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Studies on Ocimum basilicum mucilage based solid dispersions of indomethacin for enhancement of dissolution rate

Yıl 2019, Cilt: 23 Sayı: 5, 832 - 838, 27.06.2025

Sfurti S. Sakhare Fahim J. Sayyad

Öz

The main aim of this study was to enhance the dissolution rate of BCS class II drug Indomethacin (IND) by solid dispersion (SD) techniques using Ocimum basilicum mucilage (OBM) as a carrier. Solid dispersions of indomethacin were prepared by using Ocimum basilicum mucilage by four different methods. Effect of methods of preparation on dissolution rate was studied. It was found that the dissolution rate of IND from its SD was dependent on the method of preparation of solid dispersions. Dissolution study revealed that the physical mixture and kneading method were convenient and effective methods for dissolution enhancement of poorly water soluble drug IND, among various methods of preparation of SD. The prepared SD’s were characterized by FTIR, Differential Scanning Calorimetry, and X-ray diffraction studies. From the study we conclude that OBM could be used as a potential carrier in enhancing the dissolution rate and ultimately bioavailability of IND.

Anahtar Kelimeler

dissolution enhancement indomethacin Ocimum basilicum mucilage solid dispersions

Kaynakça

  • [1] Cid AG, Simonazzi A, Palma SD, Bermúdez JM. Solid dispersion technology as a strategy to improve the bioavailability of poorly soluble drugs. Ther Deliv. 2019; 10(16): 363-382. [CrossRef]
  • [2] Nair LS, Laurencin CT. Biodegradable polymers as biomaterials. Prog Polym Sci. 2007; 32(8-9): 762–798. [CrossRef]
  • [3] Patil PS. Natural excipients: Uses of pharmaceutical formulations. Int J Pharm Tech Res. 2014; 6: 21-28.
  • [4] Jani GK, Shah DP, Prajapatia VD, Jain VC. Gums and mucilages: Versatile excipients for pharmaceutical formulations. Asian J Pharm Sci. 2009; 4: 308-32.
  • [5] Shi NQ, Wang SR, Zhang Y, Huo JS, Wang LN, Cai JH, Li ZQ, Xiang B, Qi XR. Hot melt extrusion technology for improved dissolution, solubility and "spring-parachute" processes of amorphous self-micellizing solid dispersions containing BCS II drugs indomethacin and fenofibrate: Profiles and mechanisms. Eur J Pharm Sci. 2019; 130: 78-90. [CrossRef]
  • [6] Li Y, Yu J, Hu S, Chen Z, Sacchetti M, Sun CC, Yu L. Polymer nanocoating of amorphous drugs for improving stability, dissolution, powder flow, and tabletability: the case of chitosan-coated indomethacin. Mol Pharm. 2019; 16: 1305–1311. [CrossRef]
  • [7] Zhang W, Zheng N, Chen L, Xie L, Cui M, Li S, Xu L. Effect of shape on mesoporous silica nanoparticles for oral delivery of indomethacin. Pharmaceutics. 2018; 11: 1-13. [CrossRef]
  • [8] Li Y, Rantanen J, Yang M, Bohr A. Molecular structure and impact of amorphization strategies on intrinsic dissolution of spray dried indomethacin. Eur J Pharm Sci. 2019; 129: 1-9. [CrossRef]
  • [9] Bookwala M, Thipsay P, Ross S, Zhang F, Bandari S, Repka MA. Preparation of a crystalline salt of indomethacin and tromethamine by hot melt extrusion technology. Eur J Pharm Biopharm. 2018; 131: 109-119. [CrossRef]
  • [10] Semjonov K, Lust A, Kogermann K, Laidmäe I, Maunu SL, Hirvonen SP, Yliruusi J, Nurk G, Lust E, Heinämäki J. Melt-electrospinning as a method to improve the dissolution and physical stability of a poorly water-soluble drug. Eur J Pharm Sci. 2018; 121: 260-268. [CrossRef]
  • [11] Semjonov K, Salm M, Lipiäinen T, Kogermann K, Lust A, Laidmäe I, Antikainen O, Strachan CJ, Ehlers H, Yliruusi J, Heinämäki J. Interdependence of particle properties and bulk powder behavior of indomethacin in quench-cooled molten two-phase solid dispersions. Int J Pharm. 2018; 541: 188-197. [CrossRef]
  • [12] Doreth M, Löbmann K, Priemel P, Grohganz H, Taylor R, Holm R, Lopez de Diego H, Rades T. Influence of PVP molecular weight on the microwave assisted in situ amorphization of indomethacin. Eur J Pharm Biopharm. 2018; 122: 62-69. [CrossRef]
  • [13] Kasten G, Nouri K, Grohganz H, Rades T, Löbmann K. Performance comparison between crystalline and coamorphous salts of indomethacin-lysine. Int J Pharm. 2017; 533: 138-144. [CrossRef]
  • [14] Bhasin M. Ocimum-Taxonomy, medicinal potentialities and economic value of essential oil. J Biosphere. 2012; 1: 48-50.
  • [15] Sayyad FJ, Sakhare SS. Isolation, characterization and evaluation of Ocimum basilicum seed mucilage for tableting performance. Indian J Pharm Sci. 2018; 80: 282-290. [CrossRef]
  • [16] Nikghalb LA, Singh G, Singh G, Kahkeshan KF. Solid Dispersion: Methods and polymers to increase the solubility of poorly soluble drugs. J App Pharm Sci. 2012; 2: 170-175.

Yıl 2019, Cilt: 23 Sayı: 5, 832 - 838, 27.06.2025

Sfurti S. Sakhare Fahim J. Sayyad

Öz

Kaynakça

  • [1] Cid AG, Simonazzi A, Palma SD, Bermúdez JM. Solid dispersion technology as a strategy to improve the bioavailability of poorly soluble drugs. Ther Deliv. 2019; 10(16): 363-382. [CrossRef]
  • [2] Nair LS, Laurencin CT. Biodegradable polymers as biomaterials. Prog Polym Sci. 2007; 32(8-9): 762–798. [CrossRef]
  • [3] Patil PS. Natural excipients: Uses of pharmaceutical formulations. Int J Pharm Tech Res. 2014; 6: 21-28.
  • [4] Jani GK, Shah DP, Prajapatia VD, Jain VC. Gums and mucilages: Versatile excipients for pharmaceutical formulations. Asian J Pharm Sci. 2009; 4: 308-32.
  • [5] Shi NQ, Wang SR, Zhang Y, Huo JS, Wang LN, Cai JH, Li ZQ, Xiang B, Qi XR. Hot melt extrusion technology for improved dissolution, solubility and "spring-parachute" processes of amorphous self-micellizing solid dispersions containing BCS II drugs indomethacin and fenofibrate: Profiles and mechanisms. Eur J Pharm Sci. 2019; 130: 78-90. [CrossRef]
  • [6] Li Y, Yu J, Hu S, Chen Z, Sacchetti M, Sun CC, Yu L. Polymer nanocoating of amorphous drugs for improving stability, dissolution, powder flow, and tabletability: the case of chitosan-coated indomethacin. Mol Pharm. 2019; 16: 1305–1311. [CrossRef]
  • [7] Zhang W, Zheng N, Chen L, Xie L, Cui M, Li S, Xu L. Effect of shape on mesoporous silica nanoparticles for oral delivery of indomethacin. Pharmaceutics. 2018; 11: 1-13. [CrossRef]
  • [8] Li Y, Rantanen J, Yang M, Bohr A. Molecular structure and impact of amorphization strategies on intrinsic dissolution of spray dried indomethacin. Eur J Pharm Sci. 2019; 129: 1-9. [CrossRef]
  • [9] Bookwala M, Thipsay P, Ross S, Zhang F, Bandari S, Repka MA. Preparation of a crystalline salt of indomethacin and tromethamine by hot melt extrusion technology. Eur J Pharm Biopharm. 2018; 131: 109-119. [CrossRef]
  • [10] Semjonov K, Lust A, Kogermann K, Laidmäe I, Maunu SL, Hirvonen SP, Yliruusi J, Nurk G, Lust E, Heinämäki J. Melt-electrospinning as a method to improve the dissolution and physical stability of a poorly water-soluble drug. Eur J Pharm Sci. 2018; 121: 260-268. [CrossRef]
  • [11] Semjonov K, Salm M, Lipiäinen T, Kogermann K, Lust A, Laidmäe I, Antikainen O, Strachan CJ, Ehlers H, Yliruusi J, Heinämäki J. Interdependence of particle properties and bulk powder behavior of indomethacin in quench-cooled molten two-phase solid dispersions. Int J Pharm. 2018; 541: 188-197. [CrossRef]
  • [12] Doreth M, Löbmann K, Priemel P, Grohganz H, Taylor R, Holm R, Lopez de Diego H, Rades T. Influence of PVP molecular weight on the microwave assisted in situ amorphization of indomethacin. Eur J Pharm Biopharm. 2018; 122: 62-69. [CrossRef]
  • [13] Kasten G, Nouri K, Grohganz H, Rades T, Löbmann K. Performance comparison between crystalline and coamorphous salts of indomethacin-lysine. Int J Pharm. 2017; 533: 138-144. [CrossRef]
  • [14] Bhasin M. Ocimum-Taxonomy, medicinal potentialities and economic value of essential oil. J Biosphere. 2012; 1: 48-50.
  • [15] Sayyad FJ, Sakhare SS. Isolation, characterization and evaluation of Ocimum basilicum seed mucilage for tableting performance. Indian J Pharm Sci. 2018; 80: 282-290. [CrossRef]
  • [16] Nikghalb LA, Singh G, Singh G, Kahkeshan KF. Solid Dispersion: Methods and polymers to increase the solubility of poorly soluble drugs. J App Pharm Sci. 2012; 2: 170-175.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmasotik Biyoteknoloji, Farmasotik Kimya, Temel Farmakoloji
Bölüm Articles
Yazarlar

Sfurti S. Sakhare

Fahim J. Sayyad

Yayımlanma Tarihi 27 Haziran 2025
Yayımlandığı Sayı Yıl 2019 Cilt: 23 Sayı: 5

Kaynak Göster

APA S. Sakhare, S., & J. Sayyad, F. (2025). Studies on Ocimum basilicum mucilage based solid dispersions of indomethacin for enhancement of dissolution rate. Journal of Research in Pharmacy, 23(5), 832-838.
AMA S. Sakhare S, J. Sayyad F. Studies on Ocimum basilicum mucilage based solid dispersions of indomethacin for enhancement of dissolution rate. J. Res. Pharm. Temmuz 2025;23(5):832-838.
Chicago S. Sakhare, Sfurti, ve Fahim J. Sayyad. “Studies on Ocimum Basilicum Mucilage Based Solid Dispersions of Indomethacin for Enhancement of Dissolution Rate”. Journal of Research in Pharmacy 23, sy. 5 (Temmuz 2025): 832-38.
EndNote S. Sakhare S, J. Sayyad F (01 Temmuz 2025) Studies on Ocimum basilicum mucilage based solid dispersions of indomethacin for enhancement of dissolution rate. Journal of Research in Pharmacy 23 5 832–838.
IEEE S. S. Sakhare ve F. J. Sayyad, “Studies on Ocimum basilicum mucilage based solid dispersions of indomethacin for enhancement of dissolution rate”, J. Res. Pharm., c. 23, sy. 5, ss. 832–838, 2025.
ISNAD S. Sakhare, Sfurti - J. Sayyad, Fahim. “Studies on Ocimum Basilicum Mucilage Based Solid Dispersions of Indomethacin for Enhancement of Dissolution Rate”. Journal of Research in Pharmacy 23/5 (Temmuz 2025), 832-838.
JAMA S. Sakhare S, J. Sayyad F. Studies on Ocimum basilicum mucilage based solid dispersions of indomethacin for enhancement of dissolution rate. J. Res. Pharm. 2025;23:832–838.
MLA S. Sakhare, Sfurti ve Fahim J. Sayyad. “Studies on Ocimum Basilicum Mucilage Based Solid Dispersions of Indomethacin for Enhancement of Dissolution Rate”. Journal of Research in Pharmacy, c. 23, sy. 5, 2025, ss. 832-8.
Vancouver S. Sakhare S, J. Sayyad F. Studies on Ocimum basilicum mucilage based solid dispersions of indomethacin for enhancement of dissolution rate. J. Res. Pharm. 2025;23(5):832-8.