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Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics

Yıl 2023, Cilt: 27 Sayı: 2, 860 - 872, 27.06.2025

Shimul Halder M. A. K. Azad Md. Shamiul Islam Istiak Hossen Lata Shuma Eva Rahman Kabir

Öz

The main objective of this work was to improve the biopharmaceutical properties of Domperidone (DMP)-
loaded mixed polymeric micellar solid dispersion (MMSD). The apparent solubility of DMP in polymer solutions was
used to choose suitable amphiphilic polymers for the preparation of an MMSD system. Different ratios of Soluplus®
and Kolliphor® P188 (ranging 0–80 %w/w) have been used to prepare the MMSD-DMP by solvent evaporation method
and physicochemically characterized. Among the tested different ratios of Soluplus® and Kolliphor® P188, the optimal
ratio of polymers was selected based on the solubility and surface properties. The solubility of optimized MMSD-DMP
in water was found more than 17 times higher compared to that of the crystalline DMP. The crystallinity evaluations of
the optimized formulation revealed amorphization of DMP, resulting in enhanced solubility. The drug release pattern
did not change significantly between formulations of MMSD-DMP produced by rotary vacuum drying and freeze
drying. From these findings, MMSD approach might be a promising dosage option for DMP, offering enhanced
biopharmaceutical behaviors leading to improved oral absorption.

Anahtar Kelimeler

Domperidone mixed polymeric micellar solid dispersion Soluplus® Kolliphor® P188 solubility dissolution

Kaynakça

  • Osinski MA, Uchic ME, Seifert T, Shaughnessy TK, Miller LN, Nakane M, et al. Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets. Pharmacol Biochem Behav. 2005;81(1):211–9. [CrossRef]
  • Zhang C-H, Zhao B-X, Huang Y, Wang Y, Ke X-Y, Zhao B-J, et al. A Novel Domperidone Hydrogel: Preparation, Characterization, Pharmacokinetic, and Pharmacodynamic Properties. J Drug Deliv. 2011;2011:1–9. [CrossRef]
  • Silvers D, Kipnes M, Broadstone V, Patterson D, Quigley EMM, McCallum R, et al. Domperidone in the management of symptoms of diabetic gastroparesis: Efficacy, tolerability, and quality-of-life outcomes in a multicenter controlled trial. Clin Ther. 1998;20(3):438–53. [CrossRef]
  • Bacchi S, Chim I, Kramer P, Postuma RB. Domperidone for Hypotension in Parkinson’s Disease: A Systematic Review. J Parkinsons Dis. 2017;7(4):603–17. [CrossRef]
  • Grzeskowiak L, Smithers L, Amir L, Grivell R. Domperidone for increasing breast milk volume in mothers expressing breast milk for their preterm infants: a systematic review and meta-analysis. BJOG An Int J Obstet Gynaecol. 2018 Oct;125(11):1371–8. [CrossRef]
  • Patel D, Patel S, Patel C. Formulation and evaluation of fast dissolving tablet containing domperidone ternary solid dispersion. Int J Pharm Investig. 2014;4(4):174. [CrossRef]
  • Bhalani DV, Nutan B, Kumar A, Singh Chandel AK. Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics. Biomedicines. 2022; 10(9):2055. [CrossRef]
  • Bikiaris DN. Solid dispersions, Part II: New strategies in manufacturing methods for dissolution rate enhancement of poorly water-soluble drugs. Expert Opin Drug Deliv. 2011;8(12):1663–80. [CrossRef]
  • Ndlovu ST, Ullah N, Khan S, Ramharack P, Soliman M, de Matas M, et al. Domperidone nanocrystals with boosted oral bioavailability: fabrication, evaluation and molecular insight into the polymer-domperidone nanocrystal interaction. Drug Deliv Transl Res. 2019;9(1):284–97. [CrossRef]
  • Sareen S, Joseph L, Mathew G. Improvement in solubility of poor water-soluble drugs by solid dispersion. Int J Pharm Investig. 2012;2(1):12. [CrossRef]
  • Vo CLN, Park C, Lee BJ. Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs. Eur J Pharm Biopharm. 2013;85(3 PART B):799–813. [CrossRef]
  • Zhang Q, Polyakov NE, Chistyachenko YS, Khvostov M V., Frolova TS, Tolstikova TG, et al. Preparation of curcumin self-micelle solid dispersion with enhanced bioavailability and cytotoxic activity by mechanochemistry. Drug Deliv. 2018;25(1):198–209. [CrossRef]
  • Ghezzi M, Pescina S, Padula C, Santi P, Del Favero E, Cantù L, et al. Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions. J Control Release. 2021;332:312– 36. [CrossRef]
  • Ahmad Z, Shah A, Siddiq M, Kraatz H-B. Polymeric micelles as drug delivery vehicles. RSC Adv. 2014;4(33):140–70. [CrossRef]
  • Cagel M, Tesan FC, Bernabeu E, Salgueiro MJ, Zubillaga MB, Moretton MA, et al. Polymeric mixed micelles as nanomedicines: Achievements and perspectives. Eur J Pharm Biopharm. 2017;113(2017):211–28. [CrossRef]
  • ernabeu E, Gonzalez L, Cagel M, Gergic EP, Moretton MA, Chiappetta DA. Novel Soluplus®-TPGS mixed micelles for encapsulation of paclitaxel with enhanced in vitro cytotoxicity on breast and ovarian cancer cell lines. Colloids Surfaces B Biointerfaces. 2016;140:403–11. [CrossRef]
  • R.S. B, A.S. J, D.T. M, A.G. J, P.A. RH, M.S. N. Soluplus based polymeric micelles and mixed micelles of lornoxicam: Design, characterization and In vivo efficacy studies in rats. Indian J Pharm Educ Res. 2016;50(2):277–86. [CrossRef]
  • Raffin RP, Colomé LM, Hoffmeister CRD, Colombo P, Rossi A, Sonvico F, et al. Pharmacokinetics evaluation of soft agglomerates for prompt delivery of enteric pantoprazole-loaded microparticles. Eur J Pharm Biopharm. 2010;74(2):275–80. [CrossRef]
  • Hornok V. Serum Albumin Nanoparticles: Problems and Prospects. Polymers. 2021; 13(21):3759. [CrossRef]
  • Srivastava A, Prajapati A. Albumin and functionalized albumin nanoparticles: Production strategies, characterization, and target indications. Asian Biomed. 2020;14(6):217–42. [CrossRef]
  • Tran PHL, Duan W, Lee B-J, Tran TTD. Current Designs of Polymer Blends in Solid Dispersions for Improving Drug Bioavailability. cCurr Drug Metab. 2018;19(13):1111–8. [CrossRef]
  • Tran PHL, Tran TTD, Park JB, Lee BJ. Controlled release systems containing solid dispersions: Strategies and mechanisms. Vol. 28, Pharmaceutical Research. 2011. p. 2353–78. [CrossRef]
  • Prasad D, Chauhan H, Atef E. Amorphous stabilization and dissolution enhancement of amorphous ternary solid dispersions: Combination of polymers showing drug-polymer interaction for synergistic effects. J Pharm Sci. 2014;103(11):3511–23. [CrossRef]
  • Khadka P, Ro J, Kim H, Kim I, Kim JT, Kim H, et al. Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability. Asian J Pharm Sci. 2014;9(6):304–16. [CrossRef]
  • Vasconcelos T, Marques S, Sarmento B. The biopharmaceutical classification system of excipients. Ther Deliv. 2017;8(2):65–78. [CrossRef]
  • Ilie A-R, Griffin BT, Vertzoni M, Kuentz M, Kolakovic R, Prudic-Paus A, et al. Exploring precipitation inhibitors to improve in vivo absorption of cinnarizine from supersaturated lipid-based drug delivery systems. Eur J Pharm Sci. 2021;159:105691. [CrossRef]
  • Gangarde YM, T. K. S, Panigrahi NR, Mishra RK, Saraogi I. Amphiphilic Small-Molecule Assemblies to Enhance the Solubility and Stability of Hydrophobic Drugs. ACS Omega. 2020;5(43):28375–81. [CrossRef]
  • Pereira JM, Mejia-Ariza R, Ilevbare GA, McGettigan HE, Sriranganathan N, Taylor LS, et al. Interplay of Degradation, Dissolution and Stabilization of Clarithromycin and Its Amorphous Solid Dispersions. Mol Pharm. 2013 Dec 2;10(12):4640–53. [CrossRef]
  • Shi NQ, Lai HW, Zhang Y, Feng B, Xiao X, Zhang HM, et al. On the inherent properties of Soluplus and its application in ibuprofen solid dispersions generated by microwave-quench cooling technology. Pharm Dev Technol. 2018;23(6):573–86. [CrossRef]
  • Hu M, Zhang J, Ding R, Fu Y, Gong T, Zhang Z. Improved oral bioavailability and therapeutic efficacy of dabigatran etexilate via Soluplus-TPGS binary mixed micelles system. Drug Dev Ind Pharm. 2017;43(4):687–97. [CrossRef]
  • Wang T, Markham A, Thomas SJ, Wang N, Huang L, Clemens M, et al. Solution Stability of Poloxamer 188 Under Stress Conditions. J Pharm Sci. 2019;108(3):1264–71. [CrossRef]
  • Tian JL, Zhao YZ, Jin Z, Lu CT, Tang QQ, Xiang Q, et al. Synthesis and characterization of Poloxamer 188-grafted heparin copolymer. Drug Dev Ind Pharm. 2010;36(7):832–8. [CrossRef]
  • Xu W, Ling P, Zhang T. Polymeric micelles, a promising drug delivery system to enhance bioavailability of poorly water-soluble drugs. Vol. 2013, Journal of Drug Delivery. 2013. [CrossRef]
  • Dou J, Zhang H, Liu X, Zhang M, Zhai G. Preparation and evaluation in vitro and in vivo of docetaxel loaded mixed micelles for oral administration. Colloids Surfaces B Biointerfaces. 2014;114:20–7. [CrossRef]
  • Fujimori M, Kadota K, Tozuka Y. Mixed Micelle System Produced by Interaction Between Transglycosylated Stevia and an Ionic Surfactant Improves Dissolution Profile of Mefenamic Acid. J Pharm Sci. 2017;106(4):1117–23. [CrossRef]
  • Oudah MH, Rahi FA, Al-Lami MS. Preparation and characterization of domperidone nanoparticles for dissolution improvement. Iraqi J Pharm Sci. 2018;27(1):39–52. [CrossRef]
  • Li C, Zhu Y. Quantitative polarized light microscopy using spectral multiplexing interferometry. Opt Lett. 2015;40(11):2622–5. [CrossRef]
  • Onoue S, Suzuki H, Kojo Y, Matsunaga S, Sato H, Mizumoto T, et al. Self-micellizing solid dispersion of cyclosporine A with improved dissolution and oral bioavailability. Eur J Pharm Sci. 2014;62:16–22. [CrossRef]
  • Ki B, Soo J, Kang S, Young S, Hong S. Development of self-microemulsifying drug delivery systems ( SMEDDS ) for oral bioavailability enhancement of simvastatin in beagle dogs. 2004;274(1–2):65–73. [CrossRef]
  • Bai G, Wang Y, Armenante PM. Velocity profiles and shear strain rate variability in the USP Dissolution Testing Apparatus 2 at different impeller agitation speeds. Int J Pharm. 2011;403(1–2):1–14. [CrossRef]
  • Dokoumetzidis A, Macheras P. A century of dissolution research: From Noyes and Whitney to the Biopharmaceutics Classification System. Int J Pharm. 2006;321(1):1–11. [CrossRef]
  • Onoue S, Kojo Y, Aoki Y, Kawabata Y, Yamauchi Y, Yamada S. Physicochemical and pharmacokinetic characterization of amorphous solid dispersion of tranilast with enhanced solubility in gastric fluid and improved oral bioavailability. Drug Metab Pharmacokinet. 2012;27(4):379–87. [CrossRef]
  • Boonsongrit Y, Mueller BW, Mitrevej A. Characterization of drug-chitosan interaction by 1H NMR, FTIR and isothermal titration calorimetry. Eur J Pharm Biopharm. 2008;69(1):388–95. [CrossRef]
  • Pandey MM, Jaipal A, Charde SY, Goel P, Kumar L. Dissolution enhancement of felodipine by amorphous nanodispersions using an amphiphilic polymer: insight into the role of drug–polymer interactions on drug dissolution. Pharm Dev Technol. 2016;21(4):463–74. [CrossRef]
  • Prabu S, Shirwaikar A, Shirwaikar A, Kumar C, Joseph A, Kumar R. Simultaneous estimation of esomeprazole and domperidone by UV spectrophotometric method. Indian J Pharm Sci. 2008;70(1):128–31. [CrossRef]
  • Higuchi, T and Connors KA. Phase Solubility Studies. Adv Anal Chem Instrum. 1965;4:117–212. [CrossRef]
  • Rubingh DN. Mixed micelle solutions. In: Solution Chem Surfactants, [Proc Sect 52nd Colloid Surf Sci Symp]. 1979. p. 337–54.

Yıl 2023, Cilt: 27 Sayı: 2, 860 - 872, 27.06.2025

Shimul Halder M. A. K. Azad Md. Shamiul Islam Istiak Hossen Lata Shuma Eva Rahman Kabir

Öz

Kaynakça

  • Osinski MA, Uchic ME, Seifert T, Shaughnessy TK, Miller LN, Nakane M, et al. Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets. Pharmacol Biochem Behav. 2005;81(1):211–9. [CrossRef]
  • Zhang C-H, Zhao B-X, Huang Y, Wang Y, Ke X-Y, Zhao B-J, et al. A Novel Domperidone Hydrogel: Preparation, Characterization, Pharmacokinetic, and Pharmacodynamic Properties. J Drug Deliv. 2011;2011:1–9. [CrossRef]
  • Silvers D, Kipnes M, Broadstone V, Patterson D, Quigley EMM, McCallum R, et al. Domperidone in the management of symptoms of diabetic gastroparesis: Efficacy, tolerability, and quality-of-life outcomes in a multicenter controlled trial. Clin Ther. 1998;20(3):438–53. [CrossRef]
  • Bacchi S, Chim I, Kramer P, Postuma RB. Domperidone for Hypotension in Parkinson’s Disease: A Systematic Review. J Parkinsons Dis. 2017;7(4):603–17. [CrossRef]
  • Grzeskowiak L, Smithers L, Amir L, Grivell R. Domperidone for increasing breast milk volume in mothers expressing breast milk for their preterm infants: a systematic review and meta-analysis. BJOG An Int J Obstet Gynaecol. 2018 Oct;125(11):1371–8. [CrossRef]
  • Patel D, Patel S, Patel C. Formulation and evaluation of fast dissolving tablet containing domperidone ternary solid dispersion. Int J Pharm Investig. 2014;4(4):174. [CrossRef]
  • Bhalani DV, Nutan B, Kumar A, Singh Chandel AK. Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics. Biomedicines. 2022; 10(9):2055. [CrossRef]
  • Bikiaris DN. Solid dispersions, Part II: New strategies in manufacturing methods for dissolution rate enhancement of poorly water-soluble drugs. Expert Opin Drug Deliv. 2011;8(12):1663–80. [CrossRef]
  • Ndlovu ST, Ullah N, Khan S, Ramharack P, Soliman M, de Matas M, et al. Domperidone nanocrystals with boosted oral bioavailability: fabrication, evaluation and molecular insight into the polymer-domperidone nanocrystal interaction. Drug Deliv Transl Res. 2019;9(1):284–97. [CrossRef]
  • Sareen S, Joseph L, Mathew G. Improvement in solubility of poor water-soluble drugs by solid dispersion. Int J Pharm Investig. 2012;2(1):12. [CrossRef]
  • Vo CLN, Park C, Lee BJ. Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs. Eur J Pharm Biopharm. 2013;85(3 PART B):799–813. [CrossRef]
  • Zhang Q, Polyakov NE, Chistyachenko YS, Khvostov M V., Frolova TS, Tolstikova TG, et al. Preparation of curcumin self-micelle solid dispersion with enhanced bioavailability and cytotoxic activity by mechanochemistry. Drug Deliv. 2018;25(1):198–209. [CrossRef]
  • Ghezzi M, Pescina S, Padula C, Santi P, Del Favero E, Cantù L, et al. Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions. J Control Release. 2021;332:312– 36. [CrossRef]
  • Ahmad Z, Shah A, Siddiq M, Kraatz H-B. Polymeric micelles as drug delivery vehicles. RSC Adv. 2014;4(33):140–70. [CrossRef]
  • Cagel M, Tesan FC, Bernabeu E, Salgueiro MJ, Zubillaga MB, Moretton MA, et al. Polymeric mixed micelles as nanomedicines: Achievements and perspectives. Eur J Pharm Biopharm. 2017;113(2017):211–28. [CrossRef]
  • ernabeu E, Gonzalez L, Cagel M, Gergic EP, Moretton MA, Chiappetta DA. Novel Soluplus®-TPGS mixed micelles for encapsulation of paclitaxel with enhanced in vitro cytotoxicity on breast and ovarian cancer cell lines. Colloids Surfaces B Biointerfaces. 2016;140:403–11. [CrossRef]
  • R.S. B, A.S. J, D.T. M, A.G. J, P.A. RH, M.S. N. Soluplus based polymeric micelles and mixed micelles of lornoxicam: Design, characterization and In vivo efficacy studies in rats. Indian J Pharm Educ Res. 2016;50(2):277–86. [CrossRef]
  • Raffin RP, Colomé LM, Hoffmeister CRD, Colombo P, Rossi A, Sonvico F, et al. Pharmacokinetics evaluation of soft agglomerates for prompt delivery of enteric pantoprazole-loaded microparticles. Eur J Pharm Biopharm. 2010;74(2):275–80. [CrossRef]
  • Hornok V. Serum Albumin Nanoparticles: Problems and Prospects. Polymers. 2021; 13(21):3759. [CrossRef]
  • Srivastava A, Prajapati A. Albumin and functionalized albumin nanoparticles: Production strategies, characterization, and target indications. Asian Biomed. 2020;14(6):217–42. [CrossRef]
  • Tran PHL, Duan W, Lee B-J, Tran TTD. Current Designs of Polymer Blends in Solid Dispersions for Improving Drug Bioavailability. cCurr Drug Metab. 2018;19(13):1111–8. [CrossRef]
  • Tran PHL, Tran TTD, Park JB, Lee BJ. Controlled release systems containing solid dispersions: Strategies and mechanisms. Vol. 28, Pharmaceutical Research. 2011. p. 2353–78. [CrossRef]
  • Prasad D, Chauhan H, Atef E. Amorphous stabilization and dissolution enhancement of amorphous ternary solid dispersions: Combination of polymers showing drug-polymer interaction for synergistic effects. J Pharm Sci. 2014;103(11):3511–23. [CrossRef]
  • Khadka P, Ro J, Kim H, Kim I, Kim JT, Kim H, et al. Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability. Asian J Pharm Sci. 2014;9(6):304–16. [CrossRef]
  • Vasconcelos T, Marques S, Sarmento B. The biopharmaceutical classification system of excipients. Ther Deliv. 2017;8(2):65–78. [CrossRef]
  • Ilie A-R, Griffin BT, Vertzoni M, Kuentz M, Kolakovic R, Prudic-Paus A, et al. Exploring precipitation inhibitors to improve in vivo absorption of cinnarizine from supersaturated lipid-based drug delivery systems. Eur J Pharm Sci. 2021;159:105691. [CrossRef]
  • Gangarde YM, T. K. S, Panigrahi NR, Mishra RK, Saraogi I. Amphiphilic Small-Molecule Assemblies to Enhance the Solubility and Stability of Hydrophobic Drugs. ACS Omega. 2020;5(43):28375–81. [CrossRef]
  • Pereira JM, Mejia-Ariza R, Ilevbare GA, McGettigan HE, Sriranganathan N, Taylor LS, et al. Interplay of Degradation, Dissolution and Stabilization of Clarithromycin and Its Amorphous Solid Dispersions. Mol Pharm. 2013 Dec 2;10(12):4640–53. [CrossRef]
  • Shi NQ, Lai HW, Zhang Y, Feng B, Xiao X, Zhang HM, et al. On the inherent properties of Soluplus and its application in ibuprofen solid dispersions generated by microwave-quench cooling technology. Pharm Dev Technol. 2018;23(6):573–86. [CrossRef]
  • Hu M, Zhang J, Ding R, Fu Y, Gong T, Zhang Z. Improved oral bioavailability and therapeutic efficacy of dabigatran etexilate via Soluplus-TPGS binary mixed micelles system. Drug Dev Ind Pharm. 2017;43(4):687–97. [CrossRef]
  • Wang T, Markham A, Thomas SJ, Wang N, Huang L, Clemens M, et al. Solution Stability of Poloxamer 188 Under Stress Conditions. J Pharm Sci. 2019;108(3):1264–71. [CrossRef]
  • Tian JL, Zhao YZ, Jin Z, Lu CT, Tang QQ, Xiang Q, et al. Synthesis and characterization of Poloxamer 188-grafted heparin copolymer. Drug Dev Ind Pharm. 2010;36(7):832–8. [CrossRef]
  • Xu W, Ling P, Zhang T. Polymeric micelles, a promising drug delivery system to enhance bioavailability of poorly water-soluble drugs. Vol. 2013, Journal of Drug Delivery. 2013. [CrossRef]
  • Dou J, Zhang H, Liu X, Zhang M, Zhai G. Preparation and evaluation in vitro and in vivo of docetaxel loaded mixed micelles for oral administration. Colloids Surfaces B Biointerfaces. 2014;114:20–7. [CrossRef]
  • Fujimori M, Kadota K, Tozuka Y. Mixed Micelle System Produced by Interaction Between Transglycosylated Stevia and an Ionic Surfactant Improves Dissolution Profile of Mefenamic Acid. J Pharm Sci. 2017;106(4):1117–23. [CrossRef]
  • Oudah MH, Rahi FA, Al-Lami MS. Preparation and characterization of domperidone nanoparticles for dissolution improvement. Iraqi J Pharm Sci. 2018;27(1):39–52. [CrossRef]
  • Li C, Zhu Y. Quantitative polarized light microscopy using spectral multiplexing interferometry. Opt Lett. 2015;40(11):2622–5. [CrossRef]
  • Onoue S, Suzuki H, Kojo Y, Matsunaga S, Sato H, Mizumoto T, et al. Self-micellizing solid dispersion of cyclosporine A with improved dissolution and oral bioavailability. Eur J Pharm Sci. 2014;62:16–22. [CrossRef]
  • Ki B, Soo J, Kang S, Young S, Hong S. Development of self-microemulsifying drug delivery systems ( SMEDDS ) for oral bioavailability enhancement of simvastatin in beagle dogs. 2004;274(1–2):65–73. [CrossRef]
  • Bai G, Wang Y, Armenante PM. Velocity profiles and shear strain rate variability in the USP Dissolution Testing Apparatus 2 at different impeller agitation speeds. Int J Pharm. 2011;403(1–2):1–14. [CrossRef]
  • Dokoumetzidis A, Macheras P. A century of dissolution research: From Noyes and Whitney to the Biopharmaceutics Classification System. Int J Pharm. 2006;321(1):1–11. [CrossRef]
  • Onoue S, Kojo Y, Aoki Y, Kawabata Y, Yamauchi Y, Yamada S. Physicochemical and pharmacokinetic characterization of amorphous solid dispersion of tranilast with enhanced solubility in gastric fluid and improved oral bioavailability. Drug Metab Pharmacokinet. 2012;27(4):379–87. [CrossRef]
  • Boonsongrit Y, Mueller BW, Mitrevej A. Characterization of drug-chitosan interaction by 1H NMR, FTIR and isothermal titration calorimetry. Eur J Pharm Biopharm. 2008;69(1):388–95. [CrossRef]
  • Pandey MM, Jaipal A, Charde SY, Goel P, Kumar L. Dissolution enhancement of felodipine by amorphous nanodispersions using an amphiphilic polymer: insight into the role of drug–polymer interactions on drug dissolution. Pharm Dev Technol. 2016;21(4):463–74. [CrossRef]
  • Prabu S, Shirwaikar A, Shirwaikar A, Kumar C, Joseph A, Kumar R. Simultaneous estimation of esomeprazole and domperidone by UV spectrophotometric method. Indian J Pharm Sci. 2008;70(1):128–31. [CrossRef]
  • Higuchi, T and Connors KA. Phase Solubility Studies. Adv Anal Chem Instrum. 1965;4:117–212. [CrossRef]
  • Rubingh DN. Mixed micelle solutions. In: Solution Chem Surfactants, [Proc Sect 52nd Colloid Surf Sci Symp]. 1979. p. 337–54.
Toplam 47 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmasotik Biyoteknoloji
Bölüm Articles
Yazarlar

Shimul Halder 0000-0002-8445-2965

M. A. K. Azad 0000-0002-1493-8433

Md. Shamiul Islam 0000-0002-8835-3024

Istiak Hossen 0000-0002-4154-7278

Lata Shuma 0000-0001-7661-7857

Eva Rahman Kabir 0000-0001-9016-0865

Yayımlanma Tarihi 27 Haziran 2025
Yayımlandığı Sayı Yıl 2023 Cilt: 27 Sayı: 2

Kaynak Göster

APA Halder, S., Azad, M. A. K., Islam, M. S., Hossen, I., vd. (2025). Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics. Journal of Research in Pharmacy, 27(2), 860-872.
AMA Halder S, Azad MAK, Islam MS, Hossen I, Shuma L, Kabir ER. Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics. J. Res. Pharm. Haziran 2025;27(2):860-872.
Chicago Halder, Shimul, M. A. K. Azad, Md. Shamiul Islam, Istiak Hossen, Lata Shuma, ve Eva Rahman Kabir. “Strategic Application of a Mixed Polymeric Micellar Solid Dispersion System to Domperidone for Improved Biopharmaceutical Characteristics”. Journal of Research in Pharmacy 27, sy. 2 (Haziran 2025): 860-72.
EndNote Halder S, Azad MAK, Islam MS, Hossen I, Shuma L, Kabir ER (01 Haziran 2025) Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics. Journal of Research in Pharmacy 27 2 860–872.
IEEE S. Halder, M. A. K. Azad, M. S. Islam, I. Hossen, L. Shuma, ve E. R. Kabir, “Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics”, J. Res. Pharm., c. 27, sy. 2, ss. 860–872, 2025.
ISNAD Halder, Shimul vd. “Strategic Application of a Mixed Polymeric Micellar Solid Dispersion System to Domperidone for Improved Biopharmaceutical Characteristics”. Journal of Research in Pharmacy 27/2 (Haziran 2025), 860-872.
JAMA Halder S, Azad MAK, Islam MS, Hossen I, Shuma L, Kabir ER. Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics. J. Res. Pharm. 2025;27:860–872.
MLA Halder, Shimul vd. “Strategic Application of a Mixed Polymeric Micellar Solid Dispersion System to Domperidone for Improved Biopharmaceutical Characteristics”. Journal of Research in Pharmacy, c. 27, sy. 2, 2025, ss. 860-72.
Vancouver Halder S, Azad MAK, Islam MS, Hossen I, Shuma L, Kabir ER. Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics. J. Res. Pharm. 2025;27(2):860-72.