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Potensiyometrik PVC-membran ve grafit kaplı tel elektrot yöntemiyle haloperidol’ün ampulde ve idrarda miktar tayini

Yıl 2017, Cilt: 21 Sayı: 1, 110 - 120, 20.09.2016

Hazem Abu Shawish Hassan Tamous Asma A. Shaheen Khaled I. Abed Almonem Ahmed Awad Elgamel Wael S. Al-lham

https://doi.org/10.12991/marupj.259888

Öz

Sensör P olarak isimlendirilen
yeni bir PVC membran ve sensör  G olarak
isimlendirilen grafit kaplı tel Haloperidol’ün (HP)  analizi için tanımlanmıştır. Elektrotlar P ve
G için sırasıyla;  Nernst denklemine göre
en yüksek tepe noktası her onlu grup  için
3.7×10-6–1.0×10-2 mol/L -5.8 x 10-7 – 1.0 x 10-2 mol/L derişim  aralığında 57.4±0.8 and 61.1±0.4 mV;
deteksiyon alt sınırı  (LO D) ise pH
aralığı 2.5–7.5 and 2.5-8.0 için 1.6 × 10-6 mol/L  ve 4.2×10-7 mol/L olarak bulunmuştur.
Tanımlanan sensörler  HP’ün diğer gişim
yapan bileşiklerden ayrılabilmesi için yüksek 
seçicilik göstermiştir. Bahsi geçen elektrotların kullanılmasıyla  HP’ün ampül dozaj formundan ve idrar
örneklerinden analizinin  başarıyla yapılabileceği
gösterilmiştir.  

Anahtar Kelimeler

Potensiyometri Haloperidol kaplanmış tel elektrot PVC membrane elektrot iyon-seçici elektrot

Kaynakça

  • - R. N. Stradiotto, H. Yamanaka, B. V. M. Zanoni, J. Braz. Chem. Soc., 14 (2003)159-173
  • - E. G. Kulapina, O. V. Barinova, Pharm Chem J. 31 (1997) 667-672.
  • - H. M. Abu Shawish, K. I. Abed Almonem, S. M. Saadeh, W. S. Al-lham, Measurement 78 (2016) 180–186
  • - A.F. Khorshida, Y.M. Issa, Biosens Bioelectron,51 (2014) 143–149
  • - G. Singh, S. Rani, Journal of Advanced Electrochemistry (JAEC ), 2 (2016) 42–44
  • - B. Singhal, World Journal of Chemistry, 6 (2011) 59-74
  • - D. W. Kimmel, G. LeBlanc. M. E. Meschievitz, D. E. Cliffel, Anal Chem. 84 (2012) 685–707
  • - A. Radu, A.J. Meir, E. Bakker, Anal. Chem., 76 (2004) 6402
  • - S. Mathison, E. Bakker, Anal. Chem., 70 (1998) 303.
  • - N. Rubinova, K. C. Torres, E. Bakker, Sens. Actuators B, 121 (2007) 135.
  • - A. Ceresa, E. Bakker, B. Hattendorf, D. Gunther, E. Pretsch. Anal. Chem. 72 (2001) 343.
  • - E. Pretsch.TrAC, 26 (2007) 46.
  • - E. Lindner, R.E. Gyurcsányi, J. Solid State Electrochem., 13 (2009) 51–68.
  • - J. Hu, A. Stein, P. Bühlmann, TrAC 76 (2016) 102–114
  • - A. J. Giannini, N. A. Underwood, M. Condon, Am. J. Ther. 7 (2000) 389–392
  • - A. K. Dorph-Petersen, N. J. Pierri, M. J. Perel, Z. Sun, R. A. Sampson, A. D. Lewis, Neuropsychopharmacology, 30 (2005) 1649–61.
  • - S. Wu, W. Ko, H. Wu, S. Chen, J. Chromatogr. A, 846 (1999) 239-243.
  • - P. J. A. W. Demoen, J. Pharm. Sci., 50 (1961) 350–353.
  • - M. Kurzawa, A. Kowalczyk-Marzec, E. Szlyk, Chemia analityczna, 49 (2004) 91–99.
  • - M. Yasir, U. V. S. Sara. Br. J. Pharm. Res., 4 (2014) 1407-1415
  • - British Pharmacopoeia (BP), vol. II, Her Majesty’s Stationery Office, London, 1993.
  • - S. Ouanas, M. Kallel, H. Trabelsi, F. Safta, K. Bouzoouita, J. Pharm. Biomed. Anal.,17 (1998) 361-364.
  • - E. Bawelcsyk, Z. Plotkowiak, Chemical Analysis. (Warsaw), 17 (1972) 111-119.
  • - C. A. Janicki, H. R. A. Jr, J. Pharm. Sci., 63 (1974) 41–43.
  • - M Shamsipur, L. Dastgerdi, Z. Talebpour, S. Haghgoo, J. Pharm. Biomed. Anal, 43 (2007) 1116-1121.
  • - J. Krzek, A. Maslanka, Acta Poloniae Pharmaceutica-Drug Research, 57 (2000) 23-26.
  • - I. A. Zingales, J. Chromatogr. A, 54 (1971) 15–24.
  • - T. Fujii, K. Hatanaka, G. Sato, Y. Yasui, H. Arimoto, Y. Mitsutsuka, J. Chromatogr. B, 687 (1996) 395-403.
  • - H. Bagheri, A. Afkhami, Y. Panahi, H. Khoshsafar, A. Shirzadmehr. Mater. Sci. Eng. C 37 (2014) 264–270
  • - L.B. Nilsson, J. Chromatogr. B, 431 (1988) 113–122.
  • - D. R. Abernethy, D. J. Greenblatt, H. R. Ochs, C. R. Willis, D. D.Miller, R. I. Shader, J. Chromatogr. B, 307 (1984) 194–199.
  • - G. Bianchetti, P. L. Morselli, J. Chromatogr. A, 153 (1978) 203-209.
  • - T. Arinobu , H. Hattori , M. Iwai , A. Ishii , T. Kumazawa, O. Suzuki , H. Seno, J. Chromatogr. B, 776 (2002) 107–113
  • - K. Titier, S. Bouchet, F. Pehourcq, N. Moore, M. Molimard, J. Chromatogr. B,
  • (2003) 179-185.
  • - H. Ebrahimzadeh, Z. Dehghani, A. A. Asgharinezhad, N. Shekari,K. Molaei, Int. J. Pharm. 453 (2013) 601– 609
  • - K.H. Park, M.H. Lee, M.G. Lee, J. Chromatogr. B, 572 )1991( 259-267.
  • - N. Yasui-Furukori, Y. Inoue, M. Chiba, T. Tateishi, J. Chromatogr. B, 805(2004) 175-180.
  • - R. Driouich, T. Takayanagi, M. Oshima, S. Motomizu, J. Chromatogr. A, 903 (2000) 271-278.
  • - H.S. El-Desoky, M.M. Ghoneim, , J. Pharm. Biomed. Anal,38 (2005) 543-550.
  • - H. M. Abu Shawish, A. M. Khedr, K. I. Abed-Almonem, M. Gaber, Talanta 101 (2012) 211–219
  • - K. Vytras, J. Kalous, J. Jezkova, Anal. Chem. 6 (1997) 107
  • - H. M. Abu Shawish, S. M. Saadeh, H. Tamos, K. I. Abed-Almonem, o. Al khalili, Analytical Chemistry Research 2 (2014) 30–36
  • - E. Lindner, Y. Umezawa, Pure Appl. Chem. 80 (2008) 85–104
  • - E. Bakker, E. Pretsch, P. Buhlmann, Anal. Chem.72 (2000) 1127-1133
  • - A. Ceresa (2001) Ion-selective polymeric membrane electrodes for potentiometric trace level measurements, Swiss Federal Institute of Technology, Zurich
  • - P. R. Buck, E. Lindner, Pure Appl. Chem. 66 (1994) 2527–2536.
  • - Z. H. Ibupoto, K. Khun, M. Willander, Sensors 13 (2013) 1984-1997
  • - C. H. Agarwal, C. K. Singh, Anal. Sci. 23 (2007) 469

Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes

Yıl 2017, Cilt: 21 Sayı: 1, 110 - 120, 20.09.2016

Hazem Abu Shawish Hassan Tamous Asma A. Shaheen Khaled I. Abed Almonem Ahmed Awad Elgamel Wael S. Al-lham

https://doi.org/10.12991/marupj.259888

Öz

A new PVC membrane, called sensor P, and graphite coated wire, called sensor g,  for haloperidol drug (HP) are described. The electrodes P and C exhibit a Nernstian slope of 57.4±0.8 and 61.1±0.4 mV per decade over a wide concentration range from 3.7×10-6–1.0×10-2 mol/L and 5.8 x 10-7 – 1.0 x 10-2 mol/L and the limit of detection (LOD) of 1.6 × 10-6 mol/L and 4.2×10-7 mol/L over the pH range of  2.5–7.5 and 2.5-8.0 respectively. The presented sensors  show a very good selectivity for HP drug over the common interfering chemical species. The proposed electrodes were successfully used for determination of HP drug in ampoules and in urine samples with satisfactory results.

Anahtar Kelimeler

Potentiometry Haloperidol drug coated wire Electrode PVC membranes electrode Ion-selective electrode

Kaynakça

  • - R. N. Stradiotto, H. Yamanaka, B. V. M. Zanoni, J. Braz. Chem. Soc., 14 (2003)159-173
  • - E. G. Kulapina, O. V. Barinova, Pharm Chem J. 31 (1997) 667-672.
  • - H. M. Abu Shawish, K. I. Abed Almonem, S. M. Saadeh, W. S. Al-lham, Measurement 78 (2016) 180–186
  • - A.F. Khorshida, Y.M. Issa, Biosens Bioelectron,51 (2014) 143–149
  • - G. Singh, S. Rani, Journal of Advanced Electrochemistry (JAEC ), 2 (2016) 42–44
  • - B. Singhal, World Journal of Chemistry, 6 (2011) 59-74
  • - D. W. Kimmel, G. LeBlanc. M. E. Meschievitz, D. E. Cliffel, Anal Chem. 84 (2012) 685–707
  • - A. Radu, A.J. Meir, E. Bakker, Anal. Chem., 76 (2004) 6402
  • - S. Mathison, E. Bakker, Anal. Chem., 70 (1998) 303.
  • - N. Rubinova, K. C. Torres, E. Bakker, Sens. Actuators B, 121 (2007) 135.
  • - A. Ceresa, E. Bakker, B. Hattendorf, D. Gunther, E. Pretsch. Anal. Chem. 72 (2001) 343.
  • - E. Pretsch.TrAC, 26 (2007) 46.
  • - E. Lindner, R.E. Gyurcsányi, J. Solid State Electrochem., 13 (2009) 51–68.
  • - J. Hu, A. Stein, P. Bühlmann, TrAC 76 (2016) 102–114
  • - A. J. Giannini, N. A. Underwood, M. Condon, Am. J. Ther. 7 (2000) 389–392
  • - A. K. Dorph-Petersen, N. J. Pierri, M. J. Perel, Z. Sun, R. A. Sampson, A. D. Lewis, Neuropsychopharmacology, 30 (2005) 1649–61.
  • - S. Wu, W. Ko, H. Wu, S. Chen, J. Chromatogr. A, 846 (1999) 239-243.
  • - P. J. A. W. Demoen, J. Pharm. Sci., 50 (1961) 350–353.
  • - M. Kurzawa, A. Kowalczyk-Marzec, E. Szlyk, Chemia analityczna, 49 (2004) 91–99.
  • - M. Yasir, U. V. S. Sara. Br. J. Pharm. Res., 4 (2014) 1407-1415
  • - British Pharmacopoeia (BP), vol. II, Her Majesty’s Stationery Office, London, 1993.
  • - S. Ouanas, M. Kallel, H. Trabelsi, F. Safta, K. Bouzoouita, J. Pharm. Biomed. Anal.,17 (1998) 361-364.
  • - E. Bawelcsyk, Z. Plotkowiak, Chemical Analysis. (Warsaw), 17 (1972) 111-119.
  • - C. A. Janicki, H. R. A. Jr, J. Pharm. Sci., 63 (1974) 41–43.
  • - M Shamsipur, L. Dastgerdi, Z. Talebpour, S. Haghgoo, J. Pharm. Biomed. Anal, 43 (2007) 1116-1121.
  • - J. Krzek, A. Maslanka, Acta Poloniae Pharmaceutica-Drug Research, 57 (2000) 23-26.
  • - I. A. Zingales, J. Chromatogr. A, 54 (1971) 15–24.
  • - T. Fujii, K. Hatanaka, G. Sato, Y. Yasui, H. Arimoto, Y. Mitsutsuka, J. Chromatogr. B, 687 (1996) 395-403.
  • - H. Bagheri, A. Afkhami, Y. Panahi, H. Khoshsafar, A. Shirzadmehr. Mater. Sci. Eng. C 37 (2014) 264–270
  • - L.B. Nilsson, J. Chromatogr. B, 431 (1988) 113–122.
  • - D. R. Abernethy, D. J. Greenblatt, H. R. Ochs, C. R. Willis, D. D.Miller, R. I. Shader, J. Chromatogr. B, 307 (1984) 194–199.
  • - G. Bianchetti, P. L. Morselli, J. Chromatogr. A, 153 (1978) 203-209.
  • - T. Arinobu , H. Hattori , M. Iwai , A. Ishii , T. Kumazawa, O. Suzuki , H. Seno, J. Chromatogr. B, 776 (2002) 107–113
  • - K. Titier, S. Bouchet, F. Pehourcq, N. Moore, M. Molimard, J. Chromatogr. B,
  • (2003) 179-185.
  • - H. Ebrahimzadeh, Z. Dehghani, A. A. Asgharinezhad, N. Shekari,K. Molaei, Int. J. Pharm. 453 (2013) 601– 609
  • - K.H. Park, M.H. Lee, M.G. Lee, J. Chromatogr. B, 572 )1991( 259-267.
  • - N. Yasui-Furukori, Y. Inoue, M. Chiba, T. Tateishi, J. Chromatogr. B, 805(2004) 175-180.
  • - R. Driouich, T. Takayanagi, M. Oshima, S. Motomizu, J. Chromatogr. A, 903 (2000) 271-278.
  • - H.S. El-Desoky, M.M. Ghoneim, , J. Pharm. Biomed. Anal,38 (2005) 543-550.
  • - H. M. Abu Shawish, A. M. Khedr, K. I. Abed-Almonem, M. Gaber, Talanta 101 (2012) 211–219
  • - K. Vytras, J. Kalous, J. Jezkova, Anal. Chem. 6 (1997) 107
  • - H. M. Abu Shawish, S. M. Saadeh, H. Tamos, K. I. Abed-Almonem, o. Al khalili, Analytical Chemistry Research 2 (2014) 30–36
  • - E. Lindner, Y. Umezawa, Pure Appl. Chem. 80 (2008) 85–104
  • - E. Bakker, E. Pretsch, P. Buhlmann, Anal. Chem.72 (2000) 1127-1133
  • - A. Ceresa (2001) Ion-selective polymeric membrane electrodes for potentiometric trace level measurements, Swiss Federal Institute of Technology, Zurich
  • - P. R. Buck, E. Lindner, Pure Appl. Chem. 66 (1994) 2527–2536.
  • - Z. H. Ibupoto, K. Khun, M. Willander, Sensors 13 (2013) 1984-1997
  • - C. H. Agarwal, C. K. Singh, Anal. Sci. 23 (2007) 469
Toplam 49 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Hazem Abu Shawish

Hassan Tamous

Asma A. Shaheen

Khaled I. Abed Almonem

Ahmed Awad Elgamel

Wael S. Al-lham

Yayımlanma Tarihi 20 Eylül 2016
Yayımlandığı Sayı Yıl 2017 Cilt: 21 Sayı: 1

Kaynak Göster

APA Abu Shawish, H., Tamous, H., Shaheen, A. A., Almonem, K. I. A., vd. (2016). Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes. Marmara Pharmaceutical Journal, 21(1), 110-120. https://doi.org/10.12991/marupj.259888
AMA Abu Shawish H, Tamous H, Shaheen AA, Almonem KIA, Elgamel AA, Al-lham WS. Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes. J Res Pharm. Eylül 2016;21(1):110-120. doi:10.12991/marupj.259888
Chicago Abu Shawish, Hazem, Hassan Tamous, Asma A. Shaheen, Khaled I. Abed Almonem, Ahmed Awad Elgamel, ve Wael S. Al-lham. “Determination of Haloperidol Drug in Ampoules and in Urine Samples Using a Potentiometric PVC-Membrane and Graphite Coated Wire Electrodes”. Marmara Pharmaceutical Journal 21, sy. 1 (Eylül 2016): 110-20. https://doi.org/10.12991/marupj.259888.
EndNote Abu Shawish H, Tamous H, Shaheen AA, Almonem KIA, Elgamel AA, Al-lham WS (01 Eylül 2016) Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes. Marmara Pharmaceutical Journal 21 1 110–120.
IEEE H. Abu Shawish, H. Tamous, A. A. Shaheen, K. I. A. Almonem, A. A. Elgamel, ve W. S. Al-lham, “Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes”, J Res Pharm, c. 21, sy. 1, ss. 110–120, 2016, doi: 10.12991/marupj.259888.
ISNAD Abu Shawish, Hazem vd. “Determination of Haloperidol Drug in Ampoules and in Urine Samples Using a Potentiometric PVC-Membrane and Graphite Coated Wire Electrodes”. Marmara Pharmaceutical Journal 21/1 (Eylül 2016), 110-120. https://doi.org/10.12991/marupj.259888.
JAMA Abu Shawish H, Tamous H, Shaheen AA, Almonem KIA, Elgamel AA, Al-lham WS. Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes. J Res Pharm. 2016;21:110–120.
MLA Abu Shawish, Hazem vd. “Determination of Haloperidol Drug in Ampoules and in Urine Samples Using a Potentiometric PVC-Membrane and Graphite Coated Wire Electrodes”. Marmara Pharmaceutical Journal, c. 21, sy. 1, 2016, ss. 110-2, doi:10.12991/marupj.259888.
Vancouver Abu Shawish H, Tamous H, Shaheen AA, Almonem KIA, Elgamel AA, Al-lham WS. Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes. J Res Pharm. 2016;21(1):110-2.

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