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Chemical analysis and in vitro antioxidant and anticholinesterase activities of essential oils and extracts from different parts of Erica manipuliflora

Yıl 2019, Cilt: 23 Sayı: 6, 1098 - 1105, 27.06.2025

Çiğdem Kuş , Meltem Taş , Selçuk Küçükaydin Gülsen Tel-çayan , Mehmet Emin Duru

Öz

This study reports the chemical composition of essential oils and in vitro antioxidant and anticholinesterase activities of essential oils, hexane, ethyl acetate, methanol, and butanol extracts of aerial, flower and leaves parts of Erica manipuliflora. GC and GC/MS analyses were used for identification of essential oils. Totals of 47 compounds were detected in the essential oils of aerial, flower and leaves parts accounting for 99.99%, 99.88% and 99.97%, respectively. The major components of the aerial, flower and leaves parts of essential oils were Germacren D (14.76%, 15.55% and 13.58%), tau-cadinol (7.53%, 4.11% and 8.96%), caryophyllene oxide (3.92%, 5.17% and 8.55%), β caryophyllene (7.24%, 5.97% and 7.73%), and α-terpineol (6.85%, 6.14% and 4.18%), respectively. The essential oils of aerial (34.49%) and leaves (37.01%) parts consisted of mainly sesquiterpene hydrocarbons whereas essential oil of flower part (42.58%) included monoterpenoids. The essential oils and extracts were screened for their antioxidant and anticholinesterase activities. The results of activities showed that extracts possessed the highest antioxidant activity while essential oils had the highest anticholinesterase activity. This finding supposes that E. manipuliflora may be considered as valuable natural source with antioxidant and anticholinesterase properties for food, cosmetic and pharmaceutical industries.

Anahtar Kelimeler

Erica manipuliflora chemical composition essential oil extracts different parts antioxidant activity anticholinesterase activity

Kaynakça

  • [1] Mitic VD, Ilic MD, Stankov-Jovanovic VP, Stojanovic GS, Dimitrijevic MV. Essential oil composition of Erica spiculifolia Salisb - first report. Nat Prod Res. 2018;32(2):222–224. [CrossRef]
  • [2] Dias P, Martins A, Figueiredo AC, Rauter AP. Flower Colour and Essential oil composition in Erica australis L. Grown in Portugal. J Essent Oil Bear Pl. 2016;19(4):1013–1018. [CrossRef]
  • [3] Akkol EK, Yeşilada E, Güvenç A. Valuation of anti-inflammatory and antinociceptive activities of Erica species native to Turkey. J Ethnopharmacol. 2008;116(2):251–257. [CrossRef]
  • [4] Oliver EGH. Systematics of Ericeae (Ericaceae: Ericoideae) species with indehiscent and partially dehiscent fruits. Contrib Bolus Herb. 2000;9:1–483.
  • [5] Nelson EC. The original material of two Turkish species of Erica (Ericaceae) described and named by Richard Anthony Salisbury (1761–1829). Turk J Bot. 2007;31(5):463–466.
  • [6] Stevens PF. Erica L. In: Davis PH (Ed). Flora of Turkey and the East Aegean Islands, Vol. 6, Edinburgh University Press, Edinburgh, 1978, pp. 95–97.
  • [7] Güvenç A, Kendir G. The leaf anatomy of some Erica taxa native to Turkey. Turk J Bot. 2012;36(3):253–262. [CrossRef]
  • [8] Sadki C, Hacht B, Souliman A, Atmani F. Acute diuretic activity of aqueous Erica multiflora flowers and Cynodon dactylon rhizomes extracts in rats. J Ethnopharmacol. 2010;128(2):352–356. [CrossRef]
  • [9] Reyes RM, Martin-Cordero C, Ayuso Gonzalez MJ, Toro Sainz MV, Alarcon de la Lastra C. Antiulcer activity in rats by flavonoids of Erica andevalensis Cabezudo-Rivera. Phytother Res. 1996;10(4):300–303. [CrossRef]
  • [10] Santos A, Luís Â, Ferreira S, Duarte AP. Antioxidant and antimicrobial activity and potential of heather (Erica spp.) extracts in the control of Listeria monocytogenes. Int J Food Sci Tech. 2019;54(3):862–870. [CrossRef]
  • [11] Guendouze-Bouchefa N, Madani K, Chibane M, Boulekbache-Makhlouf L, Hauchard D, Kiendrebeogo M, Stevigny C, Okusa PN, Duez P. Phenolic compounds, antioxidant and antibacterial activities of three Ericaceae from Algeria. Ind Crops Prod. 2015;70:459–466. [CrossRef]
  • [12] Veličković V, Đurović S, Radojković M, Cvetanović A, Švarc-Gajić J, Vujić J, Trifunović S, Mašković PZ. Application of conventional and non-conventional extraction approaches for extraction of Erica carnea L.: Chemical profile and biological activity of obtained extracts. J Supercrit Fluid. 2017;128:331–337. [CrossRef]
  • [13] Nunes R, Rodrigues S, Pasko P, Tyszka-Czochara M, Grenha A, Saraiva de Carvalho I. Effect of Erica australis extract on Caco-2 cells, fibroblasts and selected pathogenic bacteria responsible for wound infection. Ind Crops Prod. 2014;52:99–104. [CrossRef]
  • [14] Ertürk Ö. Antibacterial and antifungal activity of ethanolic extracts from eleven spice plants. Biologia. 2006;61(3):275–278. [CrossRef]
  • [15] Şen B, Kessler S, Gurdal B, Kiemer A, Mat A. The difference between the extracts of Erica manipuliflora in flowering and fruiting periods in terms of the cytotoxic effects. J Fac Pharm. 2016;46(2):71–78.
  • [16] Pavlović RD, Lakusić B, Doslov-Kokorus Z, Kovacević N. Arbutin content and antioxidant activity of some Ericaceae species. Pharmazie. 2009;64(10):656–659. [CrossRef]
  • [17] Márquez-García B, Córdoba F. Antioxidative system in wild populations of Erica andevalensis. Environ Exp Bot. 2010;68(1):58–65. [CrossRef]
  • [18] Márquez-García B, Horemans N, Cuypers A, Guisez Y, Córdoba F. Antioxidants in Erica andevalensis: A comparative study between wild plants and cadmium-exposed plants under controlled conditions. Plant Physiol Bioch. 2011;49(1):110–115. [CrossRef]
  • [19] Márquez-García B, Fernández-Recamales M, Córdoba F. Effects of cadmium on phenolic composition and antioxidant activities of Erica andevalensis. J Bot. 2012. [CrossRef]
  • [20] Nogués I, Peñuelas J, Llusià J, Estiarte M, Munné-Bosch S, Sardans J, Loreto F. Physiological and antioxidant responses of Erica multiflora to drought and warming through different seasons. Plant Ecol. 2012;213(4):649–661. [CrossRef]
  • [21] Nazemiyeh H, Bahadori F, Delazar A, Ay M, Topçu G, Kolak U, Nahar L, Auzie AA, Sarker SD. Tricetin 4′-O-α-L-rhamnopyranoside: A new flavonoid from the aerial parts of Erica arborea. Chem Nat Compd. 2008;44(2):174. [CrossRef]
  • [22] Martin-Cordero C, Reyes M, Ayuso MJ, Toro V. Cytotoxic triterpenoids from Erica andevalensis. Z Naturforsch C. 2001;56(1–2):45–48. [CrossRef]
  • [23] Ballester A, Verwey A, Ovbreem JC. 2-Hydroxyphenylacetic acid and 2,4-dihydroxyphenyl acetonitrile from Erica scoparia. Phytochem. 1975;14(7):1667–1668. [CrossRef]
  • [24] Bennini B, Chulia AJ, Kaouadji M, Delage C. (2R,3R)-Dihydroflavonol aglycone and glycosides from Erica cinerea. Phytochem. 1993;33(5):1233–1236. [CrossRef]
  • [25] Chulia AJ, Benini B, Kaouadji M, Allais DP, Delage C. Two flavonol conjugates from Erica cinerea. J Nat Prod. 1995;58(4):560–563. [CrossRef]
  • [26] Crowden RK, Jarman JR. Anthocyanins in the genus Erica. Phytochem. 1976;15(11):1796–1797. [CrossRef]
  • [27] Méndez J. Isofraxidin in Erica flowers. Phytochem. 1978;17(4):820. [CrossRef]
  • [28] Vieitez E, Ballester A. Phenolic and coumaric components in Erica cinerea. Anales Inst Bot Cavanilles. 1972;29:129–142.
  • [29] Tzitsa E, Tzakou O, Loukis A. Volatile constituents of Erica manipuliflora Salisb. from Greece. J Essent Oil Res. 2000;12(1):67–68. [CrossRef]
  • [30] Köroğlu A, Hürkul MM, Kendir G, Küçükboyacı N. In vitro antioxidant capacities and phenolic contents of four Erica L. (Ericaceae) taxa native to Turkey. J Res Pharm. 2019;23(1):093–100. [CrossRef]
  • [31] Adams RP. Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry, 4th ed., Allured Publ. Corp, Carol Stream, IL, USA, 2007.
  • [32] Tel G, Apaydın M, Duru ME, Öztürk M. Antioxidant and cholinesterase inhibition activities of three Tricholoma species with total phenolic and flavonoid contents: The edible mushrooms from Anatolia. Food Anal Method. 2012;5(3):495–504. [CrossRef]
  • [33] Çayan F, Tel G, Duru ME, Öztürk M, Türkoğlu A, Harmandar M. Application of GC, GC-MSD, ICP-MS and spectrophotometric methods for the determination of chemical composition and in vitro bioactivities of Chroogomphus rutilus: The edible mushroom species. Food Anal Method. 2014;7(2):449–458. [CrossRef]
  • [34] Ellman GL, Courtney KD, Andres Jr V, Featherston RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961;7(2):88–90. [CrossRef]

Yıl 2019, Cilt: 23 Sayı: 6, 1098 - 1105, 27.06.2025

Çiğdem Kuş , Meltem Taş , Selçuk Küçükaydin Gülsen Tel-çayan , Mehmet Emin Duru

Öz

Kaynakça

  • [1] Mitic VD, Ilic MD, Stankov-Jovanovic VP, Stojanovic GS, Dimitrijevic MV. Essential oil composition of Erica spiculifolia Salisb - first report. Nat Prod Res. 2018;32(2):222–224. [CrossRef]
  • [2] Dias P, Martins A, Figueiredo AC, Rauter AP. Flower Colour and Essential oil composition in Erica australis L. Grown in Portugal. J Essent Oil Bear Pl. 2016;19(4):1013–1018. [CrossRef]
  • [3] Akkol EK, Yeşilada E, Güvenç A. Valuation of anti-inflammatory and antinociceptive activities of Erica species native to Turkey. J Ethnopharmacol. 2008;116(2):251–257. [CrossRef]
  • [4] Oliver EGH. Systematics of Ericeae (Ericaceae: Ericoideae) species with indehiscent and partially dehiscent fruits. Contrib Bolus Herb. 2000;9:1–483.
  • [5] Nelson EC. The original material of two Turkish species of Erica (Ericaceae) described and named by Richard Anthony Salisbury (1761–1829). Turk J Bot. 2007;31(5):463–466.
  • [6] Stevens PF. Erica L. In: Davis PH (Ed). Flora of Turkey and the East Aegean Islands, Vol. 6, Edinburgh University Press, Edinburgh, 1978, pp. 95–97.
  • [7] Güvenç A, Kendir G. The leaf anatomy of some Erica taxa native to Turkey. Turk J Bot. 2012;36(3):253–262. [CrossRef]
  • [8] Sadki C, Hacht B, Souliman A, Atmani F. Acute diuretic activity of aqueous Erica multiflora flowers and Cynodon dactylon rhizomes extracts in rats. J Ethnopharmacol. 2010;128(2):352–356. [CrossRef]
  • [9] Reyes RM, Martin-Cordero C, Ayuso Gonzalez MJ, Toro Sainz MV, Alarcon de la Lastra C. Antiulcer activity in rats by flavonoids of Erica andevalensis Cabezudo-Rivera. Phytother Res. 1996;10(4):300–303. [CrossRef]
  • [10] Santos A, Luís Â, Ferreira S, Duarte AP. Antioxidant and antimicrobial activity and potential of heather (Erica spp.) extracts in the control of Listeria monocytogenes. Int J Food Sci Tech. 2019;54(3):862–870. [CrossRef]
  • [11] Guendouze-Bouchefa N, Madani K, Chibane M, Boulekbache-Makhlouf L, Hauchard D, Kiendrebeogo M, Stevigny C, Okusa PN, Duez P. Phenolic compounds, antioxidant and antibacterial activities of three Ericaceae from Algeria. Ind Crops Prod. 2015;70:459–466. [CrossRef]
  • [12] Veličković V, Đurović S, Radojković M, Cvetanović A, Švarc-Gajić J, Vujić J, Trifunović S, Mašković PZ. Application of conventional and non-conventional extraction approaches for extraction of Erica carnea L.: Chemical profile and biological activity of obtained extracts. J Supercrit Fluid. 2017;128:331–337. [CrossRef]
  • [13] Nunes R, Rodrigues S, Pasko P, Tyszka-Czochara M, Grenha A, Saraiva de Carvalho I. Effect of Erica australis extract on Caco-2 cells, fibroblasts and selected pathogenic bacteria responsible for wound infection. Ind Crops Prod. 2014;52:99–104. [CrossRef]
  • [14] Ertürk Ö. Antibacterial and antifungal activity of ethanolic extracts from eleven spice plants. Biologia. 2006;61(3):275–278. [CrossRef]
  • [15] Şen B, Kessler S, Gurdal B, Kiemer A, Mat A. The difference between the extracts of Erica manipuliflora in flowering and fruiting periods in terms of the cytotoxic effects. J Fac Pharm. 2016;46(2):71–78.
  • [16] Pavlović RD, Lakusić B, Doslov-Kokorus Z, Kovacević N. Arbutin content and antioxidant activity of some Ericaceae species. Pharmazie. 2009;64(10):656–659. [CrossRef]
  • [17] Márquez-García B, Córdoba F. Antioxidative system in wild populations of Erica andevalensis. Environ Exp Bot. 2010;68(1):58–65. [CrossRef]
  • [18] Márquez-García B, Horemans N, Cuypers A, Guisez Y, Córdoba F. Antioxidants in Erica andevalensis: A comparative study between wild plants and cadmium-exposed plants under controlled conditions. Plant Physiol Bioch. 2011;49(1):110–115. [CrossRef]
  • [19] Márquez-García B, Fernández-Recamales M, Córdoba F. Effects of cadmium on phenolic composition and antioxidant activities of Erica andevalensis. J Bot. 2012. [CrossRef]
  • [20] Nogués I, Peñuelas J, Llusià J, Estiarte M, Munné-Bosch S, Sardans J, Loreto F. Physiological and antioxidant responses of Erica multiflora to drought and warming through different seasons. Plant Ecol. 2012;213(4):649–661. [CrossRef]
  • [21] Nazemiyeh H, Bahadori F, Delazar A, Ay M, Topçu G, Kolak U, Nahar L, Auzie AA, Sarker SD. Tricetin 4′-O-α-L-rhamnopyranoside: A new flavonoid from the aerial parts of Erica arborea. Chem Nat Compd. 2008;44(2):174. [CrossRef]
  • [22] Martin-Cordero C, Reyes M, Ayuso MJ, Toro V. Cytotoxic triterpenoids from Erica andevalensis. Z Naturforsch C. 2001;56(1–2):45–48. [CrossRef]
  • [23] Ballester A, Verwey A, Ovbreem JC. 2-Hydroxyphenylacetic acid and 2,4-dihydroxyphenyl acetonitrile from Erica scoparia. Phytochem. 1975;14(7):1667–1668. [CrossRef]
  • [24] Bennini B, Chulia AJ, Kaouadji M, Delage C. (2R,3R)-Dihydroflavonol aglycone and glycosides from Erica cinerea. Phytochem. 1993;33(5):1233–1236. [CrossRef]
  • [25] Chulia AJ, Benini B, Kaouadji M, Allais DP, Delage C. Two flavonol conjugates from Erica cinerea. J Nat Prod. 1995;58(4):560–563. [CrossRef]
  • [26] Crowden RK, Jarman JR. Anthocyanins in the genus Erica. Phytochem. 1976;15(11):1796–1797. [CrossRef]
  • [27] Méndez J. Isofraxidin in Erica flowers. Phytochem. 1978;17(4):820. [CrossRef]
  • [28] Vieitez E, Ballester A. Phenolic and coumaric components in Erica cinerea. Anales Inst Bot Cavanilles. 1972;29:129–142.
  • [29] Tzitsa E, Tzakou O, Loukis A. Volatile constituents of Erica manipuliflora Salisb. from Greece. J Essent Oil Res. 2000;12(1):67–68. [CrossRef]
  • [30] Köroğlu A, Hürkul MM, Kendir G, Küçükboyacı N. In vitro antioxidant capacities and phenolic contents of four Erica L. (Ericaceae) taxa native to Turkey. J Res Pharm. 2019;23(1):093–100. [CrossRef]
  • [31] Adams RP. Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry, 4th ed., Allured Publ. Corp, Carol Stream, IL, USA, 2007.
  • [32] Tel G, Apaydın M, Duru ME, Öztürk M. Antioxidant and cholinesterase inhibition activities of three Tricholoma species with total phenolic and flavonoid contents: The edible mushrooms from Anatolia. Food Anal Method. 2012;5(3):495–504. [CrossRef]
  • [33] Çayan F, Tel G, Duru ME, Öztürk M, Türkoğlu A, Harmandar M. Application of GC, GC-MSD, ICP-MS and spectrophotometric methods for the determination of chemical composition and in vitro bioactivities of Chroogomphus rutilus: The edible mushroom species. Food Anal Method. 2014;7(2):449–458. [CrossRef]
  • [34] Ellman GL, Courtney KD, Andres Jr V, Featherston RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961;7(2):88–90. [CrossRef]
Toplam 34 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılıkta Analitik Kimya
Bölüm Articles
Yazarlar

Çiğdem Kuş

Meltem Taş

Selçuk Küçükaydin

Gülsen Tel-çayan

Mehmet Emin Duru

Yayımlanma Tarihi 27 Haziran 2025
Yayımlandığı Sayı Yıl 2019 Cilt: 23 Sayı: 6

Kaynak Göster

APA Kuş, Ç., Taş, M., Küçükaydin, S., Tel-çayan, G., vd. (2025). Chemical analysis and in vitro antioxidant and anticholinesterase activities of essential oils and extracts from different parts of Erica manipuliflora. Journal of Research in Pharmacy, 23(6), 1098-1105.
AMA Kuş Ç, Taş M, Küçükaydin S, Tel-çayan G, Duru ME. Chemical analysis and in vitro antioxidant and anticholinesterase activities of essential oils and extracts from different parts of Erica manipuliflora. J. Res. Pharm. Temmuz 2025;23(6):1098-1105.
Chicago Kuş, Çiğdem, Meltem Taş, Selçuk Küçükaydin, Gülsen Tel-çayan, ve Mehmet Emin Duru. “Chemical Analysis and in Vitro Antioxidant and Anticholinesterase Activities of Essential Oils and Extracts from Different Parts of Erica Manipuliflora”. Journal of Research in Pharmacy 23, sy. 6 (Temmuz 2025): 1098-1105.
EndNote Kuş Ç, Taş M, Küçükaydin S, Tel-çayan G, Duru ME (01 Temmuz 2025) Chemical analysis and in vitro antioxidant and anticholinesterase activities of essential oils and extracts from different parts of Erica manipuliflora. Journal of Research in Pharmacy 23 6 1098–1105.
IEEE Ç. Kuş, M. Taş, S. Küçükaydin, G. Tel-çayan, ve M. E. Duru, “Chemical analysis and in vitro antioxidant and anticholinesterase activities of essential oils and extracts from different parts of Erica manipuliflora”, J. Res. Pharm., c. 23, sy. 6, ss. 1098–1105, 2025.
ISNAD Kuş, Çiğdem vd. “Chemical Analysis and in Vitro Antioxidant and Anticholinesterase Activities of Essential Oils and Extracts from Different Parts of Erica Manipuliflora”. Journal of Research in Pharmacy 23/6 (Temmuz 2025), 1098-1105.
JAMA Kuş Ç, Taş M, Küçükaydin S, Tel-çayan G, Duru ME. Chemical analysis and in vitro antioxidant and anticholinesterase activities of essential oils and extracts from different parts of Erica manipuliflora. J. Res. Pharm. 2025;23:1098–1105.
MLA Kuş, Çiğdem vd. “Chemical Analysis and in Vitro Antioxidant and Anticholinesterase Activities of Essential Oils and Extracts from Different Parts of Erica Manipuliflora”. Journal of Research in Pharmacy, c. 23, sy. 6, 2025, ss. 1098-05.
Vancouver Kuş Ç, Taş M, Küçükaydin S, Tel-çayan G, Duru ME. Chemical analysis and in vitro antioxidant and anticholinesterase activities of essential oils and extracts from different parts of Erica manipuliflora. J. Res. Pharm. 2025;23(6):1098-105.