Frequency, Locations and Histopathological Features of Polyps Detected in Upper Gastrointestinal System Examination and Its Association with Helicobacter Pylori Infection
Öz
Objective: Gastric polyps are often detected incidentally during endoscopic examination performed for a different purpose. Hyperplastic polyp is the most common type of polyp in the stomach. This study aimed to determine the frequency, locations and histopathological features of polyps detected in gastroscopic procedures performed at the Gastroenterology Department of Aydın State Hospital and their relationship with Helicobacter pylori (H. pylori) infection.
Materials and Methods: Data of 129 patients with polyps during 8,787 gastroscopic procedures performed between July 2016 and January 2020 at the Gastroenterology Department were retrospectively analysed. The size, location and histopathological features of the polyps, H. pylori positivity, presence of intestinal metaplasia and gastric atrophy and use of proton pump inhibitors were recorded.
Results: Polyps were localised in the corpus in 43 (33.3%) patients, in the antrum in 36 (27.9%) patients and in the fundus in 20 (15.5%) patients. On histopathological examination, hyperplastic polyp was detected in 84 (65.4%) patients, fundic gland polyp in 19 (14.7%) patients, adenomatous polyp in 11 (8.5%) patients, squamous papilloma in 6 (4.7%) patients and inflammatory polyp in 5 (3.9%) patients. H. pylori positivity was significantly higher in hyperplastic polyps compared to other polyps (40.8% vs 23.4%) (p=0.04), while it was found to be significantly less in fundic gland polyps compared to other polyps (15.8% vs 41.8%) (p=0.03).
Conclusion: In this study, hyperplastic polyp is the most common type of polyp found on gastroscopic examination. While H. pylori positivity rate was significantly higher in hyperplastic polyps, it was significantly less in fundic gland polyps. Fundic gland polyps are more common with long-term use of proton pump inhibitors. In the literature, the histopathology of polyps and the relationship of H. pylori infection show similarities.
Anahtar Kelimeler
Kaynakça
- 1. Crawford JM. The gastrointestinal tract. In: Cotran RS, Kumar V, Robbins SL, editors. Pathologic Basis of Disease. 5th ed. Philadelphia: W. B. Saunders Company; 1994: 755-829.
- 2. Al-Haddad M, Ward EM, Bouras EP, Raimondo M. Hyperplastic polyps of the gastric antrum in patients with gastrointestinal blood loss. Dig Dis Sci 2007; 52: 105-9.
- 3. Kumar A, Quick CR, Carr-Locke DL. Prolapsing gastric polyp, an unusual cause of gastric outlet obstruction: a review of the pathology and management of gastric polyps. Endoscopy 1996; 28: 452-5.
- 4. Carmack SW, Genta RM, Schuler CM, Saboorian MH. The current spectrum of gastric polyps: a 1-year national study of over 120,000 patients. Am J Gastroenterol 2009; 104: 1524-32.
- 5. Morais DJ, Yamanaka A, Zeitune JM, Andreollo NA. Gastric polyps: a retrospective analysis of 26,000 digestive endoscopies. Arq Gastroenterol 2007; 44: 14-7.
- 6. Jalving M, Koornstra JJ, Wesseling J, Boezen HM, DE Jong S, Kleibeuker JH. Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy. Aliment Pharmacol Ther 2006; 24: 1341-8.
- 7. Sen Oran E, Gencosmanoglu R. Midenin hiperplastik polipleri: tanı, tedavi ve izlemde güncel yaklaşımlar. Güncel Gastroenteroloji 2003; 7: 127-33.
- 8. Archimandritis A, Spiliadis C, Tzivras M, Vamvakousis B, Davaris P, Manika Z, et al. Gastric epithelial polyps: a retrospective endoscopic study of 12974 symptomatic patients. Ital J Gastroenterol 1996; 28: 387-90.
- 9. Soytürk M, Özdinç SA, Sarıoğlu S, Sağol Ö, Hakim GD, Topalak Ö. Endoskopik incelemede saptanan mide poliplerinin yerleşimi, histopatolojik tipleri ve Helikobakter pilori infeksiyonu ile ilişkisi. Endoskopi Gastrointestinal 2012; 20: 1-4.
- 10. Lawrence B, Gustafsson BI, Chan A, Svejda B, Kidd M, Modlin IM. The epidemiology of gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am 2011; 40: 1-18.
- 11. Oymaci E, Sari E, Ucar AD, Yakan S, Yılmaz F, Erkan N, et al. Rare polyps in endoscopic examination: type 1 gastric neuroendocrine tumor (NET-TYPE 1). İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 2014; 18: 121-5.
Öz
Kaynakça
- 1. Crawford JM. The gastrointestinal tract. In: Cotran RS, Kumar V, Robbins SL, editors. Pathologic Basis of Disease. 5th ed. Philadelphia: W. B. Saunders Company; 1994: 755-829.
- 2. Al-Haddad M, Ward EM, Bouras EP, Raimondo M. Hyperplastic polyps of the gastric antrum in patients with gastrointestinal blood loss. Dig Dis Sci 2007; 52: 105-9.
- 3. Kumar A, Quick CR, Carr-Locke DL. Prolapsing gastric polyp, an unusual cause of gastric outlet obstruction: a review of the pathology and management of gastric polyps. Endoscopy 1996; 28: 452-5.
- 4. Carmack SW, Genta RM, Schuler CM, Saboorian MH. The current spectrum of gastric polyps: a 1-year national study of over 120,000 patients. Am J Gastroenterol 2009; 104: 1524-32.
- 5. Morais DJ, Yamanaka A, Zeitune JM, Andreollo NA. Gastric polyps: a retrospective analysis of 26,000 digestive endoscopies. Arq Gastroenterol 2007; 44: 14-7.
- 6. Jalving M, Koornstra JJ, Wesseling J, Boezen HM, DE Jong S, Kleibeuker JH. Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy. Aliment Pharmacol Ther 2006; 24: 1341-8.
- 7. Sen Oran E, Gencosmanoglu R. Midenin hiperplastik polipleri: tanı, tedavi ve izlemde güncel yaklaşımlar. Güncel Gastroenteroloji 2003; 7: 127-33.
- 8. Archimandritis A, Spiliadis C, Tzivras M, Vamvakousis B, Davaris P, Manika Z, et al. Gastric epithelial polyps: a retrospective endoscopic study of 12974 symptomatic patients. Ital J Gastroenterol 1996; 28: 387-90.
- 9. Soytürk M, Özdinç SA, Sarıoğlu S, Sağol Ö, Hakim GD, Topalak Ö. Endoskopik incelemede saptanan mide poliplerinin yerleşimi, histopatolojik tipleri ve Helikobakter pilori infeksiyonu ile ilişkisi. Endoskopi Gastrointestinal 2012; 20: 1-4.
- 10. Lawrence B, Gustafsson BI, Chan A, Svejda B, Kidd M, Modlin IM. The epidemiology of gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am 2011; 40: 1-18.
- 11. Oymaci E, Sari E, Ucar AD, Yakan S, Yılmaz F, Erkan N, et al. Rare polyps in endoscopic examination: type 1 gastric neuroendocrine tumor (NET-TYPE 1). İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 2014; 18: 121-5.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Gastroenteroloji ve Hepatoloji |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Ağustos 2021 |
| Yayımlandığı Sayı | Yıl 2021 Cilt: 22 Sayı: 2 |