Öz
Kaynakça
- Anger, A.T., Gilbert, B.R., Goldstein, M., 2003. Cryopreservation of sperm: Indications, methods and results. J. Urol. 170, 1079-1084. Bashamboo, А., Ferraz-de-Souza, B., Lourenco, D., Lin, L., 2010. human male infertility associated with mutations in nr5a1 encoding steroidogenic factor 1. Am. J. Hum. Gen. 87, 505-512.
- Battinelli, E.M., Markens, B.A., Italiano, J.E., 2011. Release of angiogenesis regulatory proteins from platelet alpha granules: Modulation of physiologic and pathologic angiogenesis. Blood. 118, 1359-1369.
- Bir, S.C., Esaki, J., Marui, A., 2009. Angiogenic properties of sustained release platelet-rich plasma: Characterization in-vitro and in the ischemic hind limb of the mouse. J. Vasc. Surg. 50, 870-879.
- Chatterjee, R., Kottaridis, P.D., 2002. Treatment of gonadal damage in recipients of allogenic or autologous transplantation for hematological malignancies. Bone Marrow Transplant. 30, 629-635.
- Coppinger, J., Cagney, G., Toomey, S., 2004. Characterization proteins released from асtivated platelets leads to localization novel platelet proteins in human atherosclerotic lesions. Blood. 103, 2096-2104.
Platelet-rich plasma induces morphofunctional restoration of mice testes following doxorubomycine hydrochloride exposure
Öz
According to the World Health Organization (WHO) about 8% of couples during the reproductive period of life are faced with the problem of infertility. Thus, the efforts of doctors and researchers are aimed at finding of effective treatment methods for spermatogenesis disorders. Platelet-rich plasma (PRP) has therapeutic effect due to the presence of growth factors. This work aimed to investigate the function of PRP on mice males’ gonads in experimental toxic affection. After toxic affection of the gonads by doxorubomycine hydrochloride (DH) mice got three injections of PRP. PRP was isolated from whole blood with the processing unit SmartPrep (Harvest Corp.). The introduction of PRP under the skin of scrotum renews the testis microstructure and the state of spermatogenic epitelium in mice, normalizes the amount and functioning of the Sertoly cells. This effect, probably, is conditioned by the activity of the growth factors, which freed from platelets’ α-granules after the PRP injection. Thus, the application of the platelet rich plasma is the effective method for restoration of the gonads of mice males in the condition of toxic affection. |
Anahtar Kelimeler
Mice Platelet-rich plasma Regeneration Spermatogenesis Testis Toxic affection
Kaynakça
- Anger, A.T., Gilbert, B.R., Goldstein, M., 2003. Cryopreservation of sperm: Indications, methods and results. J. Urol. 170, 1079-1084. Bashamboo, А., Ferraz-de-Souza, B., Lourenco, D., Lin, L., 2010. human male infertility associated with mutations in nr5a1 encoding steroidogenic factor 1. Am. J. Hum. Gen. 87, 505-512.
- Battinelli, E.M., Markens, B.A., Italiano, J.E., 2011. Release of angiogenesis regulatory proteins from platelet alpha granules: Modulation of physiologic and pathologic angiogenesis. Blood. 118, 1359-1369.
- Bir, S.C., Esaki, J., Marui, A., 2009. Angiogenic properties of sustained release platelet-rich plasma: Characterization in-vitro and in the ischemic hind limb of the mouse. J. Vasc. Surg. 50, 870-879.
- Chatterjee, R., Kottaridis, P.D., 2002. Treatment of gonadal damage in recipients of allogenic or autologous transplantation for hematological malignancies. Bone Marrow Transplant. 30, 629-635.
- Coppinger, J., Cagney, G., Toomey, S., 2004. Characterization proteins released from асtivated platelets leads to localization novel platelet proteins in human atherosclerotic lesions. Blood. 103, 2096-2104.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Basic Medical Sciences |
| Yazarlar | |
| Yayımlanma Tarihi | 6 Kasım 2014 |
| Gönderilme Tarihi | 25 Nisan 2014 |
| Yayımlandığı Sayı | Yıl 2014 Cilt: 31 Sayı: 3 |
Kaynak Göster
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.