Syringic acid presents various biological properties such as antioxidant, anti-inflammatory, anticancer, and other activities. The present experiment aimed to investigate the effect of the oral administration of syringic acid (10, 50, and 100 mg/kg) on its possible nociceptive response using hot-plate and tail-flick assay in the Balb-C mice model. The mice were pre-treated with 5 mg/kg atropine 15 min before, 1mg/kg mecamylamine 20 min before, 1mg/kg ketanserin 30 min before, 1 mg/kg ondansetron 30 min before, 1mg/kg yohimbine 30 min before, 1 mg/kg prazosin 30 min before and 5 mg/kg naloxone 15min before the administration of the Syringic acid. Dose-dependent antinociceptive activity of syringic acid was reported for 50 and 100 mg/kg doses in tail-flick and hot-plate assays, respectively. In further, mecamylamine, yohimbine, and naloxone significantly reversed syringic acid-induced response to thermal stimuli in tail-flick and hot-plate assays, respectively. From the data, it was confirmed that syringic acid presents central antinociceptive effects which may be coordinated by supraspinal/spinal mediated cholinergic, opioidergic, and adrenergic, inflection.
Antinociception muscarinic receptors opioidergic receptors α2-adrenoceptors syringic acid.
Birincil Dil | İngilizce |
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Konular | Temel Farmakoloji, Tıbbi Farmakoloji |
Bölüm | Articles |
Yazarlar | |
Yayımlanma Tarihi | 27 Haziran 2025 |
Yayımlandığı Sayı | Yıl 2021 Cilt: 25 Sayı: 3 |