1986; 155: 290-293. https://doi.org/10.1016/S0008-6215(00)90161-7
  • Mladenov IV, Haralambieva IH, Iankov ID, Mitov IG. Characterisation of 20-kDa lectin-spermagglutinin from Arum maculatum that prevents Chlamydia pneumoniae infection of L-929 fibroblast cells. FEMS Immunol Med Microbiol. 2002; 32(3): 249-254. https://doi.org/10.1111/j.1574-695X.2002.tb00561.x
  • Majumder P, Mondal HA, Das S. Insecticidal activity of Arum maculatum tuber lectin and its binding to the glycosylated insect gut receptors. J Agric Food Chem. 2005; 53(17): 6725-6729. https://doi.org/10.1021/jf051155z
  • Kochmarov V, Marinov L, Kozuharova E, Hristova-Avakumova N, Hadjimitova V, Traykov T, Biljali S, Nuhiu N, Benbassat N, Momekov G. Exploration of collagenase, cyclooxigenases, angiogenesis and free radical processes as the putative pharmacological targets of Arum maculatum L. Biotechnol Biotechnol Equip. 2020; 34 (1): 126-134. https://doi.org/10.1080/13102818.2020.1722239
  • Christie WW. 13‐Phenyltridec‐9‐enoic and 15‐phenylpentadec‐9‐enoic acids in Arum maculatum seed oil. Eur J Lipid Sci Technol. 2003; 105(12): 779-780. https://doi.org/10.1002/ejlt.200300865
  • Al-Shmgani HSA, Kadri ZHM, Al-Halbosiy MMF, Dewir YH. Phytochemical analysis, cytotoxicity and antioxidant activity of cuckoo pint (Arum maculatum) leaf extract. Acta Biol Szeged. 2020; 63(2): 119-124. https://doi.org/10.14232/abs.2019.2.119-124
  • Gras A, Garnatje T, Ibanez N, Lopez-Pujol J, Nualart N, Valles J. Medicinal plant uses and names from the herbarium of Francesc Bolos (1773-1844). J Ethnopharmacol. 2017; 204: 142-168. https://doi.org/10.1016/j.jep.2017.04.002
  • Mohammed ZH, Ibraheem RM. Antioxidant activity of methanol extracts of Arum maculatum L. and Physalis peruviana L. plants. Ibn Al-Haitham J Pure Appl Sci. 2015; 28(2): 1-7.
  • Ivancheva S, Stantcheva B. Ethnobotanical inventory of medicinal plants in Bulgaria. J Ethnopharmacol. 2000; 69(2): 165-172. https://doi.org/10.1016/S0378-8741(99)00129-4
  • Abu-Darwish MS, Efferth T. Medicinal plants from near east for cancer therapy. Front Pharmacol. 2018; 9: 56. https://doi.org/10.3389/fphar.2018.00056
  • Nabeel M, Abderrahman S, Papini A. Cytogenetic effect of Arum maculatum extract on the bone marrow cells of mice. Caryologia. 2008; 61(4): 383-387. https://doi.org/10.1080/00087114.2008.10589650
  • El-Hilaly J, Hmammouchi M, Lyoussi B. Ethnobotanical studies and economic evaluation of medicinal plants in Taounate province (Northern Morocco). J Ethnopharmacol. 2003; 86(2-3): 149-158. https://doi.org/10.1016/s0378-8741(03)00012-6
  • Jaric S, Macukanovic-Jocic M, Djurdjevic L, Mitrovic M, Kostic O, Karadzic B, Pavlovic P. An ethnobotanical survey of traditionally used plants on Suva planina mountain (south-eastern Serbia). J Ethnopharmacol. 2015; 175: 93-108. https://doi.org/10.1016/j.jep.2015.09.002
  • Alachkar A, Jaddouh A, Elsheikh MS, Bilia AR, Vincieri FF. Traditional medicine in Syria: Folk medicine in Aleppo Governorate. Nat Prod Commun. 2011; 6(1): 79-84. https://doi.org/10.1177/1934578X1100600119
  • antineuralgic in the traditional medicine of Lebanon. J Ethnopharmacol. 2008; 120(3): 315-334. https://doi.org/10.1016/j.jep.2008.08.024
  • Kurt BZ, Gazioğlu I, Sevgi E, Sönmez F. Anticholinesterase, antioxidant, antiaflatoxigenic activities of ten edible wild plants from Ordu area, Turkey. Iran J Pharm Res. 2018; 17(3): 1047.
  • Everest A, Ozturk E. Focusing on the ethnobotanical uses of plants in Mersin and Adana provinces (Turkey). J Ethnobiol Ethnomed. 2005; 1(1): 1-6. https://doi.org/10.1186/1746-4269-1-6
  • Kultur S. Medicinal plants used in Kirklareli province (Turkey). J Ethnopharmacol. 2007; 111(2): 341-364. https://doi.org/10.1016/j.jep.2006.11.035
  • Uzun E, Sariyar G, Adsersen A, Karakoc B, Otuk G, Oktayoglu E, Pirildar S. Traditional medicine in Sakarya province (Turkey) and antimicrobial activities of selected species. J Ethnopharmacol. 2004; 95(2-3): 287-296. https://doi.org/10.1016/j.jep.2004.07.013
  • Tetik F, Civelek S, Cakilcioglu U. Traditional uses of some medicinal plants in Malatya (Turkey). J Ethnopharmacol. 2013; 146(1): 331-346. https://doi.org/10.1016/j.jep.2012.12.054
  • Dogan Y, Baslar S, Ay G, Mert HH. The use of wild edible plants in western and central Anatolia (Turkey). Econ Bot. 2004; 58(4): 684-690. https://doi.org/10.1663/0013-0001(2004)058[0684:TUOWEP]2.0.CO;2
  • Demirci S, Özhatay N. An ethnobotanical study in Kahramanmaraş (Turkey); wild plants used for medicinal purpose in Andirin, Kahramanmaraş. Turk J Pharm Sci. 2012; 9(1): 75-92.
  • Ugureli A. Yukarı Çukurova folklorunda tirşik. Int J TLCE. 2020; 9(1): 180-204.
  • Dayısoylu KS. Changes of antioxidant activity in different forms and meal of Arum maculatum in Kahramanmaras province from Turkey. Asian J Chem. 2010; 22(8): 6595-6599.
  • Tiğli Kaytanlioğlu EH, Fakir H. Onikişubat (Kahramanmaraş) yöresinde gıda olarak tüketilen bazı doğal bitki taksonlarına ait yöresel tarifler. Turk J Agric For. 2021: 83-90. https://doi.org/10.18182/tjf.875214
  • Berk Ş. Master's Thesis. Myrtus communis, Pistacia vera, Arum maculatum, Ceterach officinarum, Inula oculuschristi türlerinin antioksidan, anti-mikrobiyal ve DNA koruyucu aktivitelerinin araştırılması. Sivas Cumhuriyet Üniversitesi, Fen Bilimleri Enstitüsü Moleküler Biyoloji ve Genetik Sivas, Turkey, 2012.
  • Safari E, Amiri M, Bahador A, Amiri M, Esmaeili D. The study of antibacterial effects of alcoholic extracts of Arum maculatum, Allium hirtifolium and Teucrium polium against nosocomial resistance bacteria. Int J Curr Microbiol App Sci. 2014; 3(2): 601-605.
  • Mansour O, Salamma R, Abbas L. Screening of antibacterial activity in vitro of Arum maculatum L. leaves Extracts. Int. J. Pharm. Sci. Rev. Res. 2015; 31(2): 231-234.
  • Farahmandfar R, Esmaeilzadeh Kenari R, Asnaashari M, Shahrampour D, Bakhshandeh T. Bioactive compounds, antioxidant and antimicrobial activities of Arum maculatum leaves extracts as affected by various solvents and extraction methods. Food Sci Nutr. 2019; 7(2): 465-475. https://doi.org/10.1002/fsn3.815
  • Doğan G. Master's Thesis. Evaluation of protective effect of Arum maculatum against dextran sulfate sodium- induced experimental colitis in rats. Gaziantep University, Biochemistry Science and Technology, Gaziantep, Turkey, 2019.
  • Sakul AA, Okur ME, Ayla S, Daylan B, Karadag AE, Batur S, Ozdemir EM, Altinalan E, Gunal MY. Wound healing activity of Arum maculatum. Medeni Med J. 2023. https://doi.org/10.4274/MMJ.galenos.2022.73368
  • Kozuharova E. Distribution of Arum (Araceae) in Bulgaria. Flora Mediterr. 2014; 24: 51-62. https://doi.org/10.7320/FlMedit24.051
  • Alencar VB, Alencar NM, Assreuy AM, Mota ML, Brito GA, Aragao KS, Bittencourt FS, Pinto VP, Debray H, Ribeiro RA, Cavada BS. Pro-inflammatory effect of Arum maculatum lectin and role of resident cells. Int J Biochem Cell Biol. 2005; 37(9): 1805-1814. https://doi.org/10.1016/j.biocel.2005.02.027
  • Abbasi N, Vahid RK, Khairollah A, Masoumeh T, Abangah G, Morovat T, Asadollahi P. Analgesic effects of Arum maculatum plant extract in rats compared to other routine analgesics. J Med Plant Res. 2014; 8(31): 1025-1030. https://doi.org/10.5897/JMPR2013.5239
  • Zisis S, Giannakou K, Lavranos G, Lamnisos D. Alternative herbal medicine for hemorrhoids, effect of Arum maculatum on the quality of life of patients: A randomized controlled trial. J Appl Pharm Sci. 2019; 9(1): 040- 045. https://doi.org/10.7324/JAPS.2019.S105
  • Ibrahim ZH. Anti-obesity effects of Arum maculatum, Nasturtium officinale plant extracts and exercise in high fat diet-induced obese rats. KJAR. 2022: 190-198. https://doi.org/10.24017/science.2021.2.18
  • Al-Qura'n S. Ethnobotanical survey of folk toxic plants in southern part of Jordan. Toxicon. 2005; 46(2): 119- 129. https://doi.org/10.1016/j.toxicon.2005.04.010
  • Şimşek Yurt N, Türe E, Çubukçu M. Nivic grass poisoning: Arum maculatum - A case report. Ank Med J. 2019: 796-799. https://doi.org/10.17098/amj.652024
  • Raju PKNJ, Goel K, Anandhi D, Pandit VR, Surendar R, Sasikumar M. Wild tuber poisoning: Arum maculatum-A rare case report. Int J Crit Illn Inj Sci. 2018; 8(2): 111-114. https://doi.org/10.4103/IJCIIS.IJCIIS_9_18
  • Buchholzer ML, Kirch M, Kirchner C, Knoss W. Toxicological assessment compilation of selected examples of raw materials for homeopathic and anthroposophic medicinal products - Part 2. Regul Toxicol Pharmacol. 2022; 134: 105215. https://doi.org/10.1016/j.yrtph.2022.105215
  • Sorić I, Klanac A, Friganović-Huljev J. The cuckoopint (Arum maculatum)–unintentional plant poisoning in two children: Case report. Arh Zast. 2018; 62(3): 144-144.
  • Kadri ZHM, Ibrahim NA, Al-Shmgani HS. Hepatotoxicity evaluation of methanol leaves extract of Arum maculatum. A Journal of Multidisciplinary Science and Technology. 2016; 7: 435-440.
  • Cheung RCF, Wong JH, Ng TB, Naude R, Rolka K, Tse R, Tse TF, Chan H, Sze SCW. Tuber lectins with potentially exploitable bioactivities. Curr Med Chem. 2018; 25(42): 5986-6001. https://doi.org/10.2174/0929867325666180517095308
  • Dayısoylu KS, Yörükoğlu T, Ançel T. Kahramanmaraş'ın coğrafi işaretli ürünleri ve ilin potansiyel durumu. Ksu J Agric Nat. 2017; 20(1): 80-88. https://doi.org/10.18016/ksujns.14147
  • GKGM Risk Değerlendirme Daire Başkanlığı GOKBK. Division Arum sp.’nin Yaprak Kısımlarının Gıdalarda Kullanımının Güvenilirliğinin Değerlendirilmesi Hakkında Bilimsel Görüş, 2021.
Toplam 64 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmakognozi
Bölüm Reviews
Yazarlar

Burçin Ergene

Melek Karaaslan

Yayımlanma Tarihi 27 Haziran 2025
Yayımlandığı Sayı Yıl 2023 Cilt: 27 Sayı: 2

Kaynak Göster

APA Ergene, B., & Karaaslan, M. (2025). Food, medicine or a poisonous plant: Arum maculatum L. Journal of Research in Pharmacy, 27(2), 1-16.
AMA Ergene B, Karaaslan M. Food, medicine or a poisonous plant: Arum maculatum L. J. Res. Pharm. Haziran 2025;27(2):1-16.
Chicago Ergene, Burçin, ve Melek Karaaslan. “ Medicine or a Poisonous Plant: Arum Maculatum L”. Journal of Research in Pharmacy 27, sy. 2 (Haziran 2025): 1-16.
EndNote Ergene B, Karaaslan M (01 Haziran 2025) Food, medicine or a poisonous plant: Arum maculatum L. Journal of Research in Pharmacy 27 2 1–16.
IEEE B. Ergene ve M. Karaaslan, “ medicine or a poisonous plant: Arum maculatum L”., J. Res. Pharm., c. 27, sy. 2, ss. 1–16, 2025.
ISNAD Ergene, Burçin - Karaaslan, Melek. “ Medicine or a Poisonous Plant: Arum Maculatum L”. Journal of Research in Pharmacy 27/2 (Haziran 2025), 1-16.
JAMA Ergene B, Karaaslan M. Food, medicine or a poisonous plant: Arum maculatum L. J. Res. Pharm. 2025;27:1–16.
MLA Ergene, Burçin ve Melek Karaaslan. “ Medicine or a Poisonous Plant: Arum Maculatum L”. Journal of Research in Pharmacy, c. 27, sy. 2, 2025, ss. 1-16.
Vancouver Ergene B, Karaaslan M. Food, medicine or a poisonous plant: Arum maculatum L. J. Res. Pharm. 2025;27(2):1-16.