Investigating the Effect of Rosuvastatin, Paracetamol and Coadministration of Rosuvastatin and Paracetamol on Ocular Tissue
Öz
Objective: Statins and Paracetamol are two drugs that have a high prescription rate all over the world. Possible side effects can easily be augmented because they use the same cytochrome oxidase enzymes in liver. This study aimed to investigate the effect single or combined administration of these drugs on ocular tissues.
Materials and Methods: Twenty-eight 12- to 15-month-old rats were divided in four groups: Control, Rosuvastatin (10 mg/kg/day for 7 times a week), Paracetamol (50 mg/kg/day for 5 times a week) and Rosuvastatin (10 mg/kg/day for 7 times a week) + Paracetamol (50 mg/kg/day for 5 times a week) for 8 weeks. At the end of study, intraocular pressure (IOP) was measured and ocular tissues were obtained for histopathological evaluation under anaesthesia with Ketamine and Xylasine (50 mg/kg and 5 mg/kg, respectively).
Results: Rosuvastatin showed an IOP dropping effect and paracetamol did not prevent it. Histopathological evaluation mainly revealed retinal nerve fibre layer degeneration. Additionally, different pathological alterations such as corneal oedema and polypoid proliferation were observed in all the treated groups, although they were rare.
Conclusion: The IOP dropping effect of rosuvastatin shows that it is safe in glaucoma patients, but this beneficial effect was not observed with Paracetamol. Retinal nerve fibre layer degeneration with both drugs might be one of the reasons for visual disturbances in real life conditions.
Anahtar Kelimeler
Kaynakça
- 1. Schmeer C, Kretz A, Isenmann S. Therapeutic potential of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors for the treatment of retinal and eye diseases. CNS Neurol Disord Drug Targets 2007; 6: 282-7.
- 2. Borkar DS, Tham VM, Shen E, Parker JV, Uchida A, Vinoya AC, et al. Association Between Statin Use and Uveitis: Results From the Pacific Ocular Inflammation Study. Am J Ophthalmol 2015; 159: 707-13.
- 3. Mizranita V, Pratisto EH. Statin-associated ocular disorders: the FDA and ADRAC data. Int J Clin Pharm 2015; 37: 844-50.
- 4. Karbownik A, Bienert A, Płotek W, Grabowski T, CerbinKoczorowska M, Wolc A, et al. Influence of the Time of Intravenous Administration of Paracetamol on its Pharmacokinetics and Ocular Disposition in Rabbits. Eur J Drug Metab Pharmacokinet 2017; 42: 489-98.
- 5. Qian W, Shichi H. Naphthoquinone-Induced cataract in mice: possible involvement of Ca2+ release and calpain activation. J Ocul Pharmacol Ther 2001; 17: 383-92.
- 6. Pittler SJ, Fliesler SJ, Rapp LM. Novel morphological changes in rat retina induced by intravitreal injection of lovastatin. Exp Eye Res 1992; 54: 149-52.
- 7. Mohamed N, Meyer D. Intraocular pressure-lowering effect of oral paracetamol and its in vitro corneal penetration properties. Clin Ophthalmol 2013; 7: 219-27.
- 8. Jampel HD. Effect of oral paracetamol on intraocular pressure: a pilot study. Clin Exp Ophthalmol 2017; 45: 645-7.
- 9. Schmidt J, Schmitt C, Hockwin O, Paulus U, von Bergmann K. Ocular Drug Safety and HMG-CoA-Reductase Inhibitors. Ophthalmic Res 1994; 26: 352-60.
- 10. Nassini R, Materazzi S, Andre E, Sartiani L, Aldini G, Trevisani M, et al. Acetaminophen, via its reactive metabolite N-acetyl-p-benzoquinoneimine and transient receptor potential ankyrin-1 stimulation causes neurogenic inflammation in the airways and other tissues in rodents. FASEB J 2010; 24: 4904-16.
- 11. Reshma CS, Sruthi S, Syama S, Gayathri V, Mohanan PV. Assessing the Systemic Toxicity in Rabbits after Sub Acute Exposure to Ocular Irritant Chemicals. Toxicol Res 2015; 31: 49-59.
- 12. Fraunfelder FW. Ocular hemorrhage possibly the result of HMG-CoA reductase inhibitors. J Ocul Pharmacol Ther 2004; 20: 179-82.
Öz
Kaynakça
- 1. Schmeer C, Kretz A, Isenmann S. Therapeutic potential of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors for the treatment of retinal and eye diseases. CNS Neurol Disord Drug Targets 2007; 6: 282-7.
- 2. Borkar DS, Tham VM, Shen E, Parker JV, Uchida A, Vinoya AC, et al. Association Between Statin Use and Uveitis: Results From the Pacific Ocular Inflammation Study. Am J Ophthalmol 2015; 159: 707-13.
- 3. Mizranita V, Pratisto EH. Statin-associated ocular disorders: the FDA and ADRAC data. Int J Clin Pharm 2015; 37: 844-50.
- 4. Karbownik A, Bienert A, Płotek W, Grabowski T, CerbinKoczorowska M, Wolc A, et al. Influence of the Time of Intravenous Administration of Paracetamol on its Pharmacokinetics and Ocular Disposition in Rabbits. Eur J Drug Metab Pharmacokinet 2017; 42: 489-98.
- 5. Qian W, Shichi H. Naphthoquinone-Induced cataract in mice: possible involvement of Ca2+ release and calpain activation. J Ocul Pharmacol Ther 2001; 17: 383-92.
- 6. Pittler SJ, Fliesler SJ, Rapp LM. Novel morphological changes in rat retina induced by intravitreal injection of lovastatin. Exp Eye Res 1992; 54: 149-52.
- 7. Mohamed N, Meyer D. Intraocular pressure-lowering effect of oral paracetamol and its in vitro corneal penetration properties. Clin Ophthalmol 2013; 7: 219-27.
- 8. Jampel HD. Effect of oral paracetamol on intraocular pressure: a pilot study. Clin Exp Ophthalmol 2017; 45: 645-7.
- 9. Schmidt J, Schmitt C, Hockwin O, Paulus U, von Bergmann K. Ocular Drug Safety and HMG-CoA-Reductase Inhibitors. Ophthalmic Res 1994; 26: 352-60.
- 10. Nassini R, Materazzi S, Andre E, Sartiani L, Aldini G, Trevisani M, et al. Acetaminophen, via its reactive metabolite N-acetyl-p-benzoquinoneimine and transient receptor potential ankyrin-1 stimulation causes neurogenic inflammation in the airways and other tissues in rodents. FASEB J 2010; 24: 4904-16.
- 11. Reshma CS, Sruthi S, Syama S, Gayathri V, Mohanan PV. Assessing the Systemic Toxicity in Rabbits after Sub Acute Exposure to Ocular Irritant Chemicals. Toxicol Res 2015; 31: 49-59.
- 12. Fraunfelder FW. Ocular hemorrhage possibly the result of HMG-CoA reductase inhibitors. J Ocul Pharmacol Ther 2004; 20: 179-82.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Göz Hastalıkları |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Ağustos 2020 |
| Yayımlandığı Sayı | Yıl 2020 Cilt: 21 Sayı: 2 |