Araştırma Makalesi
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Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study

Yıl 2022, Cilt: 23 Sayı: 2, 175 - 181, 30.06.2022

Nezaket Ezgi Özer Özkaya , Betül Karaca , Ceyda Gürhan , Hayal Boyacıoğlu , Umut Aykutlu , Pelin Güneri

Öz

Objective: Our study assesss the clinical features of oral lesions that require histological examination and patient-reported symptoms to estimate the risk of malignancy and to determine the presence of any altered features.
Materials and Methods: Demographic characteristics of 70 patients and clinical features of lesions were analyzed using chi-square test, Fisher’s Exact test of Independence and discriminant function analysis.
Results: Margins, lymphadenopathy, patient’s self-awareness of the lesion associated with mass effect, surface texture, colour, ulceration, loss of function and pain were significant parameters indicating the risk of malignancy (p<0.05). Analyses of the parameters related to the high risk of malignancy have led to a statistical model for clinical differentiation of benign lesions from malignancies with an accuracy of 91.4% (p=0.016). The statistical model demonstrated that the most important discriminative features were margins, surface texture, patient’s self-awareness, lymphadenopathy, loss of function, ulceration, colour, and pain, respectively.
Conclusion: In our study, age, gender, duration and localization did not anticipate the nature of the lesion. Our statistical model showed that irregular/indistinct margins and surface textures and the presence of lymphadenopathy have a higher risk of malignancy.

Anahtar Kelimeler

Oral lesion oral malignancy malignancy risk

Kaynakça

  • 1. Carreras-Torras C, Gay-Escoda C. Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review. Med Oral Patol Oral Cir Bucal 2015; 20: 305-15.
  • 2. Güneri P, Epstein JB. Late-stage diagnosis of oral cancer: components and possible solutions. Oral Oncol 2014; 50: 1131-6.
  • 3. Ribeiro ACP, Silva ARS, Simonato LE, Salzedas LMP, Sundefeld MLMM, Soubhia AMP. Clinical and histopathological analysis of oral squamous cell carcinoma in young people: a descriptive study in Brazilians. Br J Oral Maxillofac Surg 2009; 47: 95-8.
  • 4. Scully C, Bagan Jv. Oral squamous cell carcinoma: overview of current understanding of aetiopathogenesis and clinical implications. Oral Dis 2009; 15: 388-99.
  • 5. Bagan J, Sarrion G, Jimenez Y. Oral cancer: clinical features. Oral Oncol 2010; 46: 414-17.
  • 6. Scully C, Field JK, Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma 2: chromosomal aberrations. Oral Oncol 2000; 36: 311-27.
  • 7. Curado MP, Hashibe M. Recent changes in the epidemiology of head and neck cancer. Curr Opin Oncol 2009; 21: 194-200.
  • 8. Bonifazi M, Malvezzi M, Bertuccio P, Edefonti V, Garavello W, Levi F, et al. Age-period-cohort analysis of oral cancer mortality in Europe: the end of an epidemic? Oral Oncol 2011; 47: 400-7.
  • 9. Olaleye O, Ekrikpo U, Lyne O, Wiseberg J. Incidence and survival trends of lip, intra-oral cavity, and tongue base cancers in southeast England. Ann R Col Surg Engl 2015; 97: 229-34.
  • 10. Ingafou M, Leao JC, Porter SR, Scully C. Oral lichen planus: a retrospective study of 690 British patients. Oral Dis 2006; 12: 463-8.
  • 11. Gooi Z, Chan JYK, Fakhry C. The epidemiology of the human papillomavirus related to oropharyngeal head and neck cancer. Laryngoscope 2016; 126: 894-900.
  • 12. Alsidawi S, Price KA, Chintakuntlawar AV, Westin GF, Garcia JJ, Ma DJ, et al. Characteristics and long-term outcomes of head and neck squamous cell carcinoma after solid organ transplantation. Oral Oncol 2017; 72: 104-9.
  • 13. Boyle P, Autier P, Bartelink H, Baselga J, Boffetta P, Burn J, et al. European Code Against Cancer and scientific justification: third version (2003). Ann Oncol 2003; 14: 973-1005.
  • 14. Walsh T, Liu JLY, Brocklehurst P, Glenny A-M, Lingen M, Kerr AR, et al. Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults. Cochrane Database Syst Rev 2013; 2013: CD010173.
  • 15. Poh CF, MacAulay CE, Laronde DM, Williams PM, Zhang L, Rosin MP. Squamous cell carcinoma and precursor lesions: diagnosis and screening in a technical era: Diagnosis & screening advances. Periodontol 2000 2011; 57: 73-88.
  • 16. Omar E. Current concepts and future of noninvasive procedures for diagnosing oral squamous cell carcinoma--a systematic review. Head Face Med 2015; 25: 11-6.

Yıl 2022, Cilt: 23 Sayı: 2, 175 - 181, 30.06.2022

Nezaket Ezgi Özer Özkaya , Betül Karaca , Ceyda Gürhan , Hayal Boyacıoğlu , Umut Aykutlu , Pelin Güneri

Öz

Kaynakça

  • 1. Carreras-Torras C, Gay-Escoda C. Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review. Med Oral Patol Oral Cir Bucal 2015; 20: 305-15.
  • 2. Güneri P, Epstein JB. Late-stage diagnosis of oral cancer: components and possible solutions. Oral Oncol 2014; 50: 1131-6.
  • 3. Ribeiro ACP, Silva ARS, Simonato LE, Salzedas LMP, Sundefeld MLMM, Soubhia AMP. Clinical and histopathological analysis of oral squamous cell carcinoma in young people: a descriptive study in Brazilians. Br J Oral Maxillofac Surg 2009; 47: 95-8.
  • 4. Scully C, Bagan Jv. Oral squamous cell carcinoma: overview of current understanding of aetiopathogenesis and clinical implications. Oral Dis 2009; 15: 388-99.
  • 5. Bagan J, Sarrion G, Jimenez Y. Oral cancer: clinical features. Oral Oncol 2010; 46: 414-17.
  • 6. Scully C, Field JK, Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma 2: chromosomal aberrations. Oral Oncol 2000; 36: 311-27.
  • 7. Curado MP, Hashibe M. Recent changes in the epidemiology of head and neck cancer. Curr Opin Oncol 2009; 21: 194-200.
  • 8. Bonifazi M, Malvezzi M, Bertuccio P, Edefonti V, Garavello W, Levi F, et al. Age-period-cohort analysis of oral cancer mortality in Europe: the end of an epidemic? Oral Oncol 2011; 47: 400-7.
  • 9. Olaleye O, Ekrikpo U, Lyne O, Wiseberg J. Incidence and survival trends of lip, intra-oral cavity, and tongue base cancers in southeast England. Ann R Col Surg Engl 2015; 97: 229-34.
  • 10. Ingafou M, Leao JC, Porter SR, Scully C. Oral lichen planus: a retrospective study of 690 British patients. Oral Dis 2006; 12: 463-8.
  • 11. Gooi Z, Chan JYK, Fakhry C. The epidemiology of the human papillomavirus related to oropharyngeal head and neck cancer. Laryngoscope 2016; 126: 894-900.
  • 12. Alsidawi S, Price KA, Chintakuntlawar AV, Westin GF, Garcia JJ, Ma DJ, et al. Characteristics and long-term outcomes of head and neck squamous cell carcinoma after solid organ transplantation. Oral Oncol 2017; 72: 104-9.
  • 13. Boyle P, Autier P, Bartelink H, Baselga J, Boffetta P, Burn J, et al. European Code Against Cancer and scientific justification: third version (2003). Ann Oncol 2003; 14: 973-1005.
  • 14. Walsh T, Liu JLY, Brocklehurst P, Glenny A-M, Lingen M, Kerr AR, et al. Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults. Cochrane Database Syst Rev 2013; 2013: CD010173.
  • 15. Poh CF, MacAulay CE, Laronde DM, Williams PM, Zhang L, Rosin MP. Squamous cell carcinoma and precursor lesions: diagnosis and screening in a technical era: Diagnosis & screening advances. Periodontol 2000 2011; 57: 73-88.
  • 16. Omar E. Current concepts and future of noninvasive procedures for diagnosing oral squamous cell carcinoma--a systematic review. Head Face Med 2015; 25: 11-6.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Diş Hekimliği (Diğer), Patoloji
Bölüm Araştırma Makalesi
Yazarlar

Nezaket Ezgi Özer Özkaya

Betül Karaca

Ceyda Gürhan

Hayal Boyacıoğlu

Umut Aykutlu

Pelin Güneri

Yayımlanma Tarihi 30 Haziran 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 23 Sayı: 2

Kaynak Göster

EndNote Özer Özkaya NE, Karaca B, Gürhan C, Boyacıoğlu H, Aykutlu U, Güneri P (01 Haziran 2022) Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study. Meandros Medical And Dental Journal 23 2 175–181.