Öz
Thyrotoxicosis is a clinical syndrome resulting from the effect of excess circulating T3 and T4 which ultimately causes an increased metabolic rate. The source of circulating T3 and T4 is usually the thyroid gland affected from a variety of pathological processes. The most common of these are, Graves’ disease, toxic nodular goitre and functioning adenoma. Although most types of thyrotoxicosis are due to hyperthyroidism, thyrotoxicosis can also be caused by destruction of thyroid tissue, leading to release of an excess of stored thyroid hormones, and by ingestion of too much thyroid hormone.
Anahtar Kelimeler
Hyperthyroidism Graves Toxic nodular goitre Methimazole Propylthiouracil Radioiodine
Kaynakça
- Bahn, R.S., Burch, H.B, Cooper, D.S., Garber, J.R., Greenlee, M.C., Klein, I., Laurberg, P., McDougall, R., Montori, V.M., Rivkees, S. A., Ross, D. S., Sosa, J.A., Stan, M.N., 2011. Hyperthyroidism and other causes of thyrotoxicosis: Management guidelines of the American thyroid association and American Association of Clinical Endocrinologists. Thyroid. 21, 593-646.
- Gündoğdu, A.S., Kabalak, T., Kamel, N., Erdoğan, G., 2008. Tiroid hastalıkları. İç Hastalıkları, 1. Baskı, Ç. Erol, ed. MN Medikal &Nobel Tıp Kitabevi, İstanbul, pp. 3708- 3776.
- Hatemi, H.H., 2007. Hipertiroidizm tirotoksikoz. Cerrahpaşa İç Hastalıkları, 1. Baskı, H. Yazıcı, V. Hamuryudan, A. Sonsuz, eds. İstanbul Medikal Yayıncılık, İstanbul, pp. 1068-1070.
- Hegedüs, L., 2009. Treatment of Grave’s hyperthyrodim: Evidence-based and emerging modalities. Endocrin. Metab. Clin. 38, 355- 371.
- Jameson, J.L., Weetman A.P., 2008. Disorder of thyroid gland. In Harrison’s principles of internal medicine, 16th Ed, D.L. Kasper, E. Braunwald, A.S. Faucı, S.L. Hauser, D.L. Longo, J.L. Jameson, eds. McGraw-Hill, New York, pp. 2104-2127.
- Kahaly, G.J., Bartalena, L., Hegedüs, L., 2011. The American Thyroid Association/American Association of Clinical Endocrinologist guidelines for hyperthyroid- ism and other causes of thyrotoicosis: A Europen perspective. Thyroid. 21, 585-591.
- Kamel, N., 2006. Tirotoksikoz. Endokrinoloji Metabolizma ve Diabet, 1. Baskı, M. Özata, A. Yönem, eds. İstanbul Medikal Yayıncılık, İstanbul, pp. 123-139.
- Ladenson, P., Kim, M., 2007. Thyroid. In Cecil Medicine, 23rd Ed, L. Goldman, D. Ausiello, eds. Saunders Elsevier, Phiadelphia, pp. 698,1713.
- Medeiros-Neto, G., Romaldini, J.H., Abalovich, M., 2011. Highlights of guidelines on the management of hyperthyroism and other causes of thyrotoxicosis. Thyroid. 21,581-584.
- Mandel, S. J., Lersen, P. R., Davies, T.F., 2011. Thyrotoxicosis. In Williams Textbook of Endocrinology, 12th. Ed. S. Melmed, K.S., Polonsky, P.R., Larsen, H.N., Krononberg, eds. Saunders Elsevier, Phiadelphia, pp. 362-404.
- Nayak, B., Hodak, S.P., 2007. Hypertiroidizm. Endocrinol. Metab. Clin. North. 36, 617-656.
- Özata, M., 2006. Tiroiditler. Endokrinoloji Metabolizma ve Diabet, 1. Baskı, M. Özata, A. Yönem, eds. İstanbul Medikal Yayıncılık, İstanbul, pp. 151-165.
- Pearce, E.N., Hennessey, J.V., McDermortt, M.T., 2011. New American thyroid association and American Association of Clinical Endocrinologists guidelines for thyrotoxicosis and other forms of hyperthyroidism: Significant Progress For The Clinician and A Guide To Future Research. Thyroid. 21, 573-576.
- Uğur, B., 2011. Endokrinolojide tiroid bezi. Endokrinolojide Temel ve Klinik bilgiler, 1. Baskı, Nobel Tıp Kitabevi, İstanbul, pp. 39-99.
- Ünal N., Gürlek, A., 2005. Amiodaron ve tiroid. Hacettepe Tıp Dergisi. 36, 152-156.
- Yamashita, S., Amino, N., Shong, Y.K., 2011. The American Thyroid Association and American Association of Clinical Endocrinologists. Hyperthyroidism and Other Causes of Thyrotoxicosis Guidelines: Viewpoints from Japan and Korea. Thyroid. 21, 577-580.
Öz
Tirotoksikoz, dolaşımda artan T3 ve T4’ün etkisiyle metabolik hız artışına neden olan klinik bir sendromdur. Artış gösteren bu T3 ve T4’ün kaynağı sıklıkla çeşitli patolojilerden etkilenen tiroid bezinin kendisidir. Hipertiroidizme yol açan bu patolojilerin çoğunu Graves hastalığı, toksik nodüler guatr ve fonksiyon gösteren adenom oluşturur. Tirotoksikozun en sık rastlanan sebepleri hipertiroidi olsa da, fazla tiroid hormonu alımı ve tiroid bezindeki destrüksiyon sonucu depolanmış hormonların kana salınması tirotoksikoz nedeni olabilir
Anahtar Kelimeler
Hipertiroidizm Graves hastalığı Toksik nodüler guatr Metimazol Propiltiyourasil Radyoiyot
Kaynakça
- Bahn, R.S., Burch, H.B, Cooper, D.S., Garber, J.R., Greenlee, M.C., Klein, I., Laurberg, P., McDougall, R., Montori, V.M., Rivkees, S. A., Ross, D. S., Sosa, J.A., Stan, M.N., 2011. Hyperthyroidism and other causes of thyrotoxicosis: Management guidelines of the American thyroid association and American Association of Clinical Endocrinologists. Thyroid. 21, 593-646.
- Gündoğdu, A.S., Kabalak, T., Kamel, N., Erdoğan, G., 2008. Tiroid hastalıkları. İç Hastalıkları, 1. Baskı, Ç. Erol, ed. MN Medikal &Nobel Tıp Kitabevi, İstanbul, pp. 3708- 3776.
- Hatemi, H.H., 2007. Hipertiroidizm tirotoksikoz. Cerrahpaşa İç Hastalıkları, 1. Baskı, H. Yazıcı, V. Hamuryudan, A. Sonsuz, eds. İstanbul Medikal Yayıncılık, İstanbul, pp. 1068-1070.
- Hegedüs, L., 2009. Treatment of Grave’s hyperthyrodim: Evidence-based and emerging modalities. Endocrin. Metab. Clin. 38, 355- 371.
- Jameson, J.L., Weetman A.P., 2008. Disorder of thyroid gland. In Harrison’s principles of internal medicine, 16th Ed, D.L. Kasper, E. Braunwald, A.S. Faucı, S.L. Hauser, D.L. Longo, J.L. Jameson, eds. McGraw-Hill, New York, pp. 2104-2127.
- Kahaly, G.J., Bartalena, L., Hegedüs, L., 2011. The American Thyroid Association/American Association of Clinical Endocrinologist guidelines for hyperthyroid- ism and other causes of thyrotoicosis: A Europen perspective. Thyroid. 21, 585-591.
- Kamel, N., 2006. Tirotoksikoz. Endokrinoloji Metabolizma ve Diabet, 1. Baskı, M. Özata, A. Yönem, eds. İstanbul Medikal Yayıncılık, İstanbul, pp. 123-139.
- Ladenson, P., Kim, M., 2007. Thyroid. In Cecil Medicine, 23rd Ed, L. Goldman, D. Ausiello, eds. Saunders Elsevier, Phiadelphia, pp. 698,1713.
- Medeiros-Neto, G., Romaldini, J.H., Abalovich, M., 2011. Highlights of guidelines on the management of hyperthyroism and other causes of thyrotoxicosis. Thyroid. 21,581-584.
- Mandel, S. J., Lersen, P. R., Davies, T.F., 2011. Thyrotoxicosis. In Williams Textbook of Endocrinology, 12th. Ed. S. Melmed, K.S., Polonsky, P.R., Larsen, H.N., Krononberg, eds. Saunders Elsevier, Phiadelphia, pp. 362-404.
- Nayak, B., Hodak, S.P., 2007. Hypertiroidizm. Endocrinol. Metab. Clin. North. 36, 617-656.
- Özata, M., 2006. Tiroiditler. Endokrinoloji Metabolizma ve Diabet, 1. Baskı, M. Özata, A. Yönem, eds. İstanbul Medikal Yayıncılık, İstanbul, pp. 151-165.
- Pearce, E.N., Hennessey, J.V., McDermortt, M.T., 2011. New American thyroid association and American Association of Clinical Endocrinologists guidelines for thyrotoxicosis and other forms of hyperthyroidism: Significant Progress For The Clinician and A Guide To Future Research. Thyroid. 21, 573-576.
- Uğur, B., 2011. Endokrinolojide tiroid bezi. Endokrinolojide Temel ve Klinik bilgiler, 1. Baskı, Nobel Tıp Kitabevi, İstanbul, pp. 39-99.
- Ünal N., Gürlek, A., 2005. Amiodaron ve tiroid. Hacettepe Tıp Dergisi. 36, 152-156.
- Yamashita, S., Amino, N., Shong, Y.K., 2011. The American Thyroid Association and American Association of Clinical Endocrinologists. Hyperthyroidism and Other Causes of Thyrotoxicosis Guidelines: Viewpoints from Japan and Korea. Thyroid. 21, 577-580.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Surgery Medical Sciences |
| Yazarlar | |
| Yayımlanma Tarihi | 7 Mayıs 2013 |
| Gönderilme Tarihi | 7 Haziran 2012 |
| Yayımlandığı Sayı | Yıl 2012 Cilt: 29 Sayı: 4S |
Kaynak Göster
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