Öz
Preeclampsia is a condition accompanied by elevated blood pressure and proteinuria thus suggestive of cardiac and renal dysfunctions. Plasma urea and plasma creatinine are known as gold standards that provide insights into kidney function and potential renal involvement in preeclampsia. In preeclamptic women, an elevation in plasma urea and creatinine levels can indicate impairment in kidney function and reduced glomerular filtration. Beta-2-microglobulin (B2M) is a protein found on the surface of body cells that is released into the blood stream as a result of normal cell turnover or certain disease processes. This study therefore aims to determine if Beta-2-microglobulin could be added to the gold standards in indicating that there is a nephropathy during preeclampsia. To do this, a prospective case-control research involving 190 women was carried out. They were divided into three groups: a preeclampsia group, a group which consisted of women with only pregnancy-induced hypertension (PIH); and a group of pregnant women with normal blood pressure. Analyses of demographic data, trimesters, severity of disease and Body Mass Index (BMI) data obtained showed that as the level of severity of preeclampsia increased, there was also a rise in the B2M levels. Perhaps, B2M levels could provide insights in the early determination of nephropathy during preeclampsia and also as an indicator for renal tubular dysfunction
Anahtar Kelimeler
Preeclampsia Beta-2-microglobulin Pregnancy-induced-hypertension Urea Creatinine
Kaynakça
- 1. Müller-Deile J, Schiffer M. Preeclampsia from a renal point of view: Insides into disease models biomarkers and therapy. World J Nephrol 2014; 3(4): 169-181. https://doi.org/10.5527/wjn.v3.i4.169
- 2. Moran P, Baylis PH, Lindheimer MD, Davison JM. Glomerular ultrafiltration in normal and preeclamptic pregnancy. Journal of the American Society of Nephrology, 2003;14(3) 648-652. https://doi.org/10.1097/01.asn.0000051724.66235.e0.
- 3. Maruyama Y, Nakayama M, Abe M, Yokoo T, Minakuchi J, Nitta K. Association between serum β2-microglobulin and mortality in Japanese peritoneal dialysis patients: A cohort study. PLoS ONE, 2022; 17(4): e0266882. https://doi.org/10.1371/journal.pone.0266882
- 4. Hill NR, Fatoba ST, Oke JL, Hirst JA, O'Callaghan CA, Lasserson DS, et al. Global Prevalence of Chronic Kidney Disease - A Systematic Review and Meta-Analysis. PLoS One. 2016 Jul 6;11(7):e0158765. doi: 10.1371/journal.pone.0158765.
- 5. Hladunewich MA, Derby GC. Renal disorders in pregnancy. In Brenner Rector’s The Kidney. Elsevier, 2016; pp 2065-2085
- 6. Pacarizi H, Begolli L, Lulaj S, Gafurri Z. Blood Urea Nitrogen/Creatinine index is a Predictor of Prerenal Damage in Preeclampsia. J Health Sci, 2012; 2 61-65.
- 7. Lequin RM. Enzyme immunoassay (EIA)/enzyme-linked immunosorbent assay (ELISA). Clin. Chem., 2005; 51(12):2415 - 2418.
- 8. Roccella EJ. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy, 2000; 183(1) s1–s22. https://doi.org/10.1067/mob.2000.107928
- 9. August P, Sibia BM. Preeclampsia: Clinical Features and Diagnosis. Uptodate.com. https://www.uptodate.com/contents/preeclampsia-clinical-features-and-diagnosis/[Accessed: 23 June 2023]; 2023
- 10. Thornton C, Makris A, Ogle R, Tooher J, Hennessy A. Role of proteinuria in defining pre-eclampsia: Clinical outcomes for women and babies. Clin Exp Pharmacol Physiol, 2010; 37(4) 466–470. https://doi.org/10.1111/j.1440-1681.2009.05334.x
- 11. Olson KN, Redman LM, Sones JL. Obesity “complements” preeclampsia. Physiological Genomics, 2019; 51(3): 73-76. Doi: 10.1152/physiolgenomics. 00102.2018
- 12. Jeyabalan A. Epidemiology of preeclampsia: impact of obesity. Nutr Rev, 2013; 71(1): S18-S25. Doi:10.1111/nure.12055
- 13. Gerchman F, Tong J, Utzschneider K. M, Zraika S, Udayasankar J, McNeely M. J et al. Body Mass Index is Associated with Increased Creatinine Clearance by a Mechanism Independent of Body Fat Distribution. J Clin Endocrinol Metab, 2009; 94(10): 3781–3788.
- 14. Ude UA, Kalu ME, Ogbonna CL, Usanga VU, Azi SO. Evaluation of urea creatinine levels and proteinuria among obese individuals within Abakaliki metropolis. Niger J Basic Clin Sci., 2022; 19:120-125.
- 15. Brouwers L, van der Meiden-van Roest AJ, Savelkoul C, Vogelvang TE, Lely AT, Franx A, et al. Recurrence of pre-eclampsia and the risk of future hypertension and cardiovascular disease: a systematic review and meta-analysis. BJOG. 2018 Dec;125(13):1642-1654. doi: 10.1111/1471-0528.15394.
- 16. Huppertz B, Kingdom J. Can placental pathology explain the progression from pre-eclampsia to HELLP syndrome? Acta Obstetricia et Gynecologica Scandinavica 2004; 83(10) 1085-1090.
- 17. Roberts JM, August PA. Preeclampsia: pathogenesis diagnosis and management. JAMA, 2019; 322(6) 579-586.
- 18. Roberts JM, Hubel CA. The two-stage model of preeclampsia: variations on the theme. Placenta, 1999; 20: S32-S37.
Öz
Kaynakça
- 1. Müller-Deile J, Schiffer M. Preeclampsia from a renal point of view: Insides into disease models biomarkers and therapy. World J Nephrol 2014; 3(4): 169-181. https://doi.org/10.5527/wjn.v3.i4.169
- 2. Moran P, Baylis PH, Lindheimer MD, Davison JM. Glomerular ultrafiltration in normal and preeclamptic pregnancy. Journal of the American Society of Nephrology, 2003;14(3) 648-652. https://doi.org/10.1097/01.asn.0000051724.66235.e0.
- 3. Maruyama Y, Nakayama M, Abe M, Yokoo T, Minakuchi J, Nitta K. Association between serum β2-microglobulin and mortality in Japanese peritoneal dialysis patients: A cohort study. PLoS ONE, 2022; 17(4): e0266882. https://doi.org/10.1371/journal.pone.0266882
- 4. Hill NR, Fatoba ST, Oke JL, Hirst JA, O'Callaghan CA, Lasserson DS, et al. Global Prevalence of Chronic Kidney Disease - A Systematic Review and Meta-Analysis. PLoS One. 2016 Jul 6;11(7):e0158765. doi: 10.1371/journal.pone.0158765.
- 5. Hladunewich MA, Derby GC. Renal disorders in pregnancy. In Brenner Rector’s The Kidney. Elsevier, 2016; pp 2065-2085
- 6. Pacarizi H, Begolli L, Lulaj S, Gafurri Z. Blood Urea Nitrogen/Creatinine index is a Predictor of Prerenal Damage in Preeclampsia. J Health Sci, 2012; 2 61-65.
- 7. Lequin RM. Enzyme immunoassay (EIA)/enzyme-linked immunosorbent assay (ELISA). Clin. Chem., 2005; 51(12):2415 - 2418.
- 8. Roccella EJ. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy, 2000; 183(1) s1–s22. https://doi.org/10.1067/mob.2000.107928
- 9. August P, Sibia BM. Preeclampsia: Clinical Features and Diagnosis. Uptodate.com. https://www.uptodate.com/contents/preeclampsia-clinical-features-and-diagnosis/[Accessed: 23 June 2023]; 2023
- 10. Thornton C, Makris A, Ogle R, Tooher J, Hennessy A. Role of proteinuria in defining pre-eclampsia: Clinical outcomes for women and babies. Clin Exp Pharmacol Physiol, 2010; 37(4) 466–470. https://doi.org/10.1111/j.1440-1681.2009.05334.x
- 11. Olson KN, Redman LM, Sones JL. Obesity “complements” preeclampsia. Physiological Genomics, 2019; 51(3): 73-76. Doi: 10.1152/physiolgenomics. 00102.2018
- 12. Jeyabalan A. Epidemiology of preeclampsia: impact of obesity. Nutr Rev, 2013; 71(1): S18-S25. Doi:10.1111/nure.12055
- 13. Gerchman F, Tong J, Utzschneider K. M, Zraika S, Udayasankar J, McNeely M. J et al. Body Mass Index is Associated with Increased Creatinine Clearance by a Mechanism Independent of Body Fat Distribution. J Clin Endocrinol Metab, 2009; 94(10): 3781–3788.
- 14. Ude UA, Kalu ME, Ogbonna CL, Usanga VU, Azi SO. Evaluation of urea creatinine levels and proteinuria among obese individuals within Abakaliki metropolis. Niger J Basic Clin Sci., 2022; 19:120-125.
- 15. Brouwers L, van der Meiden-van Roest AJ, Savelkoul C, Vogelvang TE, Lely AT, Franx A, et al. Recurrence of pre-eclampsia and the risk of future hypertension and cardiovascular disease: a systematic review and meta-analysis. BJOG. 2018 Dec;125(13):1642-1654. doi: 10.1111/1471-0528.15394.
- 16. Huppertz B, Kingdom J. Can placental pathology explain the progression from pre-eclampsia to HELLP syndrome? Acta Obstetricia et Gynecologica Scandinavica 2004; 83(10) 1085-1090.
- 17. Roberts JM, August PA. Preeclampsia: pathogenesis diagnosis and management. JAMA, 2019; 322(6) 579-586.
- 18. Roberts JM, Hubel CA. The two-stage model of preeclampsia: variations on the theme. Placenta, 1999; 20: S32-S37.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Kadın Hastalıkları ve Doğum |
| Bölüm | Research Article |
| Yazarlar | |
| Yayımlanma Tarihi | 3 Ocak 2024 |
| Gönderilme Tarihi | 23 Temmuz 2023 |
| Kabul Tarihi | 29 Ekim 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 40 Sayı: 4 |
Kaynak Göster
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