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Low-dose hydrogen sulfide ameliorates cisplatin-induced hepatotoxicity in rats

Yıl 2025, Cilt: 3 Sayı: 1, 8 - 18, 30.04.2025

Kudret Ensarioğlu Baktır , Mehmet Günata , Onural Özhan , Recep Bentli , Nigar Vardı , Yusuf Türköz , Azibe Yıldız , Ahmet Acet , Hakan Parlakpınar

https://doi.org/10.62425/rtpharma.1549787

Öz

Objective: Cisplatin (CIS) is non-specific to the cell cycle, has a cytotoxic effect, and is used in many cancers. The side effects of CIS, such as hepatotoxicity, seriously limit its clinical use. This experimental study aims to prevent hepatotoxicity, one of the clinical side effects that cisplatin may cause. At the same time, Hydrogen sulfide (H2S) will be applied prophylactically and therapeutically and its effect levels will be compared. This study aims to contribute to the literature by preventing dose restriction due to the hepatotoxicity side effect of cisplatin, which plays an important role in cancer treatment, by prophylactic application of H2S. Our study investigated the protective and therapeutic efficacy of sodium hydrosulfide (NaHS, a donor of H2S), which activates the antioxidant system on CIS-induced hepatotoxicity.
Method: Control (Vehicle), CIS (7.5 mg/kg CIS), H2S+CIS (10 µmol/kg NaHS+7.5 mg/kg CIS), CIS+H2S (7.5 mg/kg CIS+10 µmol/kg NaHS) groups were formed by using 35 rats in the study. At the end of the study, blood and liver tissue was taken, and histopathological and biochemical analyzes were performed.
Results: It was determined that sinusoidal dilatation and congestion increased significantly in the CIS group and decreased in the H2S+CIS and CIS+H2S groups. Likewise, glycogen loss occurred in the CIS group, and a significant improvement was observed in the H2S+CIS group. In addition, significant deterioration was detected in malondialdehyde, catalase, glutathione, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase values in the CIS group compared to the control group. In contrast, significant improvements were observed in both the H2S+CIS and CIS+H2S groups compared to the CIS group.
Conclusion: Both protective and therapeutic beneficial effects of H2S in CIS-induced hepatotoxicity were demonstrated by histopathological and biochemical analyses.

Anahtar Kelimeler

Cisplatin hepatotoxicity hydrogen sulfide oxidative stress rat

Etik Beyan

The study protocol was approved by the Ethics Committee on Animal Research (reference no: 2015/A-84) under the Faculty of Medicine, Inonu University, Malatya, Turkey.

Destekleyen Kurum

This work was supported by the [2209-A research grant from the Scientific and Technological Research Council of Turkey] under Grant [number 1919B011503776]

Kaynakça

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  • Aboraya, D. M., El Baz, A., Risha, E. F., & Abdelhamid, F. M. (2022). Hesperidin ameliorates cisplatin induced hepatotoxicity and attenuates oxidative damage, cell apoptosis, and inflammation in rats. Saudi Journal of Biological Sciences, 29(5), 3157–3166.
  • Ahmed, M. A. A. S. (2013). The protective effect of ginger (Zingiber officinale) against adriamycin-induced hepatotoxicity in rats: Histological study. Life Science Journal – Acta Zhengzhou University Overseas Edition, 10(1), 1412–1422.
  • Al-Malki, A. L., & Sayed, A. A. (2014). Thymoquinone attenuates cisplatin-induced hepatotoxicity via nuclear factor kappa-beta. BMC Complementary and Alternative Medicine, 14(1), 282.
  • Amirana, S., & Babby, J. (2015). A review of drug-induced liver injury. JNP – Journal for Nurse Practitioners, 11(2), 270–271.
  • Arslan, A. K., Yaşar, Ş., Çolak, C., & Yoloğlu, S. (2018). WSSPAS: An interactive web application for sample size and power analysis with R using Shiny. Turkiye Klinikleri Journal of Biostatistics, 10(3).
  • Auten, R. L., & Davis, J. M. (2009). Oxygen toxicity and reactive oxygen species: The devil is in the details. Pediatric Research, 66(2), 121–127.
  • Azarbarz, N., Shafiei Seifabadi, Z., Moaiedi, M. Z., & Mansouri, E. (2020). Assessment of the effect of sodium hydrogen sulfide (hydrogen sulfide donor) on cisplatin-induced testicular toxicity in rats. Environmental Science and Pollution Research International, 27(8), 8119–8128.
  • Bentli, R., Parlakpinar, H., Polat, A., Samdanci, E., Sarihan, M. E., & Sagir, M. (2013). Molsidomine prevents cisplatin-induced hepatotoxicity. Archives of Medical Research, 44(7), 521–528.
  • Bilgic, Y., Akbulut, S., Aksungur, Z., Erdemli, M. E., Ozhan, O., & Parlakpinar, H. (2018). Protective effect of dexpanthenol against cisplatin-induced hepatotoxicity. Experimental and Therapeutic Medicine, 16(5), 4049–4057.
  • Birk, J., Meyer, M., Aller, I., Hansen, H. G., Odermatt, A., Dick, T. P., ... (2013). Endoplasmic reticulum: Reduced and oxidized glutathione revisited. Journal of Cell Science, 126(Pt 7), 1604–1617.
  • Bitar, M. S., Nader, J., Al-Ali, W., Al Madhoun, A., Arefanian, H., & Al-Mulla, F. (2018). Hydrogen sulfide donor NaHS improves metabolism and reduces muscle atrophy in type 2 diabetes: Implication for understanding sarcopenic pathophysiology. Oxidative Medicine and Cellular Longevity, 2018, 6825452.
  • Cagin, Y. F., Erdogan, M. A., Sahin, N., Parlakpinar, H., Atayan, Y., Polat, A., ... (2015). Protective effects of apocynin on cisplatin-induced hepatotoxicity in rats. Archives of Medical Research, 46(7), 517–526.
  • Calvert, J. W., Coetzee, W. A., & Lefer, D. J. (2010). Novel insights into hydrogen sulfide–mediated cytoprotection. Antioxidants & Redox Signaling, 12(10), 1203–1217.
  • Chirino, Y. I., Sanchez-Gonzalez, D. J., Martinez-Martinez, C. M., Cruz, C., & Pedraza-Chaverri, J. (2008). Protective effects of apocynin against cisplatin-induced oxidative stress and nephrotoxicity. Toxicology, 245(1–2), 18–23.
  • Chu, G. (1994). Cellular responses to cisplatin. Journal of Biological Chemistry, 269, 787–790. Cohen, A. R., Cox, A. G., & Goessling, W. (2013). Hydrogen sulfide (H₂S) regulates liver development and protects from acetaminophen (APAP)-induced liver injury in zebrafish. Gastroenterology, 5(144), S-912.
  • Coskun, O., Oztopuz, O., & Buyuk, B. (2021). Possible protective activity of N-acetyl cysteine against cisplatin-induced hepatotoxicity in rats. Molecular Biology Reports, 48(1), 637–644.
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  • Darwish, M. A., Abo-Youssef, A. M., Khalaf, M. M., Abo-Saif, A. A., Saleh, I. G., & Abdelghany, T. M. (2017). Vitamin E mitigates cisplatin-induced nephrotoxicity due to reversal of oxidative/nitrosative stress, suppression of inflammation and reduction of total renal platinum accumulation. Journal of Biochemical and Molecular Toxicology, 31(1), 1–9.
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  • Eisa, N. H., El-Sherbiny, M., & Abo El-Magd, N. F. (2021). Betulin alleviates cisplatin-induced hepatic injury in rats: Targeting apoptosis and Nek7-independent NLRP3 inflammasome pathways. International Immunopharmacology, 99, 107925.
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Yıl 2025, Cilt: 3 Sayı: 1, 8 - 18, 30.04.2025

Kudret Ensarioğlu Baktır , Mehmet Günata , Onural Özhan , Recep Bentli , Nigar Vardı , Yusuf Türköz , Azibe Yıldız , Ahmet Acet , Hakan Parlakpınar

https://doi.org/10.62425/rtpharma.1549787

Öz

Kaynakça

  • Abd Rashid, N., Abd Halim, S. A. S., Teoh, S. L., Budin, S. B., Hussan, F., Adib Ridzuan, N. R., ... (2021). The role of natural antioxidants in cisplatin-induced hepatotoxicity. Biomedicine & Pharmacotherapy, 144, 112328.
  • Aboraya, D. M., El Baz, A., Risha, E. F., & Abdelhamid, F. M. (2022). Hesperidin ameliorates cisplatin induced hepatotoxicity and attenuates oxidative damage, cell apoptosis, and inflammation in rats. Saudi Journal of Biological Sciences, 29(5), 3157–3166.
  • Ahmed, M. A. A. S. (2013). The protective effect of ginger (Zingiber officinale) against adriamycin-induced hepatotoxicity in rats: Histological study. Life Science Journal – Acta Zhengzhou University Overseas Edition, 10(1), 1412–1422.
  • Al-Malki, A. L., & Sayed, A. A. (2014). Thymoquinone attenuates cisplatin-induced hepatotoxicity via nuclear factor kappa-beta. BMC Complementary and Alternative Medicine, 14(1), 282.
  • Amirana, S., & Babby, J. (2015). A review of drug-induced liver injury. JNP – Journal for Nurse Practitioners, 11(2), 270–271.
  • Arslan, A. K., Yaşar, Ş., Çolak, C., & Yoloğlu, S. (2018). WSSPAS: An interactive web application for sample size and power analysis with R using Shiny. Turkiye Klinikleri Journal of Biostatistics, 10(3).
  • Auten, R. L., & Davis, J. M. (2009). Oxygen toxicity and reactive oxygen species: The devil is in the details. Pediatric Research, 66(2), 121–127.
  • Azarbarz, N., Shafiei Seifabadi, Z., Moaiedi, M. Z., & Mansouri, E. (2020). Assessment of the effect of sodium hydrogen sulfide (hydrogen sulfide donor) on cisplatin-induced testicular toxicity in rats. Environmental Science and Pollution Research International, 27(8), 8119–8128.
  • Bentli, R., Parlakpinar, H., Polat, A., Samdanci, E., Sarihan, M. E., & Sagir, M. (2013). Molsidomine prevents cisplatin-induced hepatotoxicity. Archives of Medical Research, 44(7), 521–528.
  • Bilgic, Y., Akbulut, S., Aksungur, Z., Erdemli, M. E., Ozhan, O., & Parlakpinar, H. (2018). Protective effect of dexpanthenol against cisplatin-induced hepatotoxicity. Experimental and Therapeutic Medicine, 16(5), 4049–4057.
  • Birk, J., Meyer, M., Aller, I., Hansen, H. G., Odermatt, A., Dick, T. P., ... (2013). Endoplasmic reticulum: Reduced and oxidized glutathione revisited. Journal of Cell Science, 126(Pt 7), 1604–1617.
  • Bitar, M. S., Nader, J., Al-Ali, W., Al Madhoun, A., Arefanian, H., & Al-Mulla, F. (2018). Hydrogen sulfide donor NaHS improves metabolism and reduces muscle atrophy in type 2 diabetes: Implication for understanding sarcopenic pathophysiology. Oxidative Medicine and Cellular Longevity, 2018, 6825452.
  • Cagin, Y. F., Erdogan, M. A., Sahin, N., Parlakpinar, H., Atayan, Y., Polat, A., ... (2015). Protective effects of apocynin on cisplatin-induced hepatotoxicity in rats. Archives of Medical Research, 46(7), 517–526.
  • Calvert, J. W., Coetzee, W. A., & Lefer, D. J. (2010). Novel insights into hydrogen sulfide–mediated cytoprotection. Antioxidants & Redox Signaling, 12(10), 1203–1217.
  • Chirino, Y. I., Sanchez-Gonzalez, D. J., Martinez-Martinez, C. M., Cruz, C., & Pedraza-Chaverri, J. (2008). Protective effects of apocynin against cisplatin-induced oxidative stress and nephrotoxicity. Toxicology, 245(1–2), 18–23.
  • Chu, G. (1994). Cellular responses to cisplatin. Journal of Biological Chemistry, 269, 787–790. Cohen, A. R., Cox, A. G., & Goessling, W. (2013). Hydrogen sulfide (H₂S) regulates liver development and protects from acetaminophen (APAP)-induced liver injury in zebrafish. Gastroenterology, 5(144), S-912.
  • Coskun, O., Oztopuz, O., & Buyuk, B. (2021). Possible protective activity of N-acetyl cysteine against cisplatin-induced hepatotoxicity in rats. Molecular Biology Reports, 48(1), 637–644.
  • Crosas-Molist, E., & Fabregat, I. (2015). Role of NADPH oxidases in the redox biology of liver fibrosis. Redox Biology, 6, 106–111.
  • Darwish, M. A., Abo-Youssef, A. M., Khalaf, M. M., Abo-Saif, A. A., Saleh, I. G., & Abdelghany, T. M. (2017). Vitamin E mitigates cisplatin-induced nephrotoxicity due to reversal of oxidative/nitrosative stress, suppression of inflammation and reduction of total renal platinum accumulation. Journal of Biochemical and Molecular Toxicology, 31(1), 1–9.
  • De Bruijn, N. G. (1981). Asymptotic methods in analysis. Courier Corporation. Dickinson, D. A., Iles, K. E., Zhang, H., Blank, V., & Forman, H. J. (2003). Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. FASEB Journal, 17(3), 473–475.
  • Eisa, N. H., El-Sherbiny, M., & Abo El-Magd, N. F. (2021). Betulin alleviates cisplatin-induced hepatic injury in rats: Targeting apoptosis and Nek7-independent NLRP3 inflammasome pathways. International Immunopharmacology, 99, 107925.
  • El-Gizawy, M. M., Hosny, E. N., Mourad, H. H., & Abd-El Razik, A. N. (2020). Curcumin nanoparticles ameliorate hepatotoxicity and nephrotoxicity induced by cisplatin in rats. Naunyn-Schmiedeberg’s Archives of Pharmacology, 393(10), 1941–1953.
  • Ellman, G. L. (1959). Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics, 82(1), 70–77.
  • Farooqui, Z., Afsar, M., Rizwan, S., Khan, A. A., & Khan, F. (2016). Oral administration of Nigella sativa oil ameliorates the effect of cisplatin on membrane enzymes, carbohydrate metabolism and oxidative damage in rat liver. Toxicology Reports, 3, 328–335.
  • Fathy, M., Darwish, M. A., Abdelhamid, A. M., Alrashedy, G. M., Othman, O. A., Naseem, M., ... (2022). Kinetin ameliorates cisplatin-induced hepatotoxicity and lymphotoxicity via attenuating oxidative damage, cell apoptosis and inflammation in rats. Biomedicines, 10(7), 1620.
  • Fatima, S., Suhail, N., Alrashed, M., Wasi, S., Aljaser, F. S., AlSubki, R. A., ... (2021). Epigallocatechin gallate and coenzyme Q10 attenuate cisplatin-induced hepatotoxicity in rats via targeting mitochondrial stress and apoptosis. Journal of Biochemical and Molecular Toxicology, 35(4), e22701.
  • Feng, X., Zhang, H., Shi, M., Chen, Y., Yang, T., & Fan, H. (2020). Toxic effects of hydrogen sulfide donor NaHS induced liver apoptosis is regulated by complex IV subunits and reactive oxygen species generation in rats. Environmental Toxicology, 35(3), 322–332.
  • Fu, M., Zhang, W., Wu, L., Yang, G., Li, H., & Wang, R. (2012). Hydrogen sulfide (H₂S) metabolism in mitochondria and its regulatory role in energy production. Proceedings of the National Academy of Sciences of the United States of America, 109(8), 2943–2948.
  • Gao, C., Liu, C., Chen, Y., Wang, Q., & Hao, Z. (2021). Protective effects of natural products against drug-induced nephrotoxicity: A review in recent years. Food and Chemical Toxicology, 153, 112255.
  • Garcia-Cortes, M., Robles-Diaz, M., Stephens, C., Ortega-Alonso, A., Lucena, M. I., & Andrade, R. J. (2020). Drug induced liver injury: An update. Archives of Toxicology, 94(10), 3381–3407.
  • Gunata, M., & Parlakpinar, H. (2021). A review of myocardial ischaemia/reperfusion injury: Pathophysiology, experimental models, biomarkers, genetics and pharmacological treatment. Cell Biochemistry and Function, 39(2), 190–217.
  • Hashmi, S. F., Rathore, H. A., Sattar, M. A., Johns, E. J., Gan, C. Y., Chia, T. Y., ... (2021). Hydrogen sulphide treatment prevents renal ischemia-reperfusion injury by inhibiting the expression of ICAM-1 and NF-kB concentration in normotensive and hypertensive rats. Biomolecules, 11(10), 1549.
  • Hassan, H. M., Al-Wahaibi, L. H., Elmorsy, M. A., & Mahran, Y. F. (2020). Suppression of cisplatin-induced hepatic injury in rats through alarmin high-mobility group box-1 pathway by Ganoderma lucidum: Theoretical and experimental study. Drug Design, Development and Therapy, 14, 2335–2353.
  • Hwang, D. B., Won, D. H., Shin, Y. S., Kim, S. Y., Kang, B. C., Lim, K. M., ... (2020). Ccrn4l as a pre-dose marker for prediction of cisplatin-induced hepatotoxicity susceptibility. Free Radical Biology and Medicine, 148, 128–139.
  • Ibrahim, S. A., Abdel-Gaber, S. A., Ibrahim, M. A., Amin, E. F., Mohammed, R. K., & Abdelrahman, A. M. (2022). Nitric oxide modulation as a potential molecular mechanism underlying the protective role of NaHS in liver ischemia reperfusion injury. Current Molecular Pharmacology, 15(4), 676–682.
  • Ijaz, M. U., Ashraf, A., Ahmed, A., Ismail, H., Muzzamil, S., Samad, A., ... (2020). Remedial effects of casticin as an antioxidant on cisplatin induced oxidative damage in rat liver. Journal of King Saud University – Science, 32(1), 1100–1105.
  • Karimi, A., Absalan, F., Khorsandi, L., Valizadeh, A., & Mansouri, E. (2017). Sodium hydrogen sulfide (NaHS) ameliorates alterations caused by cisplatin in filtration slit diaphragm and podocyte cytoskeletal in rat kidney. Journal of Nephropathology, 6(3), 150–156.
  • Kimura, H. (2014). The physiological role of hydrogen sulfide and beyond. Nitric Oxide, 41, 4–10.
  • Ko, J. W., Lee, I. C., Park, S. H., Moon, C., Kang, S. S., Kim, S. H., ... (2014). Protective effects of pine bark extract against cisplatin-induced hepatotoxicity and oxidative stress in rats. Laboratory Animal Research, 30(4), 174–180.
  • Koroglu, O. F., Gunata, M., Vardi, N., Yildiz, A., Ates, B., Colak, C., ... (2021). Protective effects of naringin on valproic acid-induced hepatotoxicity in rats. Tissue and Cell, 72, 101526.
  • Kwon, K. W., Nam, Y., Choi, W. S., Kim, T. W., Kim, G. M., & Sohn, U. D. (2019). Hepatoprotective effect of sodium hydrosulfide on hepatic encephalopathy in rats. Korean Journal of Physiology and Pharmacology, 23(4), 263–270.
  • Li, G., Xie, Z. Z., Chua, J. M., Wong, P. C., & Bian, J. (2015). Hydrogen sulfide protects testicular germ cells against heat-induced injury. Nitric Oxide, 46, 165–171.
  • Li, S., Shi, M., Wang, Y., Xiao, Y., Cai, D., & Xiao, F. (2021). Keap1-Nrf2 pathway up-regulation via hydrogen sulfide mitigates polystyrene microplastics induced-hepatotoxic effects. Journal of Hazardous Materials, 402, 123933.
  • Lu, Y., & Cederbaum, A. I. (2006). Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1. Toxicological Sciences, 89(2), 515–523.
  • Maheshwari, R., Sailor, G., Sen, A., & Balaraman, R. (2015). Amelioration of cisplatin-induced hepatotoxicity by statins in rats. The Journal of Integrated Health Sciences, 3(1), 21–27.
  • Man, Q., Deng, Y., Li, P., Ma, J., Yang, Z., Yang, X., ... (2020). Licorice ameliorates cisplatin-induced hepatotoxicity through antiapoptosis, antioxidative stress, anti-inflammation, and acceleration of metabolism. Frontiers in Pharmacology, 11, 563750.
  • Mihara, M., & Uchiyama, M. (1978). Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Analytical Biochemistry, 86(1), 271–278.
  • Neamatallah, T., El-Shitany, N. A., Abbas, A. T., Ali, S. S., & Eid, B. G. (2018). Honey protects against cisplatin-induced hepatic and renal toxicity through inhibition of NF-κB-mediated COX-2 expression and the oxidative stress dependent BAX/Bcl-2/caspase-3 apoptotic pathway. Food & Function, 9(7), 3743–3754.
  • Omar, H. A., Mohamed, W. R., Arab, H. H., & Arafa, E. S. A. (2016). Tangeretin alleviates cisplatin-induced acute hepatic injury in rats: Targeting MAPKs and apoptosis. PLoS ONE, 11(3), e0151649.
  • Otunctemur, A., Ozbek, E., Dursun, M., Sahin, S., Besiroglu, H., & Ozsoy, O. D. (2014). Protective effect of hydrogen sulfide on gentamicin-induced renal injury. Renal Failure, 36(6), 925–931.
  • Paglia, D. E., & Valentine, W. N. (1967). Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. The Journal of Laboratory and Clinical Medicine, 70(1), 158–169.
  • Pan, T. T., Chen, Y. Q., & Bian, J. S. (2009). All in the timing: A comparison between the cardioprotection induced by H₂S preconditioning and post-infarction treatment. European Journal of Pharmacology, 616(1–3), 160–165.
  • Paul, B. D., & Snyder, S. H. (2018). Gasotransmitter hydrogen sulfide signaling in neuronal health and disease. Biochemical Pharmacology, 149, 101–109.
  • Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., ... (2020). The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. Journal of Cerebral Blood Flow & Metabolism, 40(9), 1769–1777.
  • Peres, L. A., & da Cunha, A. D., Jr. (2013). Acute nephrotoxicity of cisplatin: Molecular mechanisms. Jornal Brasileiro de Nefrologia, 35(4), 332–340.
  • Pratibha, R., Sameer, R., Rataboli, P. V., Bhiwgade, D. A., & Dhume, C. Y. (2006). Enzymatic studies of cisplatin-induced oxidative stress in hepatic tissue of rats. European Journal of Pharmacology, 532(3), 290–293.
  • Sherif, I. O. (2021). Hepatoprotective effect of arjunolic acid against cisplatin-induced hepatotoxicity: Targeting oxidative stress, inflammation, and apoptosis. Journal of Biochemical and Molecular Toxicology, 35(4), e22714.
  • Sioud, F., Ben Toumia, I., Lahmer, A., Khlifi, R., Dhaouefi, Z., & Maatouk, M., ... (2020). Methanolic extract of Ephedra alata ameliorates cisplatin-induced nephrotoxicity and hepatotoxicity through reducing oxidative stress and genotoxicity. Environmental Science and Pollution Research International, 27(11), 12792–12801.
  • Sun, Y., Oberley, L. W., & Li, Y. (1988). A simple method for clinical assay of superoxide dismutase. Clinical Chemistry, 34(3), 497–500.
  • Taghizadeh, F., Hosseinimehr, S. J., Zargari, M., Karimpour Malekshah, A., Mirzaei, M., & Talebpour Amiri, F. (2021). Alleviation of cisplatin-induced hepatotoxicity by gliclazide: Involvement of oxidative stress and caspase-3 activity. Pharmacology Research & Perspectives, 9(3), e00788.
  • Trefts, E., Gannon, M., & Wasserman, D. H. (2017). The liver. Current Biology, 27(21), R1147–R1151.
  • Tu, F. P., Li, J. X., Li, Q., & Wang, J. (2016). Effects of hydrogen sulfide on cognitive dysfunction and NR2B in rats. Journal of Surgical Research, 205(2), 426–431.
  • Wang, P., Chen, F., Wang, W., & Zhang, X. D. (2019). Hydrogen sulfide attenuates high glucose-induced human retinal pigment epithelial cell inflammation by inhibiting ROS formation and NLRP3 inflammasome activation. Mediators of Inflammation, 2019, 8908960.
  • Wang, X., Li, S., Wei, C.-C., Huang, J., Pan, M.-H., Shahidi, F., ... (2018). Anti-inflammatory effects of polymethoxyflavones from citrus peels: A review. Journal of Food Bioactives, 3, 76–86.
  • Wang, Y., Kuang, X., Yin, Y., Han, N., Chang, L., Wang, H., ... (2022). Tongxinluo prevents chronic obstructive pulmonary disease complicated with atherosclerosis by inhibiting ferroptosis and protecting against pulmonary microvascular barrier dysfunction. Biomedicine & Pharmacotherapy, 145, 112367.
  • Yan, Y., Chen, C., Zhou, H., Gao, H., Chen, L., & Chen, L., ... (2013). Endogenous hydrogen sulfide formation mediates the liver damage in endotoxemic rats. Research in Veterinary Science, 94(3), 590–595.
  • Ye, M., Yu, M., Yang, D., Li, J., Wang, H., & Chen, F., ... (2020). Exogenous hydrogen sulfide donor NaHS alleviates nickel-induced epithelial-mesenchymal transition and the migration of A549 cells by regulating TGF-beta1/Smad2/Smad3 signaling. Ecotoxicology and Environmental Safety, 195, 110464.
  • Yi, J., Yuan, Y., Zheng, J., & Zhao, T. (2019). Hydrogen sulfide alleviates uranium-induced rat hepatocyte cytotoxicity via inhibiting Nox4/ROS/p38 MAPK pathway. Journal of Biochemical and Molecular Toxicology, 33(3), e22255.
  • Yuan, Y., Zheng, J., Zhao, T., Tang, X., & Hu, N. (2017). Hydrogen sulfide alleviates uranium-induced acute hepatotoxicity in rats: Role of antioxidant and antiapoptotic signaling. Environmental Toxicology, 32(2), 581–593.
Toplam 69 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Tıbbi Farmakoloji
Bölüm Research Articles
Yazarlar

Kudret Ensarioğlu Baktır 0000-0001-5573-0084

Mehmet Günata 0000-0001-6905-4259

Onural Özhan 0000-0001-9018-7849

Recep Bentli 0000-0002-7205-0379

Nigar Vardı 0000-0003-0576-1696

Yusuf Türköz 0000-0001-5401-0720

Azibe Yıldız 0000-0001-5686-7867

Ahmet Acet 0000-0003-1131-1878

Hakan Parlakpınar 0000-0001-9497-3468

Yayımlanma Tarihi 30 Nisan 2025
Gönderilme Tarihi 23 Eylül 2024
Kabul Tarihi 17 Nisan 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 3 Sayı: 1

Kaynak Göster

APA Ensarioğlu Baktır, K., Günata, M., Özhan, O., Bentli, R., vd. (2025). Low-dose hydrogen sulfide ameliorates cisplatin-induced hepatotoxicity in rats. Recent Trends in Pharmacology, 3(1), 8-18. https://doi.org/10.62425/rtpharma.1549787
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