Araştırma Makalesi
Yıl 2013,
Cilt: 30 Sayı: 2, 171 - 174, 31.07.2013
Öz
Kaynakça
- Angelo-Khattar, M., Thulesius, O., Nilsson, T., Cherian, T., Joseph, L., 1985. Motility of the human ureter with special reference to indomethacin. Scand. J. Urol. Nephrol. 19, 261-265.
- Aygün, D., Kaplan, S., Odaci, E., Onger, M., Altunkaynak, M.E., 2012. Toxicity of non-steroidal anti-inflammatory drugs: A review of melatonin and diclofenac sodium association. Histol. Histopathol. 27, 417-436.
- Besen, A., Kose, F., Paydas, S., Gonlusen, G., Inal, T., Dogan, A., Kibar, M., Balal, M., 2009. The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide. Int. Urol. Nephrol. 41, 919-926.
- Cabrol, D., Carbonne, B., Bienkiewicz, A., Dallot, E., Alj, A.E., Cedard, L., 2009. Induction of labor and cervical maturation using mifepristone (RU 486) in the late pregnant rat. Influence of a cyclooxygenase inhibitor (diclofenac). Prostaglandins. 42, 719.
- Chagas, M.A., Babinski, M.A., Costa, W.S., Sampio, F.J.B., 2002. Stromal and acinar components of the transition zone in normal and hyperplastic human prostate. BJU Int. 89, 699-702.
- Chan, L.Y., Chiu, P.Y., Siu, S.S.N., Lau, T.K., 2001. A study of diclofenac-induced teratogenity during organogenesis using a whole rat embryo culture model. Hum. Reprod. 16, 2390-2393.
- Das, Y.K., Aksoy, A., Yavuz, O., Güvenç, D., Atmaca, E., 2013. Tocolytic effects of diclofenac potassium and diclofenac sodium on cattle myometrium pre-incubated with PCB-153. Kafkas Univ. Vet. Fak. Derg, 449-454.
- Gundersen, H.J.G., Bendtsen, T.F., Korbo, L., Marcussen, N., Moller, A., Nielsen, K., Nyengaard, J.R., Pakkenberg, B., Sorensen, F.B., Vesterby, A., West MJ. 1988. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS. 96, 379-3
- Gundersen, H.J.G., Jensen, E.B., 1987. The efficiency of systematic sampling in stereology and its prediction. J. Microscopy. 147, 229-263.
- Howard, C.V., Reed, M.G., 1998. Unbiased Stereology: Three dimensional measurement in microscopy. Bios Scientific Publishers, UK 62 pp. 55Kaplan, S., Gökyar, A., Ünal, B., Tunç, A.T., Bahadır, A., Aslan, H.A., 2005. Simple technique for localizing consecutive fiels for dissector pairs in light microscopy: Application to neuron counting in rabbit spinal cord following spinal cord injury. J. Neurosci. Methods. 145, 277-284, Kim, H., Xu, M., Lin, Y., Cousins, M.J., Eckstein, R.P., Jordan, V., Power, I., Mather, L.E., 1999. Renal dysfunction associated with the perioperative use of diclofenac. Anesth. Analg. 89, 999-1005.
- Lundstam, S., Johnsson, O., Kihl, B., Petterson, S., 1985. Prostaglandin synthesis inhibition of renal pelvis smooth muscle in the rabbit. Br. J. Urol. 57, 390-393.
- Mitchell, J.A., Warner, T.D., 1999. Cyclooxigenase-2: Pharmacology, physiology biochemistryand relevance to NSAID therapy. Br. J. Pharmacol. 128, 1121-32.
- Nobukawa, M., Yamada, S., Amano, H., 2001. Effect of diclofenac sodium on osteoclast formation. Oral. Ther. Pharmacol. 20, 196-198.
- Odaci, E., Cihan, O.F., Aslan, H., Ragbetli, M.C., Kaplan, S., 2010. Prenatal diclofenac sodium administration increases the number of Purkinje cells in female rats: A stereological study. Int. J. Dev. Neurosci. 28, 145-51.
- Ostensen, M.E., 1996. Safety of non-steroidal anti-inflammatory drugs during pregnancy and lactation. Inflammopharmacology. 4, 31-41.
- Ostensen. M., Ramsey-Goldman, R., 1998. Treatment of inflammatory rheumaticdisorders in pregnancy: What are the safest treatment options? Drug Saf, 19, 389-410.
- Power, I., Chambers, W.A., Greer, A., Ramage, D., Simon, E., 2007. Platellet function after intramuscular diclofenac. Anaesthesia. 45, 916-919. Ragbetli, C., Aydinlioglu, A., Kara, M., Ilhan F, Ragbetli,, 2009. MC, Effect of diclofenac sodium on the rat liver in postnatal period. J. Anim. Vet. Adv. 8, 1674-1677.
- Roth, S.H., 1985. Special studies of diclofenac and safety: Gastrointestinal, renal, hepatic, and other consequences of therapy. Semin. Arthrit. Rheum, 15, 99-104.
- Sivrikaya, A., Celik, O.F., Sivrikaya, N., Ozgur, G.K., 2004. The effect of diclofenac sodium and papaverine on isolated human ureteric smooth muscle. Int. Urol. Nephrol. 35, 479-483.
- Skoutakis, V.A., Carter, C.A., Mickle, T.R., Smith, V.H., Arkin, C.R., Alissandratos J., Petty, D.E., 1988. Review of diclofenac and evaluation of its place in therapy as a nonsteroidal antiinflammatory agent. Drug. Intell. Clin. Pharm. 22, 850-859.
- Todd, P.A., and Sorkin E., 1988. Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs. 3, 44-85.
- Zengin, H., Kaplan, S., Tümkaya, L., Altunkaynak, B.Z,. Ragbetli, M.C., Altunkaynak, M.E., Yılmaz, O., 2013. Diclofenac sodium. Effect of prenatal exposure to diclofenac sodium on the male rat arteries: A stereological and histopathological study. Drug. Chem. Toxicol, 36, 67-78.
The stereological ratio of stromal/parenchymal components in postnatal prostate tissue of rats prenatally treated with diclofenac sodium
Öz
Since diclofenac sodium extends the pregnancy and affects the fetus, our study aimed to stereologically investigate the components of the rat prostate with prenatally treated with diclofenac sodium. The rats were left overnight to mate. Pregnant animals were kept in a room tempreture with normal light and dark cycles and fed with normal diet. After injections to sham and treated groups for 15 days, 18 male offsprings were housed in three groups (6 placebo; 6 control; 6 treated). The 20 weeks-old animals were perfused and the prostates removed and embedded in paraffin. Tissue sections at 5μm thickness were taken at regular intervals and stained with Hematoxylin-eosin and Masson trichrome. Cavalieri principle was used for volume fractions analysis. Stereological examination revealed 55% acinar epitelium and 45% connective tissue in both control and placebo groups, as well as 60% acinar epitelium and 40% connective tissue in the treated group. Prenatally applied diclofenac sodium did not cause a statistically significant change in the prostate stroma parenchymal ratio in 20-week old rats compared to the control animals (p>0.05).
Anahtar Kelimeler
Kaynakça
- Angelo-Khattar, M., Thulesius, O., Nilsson, T., Cherian, T., Joseph, L., 1985. Motility of the human ureter with special reference to indomethacin. Scand. J. Urol. Nephrol. 19, 261-265.
- Aygün, D., Kaplan, S., Odaci, E., Onger, M., Altunkaynak, M.E., 2012. Toxicity of non-steroidal anti-inflammatory drugs: A review of melatonin and diclofenac sodium association. Histol. Histopathol. 27, 417-436.
- Besen, A., Kose, F., Paydas, S., Gonlusen, G., Inal, T., Dogan, A., Kibar, M., Balal, M., 2009. The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide. Int. Urol. Nephrol. 41, 919-926.
- Cabrol, D., Carbonne, B., Bienkiewicz, A., Dallot, E., Alj, A.E., Cedard, L., 2009. Induction of labor and cervical maturation using mifepristone (RU 486) in the late pregnant rat. Influence of a cyclooxygenase inhibitor (diclofenac). Prostaglandins. 42, 719.
- Chagas, M.A., Babinski, M.A., Costa, W.S., Sampio, F.J.B., 2002. Stromal and acinar components of the transition zone in normal and hyperplastic human prostate. BJU Int. 89, 699-702.
- Chan, L.Y., Chiu, P.Y., Siu, S.S.N., Lau, T.K., 2001. A study of diclofenac-induced teratogenity during organogenesis using a whole rat embryo culture model. Hum. Reprod. 16, 2390-2393.
- Das, Y.K., Aksoy, A., Yavuz, O., Güvenç, D., Atmaca, E., 2013. Tocolytic effects of diclofenac potassium and diclofenac sodium on cattle myometrium pre-incubated with PCB-153. Kafkas Univ. Vet. Fak. Derg, 449-454.
- Gundersen, H.J.G., Bendtsen, T.F., Korbo, L., Marcussen, N., Moller, A., Nielsen, K., Nyengaard, J.R., Pakkenberg, B., Sorensen, F.B., Vesterby, A., West MJ. 1988. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS. 96, 379-3
- Gundersen, H.J.G., Jensen, E.B., 1987. The efficiency of systematic sampling in stereology and its prediction. J. Microscopy. 147, 229-263.
- Howard, C.V., Reed, M.G., 1998. Unbiased Stereology: Three dimensional measurement in microscopy. Bios Scientific Publishers, UK 62 pp. 55Kaplan, S., Gökyar, A., Ünal, B., Tunç, A.T., Bahadır, A., Aslan, H.A., 2005. Simple technique for localizing consecutive fiels for dissector pairs in light microscopy: Application to neuron counting in rabbit spinal cord following spinal cord injury. J. Neurosci. Methods. 145, 277-284, Kim, H., Xu, M., Lin, Y., Cousins, M.J., Eckstein, R.P., Jordan, V., Power, I., Mather, L.E., 1999. Renal dysfunction associated with the perioperative use of diclofenac. Anesth. Analg. 89, 999-1005.
- Lundstam, S., Johnsson, O., Kihl, B., Petterson, S., 1985. Prostaglandin synthesis inhibition of renal pelvis smooth muscle in the rabbit. Br. J. Urol. 57, 390-393.
- Mitchell, J.A., Warner, T.D., 1999. Cyclooxigenase-2: Pharmacology, physiology biochemistryand relevance to NSAID therapy. Br. J. Pharmacol. 128, 1121-32.
- Nobukawa, M., Yamada, S., Amano, H., 2001. Effect of diclofenac sodium on osteoclast formation. Oral. Ther. Pharmacol. 20, 196-198.
- Odaci, E., Cihan, O.F., Aslan, H., Ragbetli, M.C., Kaplan, S., 2010. Prenatal diclofenac sodium administration increases the number of Purkinje cells in female rats: A stereological study. Int. J. Dev. Neurosci. 28, 145-51.
- Ostensen, M.E., 1996. Safety of non-steroidal anti-inflammatory drugs during pregnancy and lactation. Inflammopharmacology. 4, 31-41.
- Ostensen. M., Ramsey-Goldman, R., 1998. Treatment of inflammatory rheumaticdisorders in pregnancy: What are the safest treatment options? Drug Saf, 19, 389-410.
- Power, I., Chambers, W.A., Greer, A., Ramage, D., Simon, E., 2007. Platellet function after intramuscular diclofenac. Anaesthesia. 45, 916-919. Ragbetli, C., Aydinlioglu, A., Kara, M., Ilhan F, Ragbetli,, 2009. MC, Effect of diclofenac sodium on the rat liver in postnatal period. J. Anim. Vet. Adv. 8, 1674-1677.
- Roth, S.H., 1985. Special studies of diclofenac and safety: Gastrointestinal, renal, hepatic, and other consequences of therapy. Semin. Arthrit. Rheum, 15, 99-104.
- Sivrikaya, A., Celik, O.F., Sivrikaya, N., Ozgur, G.K., 2004. The effect of diclofenac sodium and papaverine on isolated human ureteric smooth muscle. Int. Urol. Nephrol. 35, 479-483.
- Skoutakis, V.A., Carter, C.A., Mickle, T.R., Smith, V.H., Arkin, C.R., Alissandratos J., Petty, D.E., 1988. Review of diclofenac and evaluation of its place in therapy as a nonsteroidal antiinflammatory agent. Drug. Intell. Clin. Pharm. 22, 850-859.
- Todd, P.A., and Sorkin E., 1988. Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs. 3, 44-85.
- Zengin, H., Kaplan, S., Tümkaya, L., Altunkaynak, B.Z,. Ragbetli, M.C., Altunkaynak, M.E., Yılmaz, O., 2013. Diclofenac sodium. Effect of prenatal exposure to diclofenac sodium on the male rat arteries: A stereological and histopathological study. Drug. Chem. Toxicol, 36, 67-78.
Toplam 22 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Basic Medical Sciences |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Temmuz 2013 |
| Gönderilme Tarihi | 16 Mayıs 2013 |
| Yayımlandığı Sayı | Yıl 2013 Cilt: 30 Sayı: 2 |
Kaynak Göster
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