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Covid-19 impact on blood sugar levels and renal function deterioration: a comparative study

Yıl 2025, Sayı: 012, 10 - 23, 30.04.2025

Hussein Mashkoor , Ebru Halvacı , Rima Nour Elhouda Tiri , Ayşenur Aygün , Nihal Yiğit Ertaş , Saadet Çeliközlü , Fatih Şen

Öz

COVID-19 is an infectious disease triggered by the SARS-CoV-2 virus. Its first emergence was documented in December 2019 in Wuhan, China, leading to a global spread and a pandemic declaration. COVID-19 symptoms usually include fever, cough, headache, fatigue, respiratory problems, and loss of sensation. Diabetes is a medical condition characterized by insufficient insulin production from the pancreas. According to previous studies, there is a two-way relationship between diabetes and Covid-19. On the one hand, it was found that diabetes leads to a fourfold increase in the risk of infection with Covid-19 in the average person. On the other hand, infection with Covid-19 can cause diabetes in patients who do not have diabetes. Renal dysfunction is a condition in which the kidneys are unable to remove waste macromolecules from the blood serum and require medical support. According to previous studies, more than one-third of patients infected with COVID-19 had acute renal dysfunction, and 15% of those infected are known to be on dialysis. Samples were collected from patients, which numbered 160 samples, the number of normal samples was 60, and the number of abnormal samples was 60. The following analyses were performed for all samples (PCR. Ferriten, LDH, D.Dimer, S.Creatinine, B. Urea, Albumin, S, Glucose ). In Covid 19, the following three analyses were chosen to diagnose the presence of the virus in the body: PCR, Ferriten, LDH, and D.Dimer. In diabetes mellitus, the following analyses were selected for this disease. These analyses are among the most accurate analyses for diagnosing diabetes which is: S, Glucose. In renal failure, the three most important analyses were chosen to diagnose the efficiency of the work and functions of the kidneys creatinine,B.UREA, and Albumin. When samples were tested by Independent T-test regarding ferritin, LDH D-dimer, and FBS, there were no significant differences between samples that were affected by COVID-19 and samples that were not infected by COVID-19. While Creatinine, Urea, and Albumin, there are significant differences between samples that are affected by COVID-19 and samples that are not infected by COVID-19. Thus, there is a relationship between Covid 19, diabetes, and kidney function impairment, and this relationship whenever there is a strong infection with the Covid 19 virus may result in kidney function impairment or diabetes. Null hypotheses There is no significant effect of COVID-19 on blood sugar levels (diabetes) and renal function impairment.

Anahtar Kelimeler

Covid-19 renal function diabetes PCR CRP LDH D-dimer

Kaynakça

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Covid-19 Impact on Blood Sugar Levels and Renal Function Deterioration: A Comparative Study

Yıl 2025, Sayı: 012, 10 - 23, 30.04.2025

Hussein Mashkoor , Ebru Halvacı , Rima Nour Elhouda Tiri , Ayşenur Aygün , Nihal Yiğit Ertaş , Saadet Çeliközlü , Fatih Şen

Öz

Covid-19 is an infectious disease triggered by the SARS-CoV-2 virus. Its first emergence was documented in December 2019 in Wuhan, China, leading to a global spread and a pandemic declaration. Covid-19 symptoms usually include fever, cough, headache, fatigue, respiratory problems, and loss of sensation. Diabetes is a medical condition characterized by insufficient insulin production from the pancreas. According to previous studies, there is a two-way relationship between diabetes and Covid-19. On the one hand, it was found that diabetes leads to a fourfold increase in the risk of infection with Covid-19 in the average person. On the other hand, infection with Covid-19 can cause diabetes in patients who do not have diabetes. Renal dysfunction is a condition in which the kidneys are unable to remove waste macromolecules from the blood serum and require medical support. According to previous studies, more than one-third of patients infected with Covid-19 had acute renal dysfunction, and 15% of those infected are known to be on dialysis. Samples were collected from patients, which numbered 120 samples, the number of normal samples was 60, and the number of abnormal samples was 60. The following analyses were performed for all samples (PCR. Ferriten, LDH, D.Dimer, S.Creatinine, B. Urea, Albumin, S, Glucose ). In Covid-19, the following four analyses were chosen to diagnose the presence of the virus in the body: PCR, Ferriten, LDH, and D.Dimer. In diabetes mellitus, the following analyses were selected for this disease. These analyses are among the most accurate analyses for diagnosing diabetes which is: S, Glucose. In renal failure, the three most important analyses were chosen to diagnose the efficiency of the work and functions of the kidneys creatinine, B.Urea, and Albumin. When samples were tested by Independent T-test regarding ferritin, LDH D-dimer, and FBS, there were no significant differences between samples that were affected by Covid-19 and samples that were not infected by Covid-19. While Creatinine, Urea, and Albumin, there are significant differences between samples that are affected by Covid-19 and samples that are not infected by Covid-19. Thus, there is a relationship between Covid-19, diabetes, and kidney function impairment, and this relationship whenever there is a strong infection with the Covid-19 virus may result in kidney function impairment or diabetes.

Anahtar Kelimeler

Covid-19 renal function diabetes PCR

Kaynakça

  • [1] C. Huang et al., “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China,” Lancet, vol. 395, no. 10223, pp. 497–506, Feb. 2020, doi: 10.1016/S0140-6736(20)30183-5.
  • [2] S. Su et al., “Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses,” Trends Microbiol., vol. 24, no. 6, pp. 490–502, Jun. 2016, doi: 10.1016/j.tim.2016.03.003.
  • [3] P. C. Y. Woo et al., “ICTV Virus Taxonomy Profile: Coronaviridae 2023,” J. Gen. Virol., vol. 104, no. 4, Apr. 2023, doi: 10.1099/jgv.0.001843.
  • [4] S. Ali, B. Bello, P. Chourasia, R. T. Punathil, Y. Zhou, and M. Patterson, “PWM2Vec: An Efficient Embedding Approach for Viral Host Specification from Coronavirus Spike Sequences,” Biology (Basel)., vol. 11, no. 3, p. 418, Mar. 2022, doi: 10.3390/biology11030418.
  • [5] A. J. Rodriguez-Morales et al., “History is Repeating Itself: Probable Zoonotic Spillover as the Cause of the 2019 Novel Coronavirus Epidemic,” Infez. Med., vol. 28, no. 1, pp. 3–5, 2020.
  • [6] O. M. Abdeldayem et al., “Viral outbreaks detection and surveillance using wastewater-based epidemiology, viral air sampling, and machine learning techniques: A comprehensive review and outlook,” Sci. Total Environ., vol. 803, p. 149834, Jan. 2022, doi: 10.1016/j.scitotenv.2021.149834.
  • [7] X. Yang et al., “Clinical Course and Outcomes of Critically Ill Patients With SARS-CoV-2 Pneumonia in Wuhan, China: a Single-Centered, Retrospective, Observational Study,” Lancet Respir. Med., vol. 8, no. 5, pp. 475–481, May 2020, doi: 10.1016/S2213-2600(20)30079-5.
  • [8] A. B. Bungum et al., “Risk of SARS-CoV-2 infection in healthcare workers with insufficient use of personal protective equipment in Denmark,” Ann. Work Expo. Heal., vol. 69, no. 1, pp. 96–103, Jan. 2025, doi: 10.1093/annweh/wxae075.
  • [9] N. van Doremalen et al., “Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1,” N. Engl. J. Med., vol. 382, no. 16, pp. 1564–1567, Apr. 2020, doi: 10.1056/NEJMc2004973.
  • [10] V. F. McNeill, “Airborne Transmission of SARS-CoV-2: Evidence and Implications for Engineering Controls,” Annu. Rev. Chem. Biomol. Eng., vol. 13, no. 1, pp. 123–140, Jun. 2022, doi: 10.1146/annurev-chembioeng-092220-111631.
  • [11] E. A. Huhn, S. W. Rossi, I. Hoesli, and C. S. Göbl, “Controversies in Screening and Diagnostic Criteria for Gestational Diabetes in Early and Late Pregnancy,” Front. Endocrinol. (Lausanne)., vol. 9, Nov. 2018, doi: 10.3389/fendo.2018.00696.
  • [12] C. C. Olisah, L. Smith, and M. Smith, “Diabetes mellitus prediction and diagnosis from a data preprocessing and machine learning perspective,” Comput. Methods Programs Biomed., vol. 220, p. 106773, Jun. 2022, doi: 10.1016/j.cmpb.2022.106773.
  • [13] H. Kaminska et al., “Impact of diabetes mellitus on in-hospital mortality in adult patients with COVID-19: a systematic review and meta-analysis,” Acta Diabetol., vol. 58, no. 8, pp. 1101–1110, Aug. 2021, doi: 10.1007/s00592-021-01701-1.
  • [14] S. Gentile, F. Strollo, and A. Ceriello, “COVID-19 Infection in Italian People With Diabetes: Lessons Learned for Our Future (An Experience to be Used),” Diabetes Res. Clin. Pract., vol. 162, p. 108137, Apr. 2020, doi: 10.1016/j.diabres.2020.108137.
  • [15] R. Muniyappa and S. Gubbi, “COVID-19 Pandemic, Coronaviruses, and Diabetes Mellitus,” Am. J. Physiol. Metab., vol. 318, no. 5, pp. E736–E741, May 2020, doi: 10.1152/ajpendo.00124.2020.
  • [16] Y. R. Rastogi, A. Sharma, R. Nagraik, A. Aygün, and F. Şen, “The Novel Coronavirus 2019-Ncov: Its Evolution and Transmission Into Humans Causing Global COVID-19 Pandemic,” Int. J. Environ. Sci. Technol., vol. 17, no. 10, pp. 4381–4388, Oct. 2020, doi: 10.1007/s13762-020-02781-2.
  • [17] E. Esra Altuner, M. Bekmezci, R. N. E. Tiri, A. Aygun, and F. Sen, “A Review: Severe Treatments, Drug and Vaccine Studies For Coronavirus Disease (Covid-19),” J. Sci. Reports-C, vol. 3, no. 21–38, pp. 2717–8633, 2022.
  • [18] B. Li et al., “Prevalence and Impact of Cardiovascular Metabolic Diseases on COVID-19 in China,” Clin. Res. Cardiol., vol. 109, no. 5, pp. 531–538, May 2020, doi: 10.1007/s00392-020-01626-9.
  • [19] G. P. Fadini, M. L. Morieri, E. Longato, and A. Avogaro, “Prevalence and Impact of Diabetes Among People Infected With SARS-CoV-2,” J. Endocrinol. Invest., vol. 43, no. 6, pp. 867–869, Jun. 2020, doi: 10.1007/s40618-020-01236-2.
  • [20] S. R. Bornstein, R. Dalan, D. Hopkins, G. Mingrone, and B. O. Boehm, “Endocrine and Metabolic Link to Coronavirus Infection,” Nat. Rev. Endocrinol., vol. 16, no. 6, pp. 297–298, Jun. 2020, doi: 10.1038/s41574-020-0353-9.
  • [21] A. Remuzzi and G. Remuzzi, “COVID-19 and Italy: What Next?,” Lancet, vol. 395, no. 10231, pp. 1225–1228, Apr. 2020, doi: 10.1016/S0140-6736(20)30627-9.
  • [22] J. Zhou, Y. Wang, and R. Xu, “Association of COVID-19 infection and the risk of new incident diabetes: a systematic review and meta-analysis,” Front. Endocrinol. (Lausanne)., vol. 15, Aug. 2024, doi: 10.3389/fendo.2024.1429848.
  • [23] J. A. Kellum, P. Romagnani, G. Ashuntantang, C. Ronco, A. Zarbock, and H.-J. Anders, “Acute kidney injury,” Nat. Rev. Dis. Prim., vol. 7, no. 1, p. 52, Jul. 2021, doi: 10.1038/s41572-021-00284-z.
  • [24] S. Shrivastava, N. Srivastava, and M. Alfanso-Jaume, “Acute Renal Failure With Cocaine and SGLT-2 Inhibitor,” Am. J. Ther., vol. 26, no. 6, pp. e762–e763, Nov. 2019, doi: 10.1097/MJT.0000000000000929.
  • [25] E. A. J. Hoste, J. A. Kellum, R. Bellomo, and C. Ronco, “What Is Acute Kidney Injury?,” in Critical Care Nephrology, Elsevier, 2009, pp. 67–71.
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Toplam 52 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Metabolik Tıp, Tarımda Bitki Biyokimyası ve Fizyolojisi
Bölüm Araştırma Makaleleri
Yazarlar

Hussein Mashkoor 0000-0003-3849-7342

Ebru Halvacı 0009-0003-6062-7622

Rima Nour Elhouda Tiri 0000-0001-8153-3738

Ayşenur Aygün 0000-0002-8547-2589

Nihal Yiğit Ertaş 0000-0002-7563-2067

Saadet Çeliközlü 0000-0001-9825-6458

Fatih Şen 0000-0001-6843-9026

Yayımlanma Tarihi 30 Nisan 2025
Gönderilme Tarihi 14 Şubat 2025
Kabul Tarihi 29 Nisan 2025
Yayımlandığı Sayı Yıl 2025 Sayı: 012

Kaynak Göster

APA Mashkoor, H., Halvacı, E., Tiri, R. N. E., Aygün, A., vd. (2025). Covid-19 impact on blood sugar levels and renal function deterioration: a comparative study. Journal of Scientific Reports-B(012), 10-23.
AMA Mashkoor H, Halvacı E, Tiri RNE, Aygün A, Yiğit Ertaş N, Çeliközlü S, Şen F. Covid-19 impact on blood sugar levels and renal function deterioration: a comparative study. Journal of Scientific Reports-B. Nisan 2025;(012):10-23.
Chicago Mashkoor, Hussein, Ebru Halvacı, Rima Nour Elhouda Tiri, Ayşenur Aygün, Nihal Yiğit Ertaş, Saadet Çeliközlü, ve Fatih Şen. “Covid-19 Impact on Blood Sugar Levels and Renal Function Deterioration: A Comparative Study”. Journal of Scientific Reports-B, sy. 012 (Nisan 2025): 10-23.
EndNote Mashkoor H, Halvacı E, Tiri RNE, Aygün A, Yiğit Ertaş N, Çeliközlü S, Şen F (01 Nisan 2025) Covid-19 impact on blood sugar levels and renal function deterioration: a comparative study. Journal of Scientific Reports-B 012 10–23.
IEEE H. Mashkoor, E. Halvacı, R. N. E. Tiri, A. Aygün, N. Yiğit Ertaş, S. Çeliközlü, ve F. Şen, “Covid-19 impact on blood sugar levels and renal function deterioration: a comparative study”, Journal of Scientific Reports-B, sy. 012, ss. 10–23, Nisan 2025.
ISNAD Mashkoor, Hussein vd. “Covid-19 Impact on Blood Sugar Levels and Renal Function Deterioration: A Comparative Study”. Journal of Scientific Reports-B 012 (Nisan 2025), 10-23.
JAMA Mashkoor H, Halvacı E, Tiri RNE, Aygün A, Yiğit Ertaş N, Çeliközlü S, Şen F. Covid-19 impact on blood sugar levels and renal function deterioration: a comparative study. Journal of Scientific Reports-B. 2025;:10–23.
MLA Mashkoor, Hussein vd. “Covid-19 Impact on Blood Sugar Levels and Renal Function Deterioration: A Comparative Study”. Journal of Scientific Reports-B, sy. 012, 2025, ss. 10-23.
Vancouver Mashkoor H, Halvacı E, Tiri RNE, Aygün A, Yiğit Ertaş N, Çeliközlü S, Şen F. Covid-19 impact on blood sugar levels and renal function deterioration: a comparative study. Journal of Scientific Reports-B. 2025(012):10-23.
 Kapak Resmi İndir