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Advancement in the therapeutic potential of drug candidates via oral films: a brief update

Yıl 2023, Cilt: 27 Sayı: 2, 595 - 608, 27.06.2025

J Venkata Krishna Preethi Sudheer

Öz

Oral disintegrating films are unique patient-friendly miniature dosage forms that can get hydrated in
saliva, disintegrate abruptly and release the drug that gets absorbed into systemic circulation via the oral mucosa. This
distinct dosage form has captured the pharmaceutical market due to its therapeutic standpoint, especially in cases
delivering drugs to psychic, un-cooperative, and ambulatory patients. This article provides an insight into oral films,
their pros and cons, formulation aids, strategies, and challenges. We also address the unique properties, of these systems
and polymers used and their properties. The review adds to case studies and also marketed formulations. We also
address the unique properties of this system and polymers used and properties.

Anahtar Kelimeler

Fast dissolving film Oral disintegrating film Oro dispersible film Mouth dissolving

Kaynakça

  • Reddy usha kiran, Reddy sunil kumar, Katta M, Thyagaraju K. a Detailed Review on Fast Dissolving Oral Films. IAJPR. 2018; 8(06): 1351–1326.
  • Desu PK, Brahmaiah B, Nagalakshmi A, Neelima K, Nama S, Baburao C. An overview on rapid dissolving films. Asian J Pharm Clin Res. 2013; 3(1): 15-23.
  • Takeuchi Y, Usui R, Ikezaki H, Tahara K, Takeuchi H. An advanced technique using an electronic taste-sensing system to evaluate the bitterness of orally disintegrating films and the evaluation of model films. Int J Pharm X. 2017; 531(1): 179-190. [CrossRef]
  • Reddy usha kiran, Reddy sunil kumar, Katta M, Thyagaraju K. a Detailed Review on Fast Dissolving Oral Films. IAJPR. 2018; 8(06): 1351–1326.
  • Speer I, Steiner D, Thabet Y, Breitkreutz J, Kwade A. Comparative study on disintegration methods for oral film preparations. Eur J Pharm Biopharm. 2018; 132(9): 50-61. [CrossRef]
  • Desu PK, Brahmaiah B, Nagalakshmi A, Neelima k, Nama S, Baburao C. An overview on rapid dissolving films. Asian J Pharm Clin Res. 2013; 3(1): 15-23.
  • And PS, Goutham P. Formulation Development and Evaluation of Taste Masked Oral Disintegrating Films of Atenolol. Innov Int J Med Pharm Sci. 2017; 2(2): 2–4. [CrossRef]
  • Bhattarai M, Gupta AK. Fast Dissolving Oral Films: A Novel Trend to Oral Drug Delivery System. Sunsari Tech Coll J. 2016; 2(1): 58–68. [CrossRef]
  • Ghodake PP, Karande KM, Osmani RA, Bhosale RR, Harkare BR, Kale BB. Mouth Dissolving Films : Innovative Vehicle for Oral Drug Delivery. Int J Pharma Clin Res. 2013; 2(10): 41–47.
  • Arya A, Chandra A, Sharma V, Pathak K. Fast dissolving oral films: An innovative drug delivery system and dosage form. Int J Chemtech Res. 2010; 2(1): 576–583.
  • Borges AF, Silva C, Coelho JF, Simões S. Oral films: Current status and future perspectives: I - Galenical development and quality attributes. J Control Release. 2015; 206: 1-19. [CrossRef]
  • Nagar P, Chauhan I, Yasir M. Insights into Polymers: Film Formers in Mouth Dissolving Films. Drug Invent Today. 2011; 3(12): 280–289.
  • Mahboob MBH, Riaz T, Jamshaid M, Bashir I, Zulfiqar S. Oral Films: A Comprehensive Review. Int J Curr Pharm Res. 2016; 5(12): 111–117. [CrossRef]
  • Siddiqui MDN, Garg G, Sharma PK. A Short Review on “ A Novel Approach in Oral Fast Dissolving Drug Delivery System and Their Patents ” Conventional oral solid dosage forms ( tablets , capsules ) Modified release tablets/capsules Fast action oral solid dosage form ( fast dissolving tablet. Adv Biol Res (Rennes). 2011; 5(6): 291– 303.
  • Chaturvedi A, Srivastava P, Yadav S, Bansal M, Garg G, Kumar Sharma P. Fast Dissolving Films: A Review. Curr Drug Deliv. 2011; 8(4): 373–380. [CrossRef]
  • Apurva G, Rushikesh J, Mrunal S. Oral thin film technology - current challenges and future scope. Int J Adv Res Eng Appl Sci. 2018; 7(2): 1–14.
  • Pimparade MB, Vo A, Maurya AS, Bae J, Morott JT, Feng X, et al. Development and evaluation of an oral fast disintegrating anti-allergic film using hot-melt extrusion technology. Eur J Pharm Biopharm. 2017; 119(06): 81–90. [CrossRef]
  • Ketul P, Patel KR, Patel MR, Patel NM. Fast Dissolving Films: a Novel Approach To Oral Drug Delivery. Int Res J Pharm. 2011; 2(12): 69–74.
  • Bala R, Pawar P, Khanna S, Arora S. Orally dissolving strips: A new approach to oral drug delivery system. Int J Pharm Investig. 2013; 3(2): 67-76. [CrossRef]
  • Dixit RP, Puthli SP. Oral strip technology: Overview and future potential. J Control Release. 2009; 139(2): 94–107. [CrossRef]
  • Tomar A, Sharma K, Chauhan NS, Mittal A, Bajaj U. Formulation and Evaluation of Fast Dissolving Oral Film of Dicyclomine as a potential route of Buccal Delivery. IJDDR. 2012; 4(2): 408–417.
  • Mushtaque M, Muhammad IN, Fareed Hassan SM, Ali A, Masood R. Development and pharmaceutical evaluation of oral fast dissolving thin film of escitalopram: A patient friendly dosage form. Pak J Pharm Sci. 2020; 33(1): 183- 189.
  • Chonkar AD, Bhagawati ST, Udupa N. An Overview of Fast Dissolving Oral Films. Asian J Pharm Technol. 2015; 5(3): 129-137. [CrossRef]
  • Ghose S. Development of Fast Dissolving Films of Timolol Maleate : Role of Hydrophillic Polyme. Int J Pharm Clin Res Sch. 2016; 5(1): 671–677.
  • Bettini R, Romani AA, Morganti MM, Borghetti AF. Physicochemical and cell adhesion properties of chitosan films prepared from sugar and phosphate-containing solutions. Eur J Pharm Biopharm. 2008; 68(1): 74–81. [CrossRef]
  • Prabhu SC, Parsekar SD, Shetty A, Monteiro SS, Azharuddin M, Shabaraya AR. A review on fast dissolving sublingual films for systemic drug delivery. Int J Pharm Chem Sci. 2014; 3(2): 501-511.
  • Sumi S, Alam MN, Chowdury MI, Mazumdar MM, Chowdhury S, Alam SA. Effective development and evaluation of oral thin film of etoricoxib. World J Pharm Res. 2015; 4: 257-272.
  • Kanekar R, Dandagi PM, Gadad AP. Formulation and evaluation of fast dissolving oral films of prochlorperazine maleate. Indian Drugs. 2015; 52(12): 23–33.
  • Talekar SD, Haware RV, Dave RH. Evaluation of self-nanoemulsifying drug delivery systems using multivariate methods to optimize permeability of captopril oral films. Eur J Pharm Sci. 2019; 130: 215-224. [CrossRef]
  • Kathpalia H, Sule B, Gupte ; Harsha Kathpalia A. Development and Evaluation of Orally Disintegrating Film of Tramadol Hydrochloride. Asian J Biomed Pharm Sci. 2013; 3(24): 27–32.
  • Jadhav YG, Galgatte UC, Chaudhari PD. Challenges in formulation development of fast dissolving oral films. IAJ PR. 2013; 3(8): 1746–1751.
  • Tamer MA, Abd-Al Hammid SN, Ahmed B. Formulation and in vitro evaluation of bromocriptine mesylate as fast dissolving oral film. IJABPT. 2018; 10(1): 7–20.
  • Bala R, Sharma S. Formulation optimization and evaluation of fast dissolving film of aprepitant by using design of experiment. Bull Fac Pharmacy, Cairo Univ. 2018; 56(2): 159–168.
  • Zayed GM, Rasoul SA, Ibrahim MA, Saddik MS, Alshora DH. In vitro and in vivo characterization of domperidone- loaded fast dissolving buccal films. Saudi Pharm J. 2020; 28(3): 266-273. [CrossRef]
  • Shukla AK, Shende S, Jain V. Formulation, Development and Evaluation of Fast Dissolving Oral Film of Levosulpiride. Asian J Pharm Educ Res. 2021; 10(2): 1–7.
  • Bhikshapathi DVRN, Madhuri VD, Rajesham V V, Suthakaran R. Preparation and Evaluation of Fast Dissolving Oral Film Containing Naratriptan HCl. Am J Pharmtech Res. 2014; 4(03): 799–812.
  • Venkateswarlu K. Preparation and evaluation of fast dissolving buccal thin films of bufotenin. Journal of In Silico & In Vitro Pharmacology. 2016; 2(4): 12.
  • Garsuch V, Breitkreutz J. Comparative investigations on different polymers for the preparation of fast-dissolving oral films. J Pharm Pharmacol. 2010; 62(4): 539-545. [CrossRef]
  • Panda BP, Dey NS, Rao ME. Development of innovative orally fast disintegrating film dosage forms: a review. IJPSN. 2012; 5(2): 1666-1674.

Yıl 2023, Cilt: 27 Sayı: 2, 595 - 608, 27.06.2025

J Venkata Krishna Preethi Sudheer

Öz

Kaynakça

  • Reddy usha kiran, Reddy sunil kumar, Katta M, Thyagaraju K. a Detailed Review on Fast Dissolving Oral Films. IAJPR. 2018; 8(06): 1351–1326.
  • Desu PK, Brahmaiah B, Nagalakshmi A, Neelima K, Nama S, Baburao C. An overview on rapid dissolving films. Asian J Pharm Clin Res. 2013; 3(1): 15-23.
  • Takeuchi Y, Usui R, Ikezaki H, Tahara K, Takeuchi H. An advanced technique using an electronic taste-sensing system to evaluate the bitterness of orally disintegrating films and the evaluation of model films. Int J Pharm X. 2017; 531(1): 179-190. [CrossRef]
  • Reddy usha kiran, Reddy sunil kumar, Katta M, Thyagaraju K. a Detailed Review on Fast Dissolving Oral Films. IAJPR. 2018; 8(06): 1351–1326.
  • Speer I, Steiner D, Thabet Y, Breitkreutz J, Kwade A. Comparative study on disintegration methods for oral film preparations. Eur J Pharm Biopharm. 2018; 132(9): 50-61. [CrossRef]
  • Desu PK, Brahmaiah B, Nagalakshmi A, Neelima k, Nama S, Baburao C. An overview on rapid dissolving films. Asian J Pharm Clin Res. 2013; 3(1): 15-23.
  • And PS, Goutham P. Formulation Development and Evaluation of Taste Masked Oral Disintegrating Films of Atenolol. Innov Int J Med Pharm Sci. 2017; 2(2): 2–4. [CrossRef]
  • Bhattarai M, Gupta AK. Fast Dissolving Oral Films: A Novel Trend to Oral Drug Delivery System. Sunsari Tech Coll J. 2016; 2(1): 58–68. [CrossRef]
  • Ghodake PP, Karande KM, Osmani RA, Bhosale RR, Harkare BR, Kale BB. Mouth Dissolving Films : Innovative Vehicle for Oral Drug Delivery. Int J Pharma Clin Res. 2013; 2(10): 41–47.
  • Arya A, Chandra A, Sharma V, Pathak K. Fast dissolving oral films: An innovative drug delivery system and dosage form. Int J Chemtech Res. 2010; 2(1): 576–583.
  • Borges AF, Silva C, Coelho JF, Simões S. Oral films: Current status and future perspectives: I - Galenical development and quality attributes. J Control Release. 2015; 206: 1-19. [CrossRef]
  • Nagar P, Chauhan I, Yasir M. Insights into Polymers: Film Formers in Mouth Dissolving Films. Drug Invent Today. 2011; 3(12): 280–289.
  • Mahboob MBH, Riaz T, Jamshaid M, Bashir I, Zulfiqar S. Oral Films: A Comprehensive Review. Int J Curr Pharm Res. 2016; 5(12): 111–117. [CrossRef]
  • Siddiqui MDN, Garg G, Sharma PK. A Short Review on “ A Novel Approach in Oral Fast Dissolving Drug Delivery System and Their Patents ” Conventional oral solid dosage forms ( tablets , capsules ) Modified release tablets/capsules Fast action oral solid dosage form ( fast dissolving tablet. Adv Biol Res (Rennes). 2011; 5(6): 291– 303.
  • Chaturvedi A, Srivastava P, Yadav S, Bansal M, Garg G, Kumar Sharma P. Fast Dissolving Films: A Review. Curr Drug Deliv. 2011; 8(4): 373–380. [CrossRef]
  • Apurva G, Rushikesh J, Mrunal S. Oral thin film technology - current challenges and future scope. Int J Adv Res Eng Appl Sci. 2018; 7(2): 1–14.
  • Pimparade MB, Vo A, Maurya AS, Bae J, Morott JT, Feng X, et al. Development and evaluation of an oral fast disintegrating anti-allergic film using hot-melt extrusion technology. Eur J Pharm Biopharm. 2017; 119(06): 81–90. [CrossRef]
  • Ketul P, Patel KR, Patel MR, Patel NM. Fast Dissolving Films: a Novel Approach To Oral Drug Delivery. Int Res J Pharm. 2011; 2(12): 69–74.
  • Bala R, Pawar P, Khanna S, Arora S. Orally dissolving strips: A new approach to oral drug delivery system. Int J Pharm Investig. 2013; 3(2): 67-76. [CrossRef]
  • Dixit RP, Puthli SP. Oral strip technology: Overview and future potential. J Control Release. 2009; 139(2): 94–107. [CrossRef]
  • Tomar A, Sharma K, Chauhan NS, Mittal A, Bajaj U. Formulation and Evaluation of Fast Dissolving Oral Film of Dicyclomine as a potential route of Buccal Delivery. IJDDR. 2012; 4(2): 408–417.
  • Mushtaque M, Muhammad IN, Fareed Hassan SM, Ali A, Masood R. Development and pharmaceutical evaluation of oral fast dissolving thin film of escitalopram: A patient friendly dosage form. Pak J Pharm Sci. 2020; 33(1): 183- 189.
  • Chonkar AD, Bhagawati ST, Udupa N. An Overview of Fast Dissolving Oral Films. Asian J Pharm Technol. 2015; 5(3): 129-137. [CrossRef]
  • Ghose S. Development of Fast Dissolving Films of Timolol Maleate : Role of Hydrophillic Polyme. Int J Pharm Clin Res Sch. 2016; 5(1): 671–677.
  • Bettini R, Romani AA, Morganti MM, Borghetti AF. Physicochemical and cell adhesion properties of chitosan films prepared from sugar and phosphate-containing solutions. Eur J Pharm Biopharm. 2008; 68(1): 74–81. [CrossRef]
  • Prabhu SC, Parsekar SD, Shetty A, Monteiro SS, Azharuddin M, Shabaraya AR. A review on fast dissolving sublingual films for systemic drug delivery. Int J Pharm Chem Sci. 2014; 3(2): 501-511.
  • Sumi S, Alam MN, Chowdury MI, Mazumdar MM, Chowdhury S, Alam SA. Effective development and evaluation of oral thin film of etoricoxib. World J Pharm Res. 2015; 4: 257-272.
  • Kanekar R, Dandagi PM, Gadad AP. Formulation and evaluation of fast dissolving oral films of prochlorperazine maleate. Indian Drugs. 2015; 52(12): 23–33.
  • Talekar SD, Haware RV, Dave RH. Evaluation of self-nanoemulsifying drug delivery systems using multivariate methods to optimize permeability of captopril oral films. Eur J Pharm Sci. 2019; 130: 215-224. [CrossRef]
  • Kathpalia H, Sule B, Gupte ; Harsha Kathpalia A. Development and Evaluation of Orally Disintegrating Film of Tramadol Hydrochloride. Asian J Biomed Pharm Sci. 2013; 3(24): 27–32.
  • Jadhav YG, Galgatte UC, Chaudhari PD. Challenges in formulation development of fast dissolving oral films. IAJ PR. 2013; 3(8): 1746–1751.
  • Tamer MA, Abd-Al Hammid SN, Ahmed B. Formulation and in vitro evaluation of bromocriptine mesylate as fast dissolving oral film. IJABPT. 2018; 10(1): 7–20.
  • Bala R, Sharma S. Formulation optimization and evaluation of fast dissolving film of aprepitant by using design of experiment. Bull Fac Pharmacy, Cairo Univ. 2018; 56(2): 159–168.
  • Zayed GM, Rasoul SA, Ibrahim MA, Saddik MS, Alshora DH. In vitro and in vivo characterization of domperidone- loaded fast dissolving buccal films. Saudi Pharm J. 2020; 28(3): 266-273. [CrossRef]
  • Shukla AK, Shende S, Jain V. Formulation, Development and Evaluation of Fast Dissolving Oral Film of Levosulpiride. Asian J Pharm Educ Res. 2021; 10(2): 1–7.
  • Bhikshapathi DVRN, Madhuri VD, Rajesham V V, Suthakaran R. Preparation and Evaluation of Fast Dissolving Oral Film Containing Naratriptan HCl. Am J Pharmtech Res. 2014; 4(03): 799–812.
  • Venkateswarlu K. Preparation and evaluation of fast dissolving buccal thin films of bufotenin. Journal of In Silico & In Vitro Pharmacology. 2016; 2(4): 12.
  • Garsuch V, Breitkreutz J. Comparative investigations on different polymers for the preparation of fast-dissolving oral films. J Pharm Pharmacol. 2010; 62(4): 539-545. [CrossRef]
  • Panda BP, Dey NS, Rao ME. Development of innovative orally fast disintegrating film dosage forms: a review. IJPSN. 2012; 5(2): 1666-1674.
Toplam 39 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri (Diğer)
Bölüm Articles
Yazarlar

J Venkata Krishna 0000-0001-9121-5477

Preethi Sudheer 0000-0002-7041-8993

Yayımlanma Tarihi 27 Haziran 2025
Yayımlandığı Sayı Yıl 2023 Cilt: 27 Sayı: 2

Kaynak Göster

APA Krishna, J. V., & Sudheer, P. (2025). Advancement in the therapeutic potential of drug candidates via oral films: a brief update. Journal of Research in Pharmacy, 27(2), 595-608.
AMA Krishna JV, Sudheer P. Advancement in the therapeutic potential of drug candidates via oral films: a brief update. J. Res. Pharm. Haziran 2025;27(2):595-608.
Chicago Krishna, J Venkata, ve Preethi Sudheer. “Advancement in the Therapeutic Potential of Drug Candidates via Oral Films: A Brief Update”. Journal of Research in Pharmacy 27, sy. 2 (Haziran 2025): 595-608.
EndNote Krishna JV, Sudheer P (01 Haziran 2025) Advancement in the therapeutic potential of drug candidates via oral films: a brief update. Journal of Research in Pharmacy 27 2 595–608.
IEEE J. V. Krishna ve P. Sudheer, “Advancement in the therapeutic potential of drug candidates via oral films: a brief update”, J. Res. Pharm., c. 27, sy. 2, ss. 595–608, 2025.
ISNAD Krishna, J Venkata - Sudheer, Preethi. “Advancement in the Therapeutic Potential of Drug Candidates via Oral Films: A Brief Update”. Journal of Research in Pharmacy 27/2 (Haziran 2025), 595-608.
JAMA Krishna JV, Sudheer P. Advancement in the therapeutic potential of drug candidates via oral films: a brief update. J. Res. Pharm. 2025;27:595–608.
MLA Krishna, J Venkata ve Preethi Sudheer. “Advancement in the Therapeutic Potential of Drug Candidates via Oral Films: A Brief Update”. Journal of Research in Pharmacy, c. 27, sy. 2, 2025, ss. 595-08.
Vancouver Krishna JV, Sudheer P. Advancement in the therapeutic potential of drug candidates via oral films: a brief update. J. Res. Pharm. 2025;27(2):595-608.