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Yıl 2025, Cilt: 38 Sayı: 1, 62 - 67, 29.01.2025

Pınar Kuru Bektaşoğlu , Jülide Hazneci , Adnan Somay Ali Börekci , Bora Gürer

https://doi.org/10.5472/marumj.1629001

Öz

Kaynakça

  • Williams MG, Wafai AM, Podmore MD. Functional outcomes of laminectomy and laminotomy for the surgical management lumbar spine stenosis. J Spine Surg 2017;3:580-6. doi: 10.21037/jss.2017.10.08.
  • Ross JS, Robertson JT, Frederickson RC, et al. Association between peridural scar and recurrent radicular pain after lumbar discectomy: magnetic resonance evaluation. ADCON-L European Study Group. Neurosurgery 1996;38:855-61.
  • Bozkurt H, Bozkurt EC, Ozpinar H, et al. Comparison of the effects of contractubex gel and benzothiazole after topical application in an experimental model of epidural fibrosis in rats. World Neurosurg 2018;117:e403-e410. doi: 10.1016/j. wneu.2018.06.044.
  • Bozkurt H, Kuru Bektaşoğlu P, Borekci A, et al. Antifibrotic effect of boric acid in rats with epidural fibrosis. World Neurosurg 2019;122:e989-e994. doi: 10.1016/j. wneu.2018.10.187.
  • Gürer B, Kahveci R, Gökçe EC, Ozevren H, Turkoglu E, Gökçe A. Evaluation of topical application and systemic administration of rosuvastatin in preventing epidural fibrosis in rats. Spine J 2015;15:522-9. doi:10.1016/j.spinee.2014.10.018.
  • Keane TJ, Horejs CM, Stevens MM. Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair. Adv Drug Deliv Rev 2018;129:407-19. doi: 10.1016/j. addr.2018.02.002.
  • Cox N. The anti-inflammatory potential of quercetin and L-2-oxothiazolidine-4-carboxylate (OTC) in developing scar tissue. September 2008, Master Thesis, University of Saskatchewan.
  • Turkoglu E, Dinc C, Tuncer C, Oktay M, Serbes G, Sekerci Z. Use of decorin to prevent epidural fibrosis in a postlaminectomy rat model. Eur J Pharmacol 2014;724:86-91. doi: 10.1016/j.ejphar.2013.12.017.
  • Bochaton-Piallat ML, Gabbiani G, Hinz B. The myofibroblast in wound healing and fibrosis: answered and unanswered questions. F1000Res 2016;5:F1000 Faculty Rev-752. doi: 10.12688/f1000research.8190.1.
  • McGrath J, Feron F, Eyles D, Mackay-Sim A. Vitamin D: the neglected neurosteroid? Trends. Neurosci 2001;24:570-2.
  • Chojnacki M, Lemieszek MK. Role of vitamin D3 in selected pulmonary diseases with particular emphasis on lung fibrosis. Ann Agric Environ Med 2023;30:31-44. doi: 10.26444/ aaem/161583.
  • Gürer B, Karakoç A, Bektaşoğlu PK, et al. Comparative effects of vitamin D and methylprednisolone against ischemia/ reperfusion injury of rabbit spinal cords. Eur J Pharmacol 2017;813:50-60. doi: 10.1016/j.ejphar.2017.07.028.
  • Ma D, Peng L. Vitamin D and pulmonary fibrosis: a review of molecular mechanisms. Int J Clin Exp Pathol 2019;12:3171-8.
  • Rydell N. Decreased granulation tissue reaction after installment of hyaluronic acid. Acta Orthop Scand 1970;41:307-11. doi: 10.3109/174.536.77008991516.
  • Bektaşoğlu PK, Somay A, Hazneci J, Borekci A, Gürer B. Cinnamaldehyde has antifibrotic effects on rats with epidural fibrosis. World Neurosurg 2024;183:e395-e400. doi: 10.1016/j. wneu.2023.12.106.
  • Erbayraktar S, Acar F, Tekinsoy B, Acar U, Güner EM. Outcome analysis of reoperations after lumbar discectomies: A report of 22 patients. Kobe J Med Sci 2002;48:33-41.
  • Denaro V, Di Martino A, Longo UG, et al. Effectiveness of a mucolythic agent as a local adjuvant in revision lumbar spine surgery. Eur Spine J 2008;17:1752-6. doi: 10.1007/ s00586.008.0802-y.
  • Makhchoune M, Collard X, Triffaux M, DE Witte O, Lubansu A. The utility of the CADISS® system in the dissection of epidural fibrosis in revision lumbar spine surgery (A case series). Ann Med Surg (Lond) 2022;83:104718. doi: 10.1016/j. amsu.2022.104718.
  • Turkoglu E, Tuncer C, Dinc C, Serbes G, Oktay M, Sekerci Z. The effect of etanercept on spinal epidural fibrosis in a postlaminectomy rat model. Turk Neurosurg 2014;24:506-11. doi: 10.5137/1019-5149.JTN.9006-13.1.
  • Aydincak O, Yilmaz MB, Emmez H, et al. The effect of temozolomide on the prevention of epidural fibrosis developing after lumbar laminectomy in rats. Turk Neurosurg 2012;22:706-11. doi: 10.5137/1019-5149.JTN.5966-12.1.
  • Karatay M, Erdem Y, Koktekir E, Erkoc YS, Caydere M, Bayar MA. The effect of bevacizumab on spinal epidural fibrosis in a postlaminectomy rat model. Turk Neurosurg 2012;22:753-7. doi: 10.5137/1019-5149.JTN.6155-12.1.
  • Savran M, Bekar A, Cansev M, Tolunay S, Ulus IH, Taskapilioglu MO. Prevention of epidural fibrosis in rats by local or systemic administration of citicoline. Turk Neurosurg 2012;22:634-40. doi: 10.5137/1019-5149.JTN.6008-12.0.
  • Borcek AO, Borcek P, Civi S, Emmez H, Sen A, Aykol S. Hyperbaric oxygen in epidural fibrosis: is there a potential for treatment? Turk Neurosurg 2013;23:607-10. doi: 10.5137/1019-5149.JTN.7217-12.2.
  • Mohi Eldin MM, Abdel Razek NM. Epidural fibrosis after lumbar disc surgery: prevention and outcome evaluation. Asian Spine J 2015;9:370-85. doi: 10.4184/asj.2015.9.3.370.
  • Laurent GJ, Chambers RC, Hill MR, McAnulty RJ. Regulation of matrix turnover: fibroblasts, forces, factors and fibrosis. Biochem Soc Trans 2007;35:647-51. doi: 10.1042/BST0350647.
  • Masopust V, Häckel M, Netuka D, Bradác O, Rokyta R, Vrabec M. Postoperative epidural fibrosis. Clin J Pain 2009;25:600-6. doi:10.1097/AJP.0b013e3181a5b665. [ Zhu J, Li Y, Shen W, et al. Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis. J Biol Chem 2007;282:25852-63. doi: 10.1074/jbc.M704146200.
  • Baeke F, Gysemans C, Korf H, Mathieu C. Vitamin D insufficiency: implications for the immune system. Pediatr Nephrol 2010;25:1597-606. doi: 10.1007/s00467.010.1452-y.
  • Chen S, Sims GP, Chen XX, Gu YY, Chen S, Lipsky PE. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol 2007;179:1634-47. doi: 10.4049/jimmunol.179.3.1634.
  • Haussler MR, Haussler CA, Whitfield GK, et al. The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the “Fountain of Youth” to mediate healthful aging. J Steroid Biochem Mol Biol 2010;121:88-97. doi: 10.1016/j.jsbmb.2010.03.019.
  • Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients 2013;5:2502-21.
  • Samuel S, Sitrin MD. Vitamin D’s role in cell proliferation and differentiation. Nutr Rev 2008;66: S116-24.
  • Meredith A, Boroomand S, Carthy J, Luo Z, McManus B. 1,25 Dihydroxyvitamin D3 ınhibits TGFβ1-mediated primary human cardiac myofibroblast activation. PLoS One 2015;10:e0128655.
  • Sari DCR, Putri MW, Leksono TP, et al. Calcitriol ameliorates kidney ınjury through reducing podocytopathy, tubular ınjury, ınflammation and fibrosis in 5/6 subtotal nephrectomy model in rats. Kobe J Med Sci 2020;65:E153-E163.
  • Wallbaum P, Rohde S, Ehlers L, et al. Antifibrogenic effects of vitamin D derivatives on Mouse pancreatic stellate cells. World J Gastroenterol 2018;24:170-8.
  • Lee CJ, Subeq YM, Lee RP, Liou HH, Hsu BG. Calcitriol decreases TGF-β1 and angiotensin II production and protects against chlorhexide digluconate-induced liver peritoneal fibrosis in rats. Cytokine 2014;65:105-18.
  • Ricca C, Aillon A, Viano M, Bergandi L, Aldieri E, Silvagno F. Vitamin D inhibits the epithelial-mesenchymal transition by a negative feedback regulation of TGF-β activity. J Steroid Biochem Mol Biol 2019;187:97-105.
  • Zheng S, Yang J, Hu X, et al. Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-β induced epithelial to mesenchymal transition. Biochem Pharmacol 2020;177:113955.
  • Zhang H, Deng W, Yang Y, Wei S, Xue L, Tao S. Pharmaceutic application of vitamin D3 on particle-induced fibrotic effects through induction of Nrf2 signals. Toxicol Res (Camb) 2020;9:55-66. doi: 10.1093/toxres/tfaa003.
  • Voisin T, Joannes A, Morzadec C, et al. Antifibrotic effects of vitamin D3 on human lung fibroblasts derived from patients with idiopathic pulmonary fibrosis. J Nutr Biochem 2024;125:109558. doi: 10.1016/j.jnutbio.2023.109558.

Vitamin D3 has antifibrotic effects on rats with epidural fibrosis

Yıl 2025, Cilt: 38 Sayı: 1, 62 - 67, 29.01.2025

Pınar Kuru Bektaşoğlu , Jülide Hazneci , Adnan Somay Ali Börekci , Bora Gürer

https://doi.org/10.5472/marumj.1629001

Öz

Objective: One unfavorable outcome of spinal operations is epidural fibrosis. Recurrent back pain and radiculopathy could negatively
impact the patient’s quality of life. In this study, using a rat laminectomy model, we sought to examine any potential antifibrotic
benefits of vitamin D3.
Patients and Methods: Control, local, and systemic vitamin D3 groups (n = 6 rats per group) were randomly assigned. Laminectomy
alone was carried out in the control group. Vitamin D3 application onto the dura was done in the local D3 group. Intraperitoneal
delivery of the systemic vitamin D3 was carried out in the systemic vitamin D3 group. Epidural fibrosis was studied macroscopically
and histopathologically four weeks later.
Results: The macroscopic epidural fibrosis score was lower in the local and systemic vitamin D3 groups compared to the control
group (p<0.001, for both groups). Comparing the local and systemic vitamin D3 groups to the control group, fibrosis thickness was
significantly decreased (p<0.01, for both groups).
Conclusion: Vitamin D3 could be an alternative treatment for preventing spinal epidural fibrosis.

Anahtar Kelimeler

Epidural fibrosis Laminectomy Vitamin D3

Kaynakça

  • Williams MG, Wafai AM, Podmore MD. Functional outcomes of laminectomy and laminotomy for the surgical management lumbar spine stenosis. J Spine Surg 2017;3:580-6. doi: 10.21037/jss.2017.10.08.
  • Ross JS, Robertson JT, Frederickson RC, et al. Association between peridural scar and recurrent radicular pain after lumbar discectomy: magnetic resonance evaluation. ADCON-L European Study Group. Neurosurgery 1996;38:855-61.
  • Bozkurt H, Bozkurt EC, Ozpinar H, et al. Comparison of the effects of contractubex gel and benzothiazole after topical application in an experimental model of epidural fibrosis in rats. World Neurosurg 2018;117:e403-e410. doi: 10.1016/j. wneu.2018.06.044.
  • Bozkurt H, Kuru Bektaşoğlu P, Borekci A, et al. Antifibrotic effect of boric acid in rats with epidural fibrosis. World Neurosurg 2019;122:e989-e994. doi: 10.1016/j. wneu.2018.10.187.
  • Gürer B, Kahveci R, Gökçe EC, Ozevren H, Turkoglu E, Gökçe A. Evaluation of topical application and systemic administration of rosuvastatin in preventing epidural fibrosis in rats. Spine J 2015;15:522-9. doi:10.1016/j.spinee.2014.10.018.
  • Keane TJ, Horejs CM, Stevens MM. Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair. Adv Drug Deliv Rev 2018;129:407-19. doi: 10.1016/j. addr.2018.02.002.
  • Cox N. The anti-inflammatory potential of quercetin and L-2-oxothiazolidine-4-carboxylate (OTC) in developing scar tissue. September 2008, Master Thesis, University of Saskatchewan.
  • Turkoglu E, Dinc C, Tuncer C, Oktay M, Serbes G, Sekerci Z. Use of decorin to prevent epidural fibrosis in a postlaminectomy rat model. Eur J Pharmacol 2014;724:86-91. doi: 10.1016/j.ejphar.2013.12.017.
  • Bochaton-Piallat ML, Gabbiani G, Hinz B. The myofibroblast in wound healing and fibrosis: answered and unanswered questions. F1000Res 2016;5:F1000 Faculty Rev-752. doi: 10.12688/f1000research.8190.1.
  • McGrath J, Feron F, Eyles D, Mackay-Sim A. Vitamin D: the neglected neurosteroid? Trends. Neurosci 2001;24:570-2.
  • Chojnacki M, Lemieszek MK. Role of vitamin D3 in selected pulmonary diseases with particular emphasis on lung fibrosis. Ann Agric Environ Med 2023;30:31-44. doi: 10.26444/ aaem/161583.
  • Gürer B, Karakoç A, Bektaşoğlu PK, et al. Comparative effects of vitamin D and methylprednisolone against ischemia/ reperfusion injury of rabbit spinal cords. Eur J Pharmacol 2017;813:50-60. doi: 10.1016/j.ejphar.2017.07.028.
  • Ma D, Peng L. Vitamin D and pulmonary fibrosis: a review of molecular mechanisms. Int J Clin Exp Pathol 2019;12:3171-8.
  • Rydell N. Decreased granulation tissue reaction after installment of hyaluronic acid. Acta Orthop Scand 1970;41:307-11. doi: 10.3109/174.536.77008991516.
  • Bektaşoğlu PK, Somay A, Hazneci J, Borekci A, Gürer B. Cinnamaldehyde has antifibrotic effects on rats with epidural fibrosis. World Neurosurg 2024;183:e395-e400. doi: 10.1016/j. wneu.2023.12.106.
  • Erbayraktar S, Acar F, Tekinsoy B, Acar U, Güner EM. Outcome analysis of reoperations after lumbar discectomies: A report of 22 patients. Kobe J Med Sci 2002;48:33-41.
  • Denaro V, Di Martino A, Longo UG, et al. Effectiveness of a mucolythic agent as a local adjuvant in revision lumbar spine surgery. Eur Spine J 2008;17:1752-6. doi: 10.1007/ s00586.008.0802-y.
  • Makhchoune M, Collard X, Triffaux M, DE Witte O, Lubansu A. The utility of the CADISS® system in the dissection of epidural fibrosis in revision lumbar spine surgery (A case series). Ann Med Surg (Lond) 2022;83:104718. doi: 10.1016/j. amsu.2022.104718.
  • Turkoglu E, Tuncer C, Dinc C, Serbes G, Oktay M, Sekerci Z. The effect of etanercept on spinal epidural fibrosis in a postlaminectomy rat model. Turk Neurosurg 2014;24:506-11. doi: 10.5137/1019-5149.JTN.9006-13.1.
  • Aydincak O, Yilmaz MB, Emmez H, et al. The effect of temozolomide on the prevention of epidural fibrosis developing after lumbar laminectomy in rats. Turk Neurosurg 2012;22:706-11. doi: 10.5137/1019-5149.JTN.5966-12.1.
  • Karatay M, Erdem Y, Koktekir E, Erkoc YS, Caydere M, Bayar MA. The effect of bevacizumab on spinal epidural fibrosis in a postlaminectomy rat model. Turk Neurosurg 2012;22:753-7. doi: 10.5137/1019-5149.JTN.6155-12.1.
  • Savran M, Bekar A, Cansev M, Tolunay S, Ulus IH, Taskapilioglu MO. Prevention of epidural fibrosis in rats by local or systemic administration of citicoline. Turk Neurosurg 2012;22:634-40. doi: 10.5137/1019-5149.JTN.6008-12.0.
  • Borcek AO, Borcek P, Civi S, Emmez H, Sen A, Aykol S. Hyperbaric oxygen in epidural fibrosis: is there a potential for treatment? Turk Neurosurg 2013;23:607-10. doi: 10.5137/1019-5149.JTN.7217-12.2.
  • Mohi Eldin MM, Abdel Razek NM. Epidural fibrosis after lumbar disc surgery: prevention and outcome evaluation. Asian Spine J 2015;9:370-85. doi: 10.4184/asj.2015.9.3.370.
  • Laurent GJ, Chambers RC, Hill MR, McAnulty RJ. Regulation of matrix turnover: fibroblasts, forces, factors and fibrosis. Biochem Soc Trans 2007;35:647-51. doi: 10.1042/BST0350647.
  • Masopust V, Häckel M, Netuka D, Bradác O, Rokyta R, Vrabec M. Postoperative epidural fibrosis. Clin J Pain 2009;25:600-6. doi:10.1097/AJP.0b013e3181a5b665. [ Zhu J, Li Y, Shen W, et al. Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis. J Biol Chem 2007;282:25852-63. doi: 10.1074/jbc.M704146200.
  • Baeke F, Gysemans C, Korf H, Mathieu C. Vitamin D insufficiency: implications for the immune system. Pediatr Nephrol 2010;25:1597-606. doi: 10.1007/s00467.010.1452-y.
  • Chen S, Sims GP, Chen XX, Gu YY, Chen S, Lipsky PE. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol 2007;179:1634-47. doi: 10.4049/jimmunol.179.3.1634.
  • Haussler MR, Haussler CA, Whitfield GK, et al. The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the “Fountain of Youth” to mediate healthful aging. J Steroid Biochem Mol Biol 2010;121:88-97. doi: 10.1016/j.jsbmb.2010.03.019.
  • Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients 2013;5:2502-21.
  • Samuel S, Sitrin MD. Vitamin D’s role in cell proliferation and differentiation. Nutr Rev 2008;66: S116-24.
  • Meredith A, Boroomand S, Carthy J, Luo Z, McManus B. 1,25 Dihydroxyvitamin D3 ınhibits TGFβ1-mediated primary human cardiac myofibroblast activation. PLoS One 2015;10:e0128655.
  • Sari DCR, Putri MW, Leksono TP, et al. Calcitriol ameliorates kidney ınjury through reducing podocytopathy, tubular ınjury, ınflammation and fibrosis in 5/6 subtotal nephrectomy model in rats. Kobe J Med Sci 2020;65:E153-E163.
  • Wallbaum P, Rohde S, Ehlers L, et al. Antifibrogenic effects of vitamin D derivatives on Mouse pancreatic stellate cells. World J Gastroenterol 2018;24:170-8.
  • Lee CJ, Subeq YM, Lee RP, Liou HH, Hsu BG. Calcitriol decreases TGF-β1 and angiotensin II production and protects against chlorhexide digluconate-induced liver peritoneal fibrosis in rats. Cytokine 2014;65:105-18.
  • Ricca C, Aillon A, Viano M, Bergandi L, Aldieri E, Silvagno F. Vitamin D inhibits the epithelial-mesenchymal transition by a negative feedback regulation of TGF-β activity. J Steroid Biochem Mol Biol 2019;187:97-105.
  • Zheng S, Yang J, Hu X, et al. Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-β induced epithelial to mesenchymal transition. Biochem Pharmacol 2020;177:113955.
  • Zhang H, Deng W, Yang Y, Wei S, Xue L, Tao S. Pharmaceutic application of vitamin D3 on particle-induced fibrotic effects through induction of Nrf2 signals. Toxicol Res (Camb) 2020;9:55-66. doi: 10.1093/toxres/tfaa003.
  • Voisin T, Joannes A, Morzadec C, et al. Antifibrotic effects of vitamin D3 on human lung fibroblasts derived from patients with idiopathic pulmonary fibrosis. J Nutr Biochem 2024;125:109558. doi: 10.1016/j.jnutbio.2023.109558.
Toplam 39 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Cerrahi (Diğer)
Bölüm Original Research
Yazarlar

Pınar Kuru Bektaşoğlu 0000-0001-9889-9955

Jülide Hazneci 0000-0003-2763-2748

Adnan Somay 0000-0002-8613-8566

Ali Börekci 0000-0002-3687-7934

Bora Gürer 0000-0003-1500-6184

Yayımlanma Tarihi 29 Ocak 2025
Gönderilme Tarihi 4 Kasım 2024
Kabul Tarihi 7 Ocak 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 38 Sayı: 1

Kaynak Göster

APA Kuru Bektaşoğlu, P., Hazneci, J., Somay, A., Börekci, A., vd. (2025). Vitamin D3 has antifibrotic effects on rats with epidural fibrosis. Marmara Medical Journal, 38(1), 62-67. https://doi.org/10.5472/marumj.1629001
AMA Kuru Bektaşoğlu P, Hazneci J, Somay A, Börekci A, Gürer B. Vitamin D3 has antifibrotic effects on rats with epidural fibrosis. Marmara Med J. Ocak 2025;38(1):62-67. doi:10.5472/marumj.1629001
Chicago Kuru Bektaşoğlu, Pınar, Jülide Hazneci, Adnan Somay, Ali Börekci, ve Bora Gürer. “Vitamin D3 Has Antifibrotic Effects on Rats With Epidural Fibrosis”. Marmara Medical Journal 38, sy. 1 (Ocak 2025): 62-67. https://doi.org/10.5472/marumj.1629001.
EndNote Kuru Bektaşoğlu P, Hazneci J, Somay A, Börekci A, Gürer B (01 Ocak 2025) Vitamin D3 has antifibrotic effects on rats with epidural fibrosis. Marmara Medical Journal 38 1 62–67.
IEEE P. Kuru Bektaşoğlu, J. Hazneci, A. Somay, A. Börekci, ve B. Gürer, “Vitamin D3 has antifibrotic effects on rats with epidural fibrosis”, Marmara Med J, c. 38, sy. 1, ss. 62–67, 2025, doi: 10.5472/marumj.1629001.
ISNAD Kuru Bektaşoğlu, Pınar vd. “Vitamin D3 Has Antifibrotic Effects on Rats With Epidural Fibrosis”. Marmara Medical Journal 38/1 (Ocak 2025), 62-67. https://doi.org/10.5472/marumj.1629001.
JAMA Kuru Bektaşoğlu P, Hazneci J, Somay A, Börekci A, Gürer B. Vitamin D3 has antifibrotic effects on rats with epidural fibrosis. Marmara Med J. 2025;38:62–67.
MLA Kuru Bektaşoğlu, Pınar vd. “Vitamin D3 Has Antifibrotic Effects on Rats With Epidural Fibrosis”. Marmara Medical Journal, c. 38, sy. 1, 2025, ss. 62-67, doi:10.5472/marumj.1629001.
Vancouver Kuru Bektaşoğlu P, Hazneci J, Somay A, Börekci A, Gürer B. Vitamin D3 has antifibrotic effects on rats with epidural fibrosis. Marmara Med J. 2025;38(1):62-7.
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