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Yıl 2021, Cilt: 25 Sayı: 4, 441 - 449, 27.06.2025

Nova Suliska , Mefani Praviska Neng Fisheri Kurniati , Elin Yulinah Sukandar

https://doi.org/10.29228/jrp.35

Öz

Kaynakça

  • [1] Webster AC, Nagler EV, Morton RL, and Masson P. Chronic kidney disease. The Lancet. 2017; 389(10075): 1238-1252. [CrossRef]
  • [2] World Health Organization. Mortality and global health estimates: Causes of death; Projections for 2015–2030; Projection of death rates. http://apps.who.int/gho/data/node.main.PROJRATEWORLD?lang=en. (accessed on 4 January 2019).
  • [3] Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, and Yang CW. Chronic kidney disease "Global dimensionsand perspectives". The Lancet. 2013; 382(9888): 260–272. [CrossRef]
  • [4] Decker B and Molitoris B. Aminoglycoside-Induced Nephrotoxicity. Comprehensive Toxicology. 2018; 14: 256-273. [CrossRef]
  • [5] William SJ, Antoine DJ, Smyth RL, and Pirmohamed M. Aminoglycoside-induced nephrotoxicity in children. Pediatr Nephrol. 2017; 32(11): 2015–2025. [CrossRef]
  • [6] Ki WM, Joonwan K, Jin HK, Ran S, Eun YL, Yeong WS, Eun BL. Risk factors for acute kidney injury by non-steroidal anti-inflammatory drugs in patients with hyperuricaemia. Rheumatology (Oxford). 2011; 50(12): 2278-2282. [CrossRef]
  • [7] Mihir YP, Mounika B, Sindhuja S, and Dinesh Pore. Nephroprotective and Antioxidant Potential of Ethanolic Extract of Flowers of Cassіa Sіamea against Gentamicin Induced Nephrotoxicity. JOJ Uro Nephron. 2019; 6(4).
  • [8] Sukandar EY, Sigit JI, and Adiwibowo LF. Study of kidney repair mechanisms of corn silk (Zea mays L. Hair)-binahong (Anredera cordifolia (Ten.) Steenis) leaves combination in rat model of kidney failure. Int J Pharmacol. 2013; 9 (1): 12–23. [CrossRef]
  • [9] Dhianawaty D, Soediro I, and Soemardji AA. Two synergetic effects of Sonchus arvensis L. leaves decoction in calcium oxalate bladder stone therapy on male Wistar rat. Int J Res Phytochem Pharmacol. 2012; 2(3): 147-149.
  • [10] Imelda, Achadiyani, Nanan Sekarwana. protective effect of ethanolic extract Sonchus arvensis L. in gentamicin-induced acute tubular necrosis on wistar rats. Indonesian J Pharm 2018; 29(2): 86–93. [CrossRef]
  • [11] Khan RA. Evaluation of flavonoids and diverse antioxidant activities of Sonchus arvensis L. Chemistry Central Journal.2012; 6(1): 1–7. [CrossRef]
  • [12] Nurianti Y, Hendriani R, Sukandar EY, Anggadiredja K, Acute and subchronic oral toxicity studies of ethyl acetate extract of Sonchus arvensis L. leaves. Int J Pharm Pharm Sci. 2014; 6(5): 343-347.
  • [13] Sukandar EY, Safitri D, Evaluation of teratogenic effect of tempuyung (Sonchus arvensis) extract on wistar rats. IJPPR. 2016; 8(5): 761-766.
  • [14] Hendriani R, Sukandar EY, Kusnandaranggadiredja. In vitro evaluation of xanthine oxidase inhibitory activity of Sonchus arvensis leaves. Int J Pharm Pharm Sci. 2014; 6(2): 501-503.
  • [15] Sukandar EY, Ridwan A, Sukmawan YP. Vasodilatation effect of ethanolic extract of Anredera cordifolia, Sonchus arvensis L, and ursolic acid on isolated rabbit aorta and frog heart. Int J Pharm Pharm Sci. 2016; 8 (2): 145-149.
  • [16] Sukandar EY, Kurniati NF, Bayu, Anti-dysentery activity of tetracycline in combination with Curcuma xanthorrhiza roxb., or Sonchus arvensis L. Asian J Pharm Clin Res. 2016; 9(6): 176-178.
  • [17] Widyarini KD, Sukandar EY, Fidrianny I. Xanthine oxidase inhibitory and antihyperuricemic activities of Anredera cordifolia (Ten) Steenis, Sonchus arvensis L., and its combination. Int J Pharm Pharm Sci. 2015; 7(3): 86-90.
  • [18] Quiros Y, Laura Vicente L, Morales AI, Lo'pez-Novoa J, and Francisco J Lo'pez-Hernandez F. An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamycin. Tox Sci. 2011; 119(2): 245–256. [CrossRef]
  • [19] Nagai J, Saito M, Adachi Y, Yumoto R., and Takano M. Inhibition of gentamycin binding to rat renal brush-border membrane by megalin ligands and basic peptides. J Control Rel. 2006; 112: 43–50. [CrossRef]
  • [20] Sandoval RM and Molitoris BA. Gentamycin traffics retrograde through the secretory pathway and is released in the cytosol via the endoplasmic reticulum. Am J Physiol Renal Physiol. 2004; 286: F617–F624. [CrossRef]
  • [21] Dixit M, Doan T, Kirschner R, Dixit N. Significant acute kidney injury due to non-steroidal anti-inflammatory drugs: inpatient setting. Pharmaceuticals. 2010; 3: 1279-1285. [CrossRef]
  • [22] Morales AI, Detaille D, Prieto M, Puente A, Briones E, Arevalo M, Leverve X, Lopez-Novoa JM, El-Mir MY. Metformin prevents experimental gentamycin-induced nephropathy by a mitochondria-dependent pathway. Kidney Int. 2010; 77: 861-869. [CrossRef]
  • [23] Daenen K, Andries A, Mekahli D, Schepdael AA, Jouret F, Bammens B. Oxidative stress in chronic kidney disease. Pediatr Nephrol. 2019; 34: 975–991. [CrossRef]
  • [24] Lykkesfeldt J, Svendsen O. Oxidants and antioxidants in disease: Oxidative stress in farm animals. Vet J. 2007; 173(3): 502-511. [CrossRef]
  • [25] Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Bio. 2007; 39(1): 44- 84. [CrossRef]
  • [26] Eugene Delyan. Analysis of component composition of volatile compounds of field sow thistle (Sonchus arvensis L) leaves using the method of gas chromatography with mass-detection. The Pharma Innovation Journal. 2016; 5(10): 118-121.
  • [27] Sukmayadi AE and Sumuwi BMI. Aktivitas Imunomodulator Ekstrak Etanol Daun tempuyung (Sonchus arvensisLinn.) terhadap peningkatan IL-2 pada tikus putih jantan galur wistar. IJPST. 2014; 1: 42-50. [CrossRef]
  • [28] Manoi F. Pengaruh kehalusan bahan dan lama ekstraksi terhadap mutu ekstrak tempuyung (Sonchus arvensis L.). Jurnal Penelitian Pertanian Terapan. 2015; 15(2): 156-161. [CrossRef]
  • [29] Mehan S, Dudi R, Kalra S. Renoprotective effect of corosolic acid in gentamycin-induced nephrotoxicity and renal dysfunction in experimental rats. Ann Pharmacol Pharm. 2017; 2(6): 1065.
  • [30] Sukandar EY, Fidrianny I, Adiwibowo LF. Efficacy of ethanol extract of Anredera cordifolia (Ten.) steenis leaves in improving kidney failure in rats. Int J Pharmacol. 2011; 7(8): 850–855. [CrossRef]
  • [31] Sukandar EY, Sigit JI., Adiwibowo LF. Study of kidney repair mechanisms of corn silk (Zea mays L. Hair)-binahong (Anredera cordifolia (Ten.) Steenis) leaves combination in rat model of kidney failure. Int J Pharmacol. 2013; 9(1): 12–23. [CrossRef]
  • [32] Liliana Torres-González, et al. Nephroprotective effect of Sonchus oleraceus extract against kidney injury induced by ischemia-reperfusion in wistar rats. Oxidative Medicine and Cellular Longevity. 2018; Article ID 9572803. [CrossRef]
  • [33] Imelda, Cherry Azaria, Teresa Lucretia. protective effect of ethanol extract tempuyung leaf (Sonchus arvensis L.) against gentamicin induced renal injury viewed from blood ureum level. J Med Health. 2017; 1(6): 575-582. [CrossRef]
  • [34] Hosaka EM, Santos OFP, Seguro AC, and Vattimo MFF. Effect of cyclooxygenase inhibitors on gentamycin inducednephrotoxicity in rats. Braz J Med Biol Res. 2004; 37: 979-985. [CrossRef]
  • [35] Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. AnalBiochem. 1979; 95: 351-358. [CrossRef]
  • [36] Aebi H. Catalase in vitro. Methods Enzymol. 1984; 105: 121-126. [CrossRef]
  • [37] Wilcox AA, Carrol WE, Sterling RE, Davis HA, and Ware AG. Use of berthelot reaction in the utomated analysis of serum urea nitrogen. Clin Chem. 1966; 12: 151-157. [CrossRef]
  • [38] Lustgarten AJ, and Wenk RE. Simple, rapid kinetic method for serum creatinine measurement. Clin Chem. 1972; 18: 1419-1422.

Nephroprotective effect of ethanol extract of Sonchus arvensis L. leaves in gentamicin-piroxicam induced rat renal failure

Yıl 2021, Cilt: 25 Sayı: 4, 441 - 449, 27.06.2025

Nova Suliska , Mefani Praviska Neng Fisheri Kurniati , Elin Yulinah Sukandar

https://doi.org/10.29228/jrp.35

Öz

Kidney failure is characterized by a decrease in the glomerular filtration rate, albuminuria, increased serum creatinine and blood urea nitrogen levels, abnormalities in kidney histology, and electrolyte disturbances. Sonchus arvensis L. contain high antioxidants such as flavonoids, glycosides, alkaloids, steroids/triterpenoids, tannins, saponins, and quinones, so it has the potential to improve kidney function. Twenty-five male Wistar albino rats were divided into five groups: negative control, positive control (induction of kidney failure), and three test groups which were administered an ethanol extract of Sonchus arvensis L. leaves of 50, 100, and 150 mg/kg b.w doses, respectively. Rats kidney failure model were using gentamycin 100 mg/kg b.w. and piroxicam, 3.6 mg/kg b.w. induction. Sonchus arvensis L. extracts were then administered for four weeks. The parameters for nephroprotective of Sonchus arvensis L. were urea and serum creatinine levels, urine volume, kidney organ histology, TBARS, and catalase activity. There was an improvement in kidney function as all Sonchus arvensis L. dosage levels were characterized by a significant decrease in serum urea levels (25-30%) and serum creatinine (16-23%), as well as significantly increased urine volume (83-167%) in the third week of therapy. At the end of treatment, there was a decrease in the TBARS levels (7-17%) and increased catalase activity (41-62%), significantly in all the treatment groups. The best effect was seen when using the 150 mg/kg b.w. the dose of Sonchus arvensis L. extract.

Anahtar Kelimeler

Sonchus arvensis L gentamicin piroxicam renal failure nephroprotective.

Kaynakça

  • [1] Webster AC, Nagler EV, Morton RL, and Masson P. Chronic kidney disease. The Lancet. 2017; 389(10075): 1238-1252. [CrossRef]
  • [2] World Health Organization. Mortality and global health estimates: Causes of death; Projections for 2015–2030; Projection of death rates. http://apps.who.int/gho/data/node.main.PROJRATEWORLD?lang=en. (accessed on 4 January 2019).
  • [3] Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, and Yang CW. Chronic kidney disease "Global dimensionsand perspectives". The Lancet. 2013; 382(9888): 260–272. [CrossRef]
  • [4] Decker B and Molitoris B. Aminoglycoside-Induced Nephrotoxicity. Comprehensive Toxicology. 2018; 14: 256-273. [CrossRef]
  • [5] William SJ, Antoine DJ, Smyth RL, and Pirmohamed M. Aminoglycoside-induced nephrotoxicity in children. Pediatr Nephrol. 2017; 32(11): 2015–2025. [CrossRef]
  • [6] Ki WM, Joonwan K, Jin HK, Ran S, Eun YL, Yeong WS, Eun BL. Risk factors for acute kidney injury by non-steroidal anti-inflammatory drugs in patients with hyperuricaemia. Rheumatology (Oxford). 2011; 50(12): 2278-2282. [CrossRef]
  • [7] Mihir YP, Mounika B, Sindhuja S, and Dinesh Pore. Nephroprotective and Antioxidant Potential of Ethanolic Extract of Flowers of Cassіa Sіamea against Gentamicin Induced Nephrotoxicity. JOJ Uro Nephron. 2019; 6(4).
  • [8] Sukandar EY, Sigit JI, and Adiwibowo LF. Study of kidney repair mechanisms of corn silk (Zea mays L. Hair)-binahong (Anredera cordifolia (Ten.) Steenis) leaves combination in rat model of kidney failure. Int J Pharmacol. 2013; 9 (1): 12–23. [CrossRef]
  • [9] Dhianawaty D, Soediro I, and Soemardji AA. Two synergetic effects of Sonchus arvensis L. leaves decoction in calcium oxalate bladder stone therapy on male Wistar rat. Int J Res Phytochem Pharmacol. 2012; 2(3): 147-149.
  • [10] Imelda, Achadiyani, Nanan Sekarwana. protective effect of ethanolic extract Sonchus arvensis L. in gentamicin-induced acute tubular necrosis on wistar rats. Indonesian J Pharm 2018; 29(2): 86–93. [CrossRef]
  • [11] Khan RA. Evaluation of flavonoids and diverse antioxidant activities of Sonchus arvensis L. Chemistry Central Journal.2012; 6(1): 1–7. [CrossRef]
  • [12] Nurianti Y, Hendriani R, Sukandar EY, Anggadiredja K, Acute and subchronic oral toxicity studies of ethyl acetate extract of Sonchus arvensis L. leaves. Int J Pharm Pharm Sci. 2014; 6(5): 343-347.
  • [13] Sukandar EY, Safitri D, Evaluation of teratogenic effect of tempuyung (Sonchus arvensis) extract on wistar rats. IJPPR. 2016; 8(5): 761-766.
  • [14] Hendriani R, Sukandar EY, Kusnandaranggadiredja. In vitro evaluation of xanthine oxidase inhibitory activity of Sonchus arvensis leaves. Int J Pharm Pharm Sci. 2014; 6(2): 501-503.
  • [15] Sukandar EY, Ridwan A, Sukmawan YP. Vasodilatation effect of ethanolic extract of Anredera cordifolia, Sonchus arvensis L, and ursolic acid on isolated rabbit aorta and frog heart. Int J Pharm Pharm Sci. 2016; 8 (2): 145-149.
  • [16] Sukandar EY, Kurniati NF, Bayu, Anti-dysentery activity of tetracycline in combination with Curcuma xanthorrhiza roxb., or Sonchus arvensis L. Asian J Pharm Clin Res. 2016; 9(6): 176-178.
  • [17] Widyarini KD, Sukandar EY, Fidrianny I. Xanthine oxidase inhibitory and antihyperuricemic activities of Anredera cordifolia (Ten) Steenis, Sonchus arvensis L., and its combination. Int J Pharm Pharm Sci. 2015; 7(3): 86-90.
  • [18] Quiros Y, Laura Vicente L, Morales AI, Lo'pez-Novoa J, and Francisco J Lo'pez-Hernandez F. An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamycin. Tox Sci. 2011; 119(2): 245–256. [CrossRef]
  • [19] Nagai J, Saito M, Adachi Y, Yumoto R., and Takano M. Inhibition of gentamycin binding to rat renal brush-border membrane by megalin ligands and basic peptides. J Control Rel. 2006; 112: 43–50. [CrossRef]
  • [20] Sandoval RM and Molitoris BA. Gentamycin traffics retrograde through the secretory pathway and is released in the cytosol via the endoplasmic reticulum. Am J Physiol Renal Physiol. 2004; 286: F617–F624. [CrossRef]
  • [21] Dixit M, Doan T, Kirschner R, Dixit N. Significant acute kidney injury due to non-steroidal anti-inflammatory drugs: inpatient setting. Pharmaceuticals. 2010; 3: 1279-1285. [CrossRef]
  • [22] Morales AI, Detaille D, Prieto M, Puente A, Briones E, Arevalo M, Leverve X, Lopez-Novoa JM, El-Mir MY. Metformin prevents experimental gentamycin-induced nephropathy by a mitochondria-dependent pathway. Kidney Int. 2010; 77: 861-869. [CrossRef]
  • [23] Daenen K, Andries A, Mekahli D, Schepdael AA, Jouret F, Bammens B. Oxidative stress in chronic kidney disease. Pediatr Nephrol. 2019; 34: 975–991. [CrossRef]
  • [24] Lykkesfeldt J, Svendsen O. Oxidants and antioxidants in disease: Oxidative stress in farm animals. Vet J. 2007; 173(3): 502-511. [CrossRef]
  • [25] Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Bio. 2007; 39(1): 44- 84. [CrossRef]
  • [26] Eugene Delyan. Analysis of component composition of volatile compounds of field sow thistle (Sonchus arvensis L) leaves using the method of gas chromatography with mass-detection. The Pharma Innovation Journal. 2016; 5(10): 118-121.
  • [27] Sukmayadi AE and Sumuwi BMI. Aktivitas Imunomodulator Ekstrak Etanol Daun tempuyung (Sonchus arvensisLinn.) terhadap peningkatan IL-2 pada tikus putih jantan galur wistar. IJPST. 2014; 1: 42-50. [CrossRef]
  • [28] Manoi F. Pengaruh kehalusan bahan dan lama ekstraksi terhadap mutu ekstrak tempuyung (Sonchus arvensis L.). Jurnal Penelitian Pertanian Terapan. 2015; 15(2): 156-161. [CrossRef]
  • [29] Mehan S, Dudi R, Kalra S. Renoprotective effect of corosolic acid in gentamycin-induced nephrotoxicity and renal dysfunction in experimental rats. Ann Pharmacol Pharm. 2017; 2(6): 1065.
  • [30] Sukandar EY, Fidrianny I, Adiwibowo LF. Efficacy of ethanol extract of Anredera cordifolia (Ten.) steenis leaves in improving kidney failure in rats. Int J Pharmacol. 2011; 7(8): 850–855. [CrossRef]
  • [31] Sukandar EY, Sigit JI., Adiwibowo LF. Study of kidney repair mechanisms of corn silk (Zea mays L. Hair)-binahong (Anredera cordifolia (Ten.) Steenis) leaves combination in rat model of kidney failure. Int J Pharmacol. 2013; 9(1): 12–23. [CrossRef]
  • [32] Liliana Torres-González, et al. Nephroprotective effect of Sonchus oleraceus extract against kidney injury induced by ischemia-reperfusion in wistar rats. Oxidative Medicine and Cellular Longevity. 2018; Article ID 9572803. [CrossRef]
  • [33] Imelda, Cherry Azaria, Teresa Lucretia. protective effect of ethanol extract tempuyung leaf (Sonchus arvensis L.) against gentamicin induced renal injury viewed from blood ureum level. J Med Health. 2017; 1(6): 575-582. [CrossRef]
  • [34] Hosaka EM, Santos OFP, Seguro AC, and Vattimo MFF. Effect of cyclooxygenase inhibitors on gentamycin inducednephrotoxicity in rats. Braz J Med Biol Res. 2004; 37: 979-985. [CrossRef]
  • [35] Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. AnalBiochem. 1979; 95: 351-358. [CrossRef]
  • [36] Aebi H. Catalase in vitro. Methods Enzymol. 1984; 105: 121-126. [CrossRef]
  • [37] Wilcox AA, Carrol WE, Sterling RE, Davis HA, and Ware AG. Use of berthelot reaction in the utomated analysis of serum urea nitrogen. Clin Chem. 1966; 12: 151-157. [CrossRef]
  • [38] Lustgarten AJ, and Wenk RE. Simple, rapid kinetic method for serum creatinine measurement. Clin Chem. 1972; 18: 1419-1422.
Toplam 38 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmakognozi, Temel Farmakoloji
Bölüm Articles
Yazarlar

Nova Suliska

Mefani Praviska

Neng Fisheri Kurniati

Elin Yulinah Sukandar

Yayımlanma Tarihi 27 Haziran 2025
Yayımlandığı Sayı Yıl 2021 Cilt: 25 Sayı: 4

Kaynak Göster

APA Suliska, N., Praviska, M., Kurniati, N. F., Sukandar, E. Y. (2025). Nephroprotective effect of ethanol extract of Sonchus arvensis L. leaves in gentamicin-piroxicam induced rat renal failure. Journal of Research in Pharmacy, 25(4), 441-449. https://doi.org/10.29228/jrp.35
AMA Suliska N, Praviska M, Kurniati NF, Sukandar EY. Nephroprotective effect of ethanol extract of Sonchus arvensis L. leaves in gentamicin-piroxicam induced rat renal failure. J. Res. Pharm. Haziran 2025;25(4):441-449. doi:10.29228/jrp.35
Chicago Suliska, Nova, Mefani Praviska, Neng Fisheri Kurniati, ve Elin Yulinah Sukandar. “Nephroprotective Effect of Ethanol Extract of Sonchus Arvensis L. Leaves in Gentamicin-Piroxicam Induced Rat Renal Failure”. Journal of Research in Pharmacy 25, sy. 4 (Haziran 2025): 441-49. https://doi.org/10.29228/jrp.35.
EndNote Suliska N, Praviska M, Kurniati NF, Sukandar EY (01 Haziran 2025) Nephroprotective effect of ethanol extract of Sonchus arvensis L. leaves in gentamicin-piroxicam induced rat renal failure. Journal of Research in Pharmacy 25 4 441–449.
IEEE N. Suliska, M. Praviska, N. F. Kurniati, ve E. Y. Sukandar, “Nephroprotective effect of ethanol extract of Sonchus arvensis L. leaves in gentamicin-piroxicam induced rat renal failure”, J. Res. Pharm., c. 25, sy. 4, ss. 441–449, 2025, doi: 10.29228/jrp.35.
ISNAD Suliska, Nova vd. “Nephroprotective Effect of Ethanol Extract of Sonchus Arvensis L. Leaves in Gentamicin-Piroxicam Induced Rat Renal Failure”. Journal of Research in Pharmacy 25/4 (Haziran 2025), 441-449. https://doi.org/10.29228/jrp.35.
JAMA Suliska N, Praviska M, Kurniati NF, Sukandar EY. Nephroprotective effect of ethanol extract of Sonchus arvensis L. leaves in gentamicin-piroxicam induced rat renal failure. J. Res. Pharm. 2025;25:441–449.
MLA Suliska, Nova vd. “Nephroprotective Effect of Ethanol Extract of Sonchus Arvensis L. Leaves in Gentamicin-Piroxicam Induced Rat Renal Failure”. Journal of Research in Pharmacy, c. 25, sy. 4, 2025, ss. 441-9, doi:10.29228/jrp.35.
Vancouver Suliska N, Praviska M, Kurniati NF, Sukandar EY. Nephroprotective effect of ethanol extract of Sonchus arvensis L. leaves in gentamicin-piroxicam induced rat renal failure. J. Res. Pharm. 2025;25(4):441-9.