Araştırma Makalesi
Yıl 2023,
Cilt: 27 Sayı: 2, 544 - 556, 27.06.2025
Öz
Curcumin has been used in many diseases due to its high therapeutical potential in recent years.
Although curcumin is a frequently used natural polyphenolic compound products, its low solubility and
poor permeability limits the dermal efficacy of curcumin. Emulgels are a new generation of semi-solid
formulations that combine the advantages of both emulsions and gels. The biggest limitation of emulsions
is surfactant related irritation problems caused by the use of high amount of surfactants. In this study, it
was aimed to increase the skin permeability of curcumin by developing surfactant-free emulgel
formulations. In the study, emulgels were developed by Carbopol 940 gels as the aqueous phase, olive oil
and curcumin methanol solution as the oil phase. No surfactant was used additionally to show the
stabilizing effect of Carbopol in emulgels.
The emulgel formulations were subjected to physicochemical characterization by means of organoleptic
properties, pH, rheological and mechanical properties. Mechanical properties were carried out by texture
profile analyzes to determine the structure related properties such as hardness, compressibility,
adhesiveness, cohesiveness and elasticity. The spreadability of the formulations was also determined with
Texture Analyzer. Obtained emulgels showed good rheological, mechanical and spreadability properties.
The transdermal permeation of the chosen emulgel was studied ex vivo against hydrogel prepared with the
same amount of Carbopol. The emulgel formulation significantly increased transdermal permeation
compared to the hydrogel. This emulgel formulation successfully passed from stress tests.
As a conclusion, the novel surfactant-free emulgel formulation was successfully developed to increase
curcumin permeation through the rat skin.
Anahtar Kelimeler
Emulgel surfactant-free curcumin texture analysis spreadability 23 factorial design
Kaynakça
- Kocaadam B, Şanlier N, Curcumin, an active component of turmeric (Curcuma longa), and its effects on health, Critical Reviews in Food Science and Nutrition, 57, 2017, 2889-2895. [CrossRef]
- Ma Z, Wang N, He H, Tang X, Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application, J Control Release, 316, 2019, 359-380. [CrossRef]
- Vollono L, Falconi M, Gaziano R, Iacovelli F, Dika E, Terracciano C, Bianchi L, Campione E, Potential of Curcumin in Skin Disorders, Nutrients, 11, 2019, 2169. [CrossRef]
- Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee RK, Turmeric and curcumin: biological actions and medicinal applications Current science, 87, 2004, 44-53.
- Batra H, Pawar S, Bahl D, Curcumin in combination with anti-cancer drugs: A nanomedicine review, Pharmacol Res, 139, 2019, 91-105. [CrossRef]
- Goel A, Kunnumakkara AB, Aggarwal BB, Curcumin as "Curecumin": from kitchen to clinic, Biochem Pharmacol, 75, 2008, 787-809. [CrossRef]
- Jantarat C, Sirathanarun P, Boonmee S, Meechoosin W, Wangpittaya H, Effect of Piperine on Skin Permeation of Curcumin from a Bacterially Derived Cellulose-Composite Double-Layer Membrane for Transdermal Curcumin Delivery, Sci Pharm, 86, 2018. [CrossRef]
- Nikolic I, Mitsou E, Pantelic I, Randjelovic D, Markovic B, Papadimitriou V, Xenakis A, Lunter DJ, Zugic A, Savic S, Microstructure and biopharmaceutical performances of curcumin-loaded low-energy nanoemulsions containing eucalyptol and pinene: Terpenes’ role overcome penetration enhancement effect?, European Journal of Pharmaceutical Sciences, 142, 2020, 105135. [CrossRef]
- Basheer H, Krishnakumar K, Dineshkumar B, Emulgel Formulation: Novel Approach for Topical Drug Delivery System, International Journal for Pharmaceutical Research Scholars, 5, 2016, 227-230. Ashara KC, Paun JS, Soniwala MM, Chavada J.R., Mori NM, Micro-emulsion based emulgel: a novel topical drug delivery system, Asian Pac J Trop Dis journal, 4, 2014, 27-32. [CrossRef]
- Ajazuddin, Alexander A, Khichariya A, Gupta S, Patel RJ, Giri TK, Tripathi DK, Recent expansions in an emergent novel drug delivery technology: Emulgel, J Control Release, 171, 2013, 122-132. [CrossRef]
- Mohamed M, Optimization of Chlorphenesin Emulgel Formulation, The AAPS Journal, 6, 2004, 1-7. [CrossRef]
- Dermopharmacy Sf. What is the Meaning of the Term "Emulsifier-free"? In: Dermotopic; 2003. 다니엘스 롤. Emulsifier-free, polymer-stabilized foam formulations. In: Korean S, ed. Patent No: KR101835712B1. South Korean2009.
- Bobin MF, Michel V, Martini, CM, Study of formulation and stability of emulsions with polymeric emulsifiers, Colloids and Surfaces A: Physicochemical and Engineering Aspects 152, 1999, 53-58. [CrossRef]
- Shahin M, Hady SA, Hammad M, Mortada N, Optimized formulation for topical administration of clotrimazole using Pemulen polymeric emulsifier, Drug Development and Industrial Pharmacy, 37, 2011, 559-568. [CrossRef]
- Combrinck J, Otto A, du Plessis J, Whey Protein/Polysaccharide-Stabilized Emulsions: Effect of Polymer Type and pH on Release and Topical Delivery of Salicylic Acid, AAPS PharmSciTech, 15, 2014, 588-600. [CrossRef]
- Peito S, Peixoto D, Ferreira-Faria I, Margarida Martins A, Margarida Ribeiro H, Veiga F, Marto J, Cláudia Paiva- Santos A, Nano- and microparticle-stabilized Pickering emulsions designed for topical therapeutics and cosmetic applications, International Journal of Pharmaceutics, 615, 2022, 121455. [CrossRef]
- Wu X, Zhang Q, Wang Z, Xu Y, Tao Q, Wang J, Kong X, Sheng K, Wang Y, Investigation of construction and characterization of carboxymethyl chitosan - sodium alginate nanoparticles to stabilize Pickering emulsion hydrogels for curcumin encapsulation and accelerating wound healing, International Journal of Biological Macromolecules, 209, 2022, 1837-1847. [CrossRef]
- Feng Y, Zhang B, Fu X, Huang Q, Starch-lauric acid complex-stabilised Pickering emulsion gels enhance the thermo-oxidative resistance of flaxseed oil, Carbohydrate Polymers, 292, 2022, 119715. [CrossRef]
- Joyce P, Dening TJ, Meola TR, Schultz HB, Holm R, Thomas N, Prestidge CA, Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges, Advanced Drug Delivery Reviews, 142, 2019, 102-117. [CrossRef]
- Williams HD, Speybroeck MV, Augustijns P, Porter CJH, Lipid-Based Formulations Solidified Via Adsorption onto the Mesoporous Carrier Neusilin® US2: Effect of Drug Type and Formulation Composition on In Vitro Pharmaceutical Performance, Journal of Pharmaceutical Sciences, 103, 2014, 1734-1746. [CrossRef]
- Shah DS, Jha DK, Gurram S, Suñé-Pou M, Garcia-Montoya E, Amin PD, A new SeDeM-SLA expert system for screening of solid carriers for the preparation of solidified liquids: A case of citronella oil, Powder Technology, 382, 2021, 605-618. [CrossRef]
- Sreevidya VS, An Overview on Emulgel, International Journal of Pharmaceutical and Phytopharmacological Research (eIJPPR), 9, 2019, 92-97.
- Viljoen JM, Cowley A, du Preez J, Gerber M, du Plessis J, Penetration enhancing effects of selected natural oils utilized in topical dosage forms, Drug Dev Ind Pharm, 41, 2015, 2045-2054. [CrossRef]
- Perioli L, Pagano C, Mazzitelli S, Rossi C, Nastruzzi C, Rheological and functional characterization of new antiinflammatory delivery systems designed for buccal administration, Int J Pharm, 356, 2008, 19-28. [CrossRef]
- de Lafuente Y, Ochoa-Andrade A, Parente ME, Palena MC, Jimenez-Kairuz AF, Preparation and evaluation of caffeine bioadhesive emulgels for cosmetic applications based on formulation design using QbD tools, Int J Cosmet Sci, 42, 2020, 548-556. [CrossRef]
- Kim J-Y, Song J-Y, Lee E-J, Park S-K, Rheological properties and microstructures of Carbopol gel network system, Colloid and Polymer Science, 281, 2003, 614-623. [CrossRef]
- Jones D, Woolfson D, Brown A, Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers, International Journal of Pharmaceutics, 151, 1997, 223-233. [CrossRef]
- Amasya G, Inal O, Sengel-Turk CT, SLN enriched hydrogels for dermal application: Full factorial design study to estimate the relationship between composition and mechanical properties, Chem Phys Lipids, 228, 2020, 104889. [CrossRef]
- Srivastava N, Patel DK, Rai VK, Pal A, Yadav NP, Development of emulgel formulation for vaginal candidiasis: Pharmaceutical characterization, in vitro and in vivo evaluation, Journal of Drug Delivery Science and Technology, 48, 2018, 490-498. [CrossRef]
- Dano MEL, Santos RSd, Silva JBd, Junqueira MV, Ferreira SBdS, Bruschi MLJJoML, Design of emulgel platforms for local propolis delivery: The influence of type and concentration of carbomer, 2021. [CrossRef]
- Inal O. Comparison of sodium alginate versus hydroxypropyl methylcellulose as adhesive polymers on polozamer based meloxicam gel In:2014.
- Maslii Y, Ruban O, Kasparaviciene G, Kalveniene Z, Materiienko A, Ivanauskas L, Mazurkeviciute A, Kopustinskiene DM, Bernatoniene J, The Influence of pH Values on the Rheological, Textural and Release Properties of Carbomer Polacril(®) 40P-Based Dental Gel Formulation with Plant-Derived and Synthetic Active Components, Molecules, 25, 2020. [CrossRef]
- Tadros TF, Léonard S, Verboom C, Wortel V, Taelman M-C, Roschzttardtz F. Personal Care Emulsions Based on Surfactant–Biopolymer Mixtures: Correlation of Rheological Parameters with Sensory Attributes (Edited by Tadros TF). In. Colloids in Cosmetics and Personal Care. Wiley Publishers 2008:107-126.
- Jaworski Z, Spychaj T, Story A, Story G, Carbomer microgels as model yield-stress fluids, Reviews in Chemical Engineering, 0, 2021. [CrossRef]
- Masmoudi H, Piccerelle P, Le Dréau Y, Kister J, A Rheological Method to Evaluate the Physical Stability of Highly Viscous Pharmaceutical Oil-in-Water Emulsions, 23, 2006, 1937 - 1947 [CrossRef].
- Hussain A, Khan GM, Jan SU, Shah SU, Shah K, Akhlaq M, Rahim N, Nawaz A, Wahab A, Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer, Pak. J. Pharm. Sci.,, 25, 2012, 365-369. PMID: 22459463]
- Ali Ashoor J, M. Mohsin J, Mohsin HM, W. Mahde B, M. Gareeb M, Permeability Enhancement of Methotrexate Transdermal Gel using Eucalyptus oil, Peppermint Oil and Olive Oil(Conference Paper )#, Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512), 30, 2022, 16-21. [CrossRef]
- Trommer H, Neubert RH, Overcoming the stratum corneum: the modulation of skin penetration. A review, Skin Pharmacol Physiol, 19, 2006, 106-121. [CrossRef]
- Shehata TM, Ibrahim MM, Elsewedy HS, Curcumin Niosomes Prepared from Proniosomal Gels: In Vitro Skin Permeability, Kinetic and In Vivo Studies, Polymers (Basel), 13, 2021 [CrossRef].
Yıl 2023,
Cilt: 27 Sayı: 2, 544 - 556, 27.06.2025
Öz
Kaynakça
- Kocaadam B, Şanlier N, Curcumin, an active component of turmeric (Curcuma longa), and its effects on health, Critical Reviews in Food Science and Nutrition, 57, 2017, 2889-2895. [CrossRef]
- Ma Z, Wang N, He H, Tang X, Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application, J Control Release, 316, 2019, 359-380. [CrossRef]
- Vollono L, Falconi M, Gaziano R, Iacovelli F, Dika E, Terracciano C, Bianchi L, Campione E, Potential of Curcumin in Skin Disorders, Nutrients, 11, 2019, 2169. [CrossRef]
- Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee RK, Turmeric and curcumin: biological actions and medicinal applications Current science, 87, 2004, 44-53.
- Batra H, Pawar S, Bahl D, Curcumin in combination with anti-cancer drugs: A nanomedicine review, Pharmacol Res, 139, 2019, 91-105. [CrossRef]
- Goel A, Kunnumakkara AB, Aggarwal BB, Curcumin as "Curecumin": from kitchen to clinic, Biochem Pharmacol, 75, 2008, 787-809. [CrossRef]
- Jantarat C, Sirathanarun P, Boonmee S, Meechoosin W, Wangpittaya H, Effect of Piperine on Skin Permeation of Curcumin from a Bacterially Derived Cellulose-Composite Double-Layer Membrane for Transdermal Curcumin Delivery, Sci Pharm, 86, 2018. [CrossRef]
- Nikolic I, Mitsou E, Pantelic I, Randjelovic D, Markovic B, Papadimitriou V, Xenakis A, Lunter DJ, Zugic A, Savic S, Microstructure and biopharmaceutical performances of curcumin-loaded low-energy nanoemulsions containing eucalyptol and pinene: Terpenes’ role overcome penetration enhancement effect?, European Journal of Pharmaceutical Sciences, 142, 2020, 105135. [CrossRef]
- Basheer H, Krishnakumar K, Dineshkumar B, Emulgel Formulation: Novel Approach for Topical Drug Delivery System, International Journal for Pharmaceutical Research Scholars, 5, 2016, 227-230. Ashara KC, Paun JS, Soniwala MM, Chavada J.R., Mori NM, Micro-emulsion based emulgel: a novel topical drug delivery system, Asian Pac J Trop Dis journal, 4, 2014, 27-32. [CrossRef]
- Ajazuddin, Alexander A, Khichariya A, Gupta S, Patel RJ, Giri TK, Tripathi DK, Recent expansions in an emergent novel drug delivery technology: Emulgel, J Control Release, 171, 2013, 122-132. [CrossRef]
- Mohamed M, Optimization of Chlorphenesin Emulgel Formulation, The AAPS Journal, 6, 2004, 1-7. [CrossRef]
- Dermopharmacy Sf. What is the Meaning of the Term "Emulsifier-free"? In: Dermotopic; 2003. 다니엘스 롤. Emulsifier-free, polymer-stabilized foam formulations. In: Korean S, ed. Patent No: KR101835712B1. South Korean2009.
- Bobin MF, Michel V, Martini, CM, Study of formulation and stability of emulsions with polymeric emulsifiers, Colloids and Surfaces A: Physicochemical and Engineering Aspects 152, 1999, 53-58. [CrossRef]
- Shahin M, Hady SA, Hammad M, Mortada N, Optimized formulation for topical administration of clotrimazole using Pemulen polymeric emulsifier, Drug Development and Industrial Pharmacy, 37, 2011, 559-568. [CrossRef]
- Combrinck J, Otto A, du Plessis J, Whey Protein/Polysaccharide-Stabilized Emulsions: Effect of Polymer Type and pH on Release and Topical Delivery of Salicylic Acid, AAPS PharmSciTech, 15, 2014, 588-600. [CrossRef]
- Peito S, Peixoto D, Ferreira-Faria I, Margarida Martins A, Margarida Ribeiro H, Veiga F, Marto J, Cláudia Paiva- Santos A, Nano- and microparticle-stabilized Pickering emulsions designed for topical therapeutics and cosmetic applications, International Journal of Pharmaceutics, 615, 2022, 121455. [CrossRef]
- Wu X, Zhang Q, Wang Z, Xu Y, Tao Q, Wang J, Kong X, Sheng K, Wang Y, Investigation of construction and characterization of carboxymethyl chitosan - sodium alginate nanoparticles to stabilize Pickering emulsion hydrogels for curcumin encapsulation and accelerating wound healing, International Journal of Biological Macromolecules, 209, 2022, 1837-1847. [CrossRef]
- Feng Y, Zhang B, Fu X, Huang Q, Starch-lauric acid complex-stabilised Pickering emulsion gels enhance the thermo-oxidative resistance of flaxseed oil, Carbohydrate Polymers, 292, 2022, 119715. [CrossRef]
- Joyce P, Dening TJ, Meola TR, Schultz HB, Holm R, Thomas N, Prestidge CA, Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges, Advanced Drug Delivery Reviews, 142, 2019, 102-117. [CrossRef]
- Williams HD, Speybroeck MV, Augustijns P, Porter CJH, Lipid-Based Formulations Solidified Via Adsorption onto the Mesoporous Carrier Neusilin® US2: Effect of Drug Type and Formulation Composition on In Vitro Pharmaceutical Performance, Journal of Pharmaceutical Sciences, 103, 2014, 1734-1746. [CrossRef]
- Shah DS, Jha DK, Gurram S, Suñé-Pou M, Garcia-Montoya E, Amin PD, A new SeDeM-SLA expert system for screening of solid carriers for the preparation of solidified liquids: A case of citronella oil, Powder Technology, 382, 2021, 605-618. [CrossRef]
- Sreevidya VS, An Overview on Emulgel, International Journal of Pharmaceutical and Phytopharmacological Research (eIJPPR), 9, 2019, 92-97.
- Viljoen JM, Cowley A, du Preez J, Gerber M, du Plessis J, Penetration enhancing effects of selected natural oils utilized in topical dosage forms, Drug Dev Ind Pharm, 41, 2015, 2045-2054. [CrossRef]
- Perioli L, Pagano C, Mazzitelli S, Rossi C, Nastruzzi C, Rheological and functional characterization of new antiinflammatory delivery systems designed for buccal administration, Int J Pharm, 356, 2008, 19-28. [CrossRef]
- de Lafuente Y, Ochoa-Andrade A, Parente ME, Palena MC, Jimenez-Kairuz AF, Preparation and evaluation of caffeine bioadhesive emulgels for cosmetic applications based on formulation design using QbD tools, Int J Cosmet Sci, 42, 2020, 548-556. [CrossRef]
- Kim J-Y, Song J-Y, Lee E-J, Park S-K, Rheological properties and microstructures of Carbopol gel network system, Colloid and Polymer Science, 281, 2003, 614-623. [CrossRef]
- Jones D, Woolfson D, Brown A, Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers, International Journal of Pharmaceutics, 151, 1997, 223-233. [CrossRef]
- Amasya G, Inal O, Sengel-Turk CT, SLN enriched hydrogels for dermal application: Full factorial design study to estimate the relationship between composition and mechanical properties, Chem Phys Lipids, 228, 2020, 104889. [CrossRef]
- Srivastava N, Patel DK, Rai VK, Pal A, Yadav NP, Development of emulgel formulation for vaginal candidiasis: Pharmaceutical characterization, in vitro and in vivo evaluation, Journal of Drug Delivery Science and Technology, 48, 2018, 490-498. [CrossRef]
- Dano MEL, Santos RSd, Silva JBd, Junqueira MV, Ferreira SBdS, Bruschi MLJJoML, Design of emulgel platforms for local propolis delivery: The influence of type and concentration of carbomer, 2021. [CrossRef]
- Inal O. Comparison of sodium alginate versus hydroxypropyl methylcellulose as adhesive polymers on polozamer based meloxicam gel In:2014.
- Maslii Y, Ruban O, Kasparaviciene G, Kalveniene Z, Materiienko A, Ivanauskas L, Mazurkeviciute A, Kopustinskiene DM, Bernatoniene J, The Influence of pH Values on the Rheological, Textural and Release Properties of Carbomer Polacril(®) 40P-Based Dental Gel Formulation with Plant-Derived and Synthetic Active Components, Molecules, 25, 2020. [CrossRef]
- Tadros TF, Léonard S, Verboom C, Wortel V, Taelman M-C, Roschzttardtz F. Personal Care Emulsions Based on Surfactant–Biopolymer Mixtures: Correlation of Rheological Parameters with Sensory Attributes (Edited by Tadros TF). In. Colloids in Cosmetics and Personal Care. Wiley Publishers 2008:107-126.
- Jaworski Z, Spychaj T, Story A, Story G, Carbomer microgels as model yield-stress fluids, Reviews in Chemical Engineering, 0, 2021. [CrossRef]
- Masmoudi H, Piccerelle P, Le Dréau Y, Kister J, A Rheological Method to Evaluate the Physical Stability of Highly Viscous Pharmaceutical Oil-in-Water Emulsions, 23, 2006, 1937 - 1947 [CrossRef].
- Hussain A, Khan GM, Jan SU, Shah SU, Shah K, Akhlaq M, Rahim N, Nawaz A, Wahab A, Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer, Pak. J. Pharm. Sci.,, 25, 2012, 365-369. PMID: 22459463]
- Ali Ashoor J, M. Mohsin J, Mohsin HM, W. Mahde B, M. Gareeb M, Permeability Enhancement of Methotrexate Transdermal Gel using Eucalyptus oil, Peppermint Oil and Olive Oil(Conference Paper )#, Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512), 30, 2022, 16-21. [CrossRef]
- Trommer H, Neubert RH, Overcoming the stratum corneum: the modulation of skin penetration. A review, Skin Pharmacol Physiol, 19, 2006, 106-121. [CrossRef]
- Shehata TM, Ibrahim MM, Elsewedy HS, Curcumin Niosomes Prepared from Proniosomal Gels: In Vitro Skin Permeability, Kinetic and In Vivo Studies, Polymers (Basel), 13, 2021 [CrossRef].
Toplam 39 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Eczacılık ve İlaç Bilimleri (Diğer) |
| Bölüm | Articles |
| Yazarlar | |
| Yayımlanma Tarihi | 27 Haziran 2025 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 27 Sayı: 2 |