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HPLC-DAD Screening and Antioxidant Activity of Phenolic Compounds of Salvia balansae de Noé Leaves Extract

Yıl 2023, Cilt: 27 Sayı: 3, 1076 - 1085, 28.06.2025

Mohamed Malik Mahdjoub Nourelimane Benzitoune Yacine Maiz Nour El Houda Aouadi Mustapha Mounir Bouhenna Nabil Kadri

Öz

Salvia balansae de Noé a have known to be an important source of a huge variety of no toxic bioactive compounds with lack of information hinders exploitation in food and pharmaceutical industries as natural antioxidants. In this work, the phenolic compounds from S. balansae leaves were extracted using an ultrasound-assisted methodology and were separated and identified by HPLC-DAD. The antioxidant activity was evaluated by ABTS, and DPPH scavenging assays, Iron (Fe2+) Chelating ability and reducing power (FRAP) tests. The total phenolic compounds (TPC) and total flavonoids content (TFC) were found with amounts of 49.63 ± 6.31 mg GAE/g DW and 8.14 ± 0.39 mg QE/g DW respectively. The ABTS, DPPH assays and metal chelating ability test demonstrated a higher antioxidant properties with IC50 values of 328.95 ± 5.29 µg/mL, 545.03 ± 3.267 µg/mL and 689.40 ± 0.86 µg/mL respectively. The reducing power at 700 nm increased considerably with concentration. In addition, the HPLC-DAD analysis showed that there were twelve detectable phenolic compounds and the benzoic acid, quercetin, myrecetin, hydroxyflavon, and ascorbic acid have been exclusively identified for the first time in S. balansae leaves extract and are rarely determined in other Salvia L. species. Therefore, these results brought new data about the main phenolic compounds presents in S. balansae leaves extract with a strong antioxidant potential, which will be an alternative source for synthetic compounds.

Anahtar Kelimeler

Salvia balansae de Noé phenolic compounds antioxidant capacity HPLC-DAD profile

Kaynakça

  • [1] Urbizo-Reyes U, San Martin-González MF, Garcia-Bravo J, Vigil ALM, Liceaga AM. Physicochemical characteristics of chia seed (Salvia hispanica) protein hydrolysates produced using ultrasonication followed by microwave-assisted hydrolysis. Food Hydrocoll. 2019; 97: 105187. https://doi.org/10.1016/j.foodhyd.2019.105187
  • [2] Carović-StanKo K, PeteK M, Grdiša M, Pintar J, Bedeković D, Satovic Z. Medicinal plants of the family Lamiaceae as functional foods–a review. Czech J Food Sci. 2016; 34 (5): 377-390. https://doi.org/10.17221/504/2015-CJFS
  • [3] Malik RA, Gupta RC, Singh V, Bala S, Kumari S. New chromosome reports in Lamiaceae of Kashmir (northwest Himalaya), India. Protoplasma. 2017; 254(2): 971-985. https://doi.org/10.1007/s00709-016-1006-7
  • [4] Özkan M. Glandular and eglandular hairs of Salvia recognita Fisch & Mey.(Lamiaceae) in Turkey. Bangladesh J Bot. 2008; 37(1): 93-95.
  • [5] Lawrence B, Harley R, Reynolds T. Chemical components of labiatae oils and their exploitation. Adv Labiate Science. 1992; pp. 399–436.
  • [6] Hamlyn P. The Marshall Cavendish Encyclopedia of Gardening. Garrod and Lofthouse International. 1969; 19: 2034.
  • [7] Kintzios SE. The Sage Plants of Greece: Distribution And Infraspecific Variation. In : Sage, CRC Press, 2000, pp. 51- 69.
  • [8] Zupko I, Hohmann J, Rédei D, Falkay G, Janicsák G, Máthé I. Antioxidant activity of leaves of Salvia species in enzyme-dependent and enzyme-independent systems of lipid peroxidation and their phenolic constituents. Planta Med. 2001; 67(04): 366-368. https://doi.org/10.1055/s-2001-14327
  • [9] Topçu G, Kuşman T. Lamiaceae family plants as a potential anticholinesterase source in the treatment of Alzheimer’s disease. Bezmialem Sci. 2014; 1: 1-25. http://doi.org/10.14235/bas.galenos.2018.2486
  • [10] Cuvelier ME, Berset C, Richard H. Antioxidant constituents in sage (Salvia officinalis). J Agric Food Chem. 1994; 42(3): 665-669. https://doi.org/10.1021/JF00039A012
  • [11] Ulubelen A. Cardioactive and antibacterial terpenoids from some Salvia species. Phytochemistry. 2003; 64(2): 395- 399. https://doi.org/10.1016/s0031-9422(03)00225-5
  • [12] Baricevic D, Bartol TV. The biological/pharmacological activity of the Salvia genus. In: The Genus Salvia. 2000.
  • [13] Dobignard A, Chatelain C. Index of synonymous flora in North Africa. Volume 4: Dicotyledoneae: Fabaceae- Nymphaeaceae. Index synonymique de la flore d'Afrique du Nord. Volume 4: Dicotyledoneae: Fabaceae - Nymphaeaceae, Conservatoire et Jardin Botaniques de la ville de Genève Publisher, Genève, 2012, pp. 431.
  • [14] Kabouche A, Boutaghane N, Kabouche Z, Seguin E, Tillequin F, Benlabed K. Components and antibacterial activity of the roots of Salvia jaminiana. Fitoterapia. 2005; 76(5): 450-452. https://doi.org/10.1016/j.fitote.2005.03.011
  • [15] Dob T, Berramdane T, Dahmane D, Benabdelkader T, Chelghoum C. Chemical composition of the essential oil of Salvia officinalis from Algeria. Chem Nat Compd. 2007; 43(4): 491-494. https://doi.org/10.1007/s10600-007-0173-3
  • [16] Krimat S, Dob T, Toumi M, Kesouri A, Noasri A. Assessment of phytochemicals, antioxidant, antimicrobial and cytotoxic properties of Salvia chudaei Batt. et Trab. endemic medicinal plant from Algeria. J Mater Environ Sci. 2015; 6: 70-78.
  • [17] Serakta M, Djerrou Z, Mansour-Djaalab H, Kahlouche-Riachi F, Hamimed S, Trifa W, Belkhiri A, Edikra N, Pacha YH. Antileishmanial activity of some plants growing in Algeria: Juglans regia, Lawsonia inermis and Salvia officinalis. Afr J Tradit Complement Altern Med. 2013; 10(3): 427-430. https://doi.org/10.4314/ajtcam.v10i3.7
  • [18] De Araújo FF, de Paulo Farias D, Neri-Numa IA, Pastore GM. Polyphenols and their applications: An approach in food chemistry and innovation potential. Food Chem. 2021; 338: 127535. https://doi.org/10.1016/j.foodchem.2020.127535
  • [19] Zhang Z, Li X, Sang S, McClements D.J, Chen L, Long J, Jiao A, Jin Z, Qiu C. Polyphenols as plant-based nutraceuticals: health effects, encapsulation, nano-delivery, and application. Foods 2022; 11(15): 2189. https://doi.org/10.3390/foods11152189
  • [20] Marranzano M, Rosa RL, Malaguarnera M, Palmeri R, Tessitori M, Barbera AC. Polyphenols: Plant sources and food industry applications. Curr Pharm Des. 2018; 24(35): 4125-4130. https://doi.org/10.2174/1381612824666181106091303
  • [21] Dzah CS, Duan Y, Zhang H, Wen C, Zhang J, Chen G, Ma H. The effects of ultrasound assisted extraction on yield, antioxidant, anticancer and antimicrobial activity of polyphenol extracts: A review. Food Biosci. 2020; 35: 100547. https://doi.org/10.1016/j.fbio.2020.100547
  • [22] Kahkonen MP, Hopia AI, Vuorela HJ, Rauha J-P, Pihlaja K, Kujala TS, Heinonen M. Antioxidant activity of plant extracts containing phenolic compounds. J Agric Food Chem. 1999; 47(10): 3954-3962. https://doi.org/10.1021/jf990146l
  • [23] Maran JP, Manikandan S. Response surface modeling and optimization of process parameters for aqueous extraction of pigments from prickly pear (Opuntia ficus-indica) fruit. Dyes Pigm. 2012; 95(3): 465-472. https://doi.org/10.1016/j.dyepig.2012.06.007
  • [24] Farhat MB, Landoulsi A, Chaouch-Hamada R, Sotomayor JA, Jordán MJ. Characterization and quantification of phenolic compounds and antioxidant properties of Salvia species growing in different habitats. Ind Crops Prod. 2013; 49: 904-914. https://doi.org/10.1007/s11130-015-0466-9
  • [25] Dincer C, Topuz A, Sahin-Nadeem H, Ozdemir K.S, Cam IB, Tontul I, Gokturk RS, Ay ST. A comparative study on phenolic composition, antioxidant activity and essential oil content of wild and cultivated sage (Salvia fruticosa Miller) as influenced by storage. Ind Crops Prod. 2012; 39: 170-176. https://doi.org/10.1007/s13197-014-1308-8
  • [26] Borneo R, León A, Aguirre A, Ribotta P, Cantero J. Antioxidant capacity of medicinal plants from the province of Córdoba (Argentina) and their in vitro testing in a model food system. Food Chem. 2009; 112(3): 664-670. https://doi.org/10.1016/j.foodchem.2008.06.027
  • [27] Sharififar F, Dehghn-Nudeh G, Mirtajaldini M. Major flavonoids with antioxidant activity from Teucrium polium L. Food Chem. 2009; 112(4): 885-888. https://doi.org/10.1016/j.foodchem.2008.06.064
  • [28] Lugasi A. The role of antioxidant phytonutrients in the prevention of diseases. Acta Biol Szeged. 2003; 47(1-4): 119- 125.
  • [29] Vallejo J, Castro I, Ruiz-García R, Cano J, Julve M, Lloret F, De Munno G, Wernsdorfer W, Pardo E. Field-induced slow magnetic relaxation in a six-coordinate mononuclear cobalt (II) complex with a positive anisotropy. J Am Chem Soc. 2012; 134(38): 15704-15707. https://doi.org/10.1021/acs.inorgchem.9b01719
  • [30] Hamrouni-Sellami I, Rahali F.Z, Rebey I.B, Bourgou S, Limam F, Marzouk B. Total phenolics, flavonoids, and antioxidant activity of sage (Salvia officinalis L.) plants as affected by different drying methods. Food Bioproc Tech. 2013; 6(3): 806-817. https://doi.org/10.1007/s11947-012-0877
  • [31] Tapas AR, Sakarkar D, Kakde R. Flavonoids as nutraceuticals: a review. Trop J Pharm Res. 2008; 7(3): 1089-1099. https://doi.org/10.4314/tjpr.v7i3.14693
  • [32] Bahorun T. Substances naturelles actives: La flore mauricienne, une source d’approvisionnement potentielle, Second Annual Meeting of Agricultural Scientists, 1998.
  • [33] Roby MHH, Sarhan MA, Selim KA-H, Khalel KI. Evaluation of antioxidant activity, total phenols and phenolic compounds in thyme (Thymus vulgaris L.), sage (Salvia officinalis L.), and marjoram (Origanum majorana L.) extracts. Ind Crops Prod. 2013; 43: 827-831. https://doi.org/10.1016/j.indcrop.2012.08.029
  • [34] Lu Y, Foo LY. Polyphenolics of Salvia—a review. Phytochemistry. 2002; 59(2): 117-140. https://doi.org/10.1016/s0031-9422(01)00415-0
  • [35] Ahmed S, Jubair A, Hossain MA, Hossain MM, Azam MS, Biswas M. Free radical-scavenging capacity and HPLCDAD screening of phenolic compounds from pulp and seed of Syzygium claviflorum fruit. J Agric Food Res. 2021; 6: 100203. https://doi.org/10.1016/j.jafr.2021.100203
  • [36] Martins N, Barros L, Santos-Buelga C, HenriquesM, Silva S, Ferreira IC. Evaluation of bioactive properties and phenolic compounds in different extracts prepared from Salvia officinalis L. Food Chem. 2015; 170: 378-385. https://doi.org/10.1016/j.foodchem.2014.08.096
  • [37] Hadjadj S, Esnault M-A, Berardocco S, Guyot S, Bouchereau A, Ghouini F, Lamini R, El Hadj-Khelil AO. Polyphenol composition and antioxidant activity of Searsia tripartita and Limoniastrum guyonianum growing in Southeastern Algeria. Sci Afr. 2020; 10: e00585. https://dx.doi.org/10.1016/j.sciaf.2020.e00585
  • [38] San Miguel-Chávez, R. Phenolic Antioxidant Capacity: A Review of the State of the Art. InTech. 2017; 8: 59-74. https://doi.org/10.5772/66897
  • [39] Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients. 2010; 2(12):1231-1246. https://doi.org/10.3390/nu2121231
  • [40] Kivrak Ş, GöktürkT, Kivrak I, Kaya E, Karababa E. Investigation of phenolic profiles and antioxidant activities of some Salvia species commonly grown in Southwest Anatolia using UPLC-ESI-MS/MS. Food Sci Technol . 2018; 39: 423-431. https://doi.org/10.1590/fst.32017.
  • [41] Kekuda T, Vinayaka K, Swathi D, Suchitha Y, Venugopal T, Mallikarjun N. Mineral composition, total phenol content and antioxidant activity of a macrolichen Everniastrum cirrhatum (Fr.) Hale (Parmeliaceae). J Chem. 2011; 8(4): 1886- 1894. https://doi.org/10.1155/2011/420673
  • [42] Mervić M, Bival Štefan M, Kindl M, Blažeković B, Marijan M, Vladimir-Knežević S. Comparative Antioxidant, antiacetylcholinesterase and anti-α-glucosidase activities of Mediterranean Salvia species. Plants. 2022; 11(5): 625. https://doi.org/10.3390%2Fplants11050625
  • [43] Gordon M. The mechanism of antioxidant action in vitro. Food antioxidants, Springer Publisher, 1990, pp. 1-18. https://doi.org/10.1007/978-94-009-0753-9_1

Yıl 2023, Cilt: 27 Sayı: 3, 1076 - 1085, 28.06.2025

Mohamed Malik Mahdjoub Nourelimane Benzitoune Yacine Maiz Nour El Houda Aouadi Mustapha Mounir Bouhenna Nabil Kadri

Öz

Kaynakça

  • [1] Urbizo-Reyes U, San Martin-González MF, Garcia-Bravo J, Vigil ALM, Liceaga AM. Physicochemical characteristics of chia seed (Salvia hispanica) protein hydrolysates produced using ultrasonication followed by microwave-assisted hydrolysis. Food Hydrocoll. 2019; 97: 105187. https://doi.org/10.1016/j.foodhyd.2019.105187
  • [2] Carović-StanKo K, PeteK M, Grdiša M, Pintar J, Bedeković D, Satovic Z. Medicinal plants of the family Lamiaceae as functional foods–a review. Czech J Food Sci. 2016; 34 (5): 377-390. https://doi.org/10.17221/504/2015-CJFS
  • [3] Malik RA, Gupta RC, Singh V, Bala S, Kumari S. New chromosome reports in Lamiaceae of Kashmir (northwest Himalaya), India. Protoplasma. 2017; 254(2): 971-985. https://doi.org/10.1007/s00709-016-1006-7
  • [4] Özkan M. Glandular and eglandular hairs of Salvia recognita Fisch & Mey.(Lamiaceae) in Turkey. Bangladesh J Bot. 2008; 37(1): 93-95.
  • [5] Lawrence B, Harley R, Reynolds T. Chemical components of labiatae oils and their exploitation. Adv Labiate Science. 1992; pp. 399–436.
  • [6] Hamlyn P. The Marshall Cavendish Encyclopedia of Gardening. Garrod and Lofthouse International. 1969; 19: 2034.
  • [7] Kintzios SE. The Sage Plants of Greece: Distribution And Infraspecific Variation. In : Sage, CRC Press, 2000, pp. 51- 69.
  • [8] Zupko I, Hohmann J, Rédei D, Falkay G, Janicsák G, Máthé I. Antioxidant activity of leaves of Salvia species in enzyme-dependent and enzyme-independent systems of lipid peroxidation and their phenolic constituents. Planta Med. 2001; 67(04): 366-368. https://doi.org/10.1055/s-2001-14327
  • [9] Topçu G, Kuşman T. Lamiaceae family plants as a potential anticholinesterase source in the treatment of Alzheimer’s disease. Bezmialem Sci. 2014; 1: 1-25. http://doi.org/10.14235/bas.galenos.2018.2486
  • [10] Cuvelier ME, Berset C, Richard H. Antioxidant constituents in sage (Salvia officinalis). J Agric Food Chem. 1994; 42(3): 665-669. https://doi.org/10.1021/JF00039A012
  • [11] Ulubelen A. Cardioactive and antibacterial terpenoids from some Salvia species. Phytochemistry. 2003; 64(2): 395- 399. https://doi.org/10.1016/s0031-9422(03)00225-5
  • [12] Baricevic D, Bartol TV. The biological/pharmacological activity of the Salvia genus. In: The Genus Salvia. 2000.
  • [13] Dobignard A, Chatelain C. Index of synonymous flora in North Africa. Volume 4: Dicotyledoneae: Fabaceae- Nymphaeaceae. Index synonymique de la flore d'Afrique du Nord. Volume 4: Dicotyledoneae: Fabaceae - Nymphaeaceae, Conservatoire et Jardin Botaniques de la ville de Genève Publisher, Genève, 2012, pp. 431.
  • [14] Kabouche A, Boutaghane N, Kabouche Z, Seguin E, Tillequin F, Benlabed K. Components and antibacterial activity of the roots of Salvia jaminiana. Fitoterapia. 2005; 76(5): 450-452. https://doi.org/10.1016/j.fitote.2005.03.011
  • [15] Dob T, Berramdane T, Dahmane D, Benabdelkader T, Chelghoum C. Chemical composition of the essential oil of Salvia officinalis from Algeria. Chem Nat Compd. 2007; 43(4): 491-494. https://doi.org/10.1007/s10600-007-0173-3
  • [16] Krimat S, Dob T, Toumi M, Kesouri A, Noasri A. Assessment of phytochemicals, antioxidant, antimicrobial and cytotoxic properties of Salvia chudaei Batt. et Trab. endemic medicinal plant from Algeria. J Mater Environ Sci. 2015; 6: 70-78.
  • [17] Serakta M, Djerrou Z, Mansour-Djaalab H, Kahlouche-Riachi F, Hamimed S, Trifa W, Belkhiri A, Edikra N, Pacha YH. Antileishmanial activity of some plants growing in Algeria: Juglans regia, Lawsonia inermis and Salvia officinalis. Afr J Tradit Complement Altern Med. 2013; 10(3): 427-430. https://doi.org/10.4314/ajtcam.v10i3.7
  • [18] De Araújo FF, de Paulo Farias D, Neri-Numa IA, Pastore GM. Polyphenols and their applications: An approach in food chemistry and innovation potential. Food Chem. 2021; 338: 127535. https://doi.org/10.1016/j.foodchem.2020.127535
  • [19] Zhang Z, Li X, Sang S, McClements D.J, Chen L, Long J, Jiao A, Jin Z, Qiu C. Polyphenols as plant-based nutraceuticals: health effects, encapsulation, nano-delivery, and application. Foods 2022; 11(15): 2189. https://doi.org/10.3390/foods11152189
  • [20] Marranzano M, Rosa RL, Malaguarnera M, Palmeri R, Tessitori M, Barbera AC. Polyphenols: Plant sources and food industry applications. Curr Pharm Des. 2018; 24(35): 4125-4130. https://doi.org/10.2174/1381612824666181106091303
  • [21] Dzah CS, Duan Y, Zhang H, Wen C, Zhang J, Chen G, Ma H. The effects of ultrasound assisted extraction on yield, antioxidant, anticancer and antimicrobial activity of polyphenol extracts: A review. Food Biosci. 2020; 35: 100547. https://doi.org/10.1016/j.fbio.2020.100547
  • [22] Kahkonen MP, Hopia AI, Vuorela HJ, Rauha J-P, Pihlaja K, Kujala TS, Heinonen M. Antioxidant activity of plant extracts containing phenolic compounds. J Agric Food Chem. 1999; 47(10): 3954-3962. https://doi.org/10.1021/jf990146l
  • [23] Maran JP, Manikandan S. Response surface modeling and optimization of process parameters for aqueous extraction of pigments from prickly pear (Opuntia ficus-indica) fruit. Dyes Pigm. 2012; 95(3): 465-472. https://doi.org/10.1016/j.dyepig.2012.06.007
  • [24] Farhat MB, Landoulsi A, Chaouch-Hamada R, Sotomayor JA, Jordán MJ. Characterization and quantification of phenolic compounds and antioxidant properties of Salvia species growing in different habitats. Ind Crops Prod. 2013; 49: 904-914. https://doi.org/10.1007/s11130-015-0466-9
  • [25] Dincer C, Topuz A, Sahin-Nadeem H, Ozdemir K.S, Cam IB, Tontul I, Gokturk RS, Ay ST. A comparative study on phenolic composition, antioxidant activity and essential oil content of wild and cultivated sage (Salvia fruticosa Miller) as influenced by storage. Ind Crops Prod. 2012; 39: 170-176. https://doi.org/10.1007/s13197-014-1308-8
  • [26] Borneo R, León A, Aguirre A, Ribotta P, Cantero J. Antioxidant capacity of medicinal plants from the province of Córdoba (Argentina) and their in vitro testing in a model food system. Food Chem. 2009; 112(3): 664-670. https://doi.org/10.1016/j.foodchem.2008.06.027
  • [27] Sharififar F, Dehghn-Nudeh G, Mirtajaldini M. Major flavonoids with antioxidant activity from Teucrium polium L. Food Chem. 2009; 112(4): 885-888. https://doi.org/10.1016/j.foodchem.2008.06.064
  • [28] Lugasi A. The role of antioxidant phytonutrients in the prevention of diseases. Acta Biol Szeged. 2003; 47(1-4): 119- 125.
  • [29] Vallejo J, Castro I, Ruiz-García R, Cano J, Julve M, Lloret F, De Munno G, Wernsdorfer W, Pardo E. Field-induced slow magnetic relaxation in a six-coordinate mononuclear cobalt (II) complex with a positive anisotropy. J Am Chem Soc. 2012; 134(38): 15704-15707. https://doi.org/10.1021/acs.inorgchem.9b01719
  • [30] Hamrouni-Sellami I, Rahali F.Z, Rebey I.B, Bourgou S, Limam F, Marzouk B. Total phenolics, flavonoids, and antioxidant activity of sage (Salvia officinalis L.) plants as affected by different drying methods. Food Bioproc Tech. 2013; 6(3): 806-817. https://doi.org/10.1007/s11947-012-0877
  • [31] Tapas AR, Sakarkar D, Kakde R. Flavonoids as nutraceuticals: a review. Trop J Pharm Res. 2008; 7(3): 1089-1099. https://doi.org/10.4314/tjpr.v7i3.14693
  • [32] Bahorun T. Substances naturelles actives: La flore mauricienne, une source d’approvisionnement potentielle, Second Annual Meeting of Agricultural Scientists, 1998.
  • [33] Roby MHH, Sarhan MA, Selim KA-H, Khalel KI. Evaluation of antioxidant activity, total phenols and phenolic compounds in thyme (Thymus vulgaris L.), sage (Salvia officinalis L.), and marjoram (Origanum majorana L.) extracts. Ind Crops Prod. 2013; 43: 827-831. https://doi.org/10.1016/j.indcrop.2012.08.029
  • [34] Lu Y, Foo LY. Polyphenolics of Salvia—a review. Phytochemistry. 2002; 59(2): 117-140. https://doi.org/10.1016/s0031-9422(01)00415-0
  • [35] Ahmed S, Jubair A, Hossain MA, Hossain MM, Azam MS, Biswas M. Free radical-scavenging capacity and HPLCDAD screening of phenolic compounds from pulp and seed of Syzygium claviflorum fruit. J Agric Food Res. 2021; 6: 100203. https://doi.org/10.1016/j.jafr.2021.100203
  • [36] Martins N, Barros L, Santos-Buelga C, HenriquesM, Silva S, Ferreira IC. Evaluation of bioactive properties and phenolic compounds in different extracts prepared from Salvia officinalis L. Food Chem. 2015; 170: 378-385. https://doi.org/10.1016/j.foodchem.2014.08.096
  • [37] Hadjadj S, Esnault M-A, Berardocco S, Guyot S, Bouchereau A, Ghouini F, Lamini R, El Hadj-Khelil AO. Polyphenol composition and antioxidant activity of Searsia tripartita and Limoniastrum guyonianum growing in Southeastern Algeria. Sci Afr. 2020; 10: e00585. https://dx.doi.org/10.1016/j.sciaf.2020.e00585
  • [38] San Miguel-Chávez, R. Phenolic Antioxidant Capacity: A Review of the State of the Art. InTech. 2017; 8: 59-74. https://doi.org/10.5772/66897
  • [39] Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients. 2010; 2(12):1231-1246. https://doi.org/10.3390/nu2121231
  • [40] Kivrak Ş, GöktürkT, Kivrak I, Kaya E, Karababa E. Investigation of phenolic profiles and antioxidant activities of some Salvia species commonly grown in Southwest Anatolia using UPLC-ESI-MS/MS. Food Sci Technol . 2018; 39: 423-431. https://doi.org/10.1590/fst.32017.
  • [41] Kekuda T, Vinayaka K, Swathi D, Suchitha Y, Venugopal T, Mallikarjun N. Mineral composition, total phenol content and antioxidant activity of a macrolichen Everniastrum cirrhatum (Fr.) Hale (Parmeliaceae). J Chem. 2011; 8(4): 1886- 1894. https://doi.org/10.1155/2011/420673
  • [42] Mervić M, Bival Štefan M, Kindl M, Blažeković B, Marijan M, Vladimir-Knežević S. Comparative Antioxidant, antiacetylcholinesterase and anti-α-glucosidase activities of Mediterranean Salvia species. Plants. 2022; 11(5): 625. https://doi.org/10.3390%2Fplants11050625
  • [43] Gordon M. The mechanism of antioxidant action in vitro. Food antioxidants, Springer Publisher, 1990, pp. 1-18. https://doi.org/10.1007/978-94-009-0753-9_1
Toplam 43 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılıkta Analitik Kimya
Bölüm Articles
Yazarlar

Mohamed Malik Mahdjoub 0000-0001-5584-6642

Nourelimane Benzitoune 0009-0004-4563-4362

Yacine Maiz

Nour El Houda Aouadi

Mustapha Mounir Bouhenna 0000-0001-6789-5636

Nabil Kadri 0000-0003-1158-696X

Yayımlanma Tarihi 28 Haziran 2025
Yayımlandığı Sayı Yıl 2023 Cilt: 27 Sayı: 3

Kaynak Göster

APA Mahdjoub, M. M., Benzitoune, N., Maiz, Y., Aouadi, N. E. H., vd. (2025). HPLC-DAD Screening and Antioxidant Activity of Phenolic Compounds of Salvia balansae de Noé Leaves Extract. Journal of Research in Pharmacy, 27(3), 1076-1085.
AMA Mahdjoub MM, Benzitoune N, Maiz Y, Aouadi NEH, Bouhenna MM, Kadri N. HPLC-DAD Screening and Antioxidant Activity of Phenolic Compounds of Salvia balansae de Noé Leaves Extract. J. Res. Pharm. Haziran 2025;27(3):1076-1085.
Chicago Mahdjoub, Mohamed Malik, Nourelimane Benzitoune, Yacine Maiz, Nour El Houda Aouadi, Mustapha Mounir Bouhenna, ve Nabil Kadri. “HPLC-DAD Screening and Antioxidant Activity of Phenolic Compounds of Salvia Balansae De Noé Leaves Extract”. Journal of Research in Pharmacy 27, sy. 3 (Haziran 2025): 1076-85.
EndNote Mahdjoub MM, Benzitoune N, Maiz Y, Aouadi NEH, Bouhenna MM, Kadri N (01 Haziran 2025) HPLC-DAD Screening and Antioxidant Activity of Phenolic Compounds of Salvia balansae de Noé Leaves Extract. Journal of Research in Pharmacy 27 3 1076–1085.
IEEE M. M. Mahdjoub, N. Benzitoune, Y. Maiz, N. E. H. Aouadi, M. M. Bouhenna, ve N. Kadri, “HPLC-DAD Screening and Antioxidant Activity of Phenolic Compounds of Salvia balansae de Noé Leaves Extract”, J. Res. Pharm., c. 27, sy. 3, ss. 1076–1085, 2025.
ISNAD Mahdjoub, Mohamed Malik vd. “HPLC-DAD Screening and Antioxidant Activity of Phenolic Compounds of Salvia Balansae De Noé Leaves Extract”. Journal of Research in Pharmacy 27/3 (Haziran 2025), 1076-1085.
JAMA Mahdjoub MM, Benzitoune N, Maiz Y, Aouadi NEH, Bouhenna MM, Kadri N. HPLC-DAD Screening and Antioxidant Activity of Phenolic Compounds of Salvia balansae de Noé Leaves Extract. J. Res. Pharm. 2025;27:1076–1085.
MLA Mahdjoub, Mohamed Malik vd. “HPLC-DAD Screening and Antioxidant Activity of Phenolic Compounds of Salvia Balansae De Noé Leaves Extract”. Journal of Research in Pharmacy, c. 27, sy. 3, 2025, ss. 1076-85.
Vancouver Mahdjoub MM, Benzitoune N, Maiz Y, Aouadi NEH, Bouhenna MM, Kadri N. HPLC-DAD Screening and Antioxidant Activity of Phenolic Compounds of Salvia balansae de Noé Leaves Extract. J. Res. Pharm. 2025;27(3):1076-85.