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Synthesis, Characterization and Investigation of Some Photophysical Properties of Novel Benzothiazole Based Pyridine Derivative

Yıl 2025, Cilt: 14 Sayı: 2, 220 - 224, 27.06.2025

Hülya Elmalı Gülbaş

https://doi.org/10.46810/tdfd.1585498

Öz

Benzotiyazol ve türevleri, heterosiklik yapıları nedeniyle kimyasal, biyolojik ve farmakolojik reaksiyonlarda önemli rol oynamaktadır. Bu çalışmada, floresan aktif yeni benzotiyazol substitue pikolinoil klorür türevi 6-((2-(benzotiyazol-2il)fenil)karbamoil)pikolinoil klorür (BTPCP) başarıyla sentezlenmiş ve karakterize edilmiştir. Sentezlenen BTPCP’nin molekül yapısı klasik spektroskopik yöntemler (FT-IR, 1H-NMR ve 13C-NMR) kullanılarak belirlenmiştir. BTPCP’nin fotofiziksel özellikleri Uv-Vıs Spektrofotometresi ve Flouresence Spektrofotometresi kullanılarak incelenmiştir. Yapılan incelemeler sonucunda benzotiyazol substitue pikolinoil klorür türevi BTPCP floresans aktivitesi gösterdiği belirlenmiştir. Yeni floresans aktif BTPCP'nin sensör çalışmaları başta olmak üzere, farklı biyolojik ve farmakolojik çalışmalarda uygulama bulması beklenmektedir.

Anahtar Kelimeler

Benzotiyazol Floresans Pikolinoil Klorür Türevi Organik Sentez Spektroskopik Analiz

Kaynakça

  • J.H. Wang, M. Li, D. Li, Chem. Sci. 4 (2013) 1793–1801.
  • M.K. Amini, B. Khezri, A.R. Firooz, Sensor Actuat B-Chem. 131 (2008) 470–478.
  • A.D. McFarland, R.P.V. Duyne, Nano Lett. 3 (2003) 1507–1511.
  • H.S. Jung, M.S. Park, J.H. Han, J.H. Lee, C. Kang, J.H. Jung, J.S. Kim, Chem. Commun. 48 (2012) 5082–5084
  • K.R. Dalton, M. J. Orr, A. J. Kwong, K. K. Deibler, H. H. Munshi, C. S. Bridges, T. J. Chen, X. Zhang, H. D. Lacorazza, K.A. Scheidt, ACS Medicinal Chemistry Letters 2023 14 (5), 606-613.
  • J.P. Vacca, J.P. Maxwell, B. Williams, J.H. Come, S. Throner, World Intellectual Property Organization, WO2023064586 A1 2023-04-20 | Language: English, Database: Caplus ESPACENET
  • J. Ling, J. Liu, World Intellectual Property Organization, WO2014183300 A1 2014-11-20 | Language: English, Database: CAplus ESPACENET
  • Ge, H. Zhang, P. Wang, Chem. Soc. Rev. 40 (2011) 3483–3495; L.-J. Fan, Y. Zhang, C.B. Murphy, S.E. Angell, M.F.L. Parker, B.R. Flynn, W.E. Jones Jr., Coord. Chem. Rev. 253 (2009) 410–422.
  • E. Hrishikesan, C. Saravanan, P. Kannan, Ind. Eng. Chem. Res. 50 (2011) 8225– 8229.
  • J. Chan, S.C. Dodani, C.J. Chang, Nat. Chem. 4 (2012) 973–984.
  • Q. Zou, H. Tian, Sensor Actuat. B-Chem. 149 (2010) 20–27.
  • X. Zhang, Y. Shiraishi, T. Hirai, Tetrahedron Lett. 48 (2007) 5455–5459.
  • A. Misra, M. Shahid, J. Phys. Chem. C 114 (2010) 16726–16739.
  • H. E. Gülbaş, S. Bozkurt, E. Halay, J. Heterocycl. Chem. 2023, 60(7), 1223.
  • O. A. Bozdemir, R. Guliyev, O. Buyukcakir, S. Selcuk, S. Kolamen,G. Gulseren, D. Nalbantoglu, H. Boyaci, E.U. Akkaya, Journal of the American Chemical Society, 132 (2010), 8029-8036.
  • F.D. Natale, A. Lancia, A. Molino, M.D. Natale, D. Karatza, D. Musmarra, J. Hazard. Mater. 132 (2006), 220–225
  • A. Renzoni, F. Zino, E. Franchi, Environ. Res. A 77 (1998) 68–72.
  • J.M. Benoit, W.F. Fitzgerald, A.W.H. Damman, Environ. Res. A 78 (1998) 118–133.
  • J. H. Wanga, Y. M. Liub, Z. M. Donga, J. B. Chaob, H. Wang, Y. Wanga, Journal of Hazardous Materials 382 (2020) 121056
  • S. Das, H. K. Indurthi, P. Asati, P. Saha, D. K. Sharma, Dyes and Pigments 199 (2022) 110074.
  • G. Dhaka, J. Singh, N. Kaur, Inorganica Chimica Acta 462 (2017), 152–157.
  • R. Hussain, M. Ashraf, S. Khan, F. Rahim, W. Rehman, M. Taha, A. Sardar, Y. Khan, I. Khan, S.A.A. Shah, J. Mol. Struct. 1295 (2024) 136582.
  • A. Sardar, O-ur-R. Abid, S. Daud, B.A. Shah, W. Shahid, M. Ashraf, M. Fatima, S. Ezzine, A.Shareef A.Wadood, H.A. Al-Ghulikah, S.A. Alissa, Arab. J. Chem. 15 (2022) 104300.
  • A.K. Jain, S. Sharma, A. Vaidya, V. Ravichandran, R.K. Agrawal, Chem. Biol. Drug Des. 81 (2013) 557–576.
  • Md. Mohasin, Z. Alam, S. Ahmad ,U. Salma , Q. Ullah , S. A. Khan, J.Mol.Struc.,1336 (2025), 142034.
  • G.C. Santos, Y.G. Kappenberg, J.M. Rosa, A. Ketzer, M.A. Martins, G. Banacorsa, J. Photochem. Photobiol., A 444, (2023), 114900.
  • T. Jabeen S. Aslam M. Yaseen, M.J. Saif, M. Ahmad, S.A. Al-Hussain M.E.A. Zaki, J. Saudi Chem. Soc. 27 (2023) 101679.
  • Y. Khan, S. Khan, R. Hussain, A. Maalik, W. Rehman, M.W. Attwa, R. Masood, H. W. Darwish, H.A. Ghabbour, Pharmaceuticals, (Basel) 16 (2023) 1650.
  • A. Khamitova, D. Berillo, A. Lozynskyi, Y. Konechnyi, D. Mural, V. Georgiyants, R. Lesyk, Mini. Rev. Med. Chem. 24 (2024).

Synthesis, Characterization and Investigation of Some Photophysical Properties of Novel Benzothiazole Based Pyridine Derivative

Yıl 2025, Cilt: 14 Sayı: 2, 220 - 224, 27.06.2025

Hülya Elmalı Gülbaş

https://doi.org/10.46810/tdfd.1585498

Öz

Benzothiazole and its derivates have been play important role in chemical, biological and pharmacological reactions due to its heterocyclic structure. In this study, fluorescent active novel benzothiazole substitute picolinoyl chloride derivate 6-((2-(benzothiazol-2 yl)phenyl)carbamoyl)picolinoyl chloride (BTPCP) successfully synthesized and characterized. Its structure was identified by classic spectroscopic methods (FT-IR, 1H-NMR and 13C-NMR). Its photophysical properties was investigated by using UV-Vis Spectrophotometer and Fluorescence Spectrophotometer. Benzothiazole substitute picolinoyl chloride derivate (BTPCP) has been shown fluorescence activity The novel fluorescence active BTPCP is expected to find application in especially sensor, different biological and pharmacological studies.

Anahtar Kelimeler

Benzothiazole picolinoyl chloride fluorescence organic synthesis spectroscopic analysis

Etik Beyan

The author declares that there no conflict of interests.

Teşekkür

Assoc. Prof. Dr. Selahattin BOZKURT is gratefully acknowledged for helpful suggestions

Kaynakça

  • J.H. Wang, M. Li, D. Li, Chem. Sci. 4 (2013) 1793–1801.
  • M.K. Amini, B. Khezri, A.R. Firooz, Sensor Actuat B-Chem. 131 (2008) 470–478.
  • A.D. McFarland, R.P.V. Duyne, Nano Lett. 3 (2003) 1507–1511.
  • H.S. Jung, M.S. Park, J.H. Han, J.H. Lee, C. Kang, J.H. Jung, J.S. Kim, Chem. Commun. 48 (2012) 5082–5084
  • K.R. Dalton, M. J. Orr, A. J. Kwong, K. K. Deibler, H. H. Munshi, C. S. Bridges, T. J. Chen, X. Zhang, H. D. Lacorazza, K.A. Scheidt, ACS Medicinal Chemistry Letters 2023 14 (5), 606-613.
  • J.P. Vacca, J.P. Maxwell, B. Williams, J.H. Come, S. Throner, World Intellectual Property Organization, WO2023064586 A1 2023-04-20 | Language: English, Database: Caplus ESPACENET
  • J. Ling, J. Liu, World Intellectual Property Organization, WO2014183300 A1 2014-11-20 | Language: English, Database: CAplus ESPACENET
  • Ge, H. Zhang, P. Wang, Chem. Soc. Rev. 40 (2011) 3483–3495; L.-J. Fan, Y. Zhang, C.B. Murphy, S.E. Angell, M.F.L. Parker, B.R. Flynn, W.E. Jones Jr., Coord. Chem. Rev. 253 (2009) 410–422.
  • E. Hrishikesan, C. Saravanan, P. Kannan, Ind. Eng. Chem. Res. 50 (2011) 8225– 8229.
  • J. Chan, S.C. Dodani, C.J. Chang, Nat. Chem. 4 (2012) 973–984.
  • Q. Zou, H. Tian, Sensor Actuat. B-Chem. 149 (2010) 20–27.
  • X. Zhang, Y. Shiraishi, T. Hirai, Tetrahedron Lett. 48 (2007) 5455–5459.
  • A. Misra, M. Shahid, J. Phys. Chem. C 114 (2010) 16726–16739.
  • H. E. Gülbaş, S. Bozkurt, E. Halay, J. Heterocycl. Chem. 2023, 60(7), 1223.
  • O. A. Bozdemir, R. Guliyev, O. Buyukcakir, S. Selcuk, S. Kolamen,G. Gulseren, D. Nalbantoglu, H. Boyaci, E.U. Akkaya, Journal of the American Chemical Society, 132 (2010), 8029-8036.
  • F.D. Natale, A. Lancia, A. Molino, M.D. Natale, D. Karatza, D. Musmarra, J. Hazard. Mater. 132 (2006), 220–225
  • A. Renzoni, F. Zino, E. Franchi, Environ. Res. A 77 (1998) 68–72.
  • J.M. Benoit, W.F. Fitzgerald, A.W.H. Damman, Environ. Res. A 78 (1998) 118–133.
  • J. H. Wanga, Y. M. Liub, Z. M. Donga, J. B. Chaob, H. Wang, Y. Wanga, Journal of Hazardous Materials 382 (2020) 121056
  • S. Das, H. K. Indurthi, P. Asati, P. Saha, D. K. Sharma, Dyes and Pigments 199 (2022) 110074.
  • G. Dhaka, J. Singh, N. Kaur, Inorganica Chimica Acta 462 (2017), 152–157.
  • R. Hussain, M. Ashraf, S. Khan, F. Rahim, W. Rehman, M. Taha, A. Sardar, Y. Khan, I. Khan, S.A.A. Shah, J. Mol. Struct. 1295 (2024) 136582.
  • A. Sardar, O-ur-R. Abid, S. Daud, B.A. Shah, W. Shahid, M. Ashraf, M. Fatima, S. Ezzine, A.Shareef A.Wadood, H.A. Al-Ghulikah, S.A. Alissa, Arab. J. Chem. 15 (2022) 104300.
  • A.K. Jain, S. Sharma, A. Vaidya, V. Ravichandran, R.K. Agrawal, Chem. Biol. Drug Des. 81 (2013) 557–576.
  • Md. Mohasin, Z. Alam, S. Ahmad ,U. Salma , Q. Ullah , S. A. Khan, J.Mol.Struc.,1336 (2025), 142034.
  • G.C. Santos, Y.G. Kappenberg, J.M. Rosa, A. Ketzer, M.A. Martins, G. Banacorsa, J. Photochem. Photobiol., A 444, (2023), 114900.
  • T. Jabeen S. Aslam M. Yaseen, M.J. Saif, M. Ahmad, S.A. Al-Hussain M.E.A. Zaki, J. Saudi Chem. Soc. 27 (2023) 101679.
  • Y. Khan, S. Khan, R. Hussain, A. Maalik, W. Rehman, M.W. Attwa, R. Masood, H. W. Darwish, H.A. Ghabbour, Pharmaceuticals, (Basel) 16 (2023) 1650.
  • A. Khamitova, D. Berillo, A. Lozynskyi, Y. Konechnyi, D. Mural, V. Georgiyants, R. Lesyk, Mini. Rev. Med. Chem. 24 (2024).
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Analitik Spektrometri, Enstrümantal Yöntemler, Sensör Teknolojisi
Bölüm Makaleler
Yazarlar

Hülya Elmalı Gülbaş 0000-0002-6041-6054

Yayımlanma Tarihi 27 Haziran 2025
Gönderilme Tarihi 14 Kasım 2024
Kabul Tarihi 31 Mayıs 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 14 Sayı: 2

Kaynak Göster

APA Elmalı Gülbaş, H. (2025). Synthesis, Characterization and Investigation of Some Photophysical Properties of Novel Benzothiazole Based Pyridine Derivative. Türk Doğa Ve Fen Dergisi, 14(2), 220-224. https://doi.org/10.46810/tdfd.1585498
AMA Elmalı Gülbaş H. Synthesis, Characterization and Investigation of Some Photophysical Properties of Novel Benzothiazole Based Pyridine Derivative. TDFD. Haziran 2025;14(2):220-224. doi:10.46810/tdfd.1585498
Chicago Elmalı Gülbaş, Hülya. “Synthesis, Characterization and Investigation of Some Photophysical Properties of Novel Benzothiazole Based Pyridine Derivative”. Türk Doğa Ve Fen Dergisi 14, sy. 2 (Haziran 2025): 220-24. https://doi.org/10.46810/tdfd.1585498.
EndNote Elmalı Gülbaş H (01 Haziran 2025) Synthesis, Characterization and Investigation of Some Photophysical Properties of Novel Benzothiazole Based Pyridine Derivative. Türk Doğa ve Fen Dergisi 14 2 220–224.
IEEE H. Elmalı Gülbaş, “Synthesis, Characterization and Investigation of Some Photophysical Properties of Novel Benzothiazole Based Pyridine Derivative”, TDFD, c. 14, sy. 2, ss. 220–224, 2025, doi: 10.46810/tdfd.1585498.
ISNAD Elmalı Gülbaş, Hülya. “Synthesis, Characterization and Investigation of Some Photophysical Properties of Novel Benzothiazole Based Pyridine Derivative”. Türk Doğa ve Fen Dergisi 14/2 (Haziran 2025), 220-224. https://doi.org/10.46810/tdfd.1585498.
JAMA Elmalı Gülbaş H. Synthesis, Characterization and Investigation of Some Photophysical Properties of Novel Benzothiazole Based Pyridine Derivative. TDFD. 2025;14:220–224.
MLA Elmalı Gülbaş, Hülya. “Synthesis, Characterization and Investigation of Some Photophysical Properties of Novel Benzothiazole Based Pyridine Derivative”. Türk Doğa Ve Fen Dergisi, c. 14, sy. 2, 2025, ss. 220-4, doi:10.46810/tdfd.1585498.
Vancouver Elmalı Gülbaş H. Synthesis, Characterization and Investigation of Some Photophysical Properties of Novel Benzothiazole Based Pyridine Derivative. TDFD. 2025;14(2):220-4.
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