Araştırma Makalesi
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Yıl 2023, Cilt: 24 Sayı: 4, 303 - 308, 30.12.2023

Dilara Nur Şengün , İnci Rana Karaca , Hasan Serdar Öztürk

Öz

Kaynakça

  • 1. Perillo B, Di Donato M, Pezone A, Di Zazzo E, Giovannelli P, GalassoG, et al. ROS in cancer therapy: the bright side of the moon. ExpMol Med 2020; 52: 192-203.
  • 2. Aggarwal V, Tuli HS, Varol A, Thakral F, Yerer MB, Sak K, et al. Role of Reactive Oxygen Species in Cancer Progression: MolecularMechanisms and Recent Advancements. Biomolecules 2019; 9: 735.
  • 3. World Health Organization. Cancer Key Facts 2022. https://www. who.int/news-room/fact-sheets/detail/cancer.
  • 4. Global Cancer Observatory. Cancer Fact Sheets 2020. https://gco. iarc.fr/today/fact-sheets-cancers.
  • 5. Abati S, Bramati C, Bondi S, Lissoni A, Trimarchi M. Oral Cancerand Precancer: A Narrative Review on the Relevance of EarlyDiagnosis. Int J Environ Res Public Health 2020; 17: 9160.
  • 6. Scrobota I, Bolfa P, Filip AG, Catoi C, Alb C, Pop O, et al. Natural chemopreventive alternatives in oral cancer chemoprevention. JPhysiol Pharmacol 2016; 67: 161-72.
  • 7. Chau L, Jabara JT, Lai W, Svider PF, Warner BM, Lin HS, et al. Topical agents for oral cancer chemoprevention: A systematic review of the literature. Oral Oncol 2017; 67: 153-9.
  • 8. Li Y, Zheng Y, Wang H. Anticancer activity of Vicenin-2 against 7,12 dimethylbenz[a]anthracene-induced buccal pouch carcinoma in hamsters. J Biochem Mol Toxicol 2021; 35: e22673.
  • 9. Suresh K, Manoharan S, Vijayaanand MA, Sugunadevi G. Chemopreventive and antioxidant efficacy of (6)-paradol in 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis. Pharmacol Rep 2010; 62: 1178-85.
  • 10. Manoharan S, Sindhu G, Vinothkumar V, Kowsalya R. Berberine prevents 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis: a biochemical approach. Eur J Cancer Prev 2012; 21: 182-92.
  • 11. Manoharan S, Vasanthaselvan M, Silvan S, Baskaran N, Kumar Singh A, Vinoth Kumar V. Carnosic acid: a potent chemopreventive agent against oral carcinogenesis. Chem Biol Interact 2010; 188: 616-22.
  • 12. Gonçalves Vde P, Ortega AA, Guimarães MR, Curylofo FA, Rossa Junior C, Ribeiro DA, et al. Chemopreventive activity of systemically administered curcumin on oral cancer in the 4-nitroquinoline 1-oxide model. J Cell Biochem 2015; 116: 787-96.
  • 13. Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003; 3: 768-80.
  • 14. Okmen G, Turkcan O, Ceylan O, Gork G. The antimicrobial activity of Liquidambar orientalis mill. against food pathogens and antioxidant capacity of leaf extracts. Afr J Tradit Complement Altern Med 2014; 11: 28-32.
  • 15. Guzman JD. Natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity. Molecules 2014; 19: 19292-349.
  • 16. Sağdiç O, Ozkan G, Ozcan M, Ozçelik S. A study on inhibitory effects of Siğla tree (Liquidambar orientalis Mill. var. orientalis) storax against several bacteria. Phytother Res 2005; 19: 549-51.
  • 17. Karadeniz B, Ulker Z, Alpsoy L. Genotoxic and cytotoxic effects of storax in vitro. Toxicol Ind Health 2013; 29: 181-6.
  • 18. Gurbuz I, Yesilada E, Demirci B, Sezik E, Demirci F, Baser KH. Characterization of volatiles and anti-ulcerogenic effect of Turkish sweetgum balsam (Styrax liquidus). J Ethnopharmacol 2013; 148: 332-6.
  • 19. Yesilada E, Gürbüz I, Bedir E, Tatli I, Khan IA. Isolation of antiulcerogenic sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis through bioassay-guided fractionation procedures in rats. J Ethnopharmacol 2004; 95: 213-9.
  • 20. Lingbeck JM, O'Bryan CA, Martin EM, Adams JP, Crandall PG. Sweetgum: An ancient source of beneficial compounds with modern benefits. Pharmacogn Rev 2015; 9: 1-11.
  • 21. Charehsaz M, Reis R, Helvacioglu S, Sipahi H, Guzelmeric E, Acar ET, et al. Safety evaluation of styrax liquidus from the viewpoint of genotoxicity and mutagenicity. J Ethnopharmacol 2016; 194: 506-12.
  • 22. Guo J, Duan JA, Tang Y, Li Y. Sedative and anticonvulsant activities of styrax after oral and intranasal administration in mice. Pharm Biol 2011; 49: 1034-8.
  • 23. Suzek H, Celik I, Dogan A, Yildirim S. Protective effect andantioxidant role of sweetgum (Liquidambar orientalis) oil against carbon tetrachloride-induced hepatotoxicity and oxidative stressinrats. Pharm Biol 2016; 54: 451-7.
  • 24. Saraç N, Şen B. Antioxidant, mutagenic, antimutagenic activities, and phenolic compounds of Liquidambar orientalis Mill. var. orientalis. Industrial Crops and Products 2014; 53: 60-4.
  • 25. Gürdal B, Kültür S. An ethnobotanical study of medicinal plantsinMarmaris (Muğla, Turkey). J Ethnopharmacol 2013; 146: 113-26.
  • 26. Zhang M, Ma Y, Chai L, Mao H, Zhang J, Fan X. Storax ProtectedOxygen-Glucose Deprivation/Reoxygenation Induced PrimaryAstrocyte Injury by Inhibiting NF-κB Activation in vitro. Front Pharmacol 2019; 9: 1527.
  • 27. Baskaran N, Manoharan S, Karthikeyan S, Prabhakar MM. Chemopreventive potential of coumarin in 7, 12-dimethylbenz[a] anthracene induced hamster buccal pouch carcinogenesis. AsianPac J Cancer Prev 2012; 13: 5273-9.
  • 28. Nagini S, Kowshik J. The Hamster Buccal Pouch Model of Oral Carcinogenesis. Methods Mol Biol 2016; 1422: 341-50.
  • 29. Babukumar S, Vinothkumar V, Velu P, Ramachandhiran D, RamadosNirmal M. Molecular effects of hesperetin, a citrus flavanone on7,12-dimethylbenz(a)anthracene induced buccal pouch squamouscell carcinoma in golden Syrian hamsters. Arch Physiol Biochem2017; 123: 265-78.
  • 30. Şengün DN, Demirci G, Karaca İR. Antioxidant Efficacy of HypericumPerforatum L. on 7,12-Dimethylbenzanthracene-Applied Rat TongueTissues. Archives of Current Medical Research 2021; 2: 33-7.
  • 31. Alias LM, Manoharan S, Vellaichamy L, BalakrishnanS, Ramachandran CR. Protective effect of ferulic acidon7,12-dimethylbenz[a]anthracene-induced skin carcinogenesisinSwiss albino mice. Exp Toxicol Pathol 2009; 61: 205-14.
  • 32. Atmaca H, Camli Pulat C, Cittan M. Liquidambar orientalis Mill. gumextract induces autophagy via PI3K/Akt/mTOR signaling pathwayinprostate cancer cells. Int J Environ Health Res 2022; 32: 1011-9.
  • 33. Cengiz Baloglu M, Yildiz Ozer L, Pirci B, Zengin G, IbrahimUbaA, Celik Altunoglu Y. Evaluation of the Potential TherapeuticProperties of Liquidambar orientalis Oil. Chem Biodivers 2023; 20: e202300291.
  • 34. Çetinkaya S, Çınar Ayan İ, Süntar İ, Dursun HG. The Phytochemical Profile and Biological Activity of Liquidambar orientalis Mill. var. orientalis via NF-κB and Apoptotic Pathways in Human Colorectal Cancer. Nutr Cancer 2022; 74: 1457-73.
  • 35. Strycharz-Dudziak M, Kiełczykowska M, Drop B, ŚwiątekŁ, Kliszczewska E, Musik I, et al. Total Antioxidant Status (TAS), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GPx) in Oropharyngeal Cancer Associated with EBV Infection. OxidMedCell Longev 2019; 2019: 5832410.
  • 36. Kolanjiappan K, Ramachandran CR, Manoharan S. Biochemical changes in tum

Antioxidant Effects of Styrax Liquidus on DMBA-exposed Rat Tongue Tissues

Yıl 2023, Cilt: 24 Sayı: 4, 303 - 308, 30.12.2023

Dilara Nur Şengün , İnci Rana Karaca , Hasan Serdar Öztürk

Öz

Objective: Natural products with antioxidant components are believed to have a strong potential for the prevention of cancer andsome degenerative diseases. Liquidambar orientalis Miller (Styrax Liquidus) has strong in vitro antioxidant activity. The purposeof this study was to evaluate the effects of Styrax Liquidus on antioxidant defense mechanisms in 7,12-dimethylbenz(a)anthracene(DMBA)-applied rat tongue tissue.
Materials and Methods: Wistar rats (n=30) were randomly divided into control, DMBA, DMBA + SL, and SL groups. The control group was treated with liquid paraffin only, the DMBA group was treated with 0.5% DMBA, DMBA and Styrax Liquidus were appliedto the DMBA + SL group, and only Styrax Liquidus was applied to the SL group. All applications were made to the oral mucosa. Sixteen weeks later, the tongue tissue of all animals were removed. Superoxide dismutase, catalase, glutathione peroxidase enzymeactivities, and malondialdehyde and total antioxidant status levels were measured.
Results: All parameters were significantly lower in the SL + DMBA group. Antioxidant enzyme activities and oxidative stressparameters were lowered in the SL + DMBA and SL groups. SL + DMBA application is believed to have an inhibitory effect ontheantioxidant enzymes measured in this study; however, the decrease in malondialdehyde levels (lipid peroxidation marker) highlightsthe antioxidant effect of Styrax Liquidus in 7,12-dimethylbenz(a)anthracene-exposed rat tongue tissues.
Conclusion: Styrax Liquidus exhibited in vivo antioxidant activity in an oral cancer model. Further research may be useful inunderstanding the exact mechanisms underlying this effect.

Anahtar Kelimeler

Antioxidant 12-Dimethylbenzanthracene Liquidambar oral cancer oxidant Styrax

Kaynakça

  • 1. Perillo B, Di Donato M, Pezone A, Di Zazzo E, Giovannelli P, GalassoG, et al. ROS in cancer therapy: the bright side of the moon. ExpMol Med 2020; 52: 192-203.
  • 2. Aggarwal V, Tuli HS, Varol A, Thakral F, Yerer MB, Sak K, et al. Role of Reactive Oxygen Species in Cancer Progression: MolecularMechanisms and Recent Advancements. Biomolecules 2019; 9: 735.
  • 3. World Health Organization. Cancer Key Facts 2022. https://www. who.int/news-room/fact-sheets/detail/cancer.
  • 4. Global Cancer Observatory. Cancer Fact Sheets 2020. https://gco. iarc.fr/today/fact-sheets-cancers.
  • 5. Abati S, Bramati C, Bondi S, Lissoni A, Trimarchi M. Oral Cancerand Precancer: A Narrative Review on the Relevance of EarlyDiagnosis. Int J Environ Res Public Health 2020; 17: 9160.
  • 6. Scrobota I, Bolfa P, Filip AG, Catoi C, Alb C, Pop O, et al. Natural chemopreventive alternatives in oral cancer chemoprevention. JPhysiol Pharmacol 2016; 67: 161-72.
  • 7. Chau L, Jabara JT, Lai W, Svider PF, Warner BM, Lin HS, et al. Topical agents for oral cancer chemoprevention: A systematic review of the literature. Oral Oncol 2017; 67: 153-9.
  • 8. Li Y, Zheng Y, Wang H. Anticancer activity of Vicenin-2 against 7,12 dimethylbenz[a]anthracene-induced buccal pouch carcinoma in hamsters. J Biochem Mol Toxicol 2021; 35: e22673.
  • 9. Suresh K, Manoharan S, Vijayaanand MA, Sugunadevi G. Chemopreventive and antioxidant efficacy of (6)-paradol in 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis. Pharmacol Rep 2010; 62: 1178-85.
  • 10. Manoharan S, Sindhu G, Vinothkumar V, Kowsalya R. Berberine prevents 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis: a biochemical approach. Eur J Cancer Prev 2012; 21: 182-92.
  • 11. Manoharan S, Vasanthaselvan M, Silvan S, Baskaran N, Kumar Singh A, Vinoth Kumar V. Carnosic acid: a potent chemopreventive agent against oral carcinogenesis. Chem Biol Interact 2010; 188: 616-22.
  • 12. Gonçalves Vde P, Ortega AA, Guimarães MR, Curylofo FA, Rossa Junior C, Ribeiro DA, et al. Chemopreventive activity of systemically administered curcumin on oral cancer in the 4-nitroquinoline 1-oxide model. J Cell Biochem 2015; 116: 787-96.
  • 13. Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003; 3: 768-80.
  • 14. Okmen G, Turkcan O, Ceylan O, Gork G. The antimicrobial activity of Liquidambar orientalis mill. against food pathogens and antioxidant capacity of leaf extracts. Afr J Tradit Complement Altern Med 2014; 11: 28-32.
  • 15. Guzman JD. Natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity. Molecules 2014; 19: 19292-349.
  • 16. Sağdiç O, Ozkan G, Ozcan M, Ozçelik S. A study on inhibitory effects of Siğla tree (Liquidambar orientalis Mill. var. orientalis) storax against several bacteria. Phytother Res 2005; 19: 549-51.
  • 17. Karadeniz B, Ulker Z, Alpsoy L. Genotoxic and cytotoxic effects of storax in vitro. Toxicol Ind Health 2013; 29: 181-6.
  • 18. Gurbuz I, Yesilada E, Demirci B, Sezik E, Demirci F, Baser KH. Characterization of volatiles and anti-ulcerogenic effect of Turkish sweetgum balsam (Styrax liquidus). J Ethnopharmacol 2013; 148: 332-6.
  • 19. Yesilada E, Gürbüz I, Bedir E, Tatli I, Khan IA. Isolation of antiulcerogenic sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis through bioassay-guided fractionation procedures in rats. J Ethnopharmacol 2004; 95: 213-9.
  • 20. Lingbeck JM, O'Bryan CA, Martin EM, Adams JP, Crandall PG. Sweetgum: An ancient source of beneficial compounds with modern benefits. Pharmacogn Rev 2015; 9: 1-11.
  • 21. Charehsaz M, Reis R, Helvacioglu S, Sipahi H, Guzelmeric E, Acar ET, et al. Safety evaluation of styrax liquidus from the viewpoint of genotoxicity and mutagenicity. J Ethnopharmacol 2016; 194: 506-12.
  • 22. Guo J, Duan JA, Tang Y, Li Y. Sedative and anticonvulsant activities of styrax after oral and intranasal administration in mice. Pharm Biol 2011; 49: 1034-8.
  • 23. Suzek H, Celik I, Dogan A, Yildirim S. Protective effect andantioxidant role of sweetgum (Liquidambar orientalis) oil against carbon tetrachloride-induced hepatotoxicity and oxidative stressinrats. Pharm Biol 2016; 54: 451-7.
  • 24. Saraç N, Şen B. Antioxidant, mutagenic, antimutagenic activities, and phenolic compounds of Liquidambar orientalis Mill. var. orientalis. Industrial Crops and Products 2014; 53: 60-4.
  • 25. Gürdal B, Kültür S. An ethnobotanical study of medicinal plantsinMarmaris (Muğla, Turkey). J Ethnopharmacol 2013; 146: 113-26.
  • 26. Zhang M, Ma Y, Chai L, Mao H, Zhang J, Fan X. Storax ProtectedOxygen-Glucose Deprivation/Reoxygenation Induced PrimaryAstrocyte Injury by Inhibiting NF-κB Activation in vitro. Front Pharmacol 2019; 9: 1527.
  • 27. Baskaran N, Manoharan S, Karthikeyan S, Prabhakar MM. Chemopreventive potential of coumarin in 7, 12-dimethylbenz[a] anthracene induced hamster buccal pouch carcinogenesis. AsianPac J Cancer Prev 2012; 13: 5273-9.
  • 28. Nagini S, Kowshik J. The Hamster Buccal Pouch Model of Oral Carcinogenesis. Methods Mol Biol 2016; 1422: 341-50.
  • 29. Babukumar S, Vinothkumar V, Velu P, Ramachandhiran D, RamadosNirmal M. Molecular effects of hesperetin, a citrus flavanone on7,12-dimethylbenz(a)anthracene induced buccal pouch squamouscell carcinoma in golden Syrian hamsters. Arch Physiol Biochem2017; 123: 265-78.
  • 30. Şengün DN, Demirci G, Karaca İR. Antioxidant Efficacy of HypericumPerforatum L. on 7,12-Dimethylbenzanthracene-Applied Rat TongueTissues. Archives of Current Medical Research 2021; 2: 33-7.
  • 31. Alias LM, Manoharan S, Vellaichamy L, BalakrishnanS, Ramachandran CR. Protective effect of ferulic acidon7,12-dimethylbenz[a]anthracene-induced skin carcinogenesisinSwiss albino mice. Exp Toxicol Pathol 2009; 61: 205-14.
  • 32. Atmaca H, Camli Pulat C, Cittan M. Liquidambar orientalis Mill. gumextract induces autophagy via PI3K/Akt/mTOR signaling pathwayinprostate cancer cells. Int J Environ Health Res 2022; 32: 1011-9.
  • 33. Cengiz Baloglu M, Yildiz Ozer L, Pirci B, Zengin G, IbrahimUbaA, Celik Altunoglu Y. Evaluation of the Potential TherapeuticProperties of Liquidambar orientalis Oil. Chem Biodivers 2023; 20: e202300291.
  • 34. Çetinkaya S, Çınar Ayan İ, Süntar İ, Dursun HG. The Phytochemical Profile and Biological Activity of Liquidambar orientalis Mill. var. orientalis via NF-κB and Apoptotic Pathways in Human Colorectal Cancer. Nutr Cancer 2022; 74: 1457-73.
  • 35. Strycharz-Dudziak M, Kiełczykowska M, Drop B, ŚwiątekŁ, Kliszczewska E, Musik I, et al. Total Antioxidant Status (TAS), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GPx) in Oropharyngeal Cancer Associated with EBV Infection. OxidMedCell Longev 2019; 2019: 5832410.
  • 36. Kolanjiappan K, Ramachandran CR, Manoharan S. Biochemical changes in tum
Toplam 36 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Diş Hekimliği (Diğer)
Bölüm Araştırma Makalesi
Yazarlar

Dilara Nur Şengün

İnci Rana Karaca

Hasan Serdar Öztürk

Yayımlanma Tarihi 30 Aralık 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 24 Sayı: 4

Kaynak Göster

EndNote Şengün DN, Karaca İR, Öztürk HS (01 Aralık 2023) Antioxidant Effects of Styrax Liquidus on DMBA-exposed Rat Tongue Tissues. Meandros Medical And Dental Journal 24 4 303–308.