Evaluating the Role of Disease Duration in Fatigue and Quality of Life Among Rheumatoid Arthritis Patients
Öz
Objective: The duration of a disease plays a critical role in understanding its progression and impact on an individual's quality of life and symptom severity. The aim was to investigate the impact of disease duration on fatigue and quality of life in patients with rheumatoid arthritis (RA).
Material and Methods: The study analyzed 92 (female:71, male:21) patients with RA. Clinical and demographic characteristics of patients were recorded. Disease activity (Disease Activity Score in 28 joints with CRP (DAS28-CRP)), fatigue (Bristol Rheumatoid Arthritis Fatigue-Multidimensional Questionnaire (BRAF-MDQ)), and quality of life (Short Form-36 questionnaire (SF-36)) were evaluated in the study. RA patients were categorized into two groups based on the disease duration: duration of the disease <10 years and duration of the disease >10 years.
Results: Significant differences were demonstrated in SF-36 subdomains of pain (p=0.022), general health (p=0.028), and health change (p=0.020). However, BRAF-MDQ scores and its subdomains showed no significant differences across groups.
Conclusion: While the duration of RA significantly affects certain aspects of quality of life such as pain and general health, it does not appear to influence fatigue levels. This highlights the persistent and debilitating nature of fatigue in RA patients regardless of disease duration, emphasizing the need for targeted interventions to address this symptom.
Anahtar Kelimeler
Rheumatoid arthritis fatigue quality of life disease duration
Etik Beyan
The study received approval from the Bingol University Ethics Committee (dated:16/04/2024, no:24/9), in accordance with the principles outlined in the Helsinki Declaration. The study was carried out at the Clinic of Rheumatology, Ankara Etlik City Hospital. Before beginning this study, all patients signed an informed consent form.
Destekleyen Kurum
None
Teşekkür
Thank you to all our patients who completed the study.
Kaynakça
- 1. van Lankveld W, Näring G, Bosch PvtP, van de Putte L. The negative effect of decreasing the level of activity in coping with pain in rheumatoid arthritis: an increase in psychological distress and disease impact. J Behav Med. 2020;23:377-391.
- 2. Aletaha D, Landewe R, Karonitsch T, Bathon J, Boers M, Bombardier C, et al. Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations. Ann Rheum Dis. 2008;59(10):1371-1377.
- 3. Wolfe F, Hawley DJ, Wilson K. The prevalence and meaning of fatigue in rheumatic disease. J Rheumatol. 1996;23(8):1407-1417.
- 4. Santos EJ, Duarte C, da Silva JA, Ferreira RJ. The impact of fatigue in rheumatoid arthritis and the challenges of its assessment. Rheumatology. 2019;58(Supplement_5):v3-v9.
- 5. Van-Hoogmoed D, Fransen J, Bleijenberg G, Van-Riel P. 2010. Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis. Rheumatology. 2010;49(7):1294-1302.
- 6. van Steenbergen HW, Tsonaka R, Huizinga TW, Boonen A, van der Helm-van AH. 2015. Fatigue in rheumatoid arthritis; a persistent problem: a large longitudinal study. RMD Open. 2015;1(1):e000041.
- 7. Benjamin O, Goyal A, Lappin SL. Disease modifying anti-rheumatic drugs (DMARD). 2018.
- 8. Goma SH, Razek MRA, Abdelbary NM. Impact of rheumatoid arthritis on the quality of life and its relation to disease activity. Egypt Rheumatol Rehabil. 2019;46:304-312.
- 9. Machin AR, Babatunde O, Haththotuwa R, Scott I, Blagojevic-Bucknall M, Corp N, et al. The association between anxiety and disease activity and quality of life in rheumatoid arthritis: a systematic review and meta-analysis. Clin Rheumatol. 2020;39:1471-1482.
- 10. Fausto S, Marina C, Sonia F, Alessandro C, Marwin G. 2018. The impact of different rheumatic diseases on health-related quality of life: a comparison with a selected sample of healthy individuals using SF-36 questionnaire, EQ-5D and SF-6D utility values. Acta Biomed. 2018;89(4):541-557.
- 11. Kim J-W, Suh C-H. Systemic manifestations and complications in patients with rheumatoid arthritis. MDPI. 2008.
- 12. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO, et al. Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62(9):2569-2581.
- 13. Aletaha D, Smolen JS. Joint damage in rheumatoid arthritis progresses in remission according to the Disease Activity Score in 28 joints and is driven by residual swollen joints. Arthritis Rheum. 2011;63(12):3702-3711.
- 14. Birrell FN, Hassell AB, Jones PW, Dawes PT. How does the short form 36 health questionnaire (SF-36) in rheumatoid arthritis (RA) relate to RA outcome measures and SF-36 population values? A cross-sectional study. Clin Rheumatol. 2000;19(3):195-199.
- 15. Sari F, Oskay D, Tufan A. Reliability, validity, and cross-cultural adaptation of the Turkish version of the Bristol Rheumatoid Arthritis Fatigue Multi-Dimensional Questionnaire. Clin Rheumatol. 2018;37(6):1465-1470.
- 16. Brazier JE, Harper R, Jones NM, O'Cathain A, Thomas KJ, Usherwood T, et al. Validating the SF-36 health survey questionnaire: new outcome measure for primary care. BMJ. 1992;305(6846):160-164.
- 17. Kaya BB, İçağasıoğlu A. Reliability and validity of the Turkish version of short form 36 (SF-36) in patients with rheumatoid arthritis. JOSAM. 2018;2(1):11-16.
- 18. Nicklin J, Cramp F, Kirwan J, Greenwood R, Urban M, Hewlett S. Measuring fatigue in rheumatoid arthritis: a cross-sectional study to evaluate the Bristol Rheumatoid Arthritis Fatigue Multi-Dimensional questionnaire, visual analog scales, and numerical rating scales. Arthritis Care Res (Hoboken). 2010;62(11):1559-1568.
- 19. Matcham F, Scott IC, Rayner L, Hotopf M, Kingsley GH, Norton S, et al. The impact of rheumatoid arthritis on quality-of-life assessed using the SF-36: a systematic review and meta-analysis. Semin Arthritis Rheum. 2014;44(2):123-130.
- 20. Kiebles JL, Doerfler B, Keefer L. Preliminary evidence supporting a framework of psychological adjustment to inflammatory bowel disease. Inflamm Bowel Dis. 2010;16(10):1685-1695.
- 21. Hillsdon MM, Brunner EJ, Guralnik JM, Marmot MG. Prospective study of physical activity and physical function in early old age. Am J Prev Med. 2005;28(3):245-251.
- 22. Barlow JH, Cullen LA, Rowe I. Comparison of knowledge and psychological well-being between patients with a short disease duration (≤ 1 year) and patients with more established rheumatoid arthritis (≥ 10 years duration). Patient Educ Couns. 1999;38(3):195-203.
- 23. Belza BL, Henke CJ, Yelin EH, Epstein WV, Gilliss CL. Correlates of fatigue in older adults with rheumatoid arthritis. Nurs Res. 1993;42(2):93-99.
- 24. Huyser BA, Parker JC, Thoreson R, Smarr KL, Johnson JC, Hoffman R. Predictors of subjective fatigue among individuals with rheumatoid arthritis. Arthritis Rheum. 1998;41(12):2230-2234.
- 25. Pollard L, Choy E, Gonzalez J, Khoshaba B, Scott D. Fatigue in rheumatoid arthritis reflects pain, not disease activity. Rheumatology. 2006;45(7):885-889.
- 26. Fifield J, McQuillan J, Tennen H, Sheehan TJ, Reisine S, Hesselbrock V, et al. History of affective disorder and the temporal trajectory of fatigue in rheumatoid arthritis. Ann Behav Med. 2001;23(1):34-41.
- 27. Scharloo M, Kaptein A, Weinman J, Hazes J, Breedveld F, Rooijmans H. Predicting functional status in patients with rheumatoid arthritis. J Rheumatol. 1999;26(8):1686-1693.
- 28. Nikolaus S, Bode C, Taal E, van de Laar MA. Fatigue and factors related to fatigue in rheumatoid arthritis: a systematic review. Arthritis Care Res. 2013;65(7):1128-1146.
Romatoid Artrit Hastalarında Hastalık Süresinin Yorgunluk ve Yaşam Kalitesi Üzerindeki Rolünün Değerlendirilmesi
Öz
Amaç: Hastalık süresi, hastalığın ilerleyişini ve hastaların yaşam kalitesi ile semptom şiddeti üzerindeki etkilerini anlamada kritik bir rol oynamaktadır. Bu çalışmanın amacı, romatoid artrit (RA) hastalarında hastalık süresinin yorgunluk ve yaşam kalitesi üzerindeki etkisinin araştırılmasıdır.
Materyal ve Metot: Enine kesitsel çalışmada, 92 (kadın:71, erkek:21) RA hastası analiz edildi. Hastaların klinik ve demografik özellikleri kaydedildi. Hastalık aktivitesi (Hastalık Aktivite Skoru (DAS28)), yorgunluk (Bristol Romatoid Artrit Yorgunluk-Multidimensional Anketi (BRAF-MDQ)) ve yaşam kalitesi (Kısa Form-36 anketi (SF-36)) değerlendirildi. RA hastaları hastalık süresine göre iki gruba ayrıldı: hastalık süresi <10 yıl ve hastalık süresi >10 yıl.
Bulgular: SF-36 alt alanları olan ağrı (p=0,022), genel sağlık (p=0,028) ve sağlık değişimi (p=0,020) açısından anlamlı farklar bulundu. Ancak, BRAF-MDQ skorları ve alt alanları gruplar arasında anlamlı fark göstermedi.
Sonuç: RA hastalarında hastalık süresi, ağrı ve genel sağlık gibi bazı yaşam kalitesi alanlarını önemli ölçüde etkilerken, yorgunluk seviyelerini etkilemediği bulundu. Bu durum, RA hastalarında yorgunluğun sürekli ve zayıflatıcı doğasını vurgulamakta ve bu semptomu ele alacak hedefe yönelik müdahalelerin gerekliliğini ortaya koymaktadır.
Anahtar Kelimeler
Kaynakça
- 1. van Lankveld W, Näring G, Bosch PvtP, van de Putte L. The negative effect of decreasing the level of activity in coping with pain in rheumatoid arthritis: an increase in psychological distress and disease impact. J Behav Med. 2020;23:377-391.
- 2. Aletaha D, Landewe R, Karonitsch T, Bathon J, Boers M, Bombardier C, et al. Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations. Ann Rheum Dis. 2008;59(10):1371-1377.
- 3. Wolfe F, Hawley DJ, Wilson K. The prevalence and meaning of fatigue in rheumatic disease. J Rheumatol. 1996;23(8):1407-1417.
- 4. Santos EJ, Duarte C, da Silva JA, Ferreira RJ. The impact of fatigue in rheumatoid arthritis and the challenges of its assessment. Rheumatology. 2019;58(Supplement_5):v3-v9.
- 5. Van-Hoogmoed D, Fransen J, Bleijenberg G, Van-Riel P. 2010. Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis. Rheumatology. 2010;49(7):1294-1302.
- 6. van Steenbergen HW, Tsonaka R, Huizinga TW, Boonen A, van der Helm-van AH. 2015. Fatigue in rheumatoid arthritis; a persistent problem: a large longitudinal study. RMD Open. 2015;1(1):e000041.
- 7. Benjamin O, Goyal A, Lappin SL. Disease modifying anti-rheumatic drugs (DMARD). 2018.
- 8. Goma SH, Razek MRA, Abdelbary NM. Impact of rheumatoid arthritis on the quality of life and its relation to disease activity. Egypt Rheumatol Rehabil. 2019;46:304-312.
- 9. Machin AR, Babatunde O, Haththotuwa R, Scott I, Blagojevic-Bucknall M, Corp N, et al. The association between anxiety and disease activity and quality of life in rheumatoid arthritis: a systematic review and meta-analysis. Clin Rheumatol. 2020;39:1471-1482.
- 10. Fausto S, Marina C, Sonia F, Alessandro C, Marwin G. 2018. The impact of different rheumatic diseases on health-related quality of life: a comparison with a selected sample of healthy individuals using SF-36 questionnaire, EQ-5D and SF-6D utility values. Acta Biomed. 2018;89(4):541-557.
- 11. Kim J-W, Suh C-H. Systemic manifestations and complications in patients with rheumatoid arthritis. MDPI. 2008.
- 12. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO, et al. Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62(9):2569-2581.
- 13. Aletaha D, Smolen JS. Joint damage in rheumatoid arthritis progresses in remission according to the Disease Activity Score in 28 joints and is driven by residual swollen joints. Arthritis Rheum. 2011;63(12):3702-3711.
- 14. Birrell FN, Hassell AB, Jones PW, Dawes PT. How does the short form 36 health questionnaire (SF-36) in rheumatoid arthritis (RA) relate to RA outcome measures and SF-36 population values? A cross-sectional study. Clin Rheumatol. 2000;19(3):195-199.
- 15. Sari F, Oskay D, Tufan A. Reliability, validity, and cross-cultural adaptation of the Turkish version of the Bristol Rheumatoid Arthritis Fatigue Multi-Dimensional Questionnaire. Clin Rheumatol. 2018;37(6):1465-1470.
- 16. Brazier JE, Harper R, Jones NM, O'Cathain A, Thomas KJ, Usherwood T, et al. Validating the SF-36 health survey questionnaire: new outcome measure for primary care. BMJ. 1992;305(6846):160-164.
- 17. Kaya BB, İçağasıoğlu A. Reliability and validity of the Turkish version of short form 36 (SF-36) in patients with rheumatoid arthritis. JOSAM. 2018;2(1):11-16.
- 18. Nicklin J, Cramp F, Kirwan J, Greenwood R, Urban M, Hewlett S. Measuring fatigue in rheumatoid arthritis: a cross-sectional study to evaluate the Bristol Rheumatoid Arthritis Fatigue Multi-Dimensional questionnaire, visual analog scales, and numerical rating scales. Arthritis Care Res (Hoboken). 2010;62(11):1559-1568.
- 19. Matcham F, Scott IC, Rayner L, Hotopf M, Kingsley GH, Norton S, et al. The impact of rheumatoid arthritis on quality-of-life assessed using the SF-36: a systematic review and meta-analysis. Semin Arthritis Rheum. 2014;44(2):123-130.
- 20. Kiebles JL, Doerfler B, Keefer L. Preliminary evidence supporting a framework of psychological adjustment to inflammatory bowel disease. Inflamm Bowel Dis. 2010;16(10):1685-1695.
- 21. Hillsdon MM, Brunner EJ, Guralnik JM, Marmot MG. Prospective study of physical activity and physical function in early old age. Am J Prev Med. 2005;28(3):245-251.
- 22. Barlow JH, Cullen LA, Rowe I. Comparison of knowledge and psychological well-being between patients with a short disease duration (≤ 1 year) and patients with more established rheumatoid arthritis (≥ 10 years duration). Patient Educ Couns. 1999;38(3):195-203.
- 23. Belza BL, Henke CJ, Yelin EH, Epstein WV, Gilliss CL. Correlates of fatigue in older adults with rheumatoid arthritis. Nurs Res. 1993;42(2):93-99.
- 24. Huyser BA, Parker JC, Thoreson R, Smarr KL, Johnson JC, Hoffman R. Predictors of subjective fatigue among individuals with rheumatoid arthritis. Arthritis Rheum. 1998;41(12):2230-2234.
- 25. Pollard L, Choy E, Gonzalez J, Khoshaba B, Scott D. Fatigue in rheumatoid arthritis reflects pain, not disease activity. Rheumatology. 2006;45(7):885-889.
- 26. Fifield J, McQuillan J, Tennen H, Sheehan TJ, Reisine S, Hesselbrock V, et al. History of affective disorder and the temporal trajectory of fatigue in rheumatoid arthritis. Ann Behav Med. 2001;23(1):34-41.
- 27. Scharloo M, Kaptein A, Weinman J, Hazes J, Breedveld F, Rooijmans H. Predicting functional status in patients with rheumatoid arthritis. J Rheumatol. 1999;26(8):1686-1693.
- 28. Nikolaus S, Bode C, Taal E, van de Laar MA. Fatigue and factors related to fatigue in rheumatoid arthritis: a systematic review. Arthritis Care Res. 2013;65(7):1128-1146.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Fizyoterapi, Rehabilitasyon |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Yayımlanma Tarihi | 25 Nisan 2025 |
| Gönderilme Tarihi | 27 Mayıs 2024 |
| Kabul Tarihi | 1 Ağustos 2024 |
| Yayımlandığı Sayı | Yıl 2025 Cilt: 16 Sayı: 1 |
