Öz
Trichoepithelioma is a well-differentiated benign follicular tumour. Clinically, it may either be solitary or multiple. Multiple trichoepitheliomas are often located on the face and its vicinity. Here, we present this case due to the increasing number of lesions over ten years, particularly with the lesions blocking the external auditory canal. This case is presented with clinical, histopathological and immunohistochemical features, with differential diagnoses. The patient was a 70-year-old female with localised papules on the external auditory canal, ear lobule, tragus, neck and lower lip. The microscopic examination of the excisional biopsy from the external auditory canal revealed a tumoural formation surrounded with stromal fibrosis and mononuclear infiltration, which is composed of basaloid cells showing peripheral palisading and keratinocytes with infundibular keratinisation. Upon immunohistochemical studies, the surrounding stroma of the tumour showed diffuse cytoplasmic positivity for CD34, and focal cytoplasmic positivity for BerEP4. There was no significant family history in this case. This pathology must be kept in mind in the differential diagnosis of tumours of the epidermis and skin appendages which occur on the face and its vicinity.
Anahtar Kelimeler
Kaynakça
- 1. Shaffelburg M, Miller R. Treatment of multiple trichoepithelioma with electrosurgery. Dermatol Surg 1998; 24: 1154-6.
- 2. Duhra P, Paul JC. Cryotherapy for multiple trichoepithelioma. J Dermatol Surg Oncol 1988; 14: 1413-5.
- 3. Çitil R, Oltulu P, Kargı MH. Bazal hücreli karsinom ile karışan trikoepitelyoma: Olgu sunumu. ŞEEAH Tıp Bülteni 2010; 44: 87-9.
- 4. Yiltok SJ, Echejoh GO, Mohammad AM, Ituen AM, Igoche MI, Dades OT. Multiple familial trichoepithelioma: A case report and review of literature. Niger J Clin Pract 2010; 13: 230-2.
- 5. Karikal A, Shetty P, Karikal A, Shetty SR. Multiple trichoepitheliomas: A rare occurrence. South Asian J Cancer 2013; 2: 54.
- 6. Miotto IZ, Romiti R. Nonfamilial Multiple Trichoepithelioma. JAMA Dermatology doi:10.1001/jamadermatol.2019.1650
- 7. Monteiro AF, Rato M, Luís P, Tavares E. Multiple Familial Trichoepithelioma. Acta Med Port 2018; 31: 180.
- 8. Saha A, Das NK, Gharami RC, Chowdhury SN, Datta PK. A clinico histopathological study of appendageal skin tumors, affecting head and neck region in patients attending the dermatology opd of a tertiary care centre in eastern India. Indian J Dermatol 2011; 56: 33-6.
- 9. Karimzadeh I, Namazi MR, Karimzadeh A. Trichoepithelioma: a comprehensive review. Acta Dermatovenerol Croat 2018; 26: 162-5.
- 10. Harada H, Hashimoto K, Ko MS. The gene for multiple familial trichoepithelioma maps to chromosome 9p21. J Invest Dermatol 1996; 107: 41-3.
- 11. Kirchmann TT, Prieto VG, Smoller BR. CD34 staining pattern distinguishes basal cell carcinoma from trichoepithelioma. Arch Dermatol 1994; 130: 589-92.
- 12. Samaka RM, Bakry OA, Seleit I, Abdelwahed MM, Hassan RA. Multiple Familial Trichoepithelioma with Malignant Transformation. Indian J Dermatol 2013; 58: 409.
- 13. Lee KH, Kim JE, Cho BK, Kim YC, Park CJ. Malignant Transformation of Multiple Familial Trichoepithelioma: Case Report and Literature Review. Acta Derm Venereol 2008; 88: 43-6.
- 14. Rosenbach A, Alster TS. Multiple trichoepitheliomas successfully treated with a high energy, pulsed carbon dioxide laser. Dermatol Surg 1997; 23: 708-10.
Öz
Kaynakça
- 1. Shaffelburg M, Miller R. Treatment of multiple trichoepithelioma with electrosurgery. Dermatol Surg 1998; 24: 1154-6.
- 2. Duhra P, Paul JC. Cryotherapy for multiple trichoepithelioma. J Dermatol Surg Oncol 1988; 14: 1413-5.
- 3. Çitil R, Oltulu P, Kargı MH. Bazal hücreli karsinom ile karışan trikoepitelyoma: Olgu sunumu. ŞEEAH Tıp Bülteni 2010; 44: 87-9.
- 4. Yiltok SJ, Echejoh GO, Mohammad AM, Ituen AM, Igoche MI, Dades OT. Multiple familial trichoepithelioma: A case report and review of literature. Niger J Clin Pract 2010; 13: 230-2.
- 5. Karikal A, Shetty P, Karikal A, Shetty SR. Multiple trichoepitheliomas: A rare occurrence. South Asian J Cancer 2013; 2: 54.
- 6. Miotto IZ, Romiti R. Nonfamilial Multiple Trichoepithelioma. JAMA Dermatology doi:10.1001/jamadermatol.2019.1650
- 7. Monteiro AF, Rato M, Luís P, Tavares E. Multiple Familial Trichoepithelioma. Acta Med Port 2018; 31: 180.
- 8. Saha A, Das NK, Gharami RC, Chowdhury SN, Datta PK. A clinico histopathological study of appendageal skin tumors, affecting head and neck region in patients attending the dermatology opd of a tertiary care centre in eastern India. Indian J Dermatol 2011; 56: 33-6.
- 9. Karimzadeh I, Namazi MR, Karimzadeh A. Trichoepithelioma: a comprehensive review. Acta Dermatovenerol Croat 2018; 26: 162-5.
- 10. Harada H, Hashimoto K, Ko MS. The gene for multiple familial trichoepithelioma maps to chromosome 9p21. J Invest Dermatol 1996; 107: 41-3.
- 11. Kirchmann TT, Prieto VG, Smoller BR. CD34 staining pattern distinguishes basal cell carcinoma from trichoepithelioma. Arch Dermatol 1994; 130: 589-92.
- 12. Samaka RM, Bakry OA, Seleit I, Abdelwahed MM, Hassan RA. Multiple Familial Trichoepithelioma with Malignant Transformation. Indian J Dermatol 2013; 58: 409.
- 13. Lee KH, Kim JE, Cho BK, Kim YC, Park CJ. Malignant Transformation of Multiple Familial Trichoepithelioma: Case Report and Literature Review. Acta Derm Venereol 2008; 88: 43-6.
- 14. Rosenbach A, Alster TS. Multiple trichoepitheliomas successfully treated with a high energy, pulsed carbon dioxide laser. Dermatol Surg 1997; 23: 708-10.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Plastik, Rekonstrüktif ve Estetik Cerrahi, Patoloji |
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Ağustos 2020 |
| Yayımlandığı Sayı | Yıl 2020 Cilt: 21 Sayı: 2 |