Evaluation of Risk Factors, Clinical Characteristics, and Prognosis in Cerebral Venous Thrombosis: A Single Tertiary Center Experience

Havva Meltem Mutlucan; Hale Zeynep Batur Çağlayan; Bijen Nazlıel; Nil Tokgöz; Murat Uçar

doi:10.4274/meandros.galenos.2022.26986

Araştırma Makalesi

Evaluation of Risk Factors, Clinical Characteristics, and Prognosis in Cerebral Venous Thrombosis: A Single Tertiary Center Experience

Yıl 2022, Cilt: 23 Sayı: 3, 355 - 360, 30.09.2022

Havva Meltem Mutlucan Hale Zeynep Batur Çağlayan , Bijen Nazlıel , Nil Tokgöz Murat Uçar

Öz

Objective: We evaluated the demographic and clinical characteristics, risk factors, involved vasculature, and prognosis in cerebral venous thrombosis.
Materials and Methods: We included 53 patients with cerebral venous thrombosis (CVT) who were followed up in our neurology inpatient clinic and neurology intensive care unit in the study. The demographic and clinical characteristics on admission, risk factors, results of laboratory tests and neuroimaging studies, treatment, outcomes at discharge, and 6th-month follow-up were reviewed.
Results: The mean age of the patients was 44.1±13.7 (19-71) years. Thirty-one (58.4%) of the patients were female. The most frequent symptom was headache (69.8%). Puerperium and malignancy were the most common risk factors for patients under 45 years of age; whereas anemia and malignancy were the most common risk factors for patients over 45 years of age. The most common localization of CVT was found to be the transverse sinus (69.8%). The modified Rankin scale (mRS) scores at discharge were 0 for 47 patients (88.6%), 1 for 4 patients (7.5%) and 4 for 2 patients. In the 6th-month follow-up, 48 (90.5 %) of the patients had an mRS score of 0 with normal neurological examination.
Conclusion: Our study, representing the experience of a single tertiary referral center, showed that CVT mostly affected women of reproductive ages. More than 90% of patients in our study had an mRS score of 0 at the 6th-month followup. The results of our study suggest that early diagnosis of CVT with advanced neuroimaging techniques recently has improved the outcomes and reduced the disability.

Anahtar Kelimeler

Cranial cerebral venous sinus thrombosis, erythrocyte indices, sinus sagittalis superior, transverse sinus thrombosis, venous infarct

Kaynakça

1. Lopez-Espejo M, Hernandez-Chavez M, Huete I. Clinical and radiological features of cerebral venous thrombosis in a children cohort. Rev Chil Pediatr 2018; 89: 621-9.
2. Duman T, Uluduz D, Midi I, Bektas H, Kablan Y, Goksel BK, et al. A Multicenter Study of 1144 Patients with Cerebral Venous Thrombosis: The VENOST Study. J Stroke Cerebrovasc Dis 2017; 26: 1848-57.
3. Shahid R, Zafar A, Nazish S, Alsulaiman A, Alabdali M, Aljaafari D, et al. Etiologic and Clinical Features of Cerebral Venous Sinus Thrombosis in Saudi Arabia. J Neurosci Rural Pract 2019; 10: 278-82.
4. Kristoffersen ES, Harper CE, Vetvik KG, Faiz KW. Cerebral venous thrombosis - epidemiology, diagnosis and treatment. Tidsskr Nor Laegeforen 2018; 138.
5. Saposnik G, Barinagarrementeria F, Brown RD, Jr., Bushnell CD, Cucchiara B, Cushman M, et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011; 42: 1158-92.
6. Ferro JM, Bousser MG, Canhao P, Coutinho JM, Crassard I, Dentali F, et al. European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis - endorsed by the European Academy of Neurology. Eur J Neurol 2017; 24: 1203-13.
7. Mehndiratta MM, Garg S, Gurnani M. Cerebral venous thrombosis--clinical presentations. J Pak Med Assoc 2006; 56: 513-6.
8. Ferro JM, Canhao P, Stam J, Bousser MG, Barinagarrementeria F, ISCVT Investigators. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke 2004; 35: 664-70.
9. Coutinho JM, Zuurbier SM, Stam J. Declining mortality in cerebral venous thrombosis: a systematic review. Stroke 2014; 45: 1338-41.
10. Ferro JM, Aguiar de Sousa D. Cerebral Venous Thrombosis: an Update. Curr Neurol Neurosci Rep 2019; 19: 74.
11. Uluduz D, Sahin S, Duman T, Ozturk S, Yayla V, Afsar N, et al. Cerebral Venous Sinus Thrombosis in Women: Subgroup Analysis of the VENOST Study. Stroke Res Treat 2020; 2020: 8610903.
12. Coutinho JM, Ferro JM, Canhao P, Barinagarrementeria F, Cantu C, Bousser MG, et al. Cerebral venous and sinus thrombosis in women. Stroke 2009; 40: 2356-61.
13. Nasr DM, Brinjikji W, Cloft HJ, Saposnik G, Rabinstein AA. Mortality in cerebral venous thrombosis: results from the national inpatient sample database. Cerebrovasc Dis 2013; 35: 40-4.
14. Munot P, De Vile C, Hemingway C, Gunny R, Ganesan V. Severe iron deficiency anaemia and ischaemic stroke in children. Arch Dis Child 2011; 96: 276-9.
15. Coutinho JM, Zuurbier SM, Gaartman AE, Dikstaal AA, Stam J, Middeldorp S, et al. Association Between Anemia and Cerebral Venous Thrombosis: Case-Control Study. Stroke 2015; 46: 2735-40.
16. Batur Caglayan HZ, Nazliel B, Irkec C, Dumlu A, Filiz A, Panpalli Ates M. Iron-Deficiency Anemia Leading to Transient Ischemic Attacks due to Intraluminal Carotid Artery Thrombus. Case Rep Neurol Med 2013; 2013: 813415.
17. Nicastro N, Schnider A, Leemann B. Iron-deficiency anemia as a rare cause of cerebral venous thrombosis and pulmonary embolism. Case Rep Med 2012; 2012: 497814.
18. Livesey JA, Manning RA, Meek JH, Jackson JE, Kulinskaya E, Laffan MA, et al. Low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and pulmonary emboli/deep venous thromboses in replicate cohorts of patients with hereditary haemorrhagic telangiectasia. Thorax 2012; 67: 328-33.
19. Ray JG. Meta-analysis of hyperhomocysteinemia as a risk factor for venous thromboembolic disease. Arch Intern Med 1998; 158: 2101-6.
20. Den Heijer M, Lewington S, Clarke R. Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. J Thromb Haemost 2005; 3: 292-9.
21. Ospina-Romero M, Cannegieter SC, den Heijer M, Doggen CJM, Rosendaal FR, Lijfering WM. Hyperhomocysteinemia and Risk of First Venous Thrombosis: The Influence of (Unmeasured) Confounding Factors. Am J Epidemiol 2018; 187: 1392-400.
22. Piazza G. Cerebral venous thrombosis. Circulation 2012; 125: 1704-9.

Yıl 2022, Cilt: 23 Sayı: 3, 355 - 360, 30.09.2022

Havva Meltem Mutlucan Hale Zeynep Batur Çağlayan , Bijen Nazlıel , Nil Tokgöz Murat Uçar

Öz

Kaynakça

1. Lopez-Espejo M, Hernandez-Chavez M, Huete I. Clinical and radiological features of cerebral venous thrombosis in a children cohort. Rev Chil Pediatr 2018; 89: 621-9.
2. Duman T, Uluduz D, Midi I, Bektas H, Kablan Y, Goksel BK, et al. A Multicenter Study of 1144 Patients with Cerebral Venous Thrombosis: The VENOST Study. J Stroke Cerebrovasc Dis 2017; 26: 1848-57.
3. Shahid R, Zafar A, Nazish S, Alsulaiman A, Alabdali M, Aljaafari D, et al. Etiologic and Clinical Features of Cerebral Venous Sinus Thrombosis in Saudi Arabia. J Neurosci Rural Pract 2019; 10: 278-82.
4. Kristoffersen ES, Harper CE, Vetvik KG, Faiz KW. Cerebral venous thrombosis - epidemiology, diagnosis and treatment. Tidsskr Nor Laegeforen 2018; 138.
5. Saposnik G, Barinagarrementeria F, Brown RD, Jr., Bushnell CD, Cucchiara B, Cushman M, et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011; 42: 1158-92.
6. Ferro JM, Bousser MG, Canhao P, Coutinho JM, Crassard I, Dentali F, et al. European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis - endorsed by the European Academy of Neurology. Eur J Neurol 2017; 24: 1203-13.
7. Mehndiratta MM, Garg S, Gurnani M. Cerebral venous thrombosis--clinical presentations. J Pak Med Assoc 2006; 56: 513-6.
8. Ferro JM, Canhao P, Stam J, Bousser MG, Barinagarrementeria F, ISCVT Investigators. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke 2004; 35: 664-70.
9. Coutinho JM, Zuurbier SM, Stam J. Declining mortality in cerebral venous thrombosis: a systematic review. Stroke 2014; 45: 1338-41.
10. Ferro JM, Aguiar de Sousa D. Cerebral Venous Thrombosis: an Update. Curr Neurol Neurosci Rep 2019; 19: 74.
11. Uluduz D, Sahin S, Duman T, Ozturk S, Yayla V, Afsar N, et al. Cerebral Venous Sinus Thrombosis in Women: Subgroup Analysis of the VENOST Study. Stroke Res Treat 2020; 2020: 8610903.
12. Coutinho JM, Ferro JM, Canhao P, Barinagarrementeria F, Cantu C, Bousser MG, et al. Cerebral venous and sinus thrombosis in women. Stroke 2009; 40: 2356-61.
13. Nasr DM, Brinjikji W, Cloft HJ, Saposnik G, Rabinstein AA. Mortality in cerebral venous thrombosis: results from the national inpatient sample database. Cerebrovasc Dis 2013; 35: 40-4.
14. Munot P, De Vile C, Hemingway C, Gunny R, Ganesan V. Severe iron deficiency anaemia and ischaemic stroke in children. Arch Dis Child 2011; 96: 276-9.
15. Coutinho JM, Zuurbier SM, Gaartman AE, Dikstaal AA, Stam J, Middeldorp S, et al. Association Between Anemia and Cerebral Venous Thrombosis: Case-Control Study. Stroke 2015; 46: 2735-40.
16. Batur Caglayan HZ, Nazliel B, Irkec C, Dumlu A, Filiz A, Panpalli Ates M. Iron-Deficiency Anemia Leading to Transient Ischemic Attacks due to Intraluminal Carotid Artery Thrombus. Case Rep Neurol Med 2013; 2013: 813415.
17. Nicastro N, Schnider A, Leemann B. Iron-deficiency anemia as a rare cause of cerebral venous thrombosis and pulmonary embolism. Case Rep Med 2012; 2012: 497814.
18. Livesey JA, Manning RA, Meek JH, Jackson JE, Kulinskaya E, Laffan MA, et al. Low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and pulmonary emboli/deep venous thromboses in replicate cohorts of patients with hereditary haemorrhagic telangiectasia. Thorax 2012; 67: 328-33.
19. Ray JG. Meta-analysis of hyperhomocysteinemia as a risk factor for venous thromboembolic disease. Arch Intern Med 1998; 158: 2101-6.
20. Den Heijer M, Lewington S, Clarke R. Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. J Thromb Haemost 2005; 3: 292-9.
21. Ospina-Romero M, Cannegieter SC, den Heijer M, Doggen CJM, Rosendaal FR, Lijfering WM. Hyperhomocysteinemia and Risk of First Venous Thrombosis: The Influence of (Unmeasured) Confounding Factors. Am J Epidemiol 2018; 187: 1392-400.
22. Piazza G. Cerebral venous thrombosis. Circulation 2012; 125: 1704-9.

Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Radyoloji ve Organ Görüntüleme, Nöroloji ve Nöromüsküler Hastalıklar
Bölüm	Araştırma Makalesi
Yazarlar	Havva Meltem Mutlucan Hale Zeynep Batur Çağlayan Bijen Nazlıel Nil Tokgöz Murat Uçar
Yayımlanma Tarihi	30 Eylül 2022
Yayımlandığı Sayı	Yıl 2022 Cilt: 23 Sayı: 3

Kaynak Göster

EndNote	Mutlucan HM, Batur Çağlayan HZ, Nazlıel B, Tokgöz N, Uçar M (01 Eylül 2022) Evaluation of Risk Factors, Clinical Characteristics, and Prognosis in Cerebral Venous Thrombosis: A Single Tertiary Center Experience. Meandros Medical And Dental Journal 23 3 355–360.

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