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Comparative biological activities of extracts from three Malaysian Beilschmiedia species

Yıl 2016, Cilt: 20 Sayı: 3, 224 - 231, 23.03.2016

WAN MOHD NUZUL HAKIMI WAN Salleh , FAREDIAH Ahmad , HENG YEN Khong RAZAUDEN MOHAMED Zulkıflı

Öz

This study was carried out to investigate the bioactivities of extracts from three Beilschmiedia species, which are Beilschmiedia glabra, B. madang, and B. pulverulenta. The bioactivity studies were determined on their antioxidant, antimicrobial, antityrosinase, anti-inflammatory, and acetylcholinesterase activities. Evaluation of antioxidant activities were tested against DPPH and phenolic content (TPC) assays. The antimicrobial activity were investigated by micro dilution method for determination of MIC, MBC and MFC. Antityrosinase and anti-inflammatory inhibition activity was analysed using mushroom tyrosinase and lipoxygenase enzyme, respectively, while acetylcholinesterase activity against acetylcholinesterase (AChE) enzyme. The MeOH stem bark extract of B. madang shows the highest activity on DPPH (IC50 of 63.2 μg/mL) and TPC (163.4 mg GA/g) assay. All extracts showed from moderate to weak activity with MIC/MBC/MFC values in the ranged of 125-1000 µg/mL. The EtOAc leaves extract of B. glabra revealed the highest percentage inhibition on tyrosinase activity (I: 82.5%), while for anti-inflammatory activity showed by the MeOH leaves extract of B. pulverulenta (I: 66.6%). The MeOH stem bark extract of B. madang demonstrated the highest activity on acetylcholinestrase activity with percentage inhibition of 62.8%. The results demonstrated that the Beilschmiedia species possess significant activities on various biological studies. 

Anahtar Kelimeler

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Kaynakça

  • REFERENCES
  • Nishida WS. Revision of Beilschmiedia (Lauraceae) in the Neotropics. Ann Missouri Bot Gard 1999; 86: 657-701.
  • Nishida WS. Taxonomic Revision of Beilschmiedia (Lauraceae) in Borneo. Blumea 2008; 53: 345-83
  • Iwu MM. Handbook of African Medicinal Plants, CRC Press: Boca Raton, FL. 1993.
  • Tchouala JM. Inventaire Ethnobotanique des plantes medicinales du Noun (Ouest-Cameroun) utilisees pour soigner les infections fongiques et bacteriennes, Memoire de Maitrise de Biologie Vegetale, Universite de Dschang, 2001.
  • Nkeng-Efouet PA. Phytochemicals from Beilschmiedia anacardioides and their biological significance, phytochemicals-A global perspective of their role in nutrition and health. In Tech. Edited by Venketeshwer R., 2012.
  • Wiart C. Medicinal Plants of Asia and the Pacific. Taylor & Francis, Boca Raton, London, New York, 2006.
  • Talontsi FM, Lamshoft M, Bauer JO, Razakarivony AA, Andriamihaja B, Strohmann C, Spiteller M. Antibacterial and antiplasmodial constituents of Beilschmiedia cryptocaryoides. J Nat Prod 2013: 76: 97-102.
  • Suarez LEC, Vargas OEB. New chalcones from Beilschmiedia tovarensis. Rev Colomb Quim 2005; 34: 35-41.
  • Fankam AG, Kuete V, Voukeng IK, Kuiate JR, Pages JM. Antibacterial activities of selected Cameroonian spices and their synergistic effects with antibiotics against multidrug-resistant phenotypes. BMC Complement Altern Med 2011; 11: 104-14.
  • Fankam AG, Kuiate JR, Kuete V. Antibacterial activities of Beilschmiedia obscura and six other Cameroonian medicinal plants against multi-drug resistant Gram-negative phenotypes. BMC Complement Altern Med 2014; 14: 241-50.
  • Lin CT, Chu FH, Tseng YH, Tsai JB, Chang ST, Wang SY. Bioactivity investigation of Lauraceae trees grown in Taiwan. Pharm Biol 2007; 45: 638-44.
  • Huang YT, Chang HS, Wang GJ, Cheng MJ, Chen CH, Yang YJ, Chen IS. Anti-inflammatory endiandric acid analogues from the roots of Beilschmiedia tsangii. J Nat Prod 2011; 74: 1875-80.
  • Kuete V, Tankeo SB, Saeed ME, Wiench B, Tane P, Efferth T. Cytotoxicity and modes of action of five Cameroonian medicinal plants against multi-factorial drug resistance of tumor cells. J Ethnopharmacol 2014; 153: 207-19.
  • Salleh WMNHW, Ahmad F, Khong HY. Chemical compositions and biological activities of the essential oils of Beilschmiedia madang Blume (Lauraceae). Arch Pharm Res 2015; 38: 485-93.
  • Shimada K, Fujikawa K, Yahara K, Nakamura T. Antioxidative properties of xanthine on autoxidation of soybean oil in cyclodextrin emulsion. J Agric Food Chem 1992; 40: 945-8.
  • Masuda T, Yamashita D, Takeda Y, Yonemori S. Screening for tyrosinase inhibitors among extracts of seashore plants and identification of potent inhibitors from Garcinia subelliptica. Biosci Biotech Biochem 2005; 69: 197-201.
  • Salleh WMNHW, Hashim NA, Ahmad F, Khong HY. Anticholinesterase and antityrosinase activities of ten Piper species from Malaysia. Adv Pharm Bull 2014; 4: 527-31.
  • Ellman GL, Courtney KD, Andres V, Feather-Stone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961; 7: 88-95.
  • Orhan I, Aslan S, Kartal M, Sener B, Baser KHC. Inhibitory effect of Turkish Rosmarinus officinalis L. on acetylcholinesterase and butyrylcholinesterase enzymes. Food Chem 2008; 108: 663-8.
  • Robards K, Prenzler PD, Tucker G, Swatsitang P, Glover W. Phenolic compounds and their role in oxidative processes in fruits. Food Chem 1999; 66: 401-36.
  • Hakkim FL, Shankar CG, Girija S. Chemical composition and antioxidant property of holy basil (Ocimum sanctum L.) leaves, stems and inflorescence and their in vitro callus cultures. J Agric Food Chem 2007; 55: 9109-17.
  • Harborne JB, Mendez J. Flavonoids of Beilschmiedia miersii. Phytochemistry 1969; 8: 763-4.
  • Lenta BN, Tantangmo F, Devkota KP, Wansi JD, Chouna JR, Soh RC, Neumann B, Stammler HG, Tsamo E, Sewald N. Bioactive constituents of the stem bark of Beilschmiedia zenkeri. J Nat Prod 2009; 72: 2130-4.
  • Brand-Williams W, Cuvelier ME, Berset C). Use of a free-radical method to evaluate antioxidant activity. LWT Food Sci Tech 1995; 28: 25-30.
  • McKee T, McKee JR. Biochemistry The Molecular Basis of Life, 3rd Ed., McGraw-Hill, USA, 2003.
  • Williams RB, Martin SM, Hu JF, Norman VL, Goering MG, Loss S, Oneil-Johnson M, Eldridge GR, Starks CM. Cytotoxic and antibacterial Beilschmiedic acids from a Gabonese Species of Beilschmiedia. J Nat Prod 2012; 75: 1319-25.
  • Mollataghi A, Hadi AH, Shiau-Chuen C. (+)-Kunstleramide, a new antioxidant and cytotoxic dienamide from the bark of Beilschmiedia kunstleri Gamble. Molecules 2012; 17: 4197-4208.
  • Kubo I, Chen QX, Nihei KI. Molecular design of antibrowning agents: antioxidative tyrosinase inhibitor. Food Chem 2003; 81: 241-7.
  • Momtaz S, Mapunya BM, Houghton PJ, Edgerly C, Hussein A, Naidoo S, Lall N. Tyrosinase inhibition by extracts and constituents of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening. J Ethnopharmacol 2008; 119: 507-12.
  • Alam N, Yoon KN, Lee KR, Kim HY, Shin PG, Cheong JC, Yoo YB, Shim MJ, Lee MW, Lee TS. Assessment of antioxidant and phenolic compound concentrations as well as xanthine oxidase and tyrosinase inhibitory properties of different extracts of Pleurotus citrinopileatus fruiting bodies. Mycobiol 2011; 39: 12-19.
  • Handoussa H, Hanafi R, Eddiasty I, El-Gendy M, El-Khatib A, Linscheid M, Mahran, Ayoub N. Anti-inflammatory and cytotoxic activities of dietary phenolics isolated from Corchorus olitorius and Vitis vinifera. J Funct Foods 2013; 5: 1204-16.
  • Lin JK, Tsai SH, Lin-Shiau SY. Anti-inflammatory and antitumor effects of flavonoids and flavanoids. Drugs Fut 2001; 26: 145-57.
  • Trouillas P, Calliste CA, Allais DP, Simon A, Marfak A, Delage C, Duroux JL. Antioxidant, anti-inflammatory and anti-proliferative properties of sixteen water plant extracts used in the Limousin countryside as herbal teas. Food Chem 2003; 80: 399-407.
  • Zarotsky V, Sramek JJ, Culter NR. Galanthamine hydrobromide: an agent for Alzheimer’s disease. Am J Health-System Pharmacist 2003; 60: 446-52.
  • Martinez A, Castro A. Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer’s disease. Expert Opin Invest Drugs 2006; 15: 1-12.
  • Mukherjee PK, Kumar V, Mal M, Houghton PJ. Acetylcholinesterase inhibitors from plants. Phytomedicine 2007; 14: 289-300.
  • Mollataghi A, Coudiere E, Hadi AHA, Mukhtar MR, Awang K, Litaudon M, Ata A. Anti-acetylcholinesterase, anti-α-glucosidase, antileishmanial and antifungal activities of chemical constituents of Beilschmiedia Species. Fitoterapia 2012; 83: 298-302.
  • Tillequin F, Koch M, Pusset J, Chauviere G. Two new morphinane alkaloids from Beilschmiedia oreophila Schlechter (Lauraceae). Heterocycles 1985; 6: 1357-61.
  • Pudjiastuti P, Mukhtar MR, Hadi AH, Saidi N, Morita H, Litaudon M, Awang K. (6,7-Dimethoxy-4-methylisoquinolinyl)-(4′-methoxyphenyl)-methanone, a new benzylisoquinoline alkaloid from Beilschmiedia brevipes. Molecules 2010; 15: 2339-46.
  • Johns SR, Lamberton JA, Sioumis AA, Tweeddale HJ. New Aporphine alkaloids from Beilschmiedia podagrica. Aust J Chem 1969; 22: 1277-81.

Yıl 2016, Cilt: 20 Sayı: 3, 224 - 231, 23.03.2016

WAN MOHD NUZUL HAKIMI WAN Salleh , FAREDIAH Ahmad , HENG YEN Khong RAZAUDEN MOHAMED Zulkıflı

Öz

Kaynakça

  • REFERENCES
  • Nishida WS. Revision of Beilschmiedia (Lauraceae) in the Neotropics. Ann Missouri Bot Gard 1999; 86: 657-701.
  • Nishida WS. Taxonomic Revision of Beilschmiedia (Lauraceae) in Borneo. Blumea 2008; 53: 345-83
  • Iwu MM. Handbook of African Medicinal Plants, CRC Press: Boca Raton, FL. 1993.
  • Tchouala JM. Inventaire Ethnobotanique des plantes medicinales du Noun (Ouest-Cameroun) utilisees pour soigner les infections fongiques et bacteriennes, Memoire de Maitrise de Biologie Vegetale, Universite de Dschang, 2001.
  • Nkeng-Efouet PA. Phytochemicals from Beilschmiedia anacardioides and their biological significance, phytochemicals-A global perspective of their role in nutrition and health. In Tech. Edited by Venketeshwer R., 2012.
  • Wiart C. Medicinal Plants of Asia and the Pacific. Taylor & Francis, Boca Raton, London, New York, 2006.
  • Talontsi FM, Lamshoft M, Bauer JO, Razakarivony AA, Andriamihaja B, Strohmann C, Spiteller M. Antibacterial and antiplasmodial constituents of Beilschmiedia cryptocaryoides. J Nat Prod 2013: 76: 97-102.
  • Suarez LEC, Vargas OEB. New chalcones from Beilschmiedia tovarensis. Rev Colomb Quim 2005; 34: 35-41.
  • Fankam AG, Kuete V, Voukeng IK, Kuiate JR, Pages JM. Antibacterial activities of selected Cameroonian spices and their synergistic effects with antibiotics against multidrug-resistant phenotypes. BMC Complement Altern Med 2011; 11: 104-14.
  • Fankam AG, Kuiate JR, Kuete V. Antibacterial activities of Beilschmiedia obscura and six other Cameroonian medicinal plants against multi-drug resistant Gram-negative phenotypes. BMC Complement Altern Med 2014; 14: 241-50.
  • Lin CT, Chu FH, Tseng YH, Tsai JB, Chang ST, Wang SY. Bioactivity investigation of Lauraceae trees grown in Taiwan. Pharm Biol 2007; 45: 638-44.
  • Huang YT, Chang HS, Wang GJ, Cheng MJ, Chen CH, Yang YJ, Chen IS. Anti-inflammatory endiandric acid analogues from the roots of Beilschmiedia tsangii. J Nat Prod 2011; 74: 1875-80.
  • Kuete V, Tankeo SB, Saeed ME, Wiench B, Tane P, Efferth T. Cytotoxicity and modes of action of five Cameroonian medicinal plants against multi-factorial drug resistance of tumor cells. J Ethnopharmacol 2014; 153: 207-19.
  • Salleh WMNHW, Ahmad F, Khong HY. Chemical compositions and biological activities of the essential oils of Beilschmiedia madang Blume (Lauraceae). Arch Pharm Res 2015; 38: 485-93.
  • Shimada K, Fujikawa K, Yahara K, Nakamura T. Antioxidative properties of xanthine on autoxidation of soybean oil in cyclodextrin emulsion. J Agric Food Chem 1992; 40: 945-8.
  • Masuda T, Yamashita D, Takeda Y, Yonemori S. Screening for tyrosinase inhibitors among extracts of seashore plants and identification of potent inhibitors from Garcinia subelliptica. Biosci Biotech Biochem 2005; 69: 197-201.
  • Salleh WMNHW, Hashim NA, Ahmad F, Khong HY. Anticholinesterase and antityrosinase activities of ten Piper species from Malaysia. Adv Pharm Bull 2014; 4: 527-31.
  • Ellman GL, Courtney KD, Andres V, Feather-Stone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961; 7: 88-95.
  • Orhan I, Aslan S, Kartal M, Sener B, Baser KHC. Inhibitory effect of Turkish Rosmarinus officinalis L. on acetylcholinesterase and butyrylcholinesterase enzymes. Food Chem 2008; 108: 663-8.
  • Robards K, Prenzler PD, Tucker G, Swatsitang P, Glover W. Phenolic compounds and their role in oxidative processes in fruits. Food Chem 1999; 66: 401-36.
  • Hakkim FL, Shankar CG, Girija S. Chemical composition and antioxidant property of holy basil (Ocimum sanctum L.) leaves, stems and inflorescence and their in vitro callus cultures. J Agric Food Chem 2007; 55: 9109-17.
  • Harborne JB, Mendez J. Flavonoids of Beilschmiedia miersii. Phytochemistry 1969; 8: 763-4.
  • Lenta BN, Tantangmo F, Devkota KP, Wansi JD, Chouna JR, Soh RC, Neumann B, Stammler HG, Tsamo E, Sewald N. Bioactive constituents of the stem bark of Beilschmiedia zenkeri. J Nat Prod 2009; 72: 2130-4.
  • Brand-Williams W, Cuvelier ME, Berset C). Use of a free-radical method to evaluate antioxidant activity. LWT Food Sci Tech 1995; 28: 25-30.
  • McKee T, McKee JR. Biochemistry The Molecular Basis of Life, 3rd Ed., McGraw-Hill, USA, 2003.
  • Williams RB, Martin SM, Hu JF, Norman VL, Goering MG, Loss S, Oneil-Johnson M, Eldridge GR, Starks CM. Cytotoxic and antibacterial Beilschmiedic acids from a Gabonese Species of Beilschmiedia. J Nat Prod 2012; 75: 1319-25.
  • Mollataghi A, Hadi AH, Shiau-Chuen C. (+)-Kunstleramide, a new antioxidant and cytotoxic dienamide from the bark of Beilschmiedia kunstleri Gamble. Molecules 2012; 17: 4197-4208.
  • Kubo I, Chen QX, Nihei KI. Molecular design of antibrowning agents: antioxidative tyrosinase inhibitor. Food Chem 2003; 81: 241-7.
  • Momtaz S, Mapunya BM, Houghton PJ, Edgerly C, Hussein A, Naidoo S, Lall N. Tyrosinase inhibition by extracts and constituents of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening. J Ethnopharmacol 2008; 119: 507-12.
  • Alam N, Yoon KN, Lee KR, Kim HY, Shin PG, Cheong JC, Yoo YB, Shim MJ, Lee MW, Lee TS. Assessment of antioxidant and phenolic compound concentrations as well as xanthine oxidase and tyrosinase inhibitory properties of different extracts of Pleurotus citrinopileatus fruiting bodies. Mycobiol 2011; 39: 12-19.
  • Handoussa H, Hanafi R, Eddiasty I, El-Gendy M, El-Khatib A, Linscheid M, Mahran, Ayoub N. Anti-inflammatory and cytotoxic activities of dietary phenolics isolated from Corchorus olitorius and Vitis vinifera. J Funct Foods 2013; 5: 1204-16.
  • Lin JK, Tsai SH, Lin-Shiau SY. Anti-inflammatory and antitumor effects of flavonoids and flavanoids. Drugs Fut 2001; 26: 145-57.
  • Trouillas P, Calliste CA, Allais DP, Simon A, Marfak A, Delage C, Duroux JL. Antioxidant, anti-inflammatory and anti-proliferative properties of sixteen water plant extracts used in the Limousin countryside as herbal teas. Food Chem 2003; 80: 399-407.
  • Zarotsky V, Sramek JJ, Culter NR. Galanthamine hydrobromide: an agent for Alzheimer’s disease. Am J Health-System Pharmacist 2003; 60: 446-52.
  • Martinez A, Castro A. Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer’s disease. Expert Opin Invest Drugs 2006; 15: 1-12.
  • Mukherjee PK, Kumar V, Mal M, Houghton PJ. Acetylcholinesterase inhibitors from plants. Phytomedicine 2007; 14: 289-300.
  • Mollataghi A, Coudiere E, Hadi AHA, Mukhtar MR, Awang K, Litaudon M, Ata A. Anti-acetylcholinesterase, anti-α-glucosidase, antileishmanial and antifungal activities of chemical constituents of Beilschmiedia Species. Fitoterapia 2012; 83: 298-302.
  • Tillequin F, Koch M, Pusset J, Chauviere G. Two new morphinane alkaloids from Beilschmiedia oreophila Schlechter (Lauraceae). Heterocycles 1985; 6: 1357-61.
  • Pudjiastuti P, Mukhtar MR, Hadi AH, Saidi N, Morita H, Litaudon M, Awang K. (6,7-Dimethoxy-4-methylisoquinolinyl)-(4′-methoxyphenyl)-methanone, a new benzylisoquinoline alkaloid from Beilschmiedia brevipes. Molecules 2010; 15: 2339-46.
  • Johns SR, Lamberton JA, Sioumis AA, Tweeddale HJ. New Aporphine alkaloids from Beilschmiedia podagrica. Aust J Chem 1969; 22: 1277-81.
Toplam 41 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

WAN MOHD NUZUL HAKIMI WAN Salleh

FAREDIAH Ahmad

HENG YEN Khong

RAZAUDEN MOHAMED Zulkıflı

Yayımlanma Tarihi 23 Mart 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 20 Sayı: 3

Kaynak Göster

APA Salleh, W. M. N. H. W., Ahmad, F., Khong, H. Y., Zulkıflı, R. M. (2016). Comparative biological activities of extracts from three Malaysian Beilschmiedia species. Marmara Pharmaceutical Journal, 20(3), 224-231. https://doi.org/10.12991/mpj.20162009162
AMA Salleh WMNHW, Ahmad F, Khong HY, Zulkıflı RM. Comparative biological activities of extracts from three Malaysian Beilschmiedia species. J Res Pharm. Mayıs 2016;20(3):224-231. doi:10.12991/mpj.20162009162
Chicago Salleh, WAN MOHD NUZUL HAKIMI WAN, FAREDIAH Ahmad, HENG YEN Khong, ve RAZAUDEN MOHAMED Zulkıflı. “Comparative Biological Activities of Extracts from Three Malaysian Beilschmiedia Species”. Marmara Pharmaceutical Journal 20, sy. 3 (Mayıs 2016): 224-31. https://doi.org/10.12991/mpj.20162009162.
EndNote Salleh WMNHW, Ahmad F, Khong HY, Zulkıflı RM (01 Mayıs 2016) Comparative biological activities of extracts from three Malaysian Beilschmiedia species. Marmara Pharmaceutical Journal 20 3 224–231.
IEEE W. M. N. H. W. Salleh, F. Ahmad, H. Y. Khong, ve R. M. Zulkıflı, “Comparative biological activities of extracts from three Malaysian Beilschmiedia species”, J Res Pharm, c. 20, sy. 3, ss. 224–231, 2016, doi: 10.12991/mpj.20162009162.
ISNAD Salleh, WAN MOHD NUZUL HAKIMI WAN vd. “Comparative Biological Activities of Extracts from Three Malaysian Beilschmiedia Species”. Marmara Pharmaceutical Journal 20/3 (Mayıs 2016), 224-231. https://doi.org/10.12991/mpj.20162009162.
JAMA Salleh WMNHW, Ahmad F, Khong HY, Zulkıflı RM. Comparative biological activities of extracts from three Malaysian Beilschmiedia species. J Res Pharm. 2016;20:224–231.
MLA Salleh, WAN MOHD NUZUL HAKIMI WAN vd. “Comparative Biological Activities of Extracts from Three Malaysian Beilschmiedia Species”. Marmara Pharmaceutical Journal, c. 20, sy. 3, 2016, ss. 224-31, doi:10.12991/mpj.20162009162.
Vancouver Salleh WMNHW, Ahmad F, Khong HY, Zulkıflı RM. Comparative biological activities of extracts from three Malaysian Beilschmiedia species. J Res Pharm. 2016;20(3):224-31.

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